Endothelin-1 (ET-1), a peptide discovered in 1988, is one of the most potent contractors of vascular smooth muscle. Since their discovery, ETs have generated enormous interest in the scientific and pharmaceutical communities, prompting extensive research. This book addresses the latest findings regarding ETs-how they function, their effects, and characteristics. Divided into five sections, the book covers: endothelin receptors, endothelin synthesis and degradation, endothelin pathophysiology, ligand structure and activity relationships, and clinical studies. Pharmacologists, toxicologists, and pharmaceutical researchers will all benefit from this thorough review of current findings and future directions in ET research.
The new edition of this classic textbook has now been extensively revised by a team of five authors, yet it follows the tradition of the original single-authored book. It continues to provide a comprehensive review of the cognitive, emotional and behavioural consequences of cerebral disorders and their manifestations in clinical practice. Enabling clinicians to formulate incisive diagnoses and appropriate treatment strategies
Examining the lives of individuals - freedmen, planters, and merchants - Willis explores the reciprocal interests of former slaves and former slaveholders. He shows how, in a cruel irony replicated in other areas of the South, the backbreaking work that African Americans did to clear, settle, and farm the land away from the river made the land ultimately too valuable for them to retain.
An intimate journey across America, as told by one of its most beloved writers To hear the speech of the real America, to smell the grass and the trees, to see the colors and the light—these were John Steinbeck's goals as he set out, at the age of fifty-eight, to rediscover the country he had been writing about for so many years. With Charley, his French poodle, Steinbeck drives the interstates and the country roads, dines with truckers, encounters bears at Yellowstone and old friends in San Francisco. Along the way he reflects on the American character, racial hostility, the particular form of American loneliness he finds almost everywhere, and the unexpected kindness of strangers.
Six new chapters on vital topics of interest such as multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays New edition responds to reviewers' and users' desire for greater coverage—now the most useful handbook on the market! Practical, concise summary of everything about genomics and emerging technologies a busy physician or medical student should know Covers concepts and techniques that are in use in medicine now, as well as those on the cutting-edge of science relevant to medicine, from bioinformatics to DNA diagnostics and proteomics NEW: Includes chapter-end exercises, enhancing the utility of the new edition as a textbook NEW: PowerPoint slides of images available at instructor website
Covering the same ground as the major motion picture The Free State of Jones, starring Matthew McConaughey, this is the extraordinary true story of the anti-slavery Southern farmer who brought together poor whites, army deserters and runaway slaves to fight the Confederacy in deepest Mississippi. "Moving and powerful." -- The Washington Post. In 1863, after surviving the devastating Battle of Corinth, Newton Knight, a poor farmer from Mississippi, deserted the Confederate Army and began a guerrilla battle against it. A pro-Union sympathizer in the deep South who refused to fight a rich man’s war for slavery and cotton, for two years he and other residents of Jones County engaged in an insurrection that would have repercussions far beyond the scope of the Civil War. In this dramatic account of an almost forgotten chapter of American history, Sally Jenkins and John Stauffer upend the traditional myth of the Confederacy as a heroic and unified Lost Cause, revealing the fractures within the South.
Toric varieties form a beautiful and accessible part of modern algebraic geometry. This book covers the standard topics in toric geometry; a novel feature is that each of the first nine chapters contains an introductory section on the necessary background material in algebraic geometry. Other topics covered include quotient constructions, vanishing theorems, equivariant cohomology, GIT quotients, the secondary fan, and the minimal model program for toric varieties. The subject lends itself to rich examples reflected in the 134 illustrations included in the text. The book also explores connections with commutative algebra and polyhedral geometry, treating both polytopes and their unbounded cousins, polyhedra. There are appendices on the history of toric varieties and the computational tools available to investigate nontrivial examples in toric geometry. Readers of this book should be familiar with the material covered in basic graduate courses in algebra and topology, and to a somewhat lesser degree, complex analysis. In addition, the authors assume that the reader has had some previous experience with algebraic geometry at an advanced undergraduate level. The book will be a useful reference for graduate students and researchers who are interested in algebraic geometry, polyhedral geometry, and toric varieties.
A comprehensive summary of air temperature, rain and snow, wind, humidity, wildfires, and floods in the Reno, Carson City, and Lake Tahoe region since records began in 1850. This information is presented in text, graphs, and photos, and is supported by explanations of weather phenomena, a glossary, and numerous photos in color and and black and white. Click on the links below to see some of the key pages.
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