Unlike other textbooks on this subject, which are more focused on end of life, the 4th edition of Principles and Practice of Palliative Care and Supportive Oncology focuses on supportive oncology. In fact, the goal of this textbook is to provide a source of both help and inspiration to all those who care for patients with cancer. Written in a more reader-friendly format, this textbook not only offers authoritative and up-to-date reviews of research and clinical care best practices, but also practical clinical applications to help readers put everything they learn to use.
This first volume of a remarkable four-volume set on the birds of British Columbia covers eight-six species of nonpasserines, from loons through to waterfowl. Detailed species accounts provide unprecedented coverage of these birds, presenting a wealth of information on the ornithological history, habitat, breeding habits, migratory movements, seasonality, and distribution patterns. Introductory chapters look at the province’s ornithological history, its environment and the methodology used in the volumes.
They are Americans, and they are mujahideen. Hundreds of men from every imaginable background have walked away from the traditional American dream to volunteer for battle in the name of Islam. Some have taken part in foreign wars that aligned with U.S. interests, while others have carried out violence against Westerners abroad, fought against the U.S. military, and even plotted terrorist attacks on American soil. This story plays out over decades and continents: from the Americans who took part in the siege of Mecca in 1979 through conflicts in Lebanon, Afghanistan, and Bosnia, and continuing today in Afghanistan and Somalia. Investigative journalist J. M. Berger profiles numerous fighters, including some who joined al Qaeda and others who chose a different path. In these pages he portrays, among others, Abdullah Rashid, who fought the Soviets in Afghanistan; Mohammed Loay Bayazid, who was present at the founding of al Qaeda; Ismail Royer, who fought in Bosnia and Kashmir, then returned to run training camps in the United States; Adam Gadahn, a Jewish Californian who is now al Qaeda's chief spokesman; and Anwar Awlaki, the Yemeni-American imam with links to 9/11 who is now considered one of the biggest threats to America's security.
The Fifth International Conference on Microreaction Technology featured more than 80 oral and poster communications, covering the entire interdisciplinary field from design, production, modelling and characterization of microreactor devices to application of microstructured systems for production, energy and transportation, including many analytical and biological applications.
Contains lecture notes from most of the courses presented at the 50th anniversary edition of the Seminaire de Mathematiques Superieure in Montreal. This 2011 summer school was devoted to the analysis and geometry of metric measure spaces, and featured much interplay between this subject and the emergent topic of optimal transportation.
Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.
The science of the virus and its effects and the clinical approaches to its treatment and transmission prevention are placed in the context of the history and epidemiology of the HIV-AIDS pandemic. Each organ system of the body is explored as to manifestations of the disease, treatment now and in the future, as well as what the disease has taught us about the immune response. The science of epidemiology, which is so important in allowing for tracking of the disease and potential limitation of transmission, is another aspect of AIDS explored in detail. The pandemic manifests differently in different parts of the world, and the relevance of the volume is enhanced by its international group of contributors. No other text provides the historical and epidemiological context of this disease along with an update of diagnosis and treatment. The underlying science and epidemiology of AIDS are not neglected, so the student or clinician who is treating patients with AIDS can gain a full understanding of HIV/AIDS in individual patients and in their communities.
Vasopressin is a hormone which has an increasingly important profile. Not only does it play a physiologically significant role in renal water regulation but it also has other renal actions and plays a role in overall cardiovascular control. Even more interesting is the recent growing interest in its potential effects on the brain, notably its influence on specific behaviours. This monograph about the polypeptide vasopressin covers all aspects relating to the production, control of release, and actions of this molecule within the body, including its roles as a hormone and as a central neurotransmitter. A consideration of the evolution of the molecule across the species and a brief historical perspective are also included. Clinical conditions associated with hypo- and hyper-production states are considered together with aspects of treatment, in addition to other clinical correlates. Sample Chapter(s). Chapter 1: Introduction to Vasopressin (204 KB). Contents: Introduction to Vasopressin; Comparative and Evolutionary Aspects of Vasopressin; The Neurohypophysial System: Synthesis and Metabolism of Vasopressin; Vasopressin Receptors, the Signalling Cascade and Mechanisms of Action; Pharmacology of the Vasopressin Receptors; Vasopressin and Its Renal Effects; Vasopressin and the Cardiovascular System; Vasopressin and Its Interactions with Other Hormones and Control Systems; Understanding the Role of Vasopressin in the Hypothalamo-Pituitary Adrenocortical Axis; Vasopressin: The Central Systems; Vasopressin Secretion: Mechanisms of Control of Secretion from the Posterior Pituitary Gland; Clinical Aspects of Vasopressin. Readership: Academics, researchers, and postgraduates in the field of endocrinology.
This book constitutes the refereed proceedings of the 7th International Conference on Intelligent Data Analysis, IDA 2007, held in Ljubljana, Slovenia. The 33 revised papers were carefully reviewed and selected from almost 100 submissions. The book covers all current aspects of this interdisciplinary field, including statistics, machine learning, data mining, classification and pattern recognition, clustering, applications, modeling, and interactive dynamic data visualization.
Used by generations of physicians who encounter patients with dermatological diseases, Lever’s Dermatopathology: Histopathology of the Skin comprehensively covers skin disease in which histopathology plays an important role in diagnosis. The updated 12th Edition, edited by Drs. David E. Elder, Rosalie Elenitsas, George F. Murphy, Misha Rosenbach, Adam I. Rubin, John T. Seykora, and Xiaowei Xu, maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a “primer” on pattern-algorithm diagnosis. It features larger images throughout, as well as thoroughly revised content with new diseases and new information on pathophysiology and molecular pathogenesis—all in an easy-to-navigate, highly readable format.
2015 BMA Medical Book Awards Highly Commended in Oncology Category!The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. - Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. - Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. - Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. - Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. - Access the entire text and illustrations online, fully searchable, at Expert Consult.
The maturation of nanotechnology has revealed it to be a unique and distinct discipline rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry, physics, or engineering text focused on nano. It must be an integrated, multidisciplinary, and specifically nano textbook. The archetype of the modern nano textbook
Part of the renowned Braunwald family of references, Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease provides today's clinicians with clear, authoritative guidance on every aspect of the latest diagnosis and management options for patients with arrhythmias. This comprehensive reference on cardiac arrhythmias lays a solid foundation of the underlying mechanisms of cardiac electrophysiology with an emphasis on identifying, understanding, and treating individual arrhythmias. Now fully updated from cover to cover, and carefully written to provide continuity and a consistent message throughout, the 4th Edition offers unparalleled coverage of cardiac arrhythmias in an accessible and user-friendly manner. - Grounds clinical techniques in basic science for managing patients with complex arrythmia disorders. - Offers increased clinical content with complete diagnostic and management options, including the latest drug-based, device-based, and device-drug therapies. - Covers new tools and techniques for atrial transseptal and percutaneous pericardial access, new ablation energies and tools, and new ACC/HRS guidelines for bradyarrhythmias. - Contains a new chapter on stroke prevention in atrial arrhythmias. - Includes significant content updates on macro-reentrant atrial tachycardias in an era of ultra-high-resolution mapping, new mapping and ablation technologies for ventricular tachycardia, new genetic mechanisms underlying arrhythmia syndromes, and much more. - Provides access to dozens of videos depicting key mapping techniques, and fluoroscopy images illustrating techniques for electrophysiologic catheter positioning, and atrial septal puncture, as well as pericardial access, cryoablation, and left atrial appendage exclusion procedures. - Uses a consistent format throughout, showing every arrhythmia in a similar manner for quick reference. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Potential theory grew out of mathematical physics, in particular out of the theory of gravitation and the theory of electrostatics. Mathematical physicists such as Poisson and Green introduced some of the central ideas of the subject. A mathematician with a general knowledge of analysis may find it useful to begin his study of classical potential theory by looking at its physical origins. Sections 2, 5 and 6 of these Notes give in part heuristic arguments based on physical considerations. These heuristic arguments suggest mathematical theorems and provide the mathematician with the problem of finding the proper hypotheses and mathematical proofs. These Notes are based on a one-semester course given by the author at Brown University in 1971. On the part of the reader, they assume a knowledge of Real Function Theory to the extent of a first year graduate course. In addition some elementary facts regarding harmonic functions are aS$umed as known. For convenience we have listed these facts in the Appendix. Some notation is also explained there. Essentially all the proofs we give in the Notes are for Euclidean 3-space R3 and Newtonian potentials ~.
Completely updated edition, written by a close-knit author team Presents a unique approach to stroke - integrated clinical management that weaves together causation, presentation, diagnosis, management and rehabilitation Includes increased coverage of the statins due to clearer evidence of their effectiveness in preventing stroke Features important new evidence on the preventive effect of lowering blood pressure Contains a completely revised section on imaging Covers new advances in interventional radiology
Forensic DNA Typing, Second Edition, is the only book available that specifically covers detailed information on mitochondrial DNA and the Y chromosome. It examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. The book covers topics from introductory level right up to cutting edge research. High-profile cases are addressed throughout the text, near the sections dealing with the science or issues behind these cases. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century. These additional chapters cover statistical genetic analysis of DNA data, an emerging field of interest to DNA research. Several chapters on statistical analysis of short tandem repeat (STR) typing data have been contributed by Dr. George Carmody, a well-respected professor in forensic genetics. Specific examples make the concepts of population genetics more understandable. This book will be of interest to researchers and practitioners in forensic DNA analysis, forensic scientists, population geneticists, military and private and public forensic laboratories (for identifying individuals through remains), and students of forensic science. *The only book available that specifically covers detailed information on mitochondrial DNA and the Y chromosome*Chapters cover the topic from introductory level right up to "cutting edge" research*High-profile cases are addressed throughout the book, near the sections dealing with the science or issues behind these cases*NEW TO THIS EDITION: D.N.A. Boxes--boxed "Data, Notes & Applications" sections throughout the book offer higher levels of detail on specific questions
Forensic Neuropathology provides superior visual examples of the more commonly encountered conditions in forensic neuropathology and answers questions that arise regarding neuropathological findings. The work includes values for frequently-encountered clinical assessments, and contains a more comprehensive summary of aging/dating of various neuropathological processes than is available in any other single current source. General pathology residents, forensic pathology and neuropathology fellows, and general pathologists and clinicians involved in referred cases will find this book extremely useful, as will individuals in allied fields such as law enforcement officers and attorneys. Forensic Neuropathology aims to: (1) provide a concise summary of practical information frequently needed in forensic neuropathology cases; (2) include selected material previously known but perhaps not significantly emphasized in current literature; and (3) where possible, to suggest aging/dating parameters for certain neuropathological findings relevant to forensic neuropathology testimony. As a selective reference, the volume emphasizes practical issues and focuses on the most commonly encountered issues among neuropathology and medical examiner professionals. - Over 800 high-quality full-color photographs, gross and microscopic as well as illustrative line drawings - Use of actual cases, briefly summarized and illustrated to emphasize key principles - Focuses on the most-commonly encountered cases as relate to forensic incident and covers these aspects in depth and detail
This book contains contributions by an impressive list of leading mathematicians. The articles include high-level survey and research papers exploring contemporary issues in geometric analysis, differential geometry, and several complex variables. Many of the articles will provide graduate students with a good entry point into important areas of modern research. The material is intended for researchers and graduate students interested in several complex variables and complex geometry.
To Catch a Virus To Catch a Virus Trace the evolution of diagnostic virology from yellow fever to COVID-19 Join expert storytellers John Booss, Marilyn J. August, and Marie Louise Landry in a journey through the history of viral epidemics and the detective work of those determined to identify the culprits and treat the infected. From the identification of the first virus in the late 1800s to the molecular techniques that enabled the rapid recognition of and vaccine development for the SARS-CoV-2 virus, viral diagnostic methods have progressed over the past century to become a formidable tool in human health care. This collection of gripping historical narratives covers a range of fascinating outbreaks and public health challenges, from yellow fever and smallpox to AIDS and COVID-19. This new edition chronicles the ongoing story of the COVID-19 pandemic, highlighting the people, the pathogen, and the progress in the diagnostic laboratory and clinical settings that has touched every aspect of global health. The many photographs and rich biographical sketches of key figures, diagrams of diagnostic procedures, micrographs of virus-infected cells, timelines, and a new glossary of key terms make To Catch a Virus compelling reading. This book serves as an excellent resource for courses in virology, immunology, microbiology, and public health. As the world struggles with the ongoing pandemic of SARS-CoV-2/COVID-19, To Catch a Virus is an insightful and superbly told story that chronicles the incredible metamorphosis of diagnostic virology and the technological advances that now make it possible to quickly and accurately detect and monitor the many disease-causing viruses that plague humankind. A stimulating, informative, and absorbing read that is highly recommended. —Richard L. Hodinka, PhD, Professor Emeritus, Perelman School of Medicine at the University of Pennsylvania; former Director, Clinical Virology Laboratory, Children’s Hospital of Philadelphia To Catch a Virus provides a beautifully written and compelling story of scientific discovery. It carefully traces the understanding of viral diseases from the turn of the twentieth century to the present. For general readers the authors provide timely and expert guidance to the extraordinary advances in diagnosis, surveillance, and therapeutics that constitute the silver lining in the otherwise somber years of COVID-19. For anyone wishing to understand the challenges confronting virologists and their accomplishments to date, this work is the place to start. —Frank M. Snowden, PhD, Andrew Downey Orrick Professor Emeritus of History, Yale University; former Chair, Program in History of Science and History of Medicine, Yale University
Across the world, cats are loved as pets or are kept or tolerated for their role in controlling some animal pests. But cats, both pets and feral, also kill many native animals and this toll can be enormous. Cats have been remarkably successful in Australia, spreading pervasively across the continent and many islands, occurring in all environments, and proving to be adept and adaptable hunters. A large proportion of Australia’s distinctive fauna is threatened and recent research highlights the significant role that cats play in the decline and extinction of native species. Cats in Australia brings this research together, documenting the extent to which cats have subverted, and are continuing to subvert, Australia’s biodiversity. But the book does much more than spotlight the impacts of cats on Australian nature. It describes the origins of cats and their global spread, their long-standing and varying relationship with people, their global impacts and their ecology. It also seeks to describe the challenge of managing cats, and the options available to constrain their impacts.
The Higgs Hunter's Guide is a definitive and comprehensive guide to the physics of Higgs bosons. In particular, it discusses the extended Higgs sectors required by those recent theoretical approaches that go beyond the Standard Model, including supersymmetry and superstring-inspired models.
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