John M. Simon's Books

A New Dictionary of the Italian and English Languages

Vol. 2

By: Guglielmo Comelati,John Davenport

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A New Dictionary of the Italian and English Languages

Vol. 2

By: Guglielmo Comelati,John Davenport

Reprint of the original, first published in 1873. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.

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Page Count

762

Publisher

BoD – Books on Demand

Published Date

ISBN 10

338281482X

ISBN 13

9783382814823

BACE

Lead Target for Orchestrated Therapy of Alzheimer's Disease

By: Varghese John

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BACE

Lead Target for Orchestrated Therapy of Alzheimer's Disease

By: Varghese John

BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.

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Page Count

282

Publisher

John Wiley & Sons

Published Date

ISBN 10

047029342X

ISBN 13

9780470293423

The Toff and the Deep Blue Sea

By: John Creasey

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The Toff and the Deep Blue Sea

By: John Creasey

The Honourable Richard Rawlinson (aka ‘The Toff’) is in Nice for seemingly the most innocent of reasons – engaging girls for M. Rambeau’s new Cabaret. An attempt on his life, however, reveals the real reason for his presence – to track down a missing girl. All enquiries appear to lead to the elusive Chico, who may act the clown, but is no fool.

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Page Count

175

Publisher

House of Stratus

Published Date

ISBN 10

0755138171

ISBN 13

9780755138173

Organizational Behavior 2

Essential Theories of Process and Structure

By: John B. Miner

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Organizational Behavior 2

Essential Theories of Process and Structure

By: John B. Miner

This comprehensive text provides a detailed review and analysis of the building-block theories in the macro-organizational behavior field. John Miner has identified the key theories that any student or scholar needs to understand to be considered literate in the discipline. Each chapter includes the background of the theorist represented, the context in which the theory arose, the initial and subsequent theoretical statements, research on the theory by the theory's author and others (including meta-analysis and reviews), and practical applications. Special features, including boxed summaries of each theory at the beginning of each chapter; two introductory chapters on the scientific method and the development of knowledge; and detailed, comprehensive references, help make this text especially useful for every student and scholar in the field.

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Page Count

687

Publisher

Routledge

Published Date

ISBN 10

1317463544

ISBN 13

9781317463542

What Your Dog Is Trying To Tell You

A Head-To-Tail Guide To Your Dog's Symptoms & Their Solutions

By: John M. Simon, D.V.M.,Stephanie Pedersen

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What Your Dog Is Trying To Tell You

A Head-To-Tail Guide To Your Dog's Symptoms & Their Solutions

By: John M. Simon, D.V.M.,Stephanie Pedersen

Your Dog Can't Speak, but His Symptoms Can The best way to ensure your dog's health is to know how to interpret his symptoms and take the proper measures to get him well again. From head to tail, from physical to behavioral problems, respected veterinarian Dr. John Simon helps you understand your dog's ailments and arrive at safe, effective solutions. Included in this dog owner's invaluable volume are: - Emergency symptoms: what kind of signals should be attended to immediately and which ones to watch closely - Home care vs. doctor care: when your dog needs to see a vet when you can remedy the problem yourself - 150 common dog health problems: outlined in clear, easy-to-understand language, Dr. Simon presents the most common pet problems and the best way to treat them - Plus: essential appendices for fast reference, including a checklist for good health, how to perform a weekly exam, a chapter of emergency symptoms and solutions--and much, much more Now you don't have to be a veterinarian to discover What Your Dog Is Trying to Tell You.

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Page Count

295

Publisher

St. Martin's Griffin

Published Date

ISBN 10

1466877359

ISBN 13

9781466877351

IP/ATM Mobile Satellite Networks

By: John Farserotu,Ramjee Prasad

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IP/ATM Mobile Satellite Networks

By: John Farserotu,Ramjee Prasad

Gain the knowledge needed to execute end-to-end performance analysis over satellite links and networks, evaluate throughput and capacity over satellite systems, and understand IP/ATM over SATCOM issues and limitations with this in-depth, practical resource. The book examines current and future land mobile satellite (LMS) communication systems, and the techniques necessary to support reliable and efficient communication.

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Page Count

300

Publisher

Artech House

Published Date

ISBN 10

1580531121

ISBN 13

9781580531122

Potato Breeding: Theory and Practice

By: John E. Bradshaw

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Potato Breeding: Theory and Practice

By: John E. Bradshaw

The potato (Solanum tuberosum) is the world’s fourth most important food crop after maize, rice and wheat with 377 million tonnes fresh-weight of tubers produced in 2016 from 19.2 million hectares of land, in 163 countries, giving a global average yield of 19.6 t ha-1 (http://faostat.fao.org). About 62% of production (234 million tonnes) was in Asia (191), Africa (25) and Latin America (18) as a result of steady increases in recent years, particularly in China and India. As a major food crop, the potato has an important role to play in the United Nations “2030 Agenda for Sustainable Development” which started on 1 January 2016 (http://faostat.fao.org). By 2030 the aim is to “ensure access by all people, in particular the poor and people in vulnerable situations, including infants, to safe, nutritious and sufficient food all year round”. By then, the world population is expected to reach 8.5 billion and continue to increase to 9.7 billion in 2050. For potatoes, the need is to increase production and improve nutritional value during a period of climate change, a key aspect of which will be the breeding of new cultivars for a wide range of target environments and consumers. The aim of the book is to help this endeavour by providing detailed information in three parts on both the theory and practice of potato breeding. Part I deals with the history of potato improvement and with potato genetics. Part II deals with breeding objectives, divided into improving yield, quality traits and resistance to the most important diseases and pests of potatoes. Part III deals with breeding methods: first, the use of landraces and wild relatives of potato in introgression breeding, base broadening and population improvement; second, breeding clonally propagated cultivars as a way to deliver potato improvement to farmers’ fields; third, as an alternative, breeding potato cultivars for propagation through true potato seed; and fourth, gene editing and genetic transformation as ways of making further improvements to already successful and widely grown cultivars. Included are marker-assisted introgression and selection of specific alleles, genomic selection of many unspecified alleles and diploid F1 hybrid breeding.

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Page Count

571

Publisher

Springer Nature

Published Date

ISBN 10

3030644146

ISBN 13

9783030644147

The Craig Kennedy Scientific Detective MEGAPACK ®

25 Classic Tales of Detection

By: Arthur B. Reeve,R. Austin Freeman,John Russell Fearn,Cleveland Moffett,Samuel Hopkins Adams,Brander Matthews,Stacy Aumonier,C.J. Cutcliffe Hyne,L. T. Meade,Robert Eustace,Clifford Halifax

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The Craig Kennedy Scientific Detective MEGAPACK ®

25 Classic Tales of Detection

By: Arthur B. Reeve,R. Austin Freeman,John Russell Fearn,Cleveland Moffett,Samuel Hopkins Adams,Brander Matthews,Stacy Aumonier,C.J. Cutcliffe Hyne,L. T. Meade,Robert Eustace,Clifford Halifax

The Craig Kennedy Scientific Detective Megapack collects 25 novels and stories. 14 are Craig Kennedy tales, plus there is 1 additional story from the same author and 10 by contemporaries of Arthur B. Reeve. They all share the same spirit of detection. Included are: INTRODUCTION: ABOUT ARTHUR B. REEVE AND HIS CRAIG KENNEDY STORIES THE SILENT BULLET, by Arthur B. Reeve THE WAR TERROR, by Arthur B. Reeve THE TREASURE-TRAIN, by Arthur B. Reeve GUY GARRICK, by Arthur B. Reeve THE SOCIAL GANGSTER, by Arthur B. Reeve THE EXPLOITS OF ELAINE, by Arthur B. Reeve THE ROMANCE OF ELAINE, by Arthur B. Reeve THE POISONED PEN, by Arthur B. Reeve THE EAR IN THE WALL, by Arthur B. Reeve GOLD OF THE GODS, by Arthur B. Reeve THE DREAM DOCTOR, by Arthur B. Reeve THE FILM MYSTERY, by Arthur B. Reeve CONSTANCE DUNLAP, by Arthur B. Reeve THE MASTER MYSTERY, by Arthur B. Reeve THE CONSPIRATORS, by Arthur B. Reeve WITHOUT WITNESSES, by L. T. Meade and Clifford Halifax A MASTER OF MYSTERIES, by L. T. Meade and Robert Eustace THE SECRET OF EMU PLAIN, by L. T. Meade and Robert Eustace THE TRAGEDY OF A THIRD SMOKER, by C.J. Cutcliffe Hyne MISS BRACEGIRDLE DOES HER DUTY, by Stacy Aumonier THE TWINKLING OF AN EYE, by Brander Matthews THE FLYING DEATH, by Samuel Hopkins Adams THROUGH THE WALL, by Cleveland Moffett THE COPPER BULLET, by John Russell Fearn JOHN THORNDYKE’S CASES, by R. Austin Freeman And don't forget to search your favorite ebook store for more entries in the Megapack series, covering science fiction, fantasy, horror, adventure, westerns, ghost stories, mysteries -- and much, much more!

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Page Count

3777

Publisher

Wildside Press LLC

Published Date

ISBN 10

1434448657

ISBN 13

9781434448651

Cell Adhesion and Migration in Skin Disease

By: Jonathan Barker,John McGrath

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Cell Adhesion and Migration in Skin Disease

By: Jonathan Barker,John McGrath

The past few years have seen considerable advances in our understanding of the molecular basis underlying cutaneous cell adhesion mechanisms. Co-authored by a number of leading experts in the field ^Cell Adhesion and Migration in Skin Disease provides a comprehensive overview of the critical role played by cell adhesion in determining the structure and function of both healthy and diseased human skin. The book is divided into three main sections, with each one addressing a principal function of adhesion molecules. The first part focuses on the epidermis, which as the skin's outermost layer, acts as the human body's primary barrier of defence. Roles played by cytoskeletal intermediate filaments and junctional complexes in cutaneous cell adhesion are emphasised with descriptions of blistering skin diseases that can arise if these molecules malfunction. The second part describes the macromolecular interactions responsible for the anchorage of cells to the underlying extracellular basement membrane. The experimental approaches detailed in the text not only reveal how the molecular components of the dermal-epidermal junction have been elucidated, but also highlight how mutations in the genes which encode these molecules are responsible for many heritable skin diseases. Leukocytes continually infiltrate the skin and patrol it for potentially harmful pathogens. Control of leukocyte adhesion to resident cells within the skin and to the extracellular matrix plays a key role in controlling these processes. These mechanisms constitute the primary focus of the final section. The pivotal role of leukocytes is examined in conjunction with the chronic inflammatory diseases which arise when components of the skin's finely tuned defence strategy go awry and the potential for these anomalies to be pinpointed as important immunotherapeutic targets for skin diseases.

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Page Count

285

Publisher

CRC Press

Published Date

ISBN 10

0203304594

ISBN 13

9780203304594

Twenty Thousand Mornings

An Autobiography

By: John Joseph Mathews

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Twenty Thousand Mornings

An Autobiography

By: John Joseph Mathews

When John Joseph Mathews (1894–1979) began his career as a writer in the 1930s, he was one of only a small number of Native American authors writing for a national audience. Today he is widely recognized as a founder and shaper of twentieth-century Native American literature. Twenty Thousand Mornings is Mathews’s intimate chronicle of his formative years. Written in 1965-67 but only recently discovered, this work captures Osage life in pre-statehood Oklahoma and recounts many remarkable events in early-twentieth-century history. Born in Pawhuska, Osage Nation, Mathews was the only surviving son of a mixed-blood Osage father and a French-American mother. Within these pages he lovingly depicts his close relationships with family members and friends. Yet always drawn to solitude and the natural world, he wanders the Osage Hills in search of tranquil swimming holes—and new adventures. Overturning misguided critical attempts to confine Mathews to either Indian or white identity, Twenty Thousand Mornings shows him as a young man of his time. He goes to dances and movies, attends the brand-new University of Oklahoma, and joins the Air Service as a flight instructor during World War I—spawning a lifelong fascination with aviation. His accounts of wartime experiences include unforgettable descriptions of his first solo flight and growing skill in night-flying. Eventually Mathews gives up piloting to become a student again, this time at Oxford University, where he begins to mature as an intellectual. In her insightful introduction and explanatory notes, Susan Kalter places Mathews’s work in the context of his life and career as a novelist, historian, naturalist, and scholar. Kalter draws on his unpublished diaries, revealing aspects of his personal life that have previously been misunderstood. In addressing the significance of this posthumous work, she posits that Twenty Thousand Mornings will challenge, defy, and perhaps redefine studies of American Indian autobiography.”

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Page Count

509

Publisher

University of Oklahoma Press

Published Date

ISBN 10

0806187484

ISBN 13

9780806187488

The Vincentians: A General History of the Congregation of the Mission

Volume 4 - Expansions and Reactions 1843-1878

By: John E. Rybolt

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The Vincentians: A General History of the Congregation of the Mission

Volume 4 - Expansions and Reactions 1843-1878

By: John E. Rybolt

Their mission was humble and simple: to reach the poor country people, who suffered from ignorance of their faith, a debased clergy, and poverty. In response, Vincent De Paul defined the vocation of his “Little Company” as preaching local missions for free, educating the clergy, and working to relieve the people’s poverty. Soon, however, this vocation was complicated by commands to minister to royal families, including Louis xiv of France and the kings and queens of Poland, which would embroil the Vincentians in international and ecclesiastical politics. In addition, they would begin dangerous foreign missions, such as ministering to the Christian captives of the Barbary pirates, the debased colonists and rebellious natives of Madagascar, and the vendetta-prone Corsicans. For the first time, modern readers have a thoroughly researched history based on original documents and the studies of numerous scholars, past and present. It portrays the Vincentians’ daily lives and describes their failings as well as their exalted acts of heroism. It also details the social and political milieus that conditioned their lives and work. It is an important, down-to-earth side of history not often told.

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Page Count

709

Publisher

New City Press

ISBN 10

1565486374

ISBN 13

9781565486379

Book's by John M. Simon

A New Dictionary of the Italian and English Languages

A New Dictionary of the Italian and English Languages

BACE

BACE

The Toff and the Deep Blue Sea

The Toff and the Deep Blue Sea

Organizational Behavior 2

Organizational Behavior 2

What Your Dog Is Trying To Tell You

What Your Dog Is Trying To Tell You

IP/ATM Mobile Satellite Networks

IP/ATM Mobile Satellite Networks

Potato Breeding: Theory and Practice

Potato Breeding: Theory and Practice

The Craig Kennedy Scientific Detective MEGAPACK ®

The Craig Kennedy Scientific Detective MEGAPACK ®

Cell Adhesion and Migration in Skin Disease

Cell Adhesion and Migration in Skin Disease

Twenty Thousand Mornings

Twenty Thousand Mornings

The Vincentians: A General History of the Congregation of the Mission

The Vincentians: A General History of the Congregation of the Mission

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