Calcium Entry Blockers (CEBs) are a new class of drugs which have been pushing back the frontiers of science and medicine for almost two decades. This report reviews some of the wealth of chemical, biological and clinical data describing the discovery and development of these compounds. The scientific importance, therapeutic benefit and marketing potential of these compounds have caused an explosion of scientific literature describing their effects in many preclinical and clinical settings. The definitional characteristics of these compounds suggest a certain predictability of their biological profile but their therapeutic usefulness varies widely dependent upon their physical properties, net hemodynamic effects, duration of action and incidence of side effects. CEBs appear uniquely suited to the treatment of the underlying complexity of cardiovascular disease. The CEBs of the future may live up to the expectations of pathophysiologically based therapeutics and allow the heart and blood vessels to outlive the cells which they support. The development of CEBs is an evolving story of epic proportions and represents the cooperative efforts of individuals in all areas of science.
The implications of population ageing have long concerned politicians, policy makers and governmental and non-governmental organizations in the welfare states of Europe. However, an ageing workforce is increasingly a matter of concern for the developed and fast-developing countries of Asia. Japan leads the field in this respect on account of the speed of its postwar economic development. But the little tigers of Hong Kong, Singapore, South Korea and Taiwan are poised to catch up, and Malaysia, though in the second tier of developing Asian economics, faces the prospect of population ageing sufficient to daunt an as yet under-prepared infrastructure for old age support. This book is the first to examine in detail the experiences and prospects of population ageing in those Asian countries with the highest GDP per capita. The authors pose the question to what extent Asia and 'old Europe' can learn from each other in terms of policy planning. The first section of the book sets out the field in terms of the demographic characteristics and policy predicaments of European and Asian countries. The second section presents case-studies of six countries: Japan, Hong Kong, Singapore, South Korea, Taiwan and Malaysia.
This volume in the St Andrews series contains a collection of essays from leading authors regarding the work of Elizabeth Anscombe, in particular issues in mind and metaphysics, and can be considered a partner work to 2016's The Moral Philosophy of Elizabeth Anscombe (also published by Imprint Academic Ltd.).
The book brings together fourteen essays from the work of John Cottingham on moral philosophy and the philosophy of religion spanning the past fifteen years. The papers are closely related in so far as they all deal with the perennial moral and spiritual challenges of human existence, and the search for meaning and value in human life. As well as being thematically linked, they also share a common style and methodology, illustrating the distinctive goal that has increasingly informed the author's work in recent years, that of promoting a more 'humane' conception of philosophizing. While in no way discarding the technical tools of the professional philosopher such as abstract argumentation and analysis, whose value and importance are unquestionable, this approach is notable for drawing on the full range of resources available to the human mind, including those that depend on literary, artistic, poetic, imaginative, aesthetic, and emotional modes of awareness. In contrast to the model of the philosopher as a kind of detached scrutineer, the essays exemplify the belief that there is a distinctive and valuable kind of philosophical understanding that requires a more involved and engaged stance. The philosophical questions dealt in the volume all fall broadly within the familiar domains of moral philosophy and the philosophy of religion, but the reflections offered on these areas of human thought and practice always aim to be sensitive to how morality and religion actually operate in the lives of the human beings involved.
In our culture, Shakespeare's works are classics and his characters have achieved mythical status. But what did William Shakespeare consider to be the great myths and classics? And who were the empowering role models for his bold and unforgettable heroines? In plays and poems throughout his career, Shakespeare explored many facets of the divine feminine, including Greek and Roman goddesses— he nearly deified Queen Elizabeth. His characters frequently refer to classical goddesses, some plays feature literal appearances of goddesses onstage, and the goddess of love starred in his epic poem Venus and Adonis. Shakespeare's Goddess explores the poet's many representations of the divine feminine, as a pantheon of individual deities, and also as diverse manifestations of a single, multifaceted goddess. This thoroughly researched sequel to Supernatural Shakespeare: Magic and Ritual in Merry Old England will appeal to scholars, but its playful and engaging tone also makes it accessible to anyone who appreciates Shakespeare.
Shortlisted for the Wolfson History Prize A radical rethinking of the Anglo-Saxon world that draws on the latest archaeological discoveries This beautifully illustrated book draws on the latest archaeological discoveries to present a radical reappraisal of the Anglo-Saxon built environment and its inhabitants. John Blair, one of the world's leading experts on this transformative era in England's early history, explains the origins of towns, manor houses, and castles in a completely new way, and sheds new light on the important functions of buildings and settlements in shaping people's lives during the age of the Venerable Bede and King Alfred. Building Anglo-Saxon England demonstrates how hundreds of recent excavations enable us to grasp for the first time how regionally diverse the built environment of the Anglo-Saxons truly was. Blair identifies a zone of eastern England with access to the North Sea whose economy, prosperity, and timber buildings had more in common with the Low Countries and Scandinavia than the rest of England. The origins of villages and their field systems emerge with a new clarity, as does the royal administrative organization of the kingdom of Mercia, which dominated central England for two centuries. Featuring a wealth of color illustrations throughout, Building Anglo-Saxon England explores how the natural landscape was modified to accommodate human activity, and how many settlements--secular and religious—were laid out with geometrical precision by specialist surveyors. The book also shows how the Anglo-Saxon love of elegant and intricate decoration is reflected in the construction of the living environment, which in some ways was more sophisticated than it would become after the Norman Conquest.
Medical Education: Theory and Practice is a new text linking the theory and the practice for graduate students and educators who want to go beyond the basics. The scholarship of medical education is, above all, a ‘practice’, but one that has a strong theoretical foundation. Neither theory nor practice stand still, and both are grounded in research. The novelty of this book lies in its interweaving of practice, theory, innovation and research. The book starts with a theorised, contemporary overview of the field. Next, it explores the theoretical foundations of medical education in depth. The remainder of the book reviews a whole a range of educational contexts, processes and outcomes. This work has been edited by a distinguished, international team of medical educationalists and written by equally accomplished authors from across the globe representing a spectrum of disciplines. This will be an invaluable text for all Masters Students in health professions education as well as PhD students and education researchers wanting a background to the discipline. Educators and medical students will also find it a very useful resource. Written by key figures in medical educational research combined with a strong editorial influence from the international editorial team. The text has a strong evidence-based approach that is fully cognisant of research methodology issues, The book provides a scholarly explanation on the topic, rather than aiming to say the last word. Written throughout in a clear and comprehensible style. The content is extensively referenced with additional suggestions for further reading.
Winner of the BMA 2011 book awards: psychiatry category Winner of the Australian Journal of Ageing book of the year award This definitive work on dementia and related disorders has been fully updated and revised to reflect recent advances in this fast-moving field. The incidence of dementia continues to rise as the population of the world ages, and the condition represents one of the most significant challenges facing societies and health professionals in the next half-century. In this, the most comprehensive single volume work available on the subject, the editors have met this challenge by assembling a team of the world's leading experts on all aspects of the condition, from history, epidemiology and social aspects to the latest neurobiological research and advanced therapeutic strategies.
The leading obstetrics reference for more than a century -- now in full-color and with a greater emphasis on evidence-based practice Written by a team of expert authors from world-renowned Parkland Hospital, this rigorously referenced, landmark resource tells you everything you need to know about the practice of obstetrics in a unified, consistent tone not found in other texts. For decades, ob-gyn practitioners and residents have hailed the book for its thoroughness, scientific orientation, and practical applicability at the bedside. Williams Obstetrics is reinforced throughout by a timely emphasis on evidence-based medicine, supported by state-of-the-art ultrasound images and original illustrations. The book's comprehensive coverage begins with an incisive look at maternal anatomy and physiology, and fetal growth and development. The text then progresses to the antepartum period, labor and delivery, the fetus and newborn, the peurperium period, obstetric complications, and medical and surgical complications. New to this Edition 1,100 brand-new, precisely rendered full-color illustrations Evidence-based medicine is highlighted in the text through the use of icons, better familiarizing you with the latest clinical guidelines and standards of care Greater use of headings and subheadings to quickly lead you to the content you need Improved algorithms and tables clearly and concisely present Class I evidence for diagnosis and treatment In-depth coverage of abnormal obstetrics -- from obstetrical hemorrhage and preterm birth, to reproductive tract abnormalities -- provides the most clinically relevant perspectives in this pivotal area
The only gynecological text of its kind—this combined medical reference and surgical procedural atlas gets you fully up to date on everything you need to know A Doody's Core Title for 2024 & 2021! Illustrated cover to cover, Williams Gynecology delivers comprehensive, evidence-based coverage of the full spectrum of gynecologic healthcare and disease management—from benign general gynecology to reproductive endocrinology, infertility, and menopause to female pelvic medicine and reconstructive surgery to gynecologic oncology. Hundreds of original drawings compliment the text. Every chapter of this authoritative guide offers a practical template enabling you to approach every diagnosis and treatment consistently and accurately—while treatment algorithms, differential diagnosis boxes, and other features make finding the right answers quick and easy. The Aspects of Gynecologic Surgery and Atlas of Gynecologic Surgery section covers benign gynecologic conditions, minimally invasive surgery, surgeries for female pelvic reconstruction, and surgeries for gynecologic malignancies. NEW content on minimally invasive procedures, benign gynecology, urogynecology, gynecologic oncology, and reproductive endocrinology 450+ full-color figures depicting operative techniques Illustrated gynecologic anatomy chapter—invaluable for surgeons Covers a wide range of surgical operations—each one illustrated in painstaking detail A cost-effective option to purchasing two separate textbooks
The only gynecology textbook to combine a comprehensive medical reference and a full color surgical atlas in one beautifully illustrated volume A Doody's Core Title for 2017! Williams Gynecology, Third Edition is specifically designed as a practical quick-reference guide for practicing gynecologists and residents, but it will also appeal to clerkship medical students, nurse practitioners, and physician assistants. Williams Gynecology provides comprehensive coverage of the full spectrum of gynecologic healthcare and disease management, including benign general gynecology; reproductive endocrinology, infertility, and menopause; female pelvic medicine and reconstructive surgery; and gynecologic oncology. The surgical management sections include Aspects of Gynecologic Surgery and Atlas of Gynecologic Surgery, which covers Surgeries of Benign Gynecologic Conditions, Minimally Invasive Surgery, Surgeries for Female Pelvic Reconstruction, and Surgeries for Gynecologic Malignancies. Williams Gynecology, Third Edition is beautifully illustrated, with hundreds of original drawings for both the surgical atlas and medical reference portions. Each chapter follows a practical template for a consistent approach to diagnosis and treatment. With its extensive use of treatment algorithms, differential diagnosis boxes, and other elements, this book is also a reliable quick-reference. The third edition has been revised to keep up with new and expanded content on the latest topics, including minimally invasive procedures, benign gynecology, and the subspecialties of urogynecology, gynecologic oncology, and reproductive endocrinology. The authors are internationally known practitioners affiliated with Parkland Memorial Hospital/University of Texas Southwestern Medical Center at Dallas, Massachusetts General Hospital/Harvard Medical School, and the National Institutes for Health. Features • Two resources in one—full-color medical text and surgical atlas—conveniently surveys the entire spectrum of gynecologic disease, including general gynecology, reproductive endocrinology and infertility, urogynecology, and gynecologic oncology • Completely illustrated atlas of gynecologic surgery contains over 450 full color figures that illuminate operative techniques • Unique templated text design ensures a consistent approach to diagnosis and treatment • Strong procedure orientation covers a vast array of surgical operations, which are illustrated in detail • Evidence-based discussion of disease evaluation reinforces and supports the clinical relevance of the book’s diagnostic and treatment methods • Distinguished authorship team from the same Parkland Memorial Hospital ObGyn department responsible for Williams Obstetrics—the leading reference in obstetrics for more than a century • Heavily illustrated gynecologic anatomy chapter created with the surgeon in mind to emphasize critical anatomy for successful surgery • New artist drawings of minimally invasive procedures, urogynecology, and gynecologic oncology • Numerous illustrations, photographs, tables, and treatment algorithms
As the title suggests, Beyond the Burghal Hidage takes the study of Anglo-Saxon civil defence away from traditional historical and archaeological fields, and uses a groundbreaking interdisciplinary approach to examine warfare and public responses to organised violence through their impact on the landscape. By bringing together the evidence from a wide range of archaeological, onomastic and historical sources, the authors are able to reconstruct complex strategic and military landscapes, and to show how important detailed knowledge of early medieval infrastructure and communications is to our understanding of Anglo-Saxon preparedness for war, and to the situating of major defensive works within their wider strategic context. The result is a significant and far-reaching re-evaluation of the evolution of late Anglo-Saxon defensive arrangements. Winner of the 2013 Verbruggen prize, given annually by De Re Militari society for the best book on medieval military history.
The only gynecology resource that combines a full-color text and a procedural atlas—revised and updated Part medical text, part surgical atlas, Williams Gynecology is written by the renowned team of ob-gyn clinicians at Dallas’ Parkland Hospital who are responsible for the landmark Williams Obstetrics. The new edition of Williams Gynecology maintains the consistent tone, leading-edge clinical insights, and quality illustrations of the successful first edition, while expanding and refreshing its content to keep pace with the most recent developments in this dynamic field. The many important topics covered in Williams Gynecology are evidence-based, yet the book is specifically designed as a practical quick-reference guide, aided throughout by helpful teaching points. Reflecting the latest clinical perspectives and research, the second edition features outstanding new coverage of minimally invasive procedures, robotics, and gynecologic anatomy. Features Two resources in one—full-color medical text and surgical atlas—conveniently surveys the entire spectrum of gynecologic disease, including general gynecology, reproductive endocrinology and infertility, urogynecology, and gynecologic oncology Atlas of gynecologic surgery contains 450 figures that illustrate operative techniques Unique consistent text design for an efficient approach to diagnosis and treatment Strong procedure orientation covers a vast array of surgical operations, which are illustrated in detail Evidence-based discussion of disease evaluation reinforces and supports the clinical relevance of the book’s diagnostic and treatment methods Distinguished authorship from the same Parkland Hospital-based team which edited Williams Obstetrics—the leading reference in obstetrics for more than a century Newly illustrated gynecologic anatomy chapter created with the surgeon in mind to emphasize critical anatomy for successful surgery New coverage of minimally invasive procedures and robotics, the latest procedures in gynecologic oncology, and in-vitro fertilization Numerous illustrations, photographs, tables, and treatment algorithms
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