1) Presents fundamental concepts including mechanism kinematics, synthesis, statics and dynamics 2) Focuses on analytical and computer-based quantitative methods 3) Provides a guide to MATLAB and Simscape Multibody suitable for those with no experience 4) Provides an extensive library of MATLAB and Simscape Multibody files to directly apply the equations and methods presented in each chapter
Kinematics and Dynamics of Mechanical Systems: Implementation in MATLAB® and SimMechanics®, Second Edition combines the fundamentals of mechanism kinematics, synthesis, statics and dynamics with real-world applications, and offers step-by-step instruction on the kinematic, static, and dynamic analyses and synthesis of equation systems. Written for students with no working knowledge of MATLAB and SimMechanics, the text provides understanding of static and dynamic mechanism analysis, and moves beyond conventional kinematic concepts—factoring in adaptive programming, 2D and 3D visualization, and simulation, and equips readers with the ability to analyze and design mechanical systems. This latest edition presents all of the breadth and depth as the past edition, but with updated theoretical content and much improved integration of MATLAB and SimMechanics in the text examples. Features: Fully integrates MATLAB and SimMechanics with treatment of kinematics and machine dynamics Revised to modify all 300 end-of-chapter problems, with new solutions available for instructors Formulated static & dynamic load equations, and MATLAB files, to include gravitational acceleration Adds coverage of gear tooth forces and torque equations for straight bevel gears Links text examples directly with a library of MATLAB and SimMechanics files for all users
Heteroepitaxy has evolved rapidly in recent years. With each new wave of material/substrate combinations, our understanding of how to control crystal growth becomes more refined. Most books on the subject focus on a specific material or material family, narrowly explaining the processes and techniques appropriate for each. Surveying the principles common to all types of semiconductor materials, Heteroepitaxy of Semiconductors: Theory, Growth, and Characterization is the first comprehensive, fundamental introduction to the field. This book reflects our current understanding of nucleation, growth modes, relaxation of strained layers, and dislocation dynamics without emphasizing any particular material. Following an overview of the properties of semiconductors, the author introduces the important heteroepitaxial growth methods and provides a survey of semiconductor crystal surfaces, their structures, and nucleation. With this foundation, the book provides in-depth descriptions of mismatched heteroepitaxy and lattice strain relaxation, various characterization tools used to monitor and evaluate the growth process, and finally, defect engineering approaches. Numerous examples highlight the concepts while extensive micrographs, schematics of experimental setups, and graphs illustrate the discussion. Serving as a solid starting point for this rapidly evolving area, Heteroepitaxy of Semiconductors: Theory, Growth, and Characterization makes the principles of heteroepitaxy easily accessible to anyone preparing to enter the field.
Progress in Heterocyclic Chemistry (PHC), Volume 28 is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on new and developing topics of particular interest to heterocyclic chemists. The highlight chapters in Volume 28 are all written by leading researchers and constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry during 2015. Additional articles in this volume include Semi-conjugated Heteroaromatic Rings and beta-Lactam Chemistry. As with previous volumes in the series, Volume 28 will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way. - Recognized as the premiere review of heterocyclic chemistry - Includes contributions from leading researchers in the field - Provides a systematic survey of the important 2015 heterocyclic chemistry literature - Presents articles on new and developing topics of interest to heterocyclic chemists
The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today’s latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at www.expertconsult.com. Discover new ways to treat and manage the full range of heart rhythm disorders with content focused on common clinical features, diagnosis, and management. Review expert management strategies to help you handle complex patient problems. Stay current with the latest molecular and technical advances as well as new treatment options implemented over the last few years. Use the latest technologies and devices to accurately diagnose and manage heart rhythm disorders. Consult new and expanded coverage of regenerative therapies, echo-guided procedures, cardiac pacing, and CRT, as well as a new section on pediatric electrophysiology and imaging. Enjoy improved visual guidance with many new full-color images. Log on to www.expertconsult.com to easily search the complete contents online and access a downloadable image library.
BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.
Urban planners in developed countries are pushing hard for closer integration of land use and transport. At the same time, gaps in knowledge and understanding are becoming more apparent, as the traditional focus has been on the shape of the city, rather than how it functions as a place to live and visit. How Great Cities Happen addresses this challenge by developing a wider, all-encompassing agenda for more productive, inclusive and sustainable cities.
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