Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.
Quantum Chemistry covers the basic principles, methods, and results of quantum chemistry, providing insights on electron behavior. This book is organized into 14 chapters that focus on ground state molecular orbital theory. After briefly dealing with some of the concepts of classical physics, the book goes on describing some simple but important particle systems. It then examines several systems with discontinuous potential energies, such as the simple harmonic oscillator and the hydrogen-like ion system. A chapter presents a set of postulates and theorems that form the formal foundation of quantum mechanics. Considerable chapters are devoted to various quantum chemical methods, as well as their basic features and application to molecular orbital evaluation. These methods include Huckel molecular orbital, variation, linear variation, extended Huckel, and SCF-LCAO-MO. The concluding chapters deal with the development of theories for molecular orbital, including time-independent Rayleigh-Schrodinger perturbation, group, and qualitative molecular orbital theories. Supplemental texts of the more complicated derivations or proofs and problems encountered in quantum chemistry are also provided. This book is an introductory text intended for organic, inorganic, and physical chemists, as well as for graduate and undergraduate students.
Assigning Structures to Ions in Mass Spectrometry describes the tools currently available for determining gas-phase ion structures. It surveys current experimental methods for ion production and separation as well as those designed to reveal qualitative and quantitative aspects of gas-phase ions. It also examines how and when to apply computational chemistry and theoretical calculations. Selected case studies illustrate specific challenges associated with ion structure assignment and thermochemical problems. Bringing together key results collected over the past four decades, the book contains the data for describing or identifying ions containing C alone and C with H, O, N, S, P, halogens, and small organic cations.
Learn the fundamentals of materials design with this all-inclusive approach to the basics in the field Study of materials science is an important aspect of curricula at universities worldwide. This text is designed to serve students at a fundamental level, positioning materials design as an essential aspect of the study of electronics, medicine, and energy storage. Now in its 3rd edition, Principles of Inorganic Materials Design is an introduction to relevant topics including inorganic materials structure/property relations and material behaviors. The new edition now includes chapters on computational materials science, intermetallic compounds, and covalent compounds. The text is meant to aid students in their studies by providing additional tools to study the key concepts and understand recent developments in materials research. In addition to the many topics covered, the textbook includes: • Accessible learning tools to help students better understand key concepts • Updated content including case studies and new information on computational materials science • Practical end-of-chapter exercises to assist students with the learning of the material • Short biographies introducing pioneers in the field of inorganic materials science For undergraduates just learning the material or professionals looking to brush up on their knowledge of current materials design information, this text covers a wide range of concepts, research, and topics to help round out their education. The foreword to the first edition was written by the 2019 Chemistry Nobel laureate Prof. John B. Goodenough.
The· simplest picture of an atom, a molecule or a solid is the picture of its distribution of charge. It is obtained by specifying the positions of the atomic nuclei and by showing how the density, p(E), of the electronic charge-cloud varies from place to place. A much more detailed picture is provided by the many-electron wavefunction. This quantity shows not only the arrangement of the electrons with respect to the nuclei, but also the arrangement of the electrons with respect to each other, and it allows the evaluation of the total energy and other properties. The many-electron wavefunction is in principle obtained by solving the many-electron Schrodinger equation for the motion of the interacting electrons under the influ ence of the nuclei, but in practice the equation is unsolvable, and it is necessary to proceed by methods of approximation. Needless to say, .such methods will as a rule depend on the complexity of the system considered.
Praised for its appealing writing style and clear pedagogy, Lowe's Quantum Chemistry is now available in its Second Edition as a text for senior undergraduate- and graduate-level chemistry students. The book assumes little mathematical or physical sophistication and emphasizes an understanding of the techniques and results of quantum chemistry, thus enabling students to comprehend much of the current chemical literature in which quantum chemical methods or concepts are used as tools. The book begins with a six-chapter introduction of standard one-dimensional systems, the hydrogen atom, many-electron atoms, and principles of quantum mechanics. It then provides thorough treatments of variation and perturbation methods, group theory, ab initio theory, Huckel and extended Huckel methods, qualitative MO theory, and MO theory of periodic systems. Chapters are completed with exercises to facilitate self-study. Solutions to selected exercises are included. - Assumes little mathematical or physical sophistication - Emphasizes understanding of the techniques and results of quantum chemistry - Includes improved coverage of time-dependent phenomena, term symbols, and molecular rotation and vibration - Provides a new chapter on molecular orbital theory of periodic systems - Features new exercise sets with solutions - Includes a helpful new appendix that compiles angular momentum rules from operator algebra
A Worlde of Wordes, the first-ever comprehensive Italian-English dictionary, was published in 1598 by John Florio. One of the most prominent linguists and educators in Elizabethan England, Florio was greatly responsible for the spreading of Italian letters and culture throughout educated English society. Especially important was Florio's dictionary, which thanks to its exuberant wealth of English definitions made it initially possible for English readers to access Italy's rich Renaissance literary and scientific culture. Award-winning author Hermann W. Haller has prepared the first critical edition of A Worlde of Wordes, which features 46,000 Italian entries among them dialect forms, erotic terminology, colloquial phrases, and proverbs of the Italian language. Haller reveals Florio as a brilliant English translator and creative writer, as well as a grammarian and language teacher. His helpful critical commentary highlights Florio's love of words and his life-long dedication to promoting Italian language and culture abroad.
The present work is a continuation of the authors' acclaimed multi-volume APractical Logic of Cognitive Systems. After having investigated the notion ofrelevance in their previous volume, Gabbay and Woods now turn to abduction. Inthis highly original approach, abduction is construed as ignorance-preservinginference, in which conjecture plays a pivotal role. Abduction is a response to acognitive target that cannot be hit on the basis of what the agent currently knows.The abducer selects a hypothesis which were it true would enable the reasoner to attain his target. He concludes from this fact that the hypothesis may be conjectured. In allowing conjecture to stand in for the knowledge he fails to have, the abducer reveals himself to be a satisficer, since an abductive solution is not a solution from knowledge. Key to the authors' analysis is the requirement that a conjectured proposition is not just what a reasoner might allow himself to assume, but a proposition he must defeasibly release as a premiss for further inferences in the domain of enquiry in which the original abduction problem has arisen.The coverage of the book is extensive, from the philosophy of science tocomputer science and AI, from diagnostics to the law, from historical explanation to linguistic interpretation. One of the volume's strongest contributions is its exploration of the abductive character of criminal trials, with special attention given to the standard of proof beyond a reasonable doubt.Underlying their analysis of abductive reasoning is the authors' conception ofpractical agency. In this approach, practical agency is dominantly a matter of thecomparative modesty of an agent's cognitive agendas, together with comparatively scant resources available for their advancement. Seen in these ways, abduction has a significantly practical character, precisely because it is a form of inference that satisfices rather than maximizes its response to the agent's cognitive target.The Reach of Abduction will be necessary reading for researchers, graduatestudents and senior undergraduates in logic, computer science, AI, belief dynamics, argumentation theory, cognitive psychology and neuroscience, linguistics, forensic science, legal reasoning and related areas.Key features:- Reach of Abduction is fully integrated with a background logic of cognitive systems.- The most extensive coverage compared to competitive works.- Demonstrates not only that abduction is a form of ignorance preservinginference but that it is a mode of inference that is wholly rational.- Demonstrates the satisficing rather than maximizing character ofabduction.- The development of formal models of abduction is considerably more extensive than one finds in existing literature. It is an especially impressive amalgam of sophisticatedconceptual analysis and extensive logical modelling.· Reach of Abduction is fully integrated with a background logic of cognitive systems.· The most extensive coverage compared to competitive works· Demonstrates not only that abduction is a form of ignorance preservinginference but that it is a mode of inference that is wholly rational.· Demonstrates the satisficing rather than maximizing character ofabduction.· The development of formal models of abduction is considerably more extensive than one finds in existing literature. It is an especially impressive amalgam of sophisticatedconceptual analysis and extensive logical modelling.
Heterocyclic compounds play a vital role in the metabolism of living cells. Their practical applications range from extensive clinical use to fields as diverse as agriculture, photography, biocide formulation and polymer science. Written by leading scholars and industry experts, the Handbook of Heterocyclic Chemistry is thoroughly updated with over 50% new content. It has been rewritten with a new expanded author team, who have carefully distilled essential information on the reactivity, structure and synthesis of heterocycles from the 2008 major reference work Comprehensive Heterocyclic Chemistry III. To bring the work up to date the author team have also added new synthetic examples and structures, key applications and new references from 2008-2010. Contains more than 1500 clearly drawn structures and reactions. The highly systematic coverage given to the subject makes this one of the most authoritative single-volume accounts of modern heterocyclic chemistry available and should be useful reference for those teaching a heterocyclic course. - Covers the structure, reactivity and synthesis of all heterocyclic compounds as distilled from the larger 15-volume reference work - Saves researchers time when they require important information on heterocycles--speeding them to thousands of clearly drawn chemical structures and pertinent reviews by leading experts - Features 35% new material to compliment the completely revised text
This edition of the Manual of Neonatal Care has been completely updated and extensively revised to reflect the changes in fetal, perinatal, and neonatal care that have occurred since the sixth edition. This portable text covers current and practical approaches to evaluation and management of conditions encountered in the fetus and the newborn, as practiced in high volume clinical services that include contemporary prenatal and postnatal care of infants with routine, as well as complex medical and surgical problems. Written by expert authors from the Harvard Program in Neonatology and other major neonatology programs across the United States, the manual’s outline format gives readers rapid access to large amounts of valuable information quickly. The Children’s Hospital Boston Neonatology Program at Harvard has grown to include 57 attending neonatologists and 18 fellows who care for more than 28,000 newborns delivered annually. The book also includes the popular appendices on topics such as common NICU medication guidelines, the effects of maternal drugs on the fetus, and the use of maternal medications during lactation. Plus, there are intubation/sedation guidelines and a guide to neonatal resuscitation on the inside covers that provide crucial information in a quick and easy format.
The Action Plan for Australian Mammals 2012 is the first review to assess the conservation status of all Australian mammals. It complements The Action Plan for Australian Birds 2010 (Garnett et al. 2011, CSIRO Publishing), and although the number of Australian mammal taxa is marginally fewer than for birds, the proportion of endemic, extinct and threatened mammal taxa is far greater. These authoritative reviews represent an important foundation for understanding the current status, fate and future of the nature of Australia. This book considers all species and subspecies of Australian mammals, including those of external territories and territorial seas. For all the mammal taxa (about 300 species and subspecies) considered Extinct, Threatened, Near Threatened or Data Deficient, the size and trend of their population is presented along with information on geographic range and trend, and relevant biological and ecological data. The book also presents the current conservation status of each taxon under Australian legislation, what additional information is needed for managers, and the required management actions. Recovery plans, where they exist, are evaluated. The voluntary participation of more than 200 mammal experts has ensured that the conservation status and information are as accurate as possible, and allowed considerable unpublished data to be included. All accounts include maps based on the latest data from Australian state and territory agencies, from published scientific literature and other sources. The Action Plan concludes that 29 Australian mammal species have become extinct and 63 species are threatened and require urgent conservation action. However, it also shows that, where guided by sound knowledge, management capability and resourcing, and longer-term commitment, there have been some notable conservation success stories, and the conservation status of some species has greatly improved over the past few decades. The Action Plan for Australian Mammals 2012 makes a major contribution to the conservation of a wonderful legacy that is a significant part of Australia’s heritage. For such a legacy to endure, our society must be more aware of and empathetic with our distinctively Australian environment, and particularly its marvellous mammal fauna; relevant information must be readily accessible; environmental policy and law must be based on sound evidence; those with responsibility for environmental management must be aware of what priority actions they should take; the urgency for action (and consequences of inaction) must be clear; and the opportunity for hope and success must be recognised. It is in this spirit that this account is offered.
Written both for the novice and for the experienced scientist, this miniature encyclopedia concisely describes over one hundred materials methodologies, including evaluation, chemical analysis, and physical testing techniques. Each technique is presented in terms of its use, sample requirements, and the engineering principles behind its methodology. Real life industrial and academic applications are also described to give the reader an understanding of the significance and utilization of technique. There is also a discussion of the limitations of each technique.
Atmospheric chemistry is central to understanding global changes ? ozone depletion, appearance of the polar ozone holes, and compositional changes which worsen the greenhouse effect. Because of its importance, work is progressing on many fronts.This volume emphasizes the troposhere and stratosphere and has chapters on gas phase, condensed phase, and heterogeneous chemistry. Present progress is emphasized, and important future directions are also described.This book fills a need not satisfied by any others and will be popular for some years to come. It informs students and newcomers to the field of the many facets of atmospheric chemistry and can be used as a text for advanced students. It is also a valuable desk reference summarizing activities by quite a number of the most active research groups.Chapter 18 by Kolb et al. on heterogeneous chemistry is especially noteworthy because it represents a unique joint effort by several groups working on a very timely subject; they describe a conceptual framework and establish conventions which will be standard in future papers on this subject.
In Leadership for Tomorrow: Beyond the School Improvement Horizon Malcolm Groves, Andrew Hobbs, and John West-Burnhampresent a vision-led analysis of what needs to change if schools are really to equip children and young people to thrive in our ever-changing world.Continually adding improvements to existing models of schooling isn't enough: we need a more radical reconceptualisation of schooling's function and purpose. We need school leaders who can look beyond the horizon and lead on the strength of lessons learned from the here and now. In Leadership for Tomorrow Groves, Hobbs, and West-Burnham expertly examine what needs to change if we are to lead our schools beyond today's limited school improvement horizon, and explore the nature of the change leadership which can make this happen. Rooted in the direct experience of innovative and successful school leaders, Leadership for Tomorrow presents a wide range of strategies and case studies that will enable and inspire leaders to future-proof their school improvement approach and to fashion better futures for the children and young people in their care. Furthermore, by sharing their research-informed insight into and vision for - the evolving nature of education, the authors hope to encourage leaders to go further in building both their own and their school's capacity to live, learn, and grow successfully. Split into three parts that interweave both theory and practice, Leadership for Tomorrow poses a number of questions throughout to stimulate thinking about current and emerging issues in education and argue that consequent responses will vary in different contexts. Part One sets out and justifies theoretically the principles and values that underpin the authors' vision for education, and signposts the evidence which highlights the limitations of short-term thinking and the reasons for why it is destined to fail. In Part Two the authors focus on more practical matters by presenting case studies of five school leaders to examine their work through the lens of the four-quadrant Schools of Tomorrow Framework, which depicts the 'beyond outstanding' school as one that delivers highly effective family and community engagement and preparation for the future, as well as the highest levels of achievement and of well-being and involvement. Part Three then blends theory and practice with an in-depth analysis of what these leaders' experiences can tell us about developing new understandings of leading change and school improvement for the future, which are at one and the same time values based and evidence informed. Leadership for Tomorrow is the result of nearly a decade of thinking, research, and observation of leadership practice which Groves, Hobbs, and West-Burnham have undertaken in a range of settings; the authors have written up some of this experience previously for Schools of Tomorrow (SoTo) a small research and development group made up of school leaders working together to shape a better future for their schools. Whilst Leadership for Tomorrow is primarily focused on changes within the English educational system, the authors hope that the lessons derived from the book's content will be of interest to leaders in other school systems too. Suitable for school leaders, those preparing for leadership, and those with an interest in leadership development and policy.
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