John M. Leong's Books

Escherichia coli

Chapter 5. Enterohemorrhagic and other Shigatoxin-producing Escherichia coli

By: Sivapriya Kailasan Vanaja,Dakshina M. Jandhyala,Emily M. Mallick,John M. Leong,Sowmya Balasubramanian

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Escherichia coli

Chapter 5. Enterohemorrhagic and other Shigatoxin-producing Escherichia coli

By: Sivapriya Kailasan Vanaja,Dakshina M. Jandhyala,Emily M. Mallick,John M. Leong,Sowmya Balasubramanian

Enterohemorrhagic Escherichia coli (EHEC) can cause food-borne disease outbreaks associated with contaminated beef or fresh produce, resulting in diarrhea, hemorrhagic colitis, and/or hemolytic uremic syndrome: the triad of anemia, thrombocytopenia, and renal failure. Intestinally colonized cattle are a major source of human infection. Upon colonic infection, EHEC utilizes a type III secretion system to translocate into mammalian cells bacterial effector proteins that target cellular functions such as epithelial barrier integrity, vesicular transport, and cytoskeletal structure. Translocated effectors induce ‘attaching and effacing’ lesions, characterized by microvillar effacement, intimate attachment, and actin ‘pedestal’ formation beneath bound bacteria. Systemic disease relies on the production of Shiga toxin, a potent inhibitor of ribosome function that triggers cell death, inflammation, and vascular damage. Most current therapies are only supportive in nature because antibiotic treatment may increase Shiga toxin production. Therefore, outbreak prevention, early diagnosis, and the development of new therapeutic strategies are critical.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128061790

ISBN 13

9780128061794

Roger's Textbook of Pediatric Intensive Care

By: Donald H. Shaffner,John J. McCloskey,Elizabeth A. Hunt,Robert C. Tasker

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Roger's Textbook of Pediatric Intensive Care

By: Donald H. Shaffner,John J. McCloskey,Elizabeth A. Hunt,Robert C. Tasker

Long recognized as the leading text in this dynamic field, Rogers’ Textbook of Pediatric Intensive Care provides comprehensive, clear explanations of both the principles underlying pediatric critical care disease and trauma as well as how these principles are applied. Led by Drs. Donald H. Shaffner, John J. McCloskey, Elizabeth A. Hunt, and Robert C. Tasker, along with a team of 27 section editors as well as more than 250 expert global contributors, the fully revised Sixth Edition brings you completely up to date on today’s understanding, treatments, technologies, and outcomes regarding critical illness in children.

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6202

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

1975174224

ISBN 13

9781975174224

If We Can Put a Man on the Moon

Getting Big Things Done in Government

By: William D. Eggers,John O'Leary

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If We Can Put a Man on the Moon

Getting Big Things Done in Government

By: William D. Eggers,John O'Leary

The American people are frustrated with their government-dismayed by a series of high-profile failures (Iraq, Katrina, the financial meltdown) that seems to just keep getting longer. Yet our nation has a proud history of great achievements: victory in World War II, our national highway system, welfare reform, the moon landing. We need more successes like these to reclaim government's legacy of competence. In If We Can Put a Man on the Moon, William Eggers and John O'Leary explain how to do it. The key? Understand-and avoid-the common pitfalls that trip up public-sector leaders during the journey from idea to results. The authors identify pitfalls including: -The Partial Map Trap: Fumbling handoffs throughout project execution -The Tolstoy Syndrome: Seeing only the possibilities you want to see -Design-Free Design: Designing policies for passage through the legislature, not for implementation -The Overconfidence Trap: Creating unrealistic budgets and timelines -The Complacency Trap: Failing to recognize that a program needs change At a time of unprecedented challenges, this book, with its abundant examples and hands-on advice, is the essential guide to making our government work better. A must-read for every public official, this book will be of interest to anyone who cares about the future of democracy.

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321

Publisher

Harvard Business Press

Published Date

ISBN 10

1422155129

ISBN 13

9781422155127

Cummings Otolaryngology - Head and Neck Surgery E-Book

Head and Neck Surgery, 3-Volume Set

By: Paul W. Flint,Bruce H. Haughey,Valerie J. Lund,John K. Niparko,K. Thomas Robbins,J. Regan Thomas,Marci M. Lesperance

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Cummings Otolaryngology - Head and Neck Surgery E-Book

Head and Neck Surgery, 3-Volume Set

By: Paul W. Flint,Bruce H. Haughey,Valerie J. Lund,John K. Niparko,K. Thomas Robbins,J. Regan Thomas,Marci M. Lesperance

Now in its 6th edition, Cummings Otolaryngology remains the world's most detailed and trusted source for superb guidance on all facets of head and neck surgery. Completely updated with the latest minimally invasive procedures, new clinical photographs, and line drawings, this latest edition equips you to implement all the newest discoveries, techniques, and technologies that are shaping patient outcomes. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Overcome virtually any clinical challenge with detailed, expert coverage of every area of head and neck surgery, authored by hundreds of leading luminaries in the field. Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes approximately 3,200 images and over 40 high quality procedural videos. Get truly diverse perspectives and worldwide best practices from a multi-disciplinary team of contributors and editors comprised of the world’s leading experts. Glean all essential, up-to-date, need-to-know information. All chapters have been meticulously updated; several extensively revised with new images, references, and content. Stay at the forefront of your field with the most updated information on minimally-invasive surgical approaches to the entire skull base, vestibular implants and vestibular management involving intratympanic and physical therapy-based approaches, radiosurgical treatment of posterior fossa and skull base neoplasms, and intraoperative monitoring of cranial nerve and CNS function. Apply the latest treatment options in pediatric care with new chapters on pediatric sleep disorders, pediatric infectious disease, and evaluation and management of the infant airway. Find what you need faster through a streamlined format, reorganized chapters, and a color design that expedites reference. Manage many of the most common disorders with treatment options derived from their genetic basis. Assess real-world effectiveness and costs associated with emergent technologies and surgical approaches introduced to OHNS over the past 10 years. Incorporate recent findings about endoscopic, microscopic, laser, surgically-implantable, radiosurgical, neurophysiological monitoring, MR- and CT-imaging, and other timely topics that now define contemporary operative OHNS. Take it with you anywhere! With Expert Consult, you'll have access the full text, video clips, and more online, and as an eBook - at no additional cost!

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4198

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323278205

ISBN 13

9780323278201

Critical Care Nephrology E-Book

By: Claudio Ronco,Rinaldo Bellomo,John Kellum,Zaccaria Ricci

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Critical Care Nephrology E-Book

By: Claudio Ronco,Rinaldo Bellomo,John Kellum,Zaccaria Ricci

Comprehensive and clinically relevant, the 3rd Edition of Critical Care Nephrology provides authoritative coverage of the latest advances in critical care procedures for patients with renal diseases or disorders. Using common guidelines and standardized approaches to critically ill patients, this multidisciplinary reference facilitates better communication among all physicians who care for critically ill patients suffering from kidney disease, electrolyte and metabolic imbalances, poisoning, severe sepsis, major organ dysfunction, and other pathological events. - Offers detailed discussions of different forms of organ support, artificial organs, infections, acute illness occurring in chronic hemodialysis patients, and much more. - Places a special emphasis on therapeutic interventions and treatment procedures for a hands on clinical reference tool. - Presents information clearly, in a format designed for easy reference – from basic sciences to clinical syndromes to diagnostic tools. - Covers special populations such as children, diabetic patients, and the elderly. - An exceptional resource for nephrologists, intensivists, surgeons, or critical care physicians – anyone who treats critically ill renal patients. - Shares a combined commitment to excellence lead by Drs. Claudio Ronco, Rinaldo Bellomo, John Kellum, and Zaccaria Ricci – unparalleled leaders in this field. - Addresses key topics with expanded coverage of acute kidney injury, stress biomarkers, and sepsis, including the latest developments on mechanisms and management. - Provides up-to-date information on extracorporeal therapies from new editor Dr. Zaccaria Ricci. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

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1843

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323511996

ISBN 13

9780323511995

Abeloff's Clinical Oncology E-Book

By: Martin D. Abeloff,James O. Armitage,John E. Niederhuber,Michael B. Kastan,W. Gillies McKenna

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Abeloff's Clinical Oncology E-Book

By: Martin D. Abeloff,James O. Armitage,John E. Niederhuber,Michael B. Kastan,W. Gillies McKenna

Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.

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2586

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

1437720560

ISBN 13

9781437720563

Silicon Heterostructure Devices

By: John D. Cressler

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Silicon Heterostructure Devices

By: John D. Cressler

SiGe HBTs are the most mature of the Si heterostructure devices and not surprisingly the most completely researched and discussed in the technical literature. However, new effects and nuances of device operation are uncovered year-after-year as transistor scaling advances and application targets march steadily upward in frequency and sophistication. Providing a comprehensive treatment of SiGe HBTs, Silicon Heterostructure Devices covers an amazingly diverse set of topics, ranging from basic transistor physics to noise, radiation effects, reliability, and TCAD simulation. Drawn from the comprehensive and well-reviewed Silicon Heterostructure Handbook, this text explores SiGe heterojunction bipolar transistors (HBTs), heterostructure FETs, various other heterostructure devices, as well as optoelectronic components. The book provides an overview, characteristics, and derivative applications for each device covered. It discusses device physics, broadband noise, performance limits, reliability, engineered substrates, and self-assembling nanostructures. Coverage of optoelectronic devices includes Si/SiGe LEDs, near-infrared detectors, photonic transistors for integrated optoelectronics, and quantum cascade emitters. In addition to this substantial collection of material, the book concludes with a look at the ultimate limits of SiGe HBTs scaling. It contains easy-to-reference appendices on topics including the properties of silicon and germanium, the generalized Moll-Ross relations, and the integral charge-control model, and sample SiGe HBT compact model parameters.

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472

Publisher

CRC Press

Published Date

ISBN 10

1420066919

ISBN 13

9781420066913

Khan's Treatment Planning in Radiation Oncology

By: Faiz M. Khan,John P. Gibbons,Paul W. Sperduto

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Khan's Treatment Planning in Radiation Oncology

By: Faiz M. Khan,John P. Gibbons,Paul W. Sperduto

This unique, full-color reference offers a total team approach to radiation oncology treatment planning, incorporating the newest imaging techniques and offering a comprehensive discussion of clinical, physical, biological and technical aspects. A clear focus on the application of physical and clinical concepts to solve treatment planning problems helps you provide effective, state-of-the-art care for cancer patients. With authoritative coverage of the latest in sophisticated radiation oncology treatment modalities, the 4th Edition of Khan’s Treatment Planning in Radiation Oncology is an essential resource for the radiation oncologist, medical physicist, dosimetrist, and radiation therapist.

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Page Count

1475

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

1469889994

ISBN 13

9781469889993

Book's by John M. Leong

Escherichia coli

Escherichia coli

Roger's Textbook of Pediatric Intensive Care

Roger's Textbook of Pediatric Intensive Care

If We Can Put a Man on the Moon

If We Can Put a Man on the Moon

Cummings Otolaryngology - Head and Neck Surgery E-Book

Cummings Otolaryngology - Head and Neck Surgery E-Book

Critical Care Nephrology E-Book

Critical Care Nephrology E-Book

Abeloff's Clinical Oncology E-Book

Abeloff's Clinical Oncology E-Book

Silicon Heterostructure Devices

Silicon Heterostructure Devices

Khan's Treatment Planning in Radiation Oncology

Khan's Treatment Planning in Radiation Oncology

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