Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity. In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (λ=600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful "dynamic duo", offering a most effective neuroprotective treatment option to patients.
Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity. In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (λ=600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful "dynamic duo", offering a most effective neuroprotective treatment option to patients.
Utilizing both words and images this book animates the lives of a selection of holy men who labored on the North American continent in the late nineteenth and twentieth centuries to give birth to the Orthodox Church in the United States, Canada, and Mexico. Some of these have been formally glorified as saints and others may yet be. This book is much more than a simple historical account or retelling of their lives and particular service in North America: it is a spiritual manual, which strives to inspire and encourage its readers in their own struggle for the attainment of the holiness that adorns the lives of those recounted here.Chronologically the lives described herein span the years from 1854 to 2019 and focus on the time each man spent laboring in North America. None of them spent all their life on this continent but they left a legacy on these shores that endures to this day and will surely continue. The text is interspersed by an extensive collection of both black and white photographs and pen and ink drawings that, together with a final section of rich color photography, contribute greatly to bringing the reality of their life and times to us.
Already known as the reference of choice for expert coverage on the structure and function of the human brain and the nervous system, Nolte’s The Human Brain continues to impress with essential updates throughout this new edition. It includes a new chapter on formation, modification, and repair of connections, with coverage of learning and memory, as well as the coming revolution of ways to fix damaged nervous systems, trophic factors, stem cells, and more. 550 full-color illustrations—more than 650 in all—support the text and depict every nuance of brain function. But, best of all, your purchase now includes access to Student Consult, including all of the book’s illustrations, video clips, and additional software, plus many other exclusive features at www.studentconsult.com. Features a single-authored approach for a more consistent, readable text. Discusses all key topics in functional neuroanatomy and neuroscience, giving you well-rounded coverage of this complex subject. Includes clinical examples throughout for a real-life perspective. Uses summary statement headings that speed you to the information you need. Presents chapter outlines that encourage you to stay organized and focused. Incorporates 3-dimensional brain images and more than 650 illustrations that add increased visual clarity and a greater understanding of every concept. Includes a glossary of key terms that elucidates every part of the text. Features updates throughout, as well as many new illustrations using the most current neuroimaging techniques, reflecting recent developments and changes in understanding to acquaint you with the very latest knowledge in the field. Discusses the hot topic of neural plasticity in a new chapter on formation, modification, and repair of connections, with coverage of learning and memory, as well as the coming revolution in ways to fix damaged nervous systems, trophic factors, stem cells, and more. Uses chapter outlines, offering you a focused approach to study. Offers unlimited access to the Student Consult, withvideo clips and additional software at www.studentconsult.com, so you can consult it anywhere you go...perform quick searches...add your own notes and bookmarks...follow Integration Links to related bonus content from other Student Consult titles...and reference all of the other Student Consult titles you own online, too—all in one place!
A young violin prodigy grows up in Harbin and Shanghai amidst the absurd and often deadly politics of mid-century China. Under the dual influences of her revolutionary parents and the White Russian intellectuals who are her tutors (and who provide her with a link, personal and tragic, to the composer Dmitri Shostakovich) she is drawn into a precarious world of ideology and espionage where music must serve not only ‘the masses’, but also the unpredictable whims and grand strategies of great leaders. Moving between China, Europe and New Zealand, the young protagonist learns how music and its artefacts link individuals across time in a chain alternately transcendent and tragic, and encounters the compromises that talent, fate and family force upon her.
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