An argument that environmental challenges will only resonate with citizens of affluent postindustrial countries if sustainability concerns emerge from everyday practices. Far-reaching efforts to address environmental issues rarely seem to resonate with citizens of the United States or other wealthy postindustrial societies. In Engaging the Everyday, John Meyer considers this impediment to action on environmental problems—which he terms “the resonance dilemma”—and argues that an environmental agenda that emerges from everyday concerns would resonate more deeply with ordinary citizens. Meyer explores the contours of this alternative, theorizing both obstacles and opportunities and then considering it in terms of three everyday areas of material practice: land use, transportation by automobile, and home dwelling. Adopting the stance of an “inside critic” (neither detached theorist nor narrow policy advocate), and taking an approach that he calls “contested materiality,” Meyer draws on a variety of theoretical perspectives to construct a framework for understanding material practices. He reimagines each of the three material practices in terms of a political idea: for land, property; for automobiles, freedom; and for homes, citizenship. His innovative analysis offers a grounded basis for reshaping our talk about political concepts and values.
Following on from 2005's Rail Human Factors: Supporting the Integrated Railway, this book brings together an even broader range of academics and practitioners from around the world to share their expertise and experience on rail human factors. The content is both comprehensive and cutting-edge, featuring more than 55 chapters addressing the following topics: ¢ Passengers and public ¢ Driver performance and workload ¢ Driving and cognition ¢ Train cab and interfaces: simulation and design ¢ Routes, signage, signals and drivability ¢ Signalling and control of the railway ¢ Planning for the railway ¢ Engineering work and maintenance ¢ Level crossings ¢ Accidents and safety ¢ Human error and human reliability ¢ SPADs: signals passed at danger ¢ Human factors integration and standards ¢ Impairments to performance ¢ Staff competencies and training. People and Rail Systems: Human Factors at the Heart of the Railway will be invaluable for all those concerned with making railways safer, more reliable, of higher quality and more efficient. It will be essential reading for policy-makers, researchers and industry around the world.
An international manual is like a world cruise: a once-in-a-lifetime experience. All the more reason to consider carefully whether it is necessary. This can hardly be the case if previous research in the selected field has already been the subject of an earlier review-or even several competing surveys. On the other hand, more thorough study is necessary if the intensity and scope of research are increasing without comprehensive assessments. That was the situation in Western societies when work began on this project in the summer of 1998. It was then, too, that the challenges emerged: any manual, espe cially an international one, is a very special type of text, which is anything but routine. It calls for a special effort: the "state of the art" has to be documented for selected subject areas, and its presentation made as compelling as possible. The editors were delighted, therefore, by the cooperation and commitment shown by the eighty-one contributors from ten countries who were recruited to write on the sixty-two different topics, by the con structive way in which any requests for changes were dealt with, and by the patient re sponse to our many queries. This volume is the result of a long process. It began with the first drafts outlining the structure of the work, which were submitted to various distinguished colleagues. Friedheim Neidhardt of Berlin, Gertrud Nunner-Winkler of Munich, and Roland Eckert of Trier, to name only a few, supplied valuable comments at this stage.
Implants into the human body, such as hip joints, heart valves and dental crowns, have been increasingly used over the last 40 years or so, and many patients have benefited from their use. But how much is known about the metals, ceramics and polymers that are used in these repairs? This book provides a state-of-the-art account of the chemistry of the synthetic materials used in medicine and dentistry. It looks at the properties and interactions of these materials within the body at a molecular level, and includes discussion of bioengineering and cell biology. In addition, there is an account of the surgical procedures used, as well as extensive coverage of the possible biological reactions to the presence of foreign materials in the body. A brief look at the emerging field of tissue engineering completes the text. Fully referenced, with detailed reviews of the current literature, The Chemistry of Medical and Dental Materials will be an essential starting-point for all those in academia and industry who are involved in the development of new and improved repair materials.
Case Studies in Infectious Disease: Neisseria meningitidis presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.
Case Studies in Infectious Disease presents forty case studies featuring the most important human infectious diseases worldwide. Written for students of microbiology and medicine this book describes the natural history of infection from point of entry of the pathogen through pathogenesis, followed by clinical presentation, diagnosis and treatment. Five core sets of questions are posed in each case. What is the nature of the infectious agent, how does it gain access to the body, what cells are infected, and how does the organism spread? What are the host defense mechanisms against the agent and how is the disease caused? What are the typical manifestations of the infection and the complications that can occur? How is the infection diagnosed and what is the differential diagnosis? How is the infection managed, and what preventative measures can be taken to avoid infection? This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms, fully integrating microbiology and immunology throughout.
The Algebra of Organic Synthesis combines the aims, philosophies, and efforts involved in organic synthesis, reaction optimization, and green chemistry with techniques for determining quantitatively just how "green" synthesis plans are. It provides the first complete quantitative description of synthesis strategy analysis in the context of green ch
The institutional theory of organizations developed by Scott, Meyer and their colleagues over the past two decades has had an enormous impact on organizational theory and research. In this book, the editors review the major theoretical advances of the past decade and the empirical testing they have done on these theories. Their work has highlighted two key themes: the interrelationship between organizational complexity and the institutional environment; and the place of the individual within the organization.
Concern over environmental problems is prompting us to reexamine established thinking about society and politics. The challenge is to find a way for the public's concern for the environment to become more integral to social, economic, and political decision making. Two interpretations have dominated Western portrayals of the nature-politics relationship, what John Meyer calls the dualist and the derivative. The dualist account holds that politics—and human culture in general—is completely separate from nature. The derivative account views Western political thought as derived from conceptions of nature, whether Aristotelian teleology, the clocklike mechanism of early modern science, or Darwinian selection. Meyer examines the nature-politics relationship in the writings of two of its most pivotal theorists, Aristotle and Thomas Hobbes, and of contemporary environmentalist thinkers. He concludes that we must overcome the limitations of both the dualist and the derivative interpretations if we are to understand the relationship between nature and politics. Human thought and action, says Meyer, should be considered neither superior nor subservient to the nonhuman natural world, but interdependent with it. In the final chapter, he shows how struggles over toxic waste dumps in poor neighborhoods, land use in the American West, and rainforest protection in the Amazon illustrate this relationship and point toward an environmental politics that recognizes the experience of place as central.
John McGuckin, a world-renowned expert on ancient Christianity, has synthesized a lifetime of work to produce the most comprehensive and accessible history of the first millennium of the Christian church. This readable account explores the history in chronological order and then examines the same period thematically, looking at issues like women, war, and the Bible.
Practising evidence-based medicine necessarily depends on the clinician having access to the best evidence available, but in a fast-moving field, keeping up to date with the latest developments is a challenging prospect. In this new volume, leading experts focus on the most important clinical issues associated with the management of lipid disorders, evaluating and interpreting the evidence available to provide the reader with a reliable summary of our current knowledge. Topics covered include therapeutical strategies for managing hereditary lipid disorders, including familial hypercholesterolemia, both in adults and children, and familial combined hypercholesterolemia. The authors also evaluate the evidence for a link between inflammatory disease and cardiovascular risk; the metabolic syndrome and the interconnections between dyslipidemias and diabetes. They also look at therapeutic challenges such as the management of patients who are statin resistant, and the control of lipid levels in those suffering renal insufficiency. Tables highlight important data, evidence from trial results and expert reports, and each section concludes with a series of key points that present a summary of evidence-based recommendations for best practice, graded according to the quality of that evidence. Evidence-based Management of Lipid Disorders provides the busy clinician with a unique analysis of the data supporting current therapies and will help the reader formulate effective strategies for treating their own patients.
From basement Bible study to leading evangelical institution Starting from humble beginnings in the late nineteenth century, the story of Trinity International University and Trinity Evangelical Divinity School is one of faithfulness. In Great Is Thy Faithfulness, scholars John D. Woodbridge, David M. Gustafson, Scott M. Manetsch, and Bradley J. Gundlach trace the journey of Trinity International University and Trinity Evangelical Divinity School. In order to tell the story of evangelicalism in America, one must know the story of Trinity International University. Great Is Thy Faithfulness is an essential resource for understanding an institution that has been at the center of evangelical theological life for decades. Readers will be encouraged by God's faithfulness to his people.
****Updated and expanded including many illustrations by George Almond. Plus clearer translations of foreign terms. Ian Fleming's James Bond: Annotations and Chronologies for Ian Fleming's Bond Stories officially approved by Ian Fleming Publications Ltd (formerly Glidrose), with a Preface by Andrew Lycett and Forewords by Zoë Watkins, Publishing Manager, Ian Fleming Publications Ltd.; Raymond Benson, author of The James Bond Bedside Companion, six original 007 novels, and numerous non-Bond novels. This book is the result of analysis of each of Fleming's James Bond novels. Within are glossaries of applicable terminology and references with detailed chronologies of events including annotations. Detailed chronologies of events are represented at a day-of-week, month, day, year, and time-of-day level. Glossaries contain translations of foreign terms, annotations, and other information of interest such as detailed information on the origin of Saramanga's name (The Man with the Golden Gun). Maps have been created for many of the novels along with in-depth information concerning specific topics such as, the Moonraker bridge game and the Goldfinger golf game. In many instances, monetary amounts have been converted to their 2001 purchasing power equivalent. Differences found between published versions and the original Fleming manuscripts archived at Indiana University's Lilly Library have been noted.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has been updated throughout to include the most recent versions of the two main classification systems---the DSM-5 and the ICD-11---used throughout the world for the diagnosis of mental disorders. In the years since publication of the first edition, many new and exciting discoveries have occurred in the biological sciences, which are having a major impact on how we study and practise psychiatry. In addition, psychiatry has fostered closer ties with philosophy, and these are leading to healthy discussions about how we should diagnose and treat mental illness. This new edition recognises these and other developments. Throughout, accounts of clinical practice are linked to the underlying science, and to the evidence for the efficacy of treatments. Physical and psychological treatments, including psychodynamic approaches, are covered in depth. The history of psychiatry, ethics, public health aspects, and public attitudes to psychiatry and to patients are all given due attention.
In a chemical system with many chemical species several questions can be asked: what species react with other species: in what temporal order: and with what results? These questions have been asked for over one hundred years about simple and complex chemical systems, and the answers constitute the macroscopic reaction mechanism. In Determination of Complex Reaction Mechanisms authors John Ross, Igor Schreiber, and Marcel Vlad present several systematic approaches for obtaining information on the causal connectivity of chemical species, on correlations of chemical species, on the reaction pathway, and on the reaction mechanism.Basic pulse theory is demonstrated and tested in an experiment on glycolysis. In a second approach, measurements on time series of concentrations are used to construct correlation functions and a theory is developed which shows that from these functions information may be inferred on the reaction pathway, the reaction mechanism, and the centers of control in that mechanism. A third approach is based on application of genetic algorithm methods to the study of the evolutionary development of a reaction mechanism, to the attainment given goals in a mechanism, and to the determination of a reaction mechanism and rate coefficients by comparison with experiment. Responses of non-linear systems to pulses or other perturbations are analyzed, and mechanisms of oscillatory reactions are presented in detail. The concluding chapters give an introduction to bioinformatics and statistical methods for determining reaction mechanisms.
This monograph is the first roadmap for transparent electronics. It defines and assesses what and where the field is, where it is going, and what needs to happen to get it there. Although the central focus of this monograph involves transparent electronics, many of the materials, devices, circuits, and process integration strategies discussed will be of great interest to researchers working in other emerging fields, including printed electronics, large-area electronics, low-cost electronics, and disposable electronics.
A leading economist charts the indirect road to happiness and wealth. Using dozens of practical examples from the worlds of business, politics, science, sports, literature, even parenting, esteemed economist John Kay proves a notion that feels at once paradoxical and deeply commonsensical: The best way to achieve any complex or broadly defined goal-from happiness to wealth to profit to preventing forest fires-is the indirect way. As Kay points out, we rarely know enough about the intricacies of important problems to tackle them head-on. And our unpredictable interactions with other people and the world at large mean that the path to our goals-and sometimes the goals themselves-will inevitably change. We can learn about our objectives and how to achieve them only through a gradual process of risk taking and discovery-what Kay calls obliquity. Kay traces this pathway to satisfaction as it manifests itself in nearly every aspect of life. The wealthiest people-from Andrew Carnegie to Bill Gates-achieved their riches through a passion for their work, not because they set materialistic goals. Research has shown that companies whose goal (as declared in mission statements) is excellent products or service are more profitable than companies whose stated goal is increasing profits. In the personal realm, a large body of evidence shows that parenthood is on a daily basis far more frustrating than happy- making. Yet parents are statistically happier than nonparents. Though their short-term pleasure is often thwarted by the demands of childrearing, the subtle-oblique-rewards of parenthood ultimately make them happier. Once he establishes the ubiquity of obliquity, Kay offers a wealth of practical guidance for avoiding the traps laid by the direct approach to complex problems. Directness blinds us to new information that contradicts our presumptions, fools us into confusing logic with truth, cuts us off from our intuition (which is the subconscious expression of our experience), shunts us away from alternative solutions that may be better than the one we're set on, and more. Kay also shows us how to acknowledge our limitations, redefine our goals to fit our skills, open our minds to new data and solutions, and otherwise live life with obliquity. This bracing manifesto will convince readers-or confirm their conviction-that the best route to satisfaction and success does not run through the bottom line.
This book introduces semantic representations of multiscale, multidomain physiological systems that link to qualitative reasoning and to quantitative analysis of biophysical processes in health and disease. Two major public health problems, diabetes and hypertension, serve as use-cases to illustrate the depth and rigor of such representations for logical inference and quantitative analysis. Central to this approach is the Ontology of Physics for Biology (OPB) that formally represents the foundations of classical physics and engineering system dynamics that are the basis for our understanding of biomedical entities, processes, and functional relationships. Furthermore, we introduce OPB-based software for annotating and abstracting available biosimulation models for reuse, recombination, and for archiving of physics-based biomedical knowledge. We have formalized and leveraged physics-based biological knowledge as a working view of physiology and biophysics from three distinct perspectives: (1) biologists and biomedical investigators, (2) biophysicists and bioengineers, and (3) biomedical ontologists and informaticists. We present a logical and intuitive semantics of classical physics as a tool for mediating and translating biophysical knowledge among biomedical domains. Daniel L. Cook, MD, PhD John H. Gennari, PhD Maxwell L. Neal, PhD
Vascular Protection explores advances in vascular biology and how they translate into innovations in drug therapy for vascular disease. It addresses recent advances in the knowledge of endothelial vasoactive factors and other biologically active molecules as well as gene therapy. Written by leading experts in their respective fields, each chapter e
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