Although the electroencephalogram - discovered more than a century ago - has been used for years as a non-invasive diagnostic tool, it is still poorly understood. In this book, John Barlow describes an ingenious new hypothesis for a comprehensive model of the EEG that is able to emulate a large variety of known EEG patterns with few variables.In contrast to previous hypotheses and models which have treated only selected EEG patterns (rhythmic activity such as alpha activity and sleep spindles seen largely as "filtered noise," or irregular activity, or certain types of epileptiform activity such as spikes) this approach, which is based on an oscillator with two separate input modulations of the extremes and the slopes of waves, covers all types of EEG patterns, and stems from specific features of the EEG itself rather than from arbitrary signals.Barlow describes the hypothesis in detail, then tests predictions for normal and abnormal EEGs with the aid of a hardware model and with specially developed methods of analysis. The hypothesis is further evaluated in the light of extensive reviews of other EEG models and methods of analysis and of the underlying anatomy, physiology, and pathophysiology of cerebral electrical activity. A technological section details the hardware model and the methodology for testing the hypothesis. Appendixes present some new approaches to traditional methods of EEG analysis and artifact minimization, areas in which Barlow has achieved international recognition.John S. Barlow, M.D., is a Neurophysiologist in the Neurology Service at Massachusetts General Hospital, Senior Research Associate in Neurology (Neurophysiology) at Harvard Medical School, and a Research Affiliate in the Research Laboratory of Electronics at the Massachusetts Institute of Technology.
This much-awaited final volume of The Birds of British Columbia completes what some have called one of the most important regional ornithological works in North America. It is the culmination of more than 25 years of effort by the authors who, with the assistance of thousands of dedicated volunteers throughout the province, have created the basic reference work on the avifauna of British Columbia.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
An Economic History of Malaysia, c.1800-1990 , provides the first general history of the Malaysian economy over the past two centuries, including a survey of the pre-colonial era. A unique feature is that it integrates the historical experiences of Peninsular Malaysia, Sabah and Sarawak as a case study in the onset of modern economic growth. Particular attention is paid to explaining Malaysia's signal success in achieving a relatively smooth shift away from the primary commodity export economy of the colonial period to near-NIC status by 1990.
Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. - Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. - Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. - Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. - Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. - Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. - Discusses today's key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.
This issue of Surgical Clinics of North America focuses on Cardiothoracic Surgery, and is edited by Dr. John H. Braxton. Articles will include: Review of ICU Management of the Cardiac and Thoracic Surgery Patient and the Team Approach; Minimally Invasive and Robotically Assisted Cardiac Surgery; Surgical Treatment of Heart Failure; The Changing Face of the Cardiothoracic Surgical Team; Thoracic Trauma and Management; Minimally Invasive and Robotically Assisted Thoracic Surgery; The Impact on Less Invasive Surgery on Esophageal Diseases; Lung Cancer Screening and its Impact of Surgical Volume; The Surgical Treatment of Coronary Artery Occlusive Disease: Modern Treatment Strategies for an Age Old Problem; Transcutaneous Valve Repair and Update; Robotic Lobectomy and Segmentectomy: Technical Details and Results; Diagnostic Imaging and Newer Modalities for Thoracic Diseases: PET Imaging and EBUS for Staging and its Implication for Lung Cancer; Mitral Valve Repair: French Correction vs. American Correction; Cardiac Screening in the Noncardiac Surgery Patient; and more!
With a user-friendly A to Z layout, this volume contains 1,200 entries on the men and women who have influenced the course of Christian history. Founding fathers, monarchs, Popes, saints, philanthropists, heretics, theologians, and missionaries are profiled with detailed bibliographic information on each prominent figure. Glossary and Chronological table.
New Techniques in Metabolic Bone Disease presents reviews of the major metabolic bone diseases and the advancement in the techniques used in both research and practice. The text particularly focuses on diagnostic, assessment, and measurement concerns and methodologies such as humoral and local factors affecting bone formation and resorption; photon absorptiometric techniques for measurement of bone mass; and computerized axial tomography scanning. The book will be of great use to both researchers and practitioners of medical fields concerned with bone disease, such as orthopedics.
This textbook considers the physical, social and economic aspects of the global climate system, through readable accounts of recent in climatology. Chapters contain essays by respected specialists in the field to enhance the understanding of selected topics. It is invaluable to advanced students of climatology and atmospheric science.
Written by leading scholars, this collection provides a comprehensive and authoritative overview of modern empires. Spanning the era of modern imperial history from the early sixteenth century to the present, it challenges both the rather insular focuses on specific experiences, and gives due attention to imperial formations outside the West including the Russian, Japanese, Mughal, Ottoman and Chinese. The companion is divided into three broad sections. Part I - Times - surveys the three main eras of modern imperialism. The first was that dominated by the settlement impulse, with migrants - many voluntarily and many more by force - making new lives in the colonies. This impulse gave way, most especially in the nineteenth century, to a period of busy and rapid expansion which was less likely to promote new settlement, and in which colonists more frequently saw their sojourn in colonial lands as temporary and related to the business mostly of governance and trade. Lastly, in the twentieth century in particular, empires began to fail and to fall. Part II - Spaces - studies the principal imperial formations of the modern world. Each chapter charts the experience of a specific empire while at the same time placing it within the complex patterns of wider imperial constellations. The individual chapters thus survey the broad dynamics of change within the empires themselves and their relationships with other imperial formations, and reflect critically on the ways in which these topics have been approached in the literature. In Part III - Themes - scholars think critically about some of the key features of imperial expansion and decline. These chapters are brief and many are provocative. They reflect the current state of the field, and suggest new lines of inquiry which may follow from more comparative perspectives on empire. The broad range of themes captures the vitality and diversity of contemporary scholarship on questions of empire and colonialism, encompassing political, economic and cultural processes central to the formation and maintenance of empires as well as institutions, ideologies and social categories that shaped the lives both of those implementing and those experiencing the force of empire. In these pages the reader will find the slave and the criminal, the merchant and the maid, the scientist and the artist alongside the structures which sustained their lives and their livelihoods. Overall, the companion emphasises the diversity of imperial experience and process. Comprehensive in its scope, it draws attention to the particularities of individual empires, rather than over-generalising as if all empires, at all times, and in all places, behaved in a similar manner. It is this contingent and historical specificity that enables us to explore in expansive ways precisely what constituted the modern empire.
Molecular Sensors and Nanodevices: Principles, Designs and Applications in Biomedical Engineering, Second Edition is designed to be used as a foundational text, aimed at graduates, advanced undergraduates, early-career engineers and clinicians. The book presents the essential principles of molecular sensors, including theories, fabrication techniques and reviews. In addition, important devices and recently, highly-cited research outcomes are also cited. This differentiates the book from other titles on the market whose primary focus is more research-oriented and aimed at more of a niche market. - Covers the fundamental principles of device engineering and molecular sensing, sensor theories and applications in biomedical science and engineering - Introduces nano/micro fabrication techniques, including MEMS, bioMEMS, microTAS and nanomaterials science that are essential in the miniaturization of versatile molecular sensors - Explores applications of nanomaterials and biomaterials, including proteins, DNAs, nanoparticles, quantum dots, nanotubes/wires and graphene in biomedicine
Written for new and existing managers, undergraduate and postgraduate students of the public services, this essential text book explores the meaning and significance of financial management for the public services, in a way which combines both theoretical arguments and practical applications. Written for the non-specialist, it: examines the economics of public services considers the extent to which the management of public services has actually changed in practice explains the meaning and applicability of financial management tools including those relating to budgets and capital investment presents original work on the issue of audit expectations presents case studies on the problems which can arise when traditional concerns on probity and stewardship are neglected considers the benefits and problems of measuring performance in the public services includes specific chapters on financial management in health services and local government.
This most widely used textbook in the field has been thoroughly revised and updated to reflect changes in the health care industry and the renewed focus on health care information technology initiatives. Two new chapters cover Federal efforts to enhance quality of patient care through the use of health care information technology and strategy considerations. Additionally, reflecting the increased focus on global health, the book features an international perspective on health care information technology. Case studies of organizations experiencing management-related information system challenges have been updated and several new cases have been added. These reality-based cases are designed to stimulate discussion among students and enable them to apply concepts in the book to real-life scenarios. The book's companion Web site features lecture slides, a test bank, and other materials to enhance students' understanding.
Solid Freeform Fabrication is a set of manufacturing processes that are capable of producing complex freeform solid objects directly from a computer model of an object without part-specific tooling or knowledge. In essence, these methods are miniature manufacturing plants which come complete with material handling, information processing and materials processing. As such, these methods require technical knowledge from many disciplines; therefore, researchers, engineers, and students in Mechanical, Chemical, Electrical, and Manufacturing Engineering and Materials and Computer Science will all find some interest in this subject. Particular subareas of concern include manufacturing methods, polymer chemistry, computational geometry, control, heat transfer, metallurgy, ceramics, optics, and fluid mechanics. History of technology specialists may also find Chapter 1 of interest. Although this book covers the spectrum of different processes, the emphasis is clearly on the area in which the authors have the most experience, thermal laser processing. In particular, the authors have all been developers and inventors of techniques for the Selective Laser Sintering process and laser gas phase techniques (Selective Area Laser Deposition). This is a research book on the subject of Solid Freeform Fabrication.
Covering more than 250 of the most common dermatologic conditions from A to Z, Treatment of Skin Disease, 5th Edition, by Drs. Mark G. Lebwohl, Warren R. Heymann, John Berth-Jones, and Ian Coulson, is your go-to resource for authoritative, evidence-based treatment strategies in your daily practice. This award-winning text provides guidance on the fast-moving dermatological therapy options for virtually any skin disease you’re likely to encounter, including third-line and unusual therapies when initial options have not been successful. Summaries of each treatment strategy are accompanied by detailed discussions of treatment choices, with ratings on a consistent scale ranging from clinical studies to anecdotal reports. Puts every possible therapeutic option at your disposal – including management strategies and first- to third-line therapies – for a truly complete guide to the vast array of dermatologic treatment options. Presents information in a consistent, tabular format, with checklists of diagnostic and investigative pearls and color-coded boxes for quick reference. Offers the combined knowledge and expertise of the world’s leading authorities in dermatology. Features eight all-new chapters on Atypical Fibroxanthoma, Confluent and Reticulated Papillomatosis, Cryopyrin Associated Periodic Syndromes (CAPS), Hypopigmented Dermatoses, Nail Psoriasis, Necrolytic Acral Erythema, Post-inflammatory Hyperpigmentation, and Regional Pain. Provides more than 250 full-color clinical images of skin diseases, most of which are new to this edition. Includes off-label uses, new treatments like therapeutic antibodies and hedgehog inhibitors, and new indications for existing treatments.
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