Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential. Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections: Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry. Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses. Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products. Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.
This book is a tribute to Malcolm Coulthard, who has been remarkably active and influential across a wide range of English Language Studies. He is particularly well-known for his pioneering work in spoken and written discourse analysis and most recently, for his work in forensic linguistics. This collection of specially commissioned, state-of-the-art pieces by leading international linguists is dedicated to the man and his achievements and provides a showcase for the most exciting developments in applied discourse studies. All the papers share common assumptions about language study: that descriptions should be data-based, data-tested and replicable. The collection as a whole contains original and important new research on descriptions, with intriuging applications to forensic, gender and literary studies.
The past hundred years of Europe are distilled in the experiences of the citizens of Strasbourg. From the turn of the twentieth century until 1945, Europe's ruling idea of nationalism rendered Strasbourg/Straßburg the prize in a tug-of-war between the two greatest continental powers, France and Germany. Then, in the immediate post-war period, ideals for European unity set up various European institutions, some headquartered in Strasbourg, which have gradually created a partially supranational Europe. At the end of the 1950s, a third theme arises: the large-scale settling in Strasbourg and other such richer, western European cities of persons from poorer lands, frequently ex-colonial territories, whose appearance and cultural practices render them essentially "different" to local eyes: expressions of racism thereby jostle with professions of multiculturalism. Now in the globalisation era, the issue of "immigration" has broadened yet further into transnationalism: the experience of persons who are embedded in varying manner in both Strasbourg and in their land of origin. Based on in-depth, lively interviews with 80 men and 80 women ranging from 101 to 20 years, and from all over the world (France, Germany, Alsace-Lorraine, Portugal, Italy, ex-Yugoslavia, Albania, Algeria, Morocco, Turkey, Cameroon, and Afghanistan amongst other countries), the author draws out of these compelling testimonies all sorts of compelling insights into issues of identity, race, nationality, culture, politics, heritage and representation, giving a unique and valuable view of what it means (and has meant over the past century) to be a European.
This 1989 book is a distinctive work in the field of human-computer interaction (HCI). Cognitive ergonomics and HCI encompass a wide range of research and development activities in both academic and industrial environments, and this book satisfies a clear need for the dissemination of the knowledge generated by work in progress or completed.
This book is available to instructors and students in an electronic version! Addressing the full range of curricular and instructional issues that face professionals working in middle school, high school, and post-high school programs, Successful Transition Programs: Pathways for Students With Intellectual and Developmental Disabilities, Second Edition is the most relevant text available for teachers and administrators. Authors John McDonnell and Michael L. Hardman take the position that the most effective transition programs are those that cumulatively build on the capacity of students for employment, community living, and citizenship. Key Features and Benefits Covers systematic transition planning, employment preparation, participation in the general education curriculum, instruction in community settings, and preparing students to live as independently as possible Aligns with recommended practice in the field and with federal legislation governing educational and community service programs Contains ecological curriculum models for students with intellectual and developmental disabilities Includes focus review questions, real-life example windows, and point/counterpoint boxes from key researchers on controversial issues to help readers connect the book′s concepts with the typical needs of students
Includes historical aspects of plant collecting on Kinabalu andenumeration of half the dicotyledons, 83 families, 430 genera and 1,575 species, subspecies and varieties.
This is the first published edition of John Sinclair, Susan Jones and Robert Daley's research on collocation undertaken in 1970. The unpublished report was circulated amongst a small group of academics and was enormously influential, sparking a growth of interest in collocation amongst researchers in linguistics. Collocation was first viewed as important in computational linguistics in the work of Harold Palmer in Japan. Later M.A.K. Halliday and John Sinclair published on collocation in the 1960s. English Collocation Studies is a report on empirical research into collocation, devised by Halliday with Sinclair acting as the Principal Investigator and editor of the resultant OSTI report. The present edition contains an introduction by Professor Wolfgang Teubert based on his interview with John Sinclair. The introduction assesses the extent to which the findings of the original research have developed in the intervening years, and how some of the techniques mentioned in the report were implemented in the COBUILD project at Birmingham University in the 1980s.
Australia was born with its eyes wide open. Although politicians spoke publicly of loyalty to Britain and the empire, in secret they immediately set about protecting Australia's interests from the Germans, the Japanese - and from Britain itself. As an experienced intelligence officer, John Fahey knows how the security services disguise their activities within government files. He has combed the archives to compile the first account of Australia's intelligence operations in the years from Federation to the end of World War II. He tells the stories of dedicated patriots who undertook dangerous operations to protect their new nation, despite a lack of training and support. He shows how the early adoption of advanced radio technology by Australia contributed to the war effort in Europe. He also exposes the bureaucratic mismanagement in World War II that cost many lives, and the leaks that compromised Australia's standing with its wartime allies so badly that Australia was nearly expelled from the Anglo-Saxon intelligence network. Australia's First Spies shows Australia always has been a far savvier operator in international affairs than much of the historical record suggests, and it offers a glimpse into the secret history of the nation. 'Fills a major gap in the history of Australian intelligence organisations.' - Professor David Horner, author of The Spy Catchers: The Official History of ASIO 1949-1963 'Great intelligence is often shared by great story telling, and John Fahey shares a great story in Australia's First Spies.' - Rear Admiral Paul Becker, USN (Retired), Former Director for Intelligence of the U.S. Pacific Command and Joint Chiefs of Staff
This unique book presents an approach to viewing trauma. It examines the cellular consequences of trauma at a molecular level and provides new insights into the treatment of traumatic injury, based on cellular responses. The current of trauma research is reviewed, previously unpublished information on the topic is presented, and research directions are included.
This book covers the experimental and theoretical understanding of surface and thin film processes. It presents a unique description of surface processes in adsorption and crystal growth, including bonding in metals and semiconductors. Emphasis is placed on the strong link between science and technology in the description of, and research for, new devices based on thin film and surface science. Practical experimental design, sample preparation and analytical techniques are covered, including detailed discussions of Auger electron spectroscopy and microscopy. Thermodynamic and kinetic models of structure are emphasised throughout. The book provides extensive leads into practical and research literature, as well as resources on the World Wide Web (see http://venables.asu.edu/book). Each chapter contains problems which aim to develop awareness of the subject and the methods used. Aimed as a graduate textbook, this book will also be useful as a sourcebook for graduate students, researchers and practitioners in physics, chemistry, materials science and engineering.
This Palgrave Pivot strives to recount and understand Indigenous Law, as set within a remote community in northern Australia. It pays close attention to the realpolitik and high-level political functioning of Indigenous Laws, which inspires a discussion of how this Law models the relational, influences governance and emplaces people in an ordered kincentric lifeworld. The book argues that Indigenous Law can be examined for the ways in which it is a deliberate, stabilizing and powerful force to maintain communal order in relation to Country, a counter framing to popular and ‘soft law or soft power asset’ visions of such Laws often held in the national and international imaginary. It is the latter which too often renders this knowledge esoteric and relinquishes it to a category of lore or folklore. This is an open access book.
Now in its updated Seventh Edition, Lovell and Winter’s Pediatric Orthopaedics remains a must-have for physicians and residents treating infants, children, and adolescents with orthopaedic problems. This classic, comprehensive reference covers the basic science, clinical manifestations, and management of orthopaedic problems in children. Now in full color, the foremost orthopaedists examine normal musculoskeletal development and the causes, diagnosis, and treatment of the entire range of abnormalities, with emphasis on evidence-based decision making in treatment selection. The clinical chapters include pearls and pitfalls and a description of the author's preferred approach. The book will now cover surgical techniques of management with step-by-step illustrations from the Atlas of Pediatric Orthopaedic Surgery.
This book provides a wide-ranging comparative analysis of contemporary economic, social, political and environmental change in small islands, island states and territories, through every ocean. It focuses on those island realms conventionally perceived as developing, rather than developed, in the Caribbean, Pacific and Indian Oceans. John Connell examines the decline of agriculture and the rise of tourism, the problems of urbanization, and the particular role of migration and remittances, within a culture of migration. He seeks to balance economic challenges with environmental threats, notably that of climate change, and social changes with the survival of culture, pointing to awkward and hybrid development futures. This unique study comprehensively balances environmental, social and economic changes to provide a more wide-ranging assessment of sustainability that will be invaluable for academics and postgraduate students on environment and international development courses.
The gold standard comprehensive reference in pediatric orthopaedics is a must-have resource for physicians and residents treating infants, children, and adolescents with orthopaedic problems. Lovell and Winter’s Pediatric Orthopaedics, 8th Edition, brings you fully up to date in the field with new content, a new editor, and many new contributing authors who cover all aspects of basic science, clinical manifestations, and management. You’ll find complete, expert coverage of normal musculoskeletal development and the causes, diagnosis, and treatment of the entire range of abnormalities, with emphasis on evidence-based decision making in treatment selection.
John M. Hill discerns a distinctive 'narrative pulse' arising out of the poem's many scenes of arrival and departure. He argues that such scenes, far from being fixed or 'type' scenes, are socially dramatic and a key to understanding the structural density of the poem.
Guidebook which aims to improve MPA management by providing a framework that links the goals and objectives of MPAs with indicators that measure management effectiveness. The framework and indicators were field-tested in 18 sites around the world, and results of these pilots were incorporated into the guidebook. Published as a result of a 4-year partnership of IUCN's World Commission on Protected Areas-Marine, World Wildlife Fund, and the NOAA National Ocean Service International Program Office.
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