Microspheres and Regional Cancer Therapy takes an interdisciplinary approach to the subject of microspheres and regional cancer therapy. It synthesizes laboratory and clinical data to demonstrate the utility of microsphere-based strategies in the treatment of localized solid tumors (particularly in the liver) not amenable to surgery and as a component of strategies for treatment of disseminated disease. Using the same techniques that show the deficiencies of delivery strategies involving antibodies, liposomes, and synthetic polymers, clear evidence is presented describing how microspheres of appropriate size can be localized in solid tumor deposits in the liver with little exposure to other organs. To exploit this phenomenon, the extent and nature of the incorporation of active agents within microspheres is discussed in relation to release, pharmacokinetics, and tumor response achieved by intensification of therapy in the manner described. This book will benefit laboratory-based scientists and clinicians in pharmaceutics, pharmacology, physiology, surgical oncology, and nuclear medicine. In addition, cancer clinicians interested in the value of regional therapy will be able to evaluate the underlying theory and learn the necessary methodology.
Heterocyclic compounds play a vital role in the metabolism of living cells. Their practical applications range from extensive clinical use to fields as diverse as agriculture, photography, biocide formulation and polymer science. Written by leading scholars and industry experts, the Handbook of Heterocyclic Chemistry is thoroughly updated with over 50% new content. It has been rewritten with a new expanded author team, who have carefully distilled essential information on the reactivity, structure and synthesis of heterocycles from the 2008 major reference work Comprehensive Heterocyclic Chemistry III. To bring the work up to date the author team have also added new synthetic examples and structures, key applications and new references from 2008-2010. Contains more than 1500 clearly drawn structures and reactions. The highly systematic coverage given to the subject makes this one of the most authoritative single-volume accounts of modern heterocyclic chemistry available and should be useful reference for those teaching a heterocyclic course. - Covers the structure, reactivity and synthesis of all heterocyclic compounds as distilled from the larger 15-volume reference work - Saves researchers time when they require important information on heterocycles--speeding them to thousands of clearly drawn chemical structures and pertinent reviews by leading experts - Features 35% new material to compliment the completely revised text
The 21st century has witnessed important changes in retail logistics. Supply chain managers are presented with key challenges as retailers have recognised the strategic role that supply chains play in cost reduction and customer service. The 4th edition of Logistics and Retail Management has been substantially updated to take account of these recent developments in retail logistics. Logistics and Retail Management provides the most up-to-date thinking in retail supply chain management, reflecting the changing needs of the global marketplace and the challenges faced by retailers in the 21st century. With contributions from acclaimed academics and practitioners, it covers global logistics, fashion logistics, e-logistics and green supply chains. The 4th edition features brand new chapters on supply chain management in international fashion and corporate social responsibility in the textile supply chain.
The Year Book of Surgery brings you abstracts of the articles that reported the year's breakthrough developments in general surgery, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. The Year Book of Surgery is published annually in June, and includes topics such as: General Surgery; Trauma; Burns; Critical Care; Transplantation; Surgical Infections; Would Healing; Oncology; Vascular Surgery; and General Thoracic Surgery.
The elucidation of the cellular and molecular bases underlying the inte grated function of the central nervous system, both in disease and in health, must ultimately come from the combined efforts of scientists from many disciplines, including biology, chemistry, histology, pathology, physiology, pharmacology, and psychology. Communication between scientists from these various disciplines-vital to the advancement of our understanding of the function of the nervous system-has become more and more difficult in recent years. Both increasing specialization and the incredible increases in publications pertinent to brain research in a wide spectrum of journals, in symposium volumes, in monographs, in abstracts, and in reviews contrib ute to the problems of cross-communication and even of communication within a scientific discipline. Research on the significance of cyclic nucleo tides to the function of nervous systems is particularly illustrative of the communication problem. Since the initial publications by Sutherland, Rall, and Butcher in the late fifties and early sixties on high levels of adenylate cyclase, phosphodiesterases, and cyclic AMP in brain, the ensuing litera ture of this field has expanded exponentially. At the present time, from five to ten publications relevant to cyclic nucleotides and the nervous system appear each week. Indeed, these are minimal numbers based mainly on examination of literature titles and key index words. Many articles concerned with some aspect of central function contain, buried within their text, experiments with or related to cyclic nucleotides.
In The Triumph of Sociobiology, John Alcock reviews the controversy that has surrounded evolutionary studies of human social behavior following the 1975 publication of E.O. Wilson's classic, Sociobiology, The New Synthesis. Denounced vehemently as an "ideology" that has justified social evils and inequalities, sociobiology has survived the assault. Twenty-five years after the field was named by Wilson, the approach he championed has successfully demonstrated its value in the study of animal behavior, including the behavior of our own species. Yet, misconceptions remain--to our disadvantage. In this straight-forward, objective approach to the sociobiology debate, noted animal behaviorist John Alcock illuminates how sociobiologists study behavior in all species. He confronts the chief scientific and ideological objections head on, with a compelling analysis of case histories that involve such topics as sexual jealousy, beauty, gender difference, parent-offspring relations, and rape. In so doing, he shows that sociobiology provides the most satisfactory scientific analysis of social behavior available today. Alcock challenges the notion that sociobiology depends on genetic determinism while showing the shortcoming of competing approaches that rely on cultural or environmental determinism. He also presents the practical applications of sociobiology and the progress sociobiological research has made in the search for a more complete understanding of human activities. His reminder that "natural" behavior is not "moral" behavior should quiet opponents fearing misapplication of evolutionary theory to our species. The key misconceptions about this evolutionary field are dissected one by one as the author shows why sociobiologists have had so much success in explaining the puzzling and fascinating social behavior of nonhuman animals and humans alike.
In the complex field of pharmacokinetics, one reference guide has an identity all its own: Clinical Pharmacokinetics. Now the fully updated 5th edition brings to experienced practitioners and students alike the fresh information they need most: · Content organized for fast reference to specific drugs · The latest on dosing in obese and overweight patients · Dosing considerations for neonatal, pediatric and geriatric patients · A look at protein binding and its implications · Population values for a variety of drugs to initiate dosing · Drug dosing in renal disease and creatinine clearance estimation A Distinctively Straightforward Guide is Now Even Better The 5th Edition of Clinical Pharmacokinetics is completely revised and updated, making a handy clinical guide even easier to use than ever. · Reorganized content features two sections: Basic Concepts and Special Populations and Specific Drugs and Drug Classes · Sections on special populations, including Dosing in Overweight and Obese Patients, have been conveniently grouped together · Comprehensive introduction covers means, measurements and monitoring · Also conveniently placed up front” a glossary of pharmacokinetics basics and commonly used equations
* Richly illustrated overview of clinical oncology, covering both general aspects of cancer, and detailing specific cancers by organ system * Detailed information on demographics, etiology, tumor biology, diagnostics, therapeutic techniques, and nutrition * Includes tumor classification, staging and treatment options for cancers of the skin, head and neck, lungs, esophagus, stomach, pancreas, small intestine, large bowel, breast and more.
La obra contiene, extractados, todos los libros de emblemas que se publicaron en español durante los siglos XVI y XVII. Se trata de un material de difícil acceso que de este modo se pone a disposición del lector, ya sea investigador o mero aficionado a la riquísima cultura simbólica cifrada en el género de la literatura emblemática. El libro se presenta en primera instancia como índice alfabético de los motivos iconográficos principales presentes en cada emblema. Pero, además, se podrá acceder a los emblemas mediante búsquedas realizadas a partir de los índices complementarios: de autores, lemas, fuentes y claves temáticas, aparte de los motivos iconográficos secundarios. Completa el volumen un glosario terminológico y de personajes que ayuda a la comprensión de los significados. El desarrollo de los estudios de emblemática en el ámbito internacional (existe una extensa Society for Emblem Studies) ha hecho aconsejable introducir traducción al inglés de los campos de información más relevantes. Y las ventajas que proporcionan las nuevas tecnologías han sido aprovechadas con la incorporación de un CD-ROM (ejecutable por igual en los sistemas Macintosh y PC) que agiliza la combinación de búsquedas complejas. Tanto el CD-ROM como el libro reproducen los grabados de los 1.732 emblemas estudiados.
This book is so much more than a recounting of old games. The football fates of Michigan and NotreDame have been intertwined since the first meeting in November 1887, and this richly illustrated, updated edition weaves these two chronologies together to produce a college-football-rivalry book like no other.
In this book, sociology professor John F. Conway looks at families past, present and future and examines the changing nature of family. Figures from the first decade of the new milennium tell us that one marriage in two may well end in divorce. Conway considers the implications of divorce, the impact of social changes on men, women and children, and suggests how these issues might be better addressed through family policy. The new edition addresses the harsh new reality facing Canadian families, especially those most vulnerable as a result of the crisis of the family. The Canadian Family in Crisis is the first book to examine the drastic changes in the Canadian family over the last thirty years.
Canada's embrace of Gaelic games has provided wonderful memories for those of the Irish-Canadian community and has created an opportunity for all to discover an exciting facet of Ireland's culture.
Why do people resort to plastic surgery to look young? Why are stepchildren at greatest risk of fatal abuse? Why do we prefer gossip to algebra? Why must Dogon wives live alone in a dark hut for five days a month? Why are young children good at learning language but not sharing? Over the past decade, psychologists and behavioral ecologists have been finding answers to such seemingly unrelated questions by applying an evolutionary perspective to the study of human behavior and psychology. Human Evolutionary Psychology is a comprehensive, balanced, and readable introduction to this burgeoning field. It combines a sophisticated understanding of the basics of evolutionary theory with a solid grasp of empirical case studies. Covering not only such traditional subjects as kin selection and mate choice, this text also examines more complex understandings of marriage practices and inheritance rules and the way in which individual action influences the structure of societies and aspects of cultural evolution. It critically assesses the value of evolutionary explanations to humans in both modern Western society and traditional preindustrial societies. And it fairly presents debates within the field, identifying areas of compatibility among sometimes competing approaches. Combining a broad scope with the more in-depth knowledge and sophisticated understanding needed to approach the primary literature, this text is the ideal introduction to the exciting and rapidly expanding study of human evolutionary psychology.
Suicide is one of the leading causes of death worldwide, with more than one million fatalities each year. During the post-war period, the rate of completed suicides has risen dramatically, especially among young men and Aboriginal peoples living in the Western world. While this has naturally led to growing concern amongst health care practitioners and policy experts, relatively little is known about the history of attempted and completed suicide. Histories of Suicide is the first book to examine the history of suicide in diverse national contexts, including Japan, Scotland, Australia, Soviet Russia, Peru, United States, France, South Africa, and Canada, to reveal the different social, political, economic, and cultural factors that inform our understanding of suicide. This interdisciplinary collection of essays assembles historians, health economists, anthropologists, and sociologists, who examine the history of suicide from a variety of approaches to provide crucial insight into how suicide differs across nations, cultures, and time periods. Focusing on developments from the eighteenth century to the present, the contributors examine vitally important topics such as the medicalization of suicide, representations of mental illness, psychiatric disputes, and the frequency of suicide amongst soldiers. An illuminating volume of studies, Histories of Suicide is a fascinating examination of the phenomenon of self-destruction throughout different historical periods and nations.
Highly Commended, BMA Medical Book Awards 2014 Comprehensive and erudite, Forensic Psychiatry: Clinical, Legal and Ethical Issues, Second Edition is a practical guide to the psychiatry of offenders, victims, and survivors of crime. This landmark publication has been completely updated but retains all the features that made the first edition such a well-established text. It integrates the clinical, legal, and ethical aspects of forensic psychiatry with contributions from internationally regarded experts from a range of clinical professions. The Second Edition features updates to all current chapters and several new chapters that explore: The genetics of antisocial behavior Disorders of brain structure and function that relate to crime Offenders with intellectual disabilities Older people and the criminal justice system Deviant and mentally ill staff Although the book focuses on jurisdictions in the UK, a substantial comparative chapter written by an international group from all five continents explores the different philosophies, legal principles, and style of services elsewhere. This book is an essential reference for specialists and postgraduate trainees in forensic psychiatry but also for general psychiatrists, and clinical and forensic psychologists. It is also an invaluable resource for other forensic mental health professionals, including nurses, social workers, occupational therapists, probation service staff, police, attorneys, criminologists, and sociologists.
Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has been updated throughout to include the most recent versions of the two main classification systems---the DSM-5 and the ICD-11---used throughout the world for the diagnosis of mental disorders. In the years since publication of the first edition, many new and exciting discoveries have occurred in the biological sciences, which are having a major impact on how we study and practise psychiatry. In addition, psychiatry has fostered closer ties with philosophy, and these are leading to healthy discussions about how we should diagnose and treat mental illness. This new edition recognises these and other developments. Throughout, accounts of clinical practice are linked to the underlying science, and to the evidence for the efficacy of treatments. Physical and psychological treatments, including psychodynamic approaches, are covered in depth. The history of psychiatry, ethics, public health aspects, and public attitudes to psychiatry and to patients are all given due attention.
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