Two areas that continue to fascinate the chemistry community are the total synthesis of complex natural products and the application of combinatorial chemistry to natural products and natural product-like molecules. This thesis outlines recent studies in both of these frontiers in chemistry. First, the daunting chemical architecture of azadirachtin has flummoxed synthetic chemists for over two decades. A recent effort was undertaken by our laboratory to create novel solutions to the overarching problem in the synthesis of azadirachtin, namely the formation of the C 8 -C14 bond. Chapter two describes our initial explorations toward C8 -C14 bond formation via organometallic chemistry. Chapter three details an enantioselective entry into the azadirachtin framework through radical chemistry and cascade reactions. This route remains our central focus in the drive toward the total synthesis of azadirachtin. Second, chapter four details a study in the application of natural product-like libraries to chemical biology. Specifically, we utilized a novel library based on a 2,2-dimethylbenzopyran scaffold to discover potent and selective agonists for the farnesoid X receptor (FXR). Finally, chapter five outlines an exploration in the technology development of privileged templates on solid support, namely indolines and indoles. Using a novel phenylselenenyl bromide resin, we were able to develop several novel solid phase syntheses of 2-methyl indolines, polycyclic indolines, 2-methyl indoles, and 2-propenyl indolines.
The most comprehensive guide to developing e-learning projects in academia and the corporate education/training available E-learning is big business: Estimated growth by 2008 of the e-learning/distance education worldwide is huge: $3.2 billion in 2002 to – $23 billion in the post-compulsory sector, and £3.6 billion to $36 billion in workforce development Maggie McVay Lynch is an international figure in e-learning and instructional design John Roecker is head of e-learning with PMI (Project Management Institute), an international membership organization of over 200,000 members in 125 countries
Rialto, California has always been a growing place. At first a charming town populated mostly by citrus growers, the city seemed to know no limits in the 1950s as Route 66 attracted more and more commuters to the area. For several years, Rialto was officially the fastest-growing city in the United States. Rialto's lush groves and towering eucalyptus windbreaks were gradually replaced by subdivisions, but the spectacular San Gabriel and San Bernardino Mountains remained.
On March 31, 1943, the musical Oklahoma! premiered and the modern era of the Broadway musical was born. Since that time, the theatres of Broadway have staged hundreds of musicals--some more noteworthy than others, but all in their own way a part of American theatre history. With more than 750 entries, this comprehensive reference work provides information on every musical produced on Broadway since Oklahoma's 1943 debut. Each entry begins with a brief synopsis of the show, followed by a three-part history: first, the pre-Broadway story of the show, including out-of-town try-outs and Broadway previews; next, the Broadway run itself, with dates, theatres, and cast and crew, including replacements, chorus and understudies, songs, gossip, and notes on reviews and awards; and finally, post-Broadway information with a detailed list of later notable productions, along with important reviews and awards.
The result of twenty-five years of research on three continents, Brecht and Company is a revolutionary portrait of one of the world's greatest theater artists -- and the people upon whom he built his reputation. A noted Brecht scholar, John Fuegi traces the evolution of Brecht's parasitic relationships and aggressive ambition through close analysis of diaries, letters, and drafts of the literary works, revealing a man who was personally dazzling, a genius at assembling and directing the plays created in his workshop, but ultimately lacking in literary stamina, for which he depended on his lovers. A landmark study about the life and times of one of the most influential figures in twentieth-century theater, Brecht and Co. will forever change our understanding of Brecht and his oeuvre. "[An] enormous, fascinating biography." -- The New Yorker "One of the most important critical studies of the century." -- New York Magazine
Introduction to heat and mass transfer for advanced undergraduate and graduate engineering students, used in classrooms for over 38 years and updated regularly. Topics include conduction, convection, radiation, and phase-change. 2019 edition.
I am now writing up some notes, but when they will be ready for publication I do not know... It will be a long time before anything is arranged in book form." These words of John Muir, written in June 1912 to a friend, proved prophetic. The journals and notes to which the great naturalist and environmental figure was referring have languished, unpublished and virtually untouched, for nearly a century. Until now. Here edited and published for the first time, John Muir's travel journals from 1911-12, along with his associated correspondence, finally allow us to read in his own words the remarkable story of John Muir's last great journey. Leaving from Brooklyn, New York, in August 1911, John Muir, at the age of seventy-three and traveling alone, embarked on an eight-month, 40,000-mile voyage to South America and Africa. The 1911-12 journals and correspondence reproduced in this volume allow us to travel with him up the great Amazon, into the jungles of southern Brazil, to snowline in the Andes, through southern and central Africa to the headwaters of the Nile, and across six oceans and seas in order to reach the rare forests he had so long wished to study. Although this epic journey has received almost no attention from the many commentators on Muir's work, Muir himself considered it among the most important of his life and the fulfillment of a decades-long dream. John Muir's Last Journey provides a rare glimpse of a Muir whose interests as a naturalist, traveler, and conservationist extended well beyond the mountains of California. It also helps us to see John Muir as a different kind of hero, one whose endurance and intellectual curiosity carried him into far fields of adventure even as he aged, and as a private person and family man with genuine affections, ambitions, and fears, not just an iconic representative of American wilderness. With an introduction that sets Muir's trip in the context of his life and work, along with chapter introductions and a wealth of explanatory notes, the book adds important dimensions to our appreciation of one of America's greatest environmentalists. John Muir's Last Journey is a must reading for students and scholars of environmental history, American literature, natural history, and related fields, as well as for naturalists and armchair travelers everywhere.
Relive the exciting early days of skiing when Snoqualmie Pass was the epicenter of the sport. Ski jumping tournaments attracted world-class competitors to Cle Elum, Beaver Lake on the Summit and the Milwaukee Ski Bowl. The Mountaineers' twenty-mile race from Snoqualmie to Stampede Pass, dubbed "the world's longest and hardest race," was a pinnacle of cross-country skiing. Alpine skiing began in private ski clubs and expanded in 1934 with the country's first municipal ski area, known as the Seattle Municipal Ski Park. And the sport peaked when the Milwaukee Ski Bowl at Hyak opened in 1938. With train access, a modern ski lodge, an overhead cable lift and free ski lessons from the Seattle Times, the Ski Bowl revolutionized local skiing. Lawyer and local ski historian John W. Lundin follows the historic tracks through the genesis of American skiing.
Endocarditis Essentials 2011 is a concise, current and practical review of the epidemiology, evaluation, treatment and prevention of infective endocarditis. Written by experts in the field, this quick reference guide provides useful information for cardiologists, residents, fellows and other clinicians interested in the clinical and pathological features of infective endocarditis.
This is the first book to concentrate on dysphagia in rare conditions those that occur infrequently or those that may occur more frequently but are only sometimes associated with dysphagia. Covering a wide range of conditions from progressive supranuclear palsy (PSP), through connective tissue disease, to conditions as diverse as West Nile virus the editors and expert contributors efficiently synthesize the available information to provide the essentials needed to help clinicians to perform sophisticated assessments, based on their knowledge of both the conditions and the expected swallowing signs and treatments. Each entry covers the neurology of the given condition, including the signs and symptoms, neuropathology, epidemiology and genetics. Thereafter, coverage of swallowing in each condition examines the diagnostic signs and symptoms, etiology, swallowing neuropathology, associated cognitive, linguistic, and communicative signs and symptoms, special diagnostic considerations, treatment, nutrition, hydration, and medications.
This is the first guide yet produced to the amphibians and reptiles of New York State, a large and heavily populated state that hosts a surprisingly diverse and interesting community of amphibians and reptiles. This much needed guide to the identification, distribution, natural history and conservation of the amphibians and reptiles of New York State fill a long-empty niche. The book is the first comprehensive presentation of the distributional data gathered for the New York State Amphibian and Reptile Atlas project. With more than 60,000 records compiled from 1990-1999, this extraordinary and up-to-date database provides a rich foundation for the book. This volume provides detailed narratives on the 69 species native to New York State. With a heavy emphasis on conservation biology, the book also includes chapters on threats, legal protections, habitat conservation guidelines, and conservation case studies. Also included are 67 distribution maps and 62 pages of color photographs contributed by more than 30 photographers. As a field guide or a desk reference, The Amphibians and Reptiles of New York State is indispensable for anyone interested in the vertebrate animals of the Northeast, as well as students, field researchers and natural resource professionals.
The science taught in high schools-Newton's theory of universal gravitation, basic structure of the atom, cell division, DNA replication-is accepted as the way nature works. What is puzzling is how this precisely specified knowledge could come from an intellectual process-the scientific method-that has been incredibly difficult to describe or characterize with any precision. Philosophers, sociologists, and scientists have weighed in on how science operates without arriving at any consensus. Despite this confusion, the scientific method has been one of the highest priorities of science teaching in the United States over the past 150 years. Everyone agrees that high school students and the public more generally should understand the process of science, if only we could determine exactly what it is. From the rise of the laboratory method in the late nineteenth century, through the "five step" method, to the present day, John Rudolph tracks the changing attitudes, methods, and impacts of science education. Of particular interest is the interplay between various stakeholders: students, school systems, government bodies, the professional science community, and broader culture itself. Rudolph demonstrates specifically how the changing depictions of the processes of science have been bent to different social purposes in various historical periods. In some eras, learning about the process of science was thought to contribute to the intellectual and moral improvement of the individual, while in others it was seen as a way to minimize public involvement (or interference) in institutional science. Rudolph ultimately shows that how we teach the methodologies of science matters a great deal, especially in our current era, where the legitimacy of science is increasingly under attack.--
First written by Philip Stell and Arnold Maran in 1972, Stell & Maran's Textbook of Head and Neck Surgery and Oncology has been revised in both content and approach over the years to reflect the enormous progress made in the area. Now in its fifth edition, the book remains a key textbook for trainees in otolaryngology and head and neck surgery.
Here's an essential reference for anyone needing an advanced understanding of the nature and treatment of hypertension. Dr. Laragh, a pioneering clinician and scientist, demonstrates the central role of an overactive renin system for causing most hypertension. In his new book, Dr. Laragh discusses his research and its relevance to caring for everything from asymptomatic patients to hypertensive emergencies. And, he provides visit-by-visit details of his new pathophysiologically and biochemically guided treatment. The result of his work is a specific approach that makes it possible to more effectively prevent, arrest, and treat hypertension and its consequences--including congestive heart failure, myocardial infarction, kidney failure and stroke.
Ski jumping, once Washington's most popular winter sport, was introduced by Norwegian immigrants in the early twentieth century. It began at Spokane's Browne's Mountain and Seattle's Queen Anne Hill, moved to midsummer tournaments on Mount Rainier in 1917 and expanded statewide as new ski clubs formed. Washington tournaments attracted the world's best jumpers--Birger and Sigurd Ruud, Alf Engen, Sigurd Ulland and Reidar Andersen, among others. In 1941, Torger Tokle set two national distance records here in just three weeks. Regional ski areas hosted national and international championships as well as Olympic tryouts, entertaining spectators until Leavenworth's last tournament in 1978. Lawyer, historian and award-winning author John W. Lundin re-creates the excitement of this nearly forgotten ski jumping heritage.
Now long out of print, John Dunning's Tune in Yesterday was the definitive one-volume reference on old-time radio broadcasting. Now, in On the Air, Dunning has completely rethought this classic work, reorganizing the material and doubling its coverage, to provide a richer and more informative account of radio's golden age. Here are some 1,500 radio shows presented in alphabetical order. The great programs of the '30s, '40s, and '50s are all here--Amos 'n' Andy, Fibber McGee and Molly, The Lone Ranger, Major Bowes' Original Amateur Hour, and The March of Time, to name only a few. For each, Dunning provides a complete broadcast history, with the timeslot, the network, and the name of the show's advertisers. He also lists major cast members, announcers, producers, directors, writers, and sound effects people--even the show's theme song. There are also umbrella entries, such as "News Broadcasts," which features an engaging essay on radio news, with capsule biographies of major broadcasters, such as Lowell Thomas and Edward R. Murrow. Equally important, Dunning provides a fascinating account of each program, taking us behind the scenes to capture the feel of the performance, such as the ghastly sounds of Lights Out (a horror drama where heads rolled and bones crunched), and providing engrossing biographies of the main people involved in the show. A wonderful read for everyone who loves old-time radio, On the Air is a must purchase for all radio hobbyists and anyone interested in 20th-century American history. It is an essential reference work for libraries and radio stations.
(Theatre World). Theatre World, the statistical and pictorial record of the Broadway and off-Broadway season, touring companies, and professional regional companies throughout the United States, has become a classic in its field. The book is complete with cast listings, replacement producers, directors, authors, composers, opening and closing dates, song titles, and much, much more. There are special sections with biographical data, obituary information, listings of annual Shakespeare festivals and major drama awards.
Continuing the tradition of excellence that began in 1972, this latest edition of Tachdjian?s Pediatric Orthopaedics offers the detailed visual guidance; and unmatched expertise you need to effectively diagnose and treat pediatric musculoskeletal disorders. Extensive updates offer you the latest knowledge on etiology, imaging, differential diagnosis, and non-operative and surgical techniques for a wide range of pediatric orthopaedic conditions. "... delivers the most comprehensive text on this subject." Reviewed by Dr. Neel Kamal on behalf of BACCH Newsletter, March 2015 Access expert guidance on difficult diagnostic and clinical management issues for your most challenging cases. Perfect your technique with the visual guidance of nearly 2,500 full-color illustrations and 60 videos of pediatric surgical procedures, including a number that highlight clinical examination and unusual clinical findings. Produce the best possible outcomes using today's most effective approaches for management of severe spinal deformities, hip impingement, early-onset scoliosis, and other pediatric musculoskeletal conditions. See exactly how to proceed step-by-step with instructional videos demonstrating repair of bilateral dislocated hips, triple arthrodesis for planovalgus foot, patellofemoral ligament reconstruction, elbow arthroscopy, and more. Access the full contents online at Expert Consult.
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