A comprehensive review of current research on synaptic plasticity. The traditional model of synapses as fixed structures has been replaced by a dynamic one in which synapses are constantly being deleted and replaced. This book, written by a leading researcher on the neurochemistry of schizophrenia, integrates material from neuroscience and cell biology to provide a comprehensive account of our current knowledge of the neurochemical basis of synaptic plasticity. The book presents the evidence for synaptic plasticity, an account of the dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the biochemical basis of the Hebbian synapse. It discusses the role of endocytosis, special proteins, and local protein synthesis. Additional topics include volume transmission, arachidonic acid signaling, hormonal modulation, and psychological stress. Finally, the book considers pharmacological and clinical implications of current research, particularly with reference to schizophrenia and Alzheimer's disease.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
Singing has been a characteristic behaviour of humanity across several millennia. Chorus America (2009) estimated that 42.6 million adults and children regularly sing in one of 270,000 choruses in the US, representing more than 1:5 households. Similarly, recent European-based data suggest that more than 37 million adults take part in group singing. The Oxford Handbook of Singing is a landmark text on this topic. It is a comprehensive resource for anyone who wishes to know more about the pluralistic nature of singing. In part, the narrative adopts a lifespan approach, pre-cradle to senescence, to illustrate that singing is a commonplace behaviour which is an essential characteristic of our humanity. In the overall design of the Handbook, the chapter contents have been clustered into eight main sections, embracing fifty-three chapters by seventy-two authors, drawn from across the world, with each chapter illustrating and illuminating a particular aspect of singing. Offering a multi-disciplinary perspective embracing the arts and humanities, physical, social and clinical sciences, the book will be valuable for a broad audience within those fields.
Human Resource Management: Functions, Applications, and Skill Development, Second Edition, featuring the 2013 Society for Human Resource Management (SHRM) Human Resource Curriculum Guide, explores important HRM concepts and functions with a strong emphasis on skill development, critical thinking, and application. In this fully-revised edition, all 210 required SHRM topics are noted within the chapter content as Robert N. Lussier and John Hendon prepare students to develop HRM skills they can use in their personal and professional lives. Students stay engaged through a wide variety of activities and tools that allow them to immediately apply HR functions and concepts.
Fundamentals of Human Resource Management: Functions, Applications, Skill Development helps students of all majors build the skills they need to recruit, select, train, and develop employees. Bestselling authors Robert N. Lussier and John R. Hendon explore the important strategic function HR plays in today′s organizations. A wide variety of applications, self-assessments, and experiential exercises keep students engaged and help them see the relevancy of HR as they learn skills they can use in their personal and professional lives. The Second Edition includes 13 new case studies and new coverage of the agile workplace, generational differences, gamification, social media, and diversity and inclusion. This title is accompanied by a complete teaching and learning package.
Includes 3 charts, 7 tables and 137 photos December 7, 1941, was by any assessment a devastating day. The Hawaiian Air Force suffered a crippling blow, but the genesis of recovery and final victory over the enemy emerged in the valor of those who weathered the onslaught and fought back with everything they had. In the 50 years since then, the attack has become a faded memory for some and to many members of the younger generation just another moment in history. It deserves better understanding and commemoration, however, for this sudden, damaging strike on our forces marked the beginning of America's involvement in a terrible global war that was massive in scope and destruction. At Hickam Air Force Base, reminders of the attack are still visible. The tattered flag that flew over the base that fateful morning is encased and on display in the lobby of the Pacific Air Forces Headquarters building, where bullet-scarred walls serve as a constant reminder to never again be caught unprepared. Memorial tablets surrounding the base flagpole pay tribute to those who sacrificed their lives for our country. Our predecessors, with their blood and sweat, boldly wrote a major chapter of our military history. We must never forget their story and the legacy of their experience--that the price of freedom is eternal vigilance and readiness.
This state-of-the-art Handbook provides a comprehensive understanding and assessment of the field of global supply chain management (GSCM). Editors John T. Mentzer, Matthew B. Myers, and Theodore P. Stank bring together a distinguished group of contributors to describe and critically examine the key perspectives guiding GSCM, taking stock of what we know (and do not know) about them.
With chapters revolving around practical issues and real-world contexts, this Handbook offers much-needed insights into the ethics of primary healthcare. An international set of contributors from a broad range of areas in ethics and practice address a challenging array of topics. These range from the issues arising in primary care interactions, to working with different sources of vulnerability among patients, from contexts connected with teaching and learning, to issues in relation to justice and resources. The book is both interdisciplinary and inter-professional, including not just ‘standard’ philosophical clinical ethics but also approaches using the humanities, clinical empirical research, management theory and much else besides. This practical handbook will be an invaluable resource for anyone who is seeking a better appreciation and understanding of the ethics ‘in’, ‘of’ and ‘for’ primary healthcare. That includes clinicians and commissioners, but also policymakers and academics concerned with primary care ethics. Readers are encouraged to explore and critique the ideas discussed in the 44 chapters; whether or not readers agree with all the authors’ views, this volume aims to inform, educate and, in many cases, inspire. Chapter 4 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution (CC-BY) 4.0 license.
Here is a comprehensive and practical guide to using the Five Element model in your daily life in ways that can improve your physical health, foster mental ease and clarity, create more emotional balance, and bring you closer to spirit. Having introduced the philosophical and practical principles of the Five Elements, the author invites you to 'live the book', immersing yourself in the many aspects of each Element during its corresponding season. He offers a range of methods of doing this, including activities such as movement, cooking, gardening, journaling, visualisation, meditation, dialogue and self-acupressure. In working with each Element, he explores the three levels or expressions of human life - the physical (structures, organs, tissues and systems), the psycho-emotional (thoughts, beliefs, self-images, emotions and reactions), and the spirit. Detailed information is provided on each Element's specific attributes, associations, resonances and gifts, and anatomical illustrations are included for further guidance. An invaluable reference book for practitioners and students of Chinese Medicine who hope to become better practitioners to others, the book also provides the means to become a practitioner to yourself.
Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient's health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you're concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. - An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. - Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. - The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. - The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. - Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. - Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. - Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. - New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. - A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. - An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. - Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.
This IBM® Redpaper publication describes IBM Spectrum® LSF® Suite best practices installation topics, application checks for workload management, and high availability configurations by using theoretical knowledge and hands-on exercises. These findings are documented by way of sample scenarios. This publication addresses topics for sellers, IT architects, IT specialists, and anyone who wants to implement and manage a high-performing workload management solution with LSF. Moreover, this guide provides documentation to transfer how-to-skills to the technical teams, and solution guidance to the sales team. This publication compliments documentation that is available at IBM Knowledge Center, and aligns with educational materials that are provided by IBM Systems.
Creating the Suburban School Advantage explains how American suburban school districts gained a competitive edge over their urban counterparts. John L. Rury provides a national overview of the process, focusing on the period between 1950 and 1980, and presents a detailed study of metropolitan Kansas City, a region representative of trends elsewhere. While big-city districts once were widely seen as superior and attracted families seeking the best educational opportunities for their children, suburban school systems grew rapidly in the post–World War II era as middle-class and more affluent families moved to those communities. As Rury relates, at the same time, economically dislocated African Americans migrated from the South to center-city neighborhoods, testing the capacity of urban institutions. As demographic trends drove this urban-suburban divide, a suburban ethos of localism contributed to the socioeconomic exclusion that became a hallmark of outlying school systems. School districts located wholly or partly within the municipal boundaries of Kansas City, Missouri, make for revealing cases that illuminate our understanding of these national patterns. As Rury demonstrates, struggles to achieve greater educational equity and desegregation in urban centers contributed to so-called white flight and what Senator Daniel Patrick Moynihan considered to be a crisis of urban education in 1965. Despite the often valiant efforts made to serve inner city children and bolster urban school districts, this exodus, Rury cogently argues, created a new metropolitan educational hierarchy—a mirror image of the urban-centric model that had prevailed before World War II. The stubborn perception that suburban schools are superior, based on test scores and budgets, has persisted into the twenty-first century and instantiates today's metropolitan landscape of social, economic, and educational inequality.
This introductory text explores the historical origins of the main legal institutions that came to characterize the Anglo-American legal tradition, and to distinguish it from European legal systems. The book contains both text and extracts from historical sources and literature. The book is published in color, and contains over 250 illustrations, many in color, including medieval illuminated manuscripts, paintings, books and manuscripts, caricatures, and photographs. Two great themes dominate the book: (1) the origins, development, and pervasive influence of the jury system and judge/jury relations across eight centuries of Anglo-American civil and criminal justice; and (2) the law/equity division, from the emergence of the Court of Chancery in the fourteenth century down through equity's conquest of common law in the Federal Rules of Civil Procedure. The chapters on criminal justice explore the history of pretrial investigation, policing, trial, and sentencing, as well as the movement in modern times to nonjury resolution through plea bargaining. Considerable attention is devoted to distinctively American developments, such as the elective bench, and the influence of race relations on the law of criminal procedure. Other major subjects of this book include the development of the legal profession, from the serjeants, barristers, and attorneys of medieval times down to the transnational megafirms of twenty-first century practice; the literature of the law, especially law reports and treatises, from the Year Books and Bracton down to the American state reports and today's electronic services; and legal education, from the founding of the Inns of Court to the emergence and growth of university law schools in the United States.
Attention Baby Boomers! Have you wondered what you want to be when you retire? Where you want to live? And how to do it all? In “The Best of Our Lives: Sharing the Secrets of a Healthy and Happy Retired Life,” authors Trisha and John Parker, a married couple going through the retirement process themselves, present current research, expert advice, and personal insights into the joys and challenges of retired life. The Parkers provide useful professional recommendations along with their unique solutions, suggestions, and experiences regarding topics such as managing retirement finances, attaining mental and physical health, planning budget travel, starting second careers, and making a home safe for the retirement years. Several helpful original checklists and forms are included to assist the reader in making an informed and painless transition to retired life. Written in an honest and conversational style, The Best of Our Lives reflects the authors' passion for life, family, and friends.
Guidance to help you grasp even the most complex network structures and signaling protocols The Second Edition of Signaling in Telecommunication Networks has been thoroughly updated, offering new chapters and sections that cover the most recent developments in signaling systems and procedures. This acclaimed book covers subscriber and network signaling in both fixed and mobile networks. Coverage begins with an introduction to circuit-switched telephone networks, including an examination of trunks, exchanges, access systems, transmission systems, and other basic components. Next, the authors introduce signaling concepts, beginning with older Channel Associated Signaling (CAS) systems and progressing to today's Common Channel Signaling (CCS) systems. The book then examines packet networks and their use in transmitting voice (VoIP), TCP/IP protocols, VoIP signaling protocols, and ATM protocols. Throughout the book, the authors emphasize functionality, particularly the roles of individual protocols and how they fit in network architectures, helping readers grasp even the most complex network structures and signaling protocols. Highlights of the Second Edition include: Coverage of the latest developments and topics, including new chapters on access networks, intelligent network application part, signaling for voice communication in packet networks, and ATM signaling Drawings and tables that help readers understand and visualize complex systems Comprehensive, updated references for further study Examples to help readers make the bridge from theory to application With the continued growth and expansion of the telecommunications industry, the Second Edition is essential reading for telecommunications students as well as anyone involved in this dynamic industry needing a solid understanding of the different signaling systems and how they work. Moreover, the book helps readers wade through the voluminous and complex technical standards by providing the essential structure, terminology, and functionality needed to understand them.
John M. Findlay presents a historical overview of the American West between 1940 and 2000, arguing that during the years of U.S. mobilization for World War II and the Cold War, the West remained a significant and distinctive region.
“Lakes is my favorite kind of natural history: meticulously researched, timely, comprehensive, and written with imagination and verve.”—Jerry Dennis, author of The Living Great Lakes Lakes might be the most misunderstood bodies of water on earth. And while they may seem commonplace, without lakes our world would never be the same. In this revealing look at these lifegiving treasures, John Richard Saylor shows us just how deep our connection to still waters run. Lakes is an illuminating tour through the most fascinating lakes around the world. Whether it’s Lake Vostok, located more than two miles beneath the surface of Antarctica, whose water was last exposed to the atmosphere perhaps a million years ago; Lake Baikal in southern Siberia, the world’s deepest and oldest lake formed by a rift in the earth’s crust; or Lake Nyos, the so-called Killer Lake that exploded in 1986, resulting in hundreds of deaths, Saylor reveals to us the wonder that exists in lakes found throughout the world. Along the way we learn all the many forms that lakes take—how they come to be and how they feed and support ecosystems—and what happens when lakes vanish.
In Guardians of the Yosemite: A Story of the First Rangers, which was first published in 1961, John W. Bingaman provides the reader with a fascinating account of the early days of park rangers, who took charge just as the U.S. Army withdrew from Yosemite. As Dr. Carl Parcher Russell puts it so succinctly, “the precedents and practices established by [the park ranger] were all-important in shaping the protection principles which characterize the present-day Ranger Department.” In the author’s own words, “the purpose in writing this book is to leave permanent records of the First Rangers who contributed so much during their long years of service, and to bridge the gap from the military to the civilian protection and administration of Yosemite National Park. “During the years of my service in Yosemite, from 1918 to 1956, I found there was very little information on the lives and activities of the First Rangers. Some of these men were still in service when I became a Ranger. However, many had died and their records were few and scattered. “In the old days, one would hear the remark, ‘It is a privilege to work for the Park Service.’ It was a privilege for me to serve thirty-eight years in the Yosemite Ranger Service, to be associated with the many fine Park people and the guardians and administrators of the National Park Service whose principal purpose was to serve loyally the cause of the parks.”
These essays examine how and why inequality affects the patterning of crime and criminal justice. They evaluate the merits of various theoretical ideas, debates, and controversies regarding crime and inequality; document the dynamics of inequality in varied crime settings; examine methodologies used in exploring the crime-inequality relationship; and set forth new research and policy agendas for future work.
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