The hippocampus mediates several higher brain functions, such as learning, memory, and spatial coding. The input region of the hippocampus, the dentate gyrus, plays a critical role in these processes. Several lines of evidence suggest that the dentate gyrus acts as a preprocessor of incoming information, preparing it for subsequent processing in CA3. For example, the dentate gyrus converts input from the entorhinal cortex, where cells have multiple spatial fields, into the spatially more specific place cell activity characteristic of the CA3 region. Furthermore, the dentate gyrus is involved in pattern separation, transforming relatively similar input patterns into substantially different output patterns. Finally, the dentate gyrus produces a very sparse coding scheme in which only a very small fraction of neurons are active at any one time. How are these unique functions implemented at the level of cells and synapses? Dentate gyrus granule cells receive excitatory neuron input from the entorhinal cortex and send excitatory output to the hippocampal CA3 region via the mossy fibers. Furthermore, several types of GABAergic interneurons are present in this region, providing inhibitory control over granule cell activity via feedback and feedforward inhibition. Additionally, hilar mossy cells mediate an excitatory loop, receiving powerful input from a small number of granule cells and providing highly distributed excitatory output to a large number of granule cells. Finally, the dentate gyrus is one of the few brain regions exhibiting adult neurogenesis. Thus, new neurons are generated and functionally integrated throughout life. How these specific cellular and synaptic properties contribute to higher brain functions remains unclear. One way to understand these properties of the dentate gyrus is to try to integrate experimental data into models, following the famous Hopfield quote: “Build it, and you understand it.” However, when trying this, one faces two major challenges. First, hard quantitative data about cellular properties, structural connectivity, and functional properties of synapses are lacking. Second, the number of individual neurons and synapses to be represented in the model is huge. For example, the dentate gyrus contains ~1 million granule cells in rodents, and ~10 million in humans. Thus, full scale models will be complex and computationally demanding. In this Frontiers Research Topic, we collect important information about cells, synapses, and microcircuit elements of the dentate gyrus. We have put together a combination of original research articles, review articles, and a methods article. We hope that the collected information will be useful for both experimentalists and modelers. We also hope that the papers will be interesting beyond the small world of “dentology,” i.e., for scientists working on other brain areas. Ideally, the dentate gyrus may serve as a blueprint, helping neuroscientists to define strategies to analyze network organization of other brain regions.
With our American Philosophy and Religion series, Applewood reissues many primary sources published throughout American history. Through these books, scholars, interpreters, students, and non-academics alike can see the thoughts and beliefs of Americans who came before us.
John Bachman (1790-1874) was an internationally renowned naturalist and a prominent Lutheran minister. This is the first collection of his writings, containing selections from his three major books, his letters, and his articles on plants and animals, education, religion, agriculture, and the human species. Bachman was the leading authority on North American mammals. He was responsible for the descriptions of the 147 mammal species included in Viviparous Quadrupeds of North America, a massive work produced in collaboration with John James Audubon. Bachman relied entirely on scientific evidence in his work and was exceptional among his fellow naturalists for studying the whole of natural history. Bachman also relied on scientific evidence in his Doctrine of the Unity of the Human Race. He showed that human beings constitute a single species that developed as varieties equivalent to the varieties of domesticated animals. In this work, perhaps his most significant accomplishment, Bachman stood nearly alone in challenging the polygenetic views of Louis Agassiz and others that white and black people descended from different progenitors. Bachman was also an important figure in the establishment of Lutheranism in the Southeast. He wrote the first American monograph on the doctrines of Martin Luther and the history of the Reformation. Bachman served for fifty-six years as minister of St. John's Lutheran Church in Charleston, South Carolina, and was one of the founders of Newberry College.
Reprint of the original. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.
This edition gathers into one volume and in chronological order all of the known essays, epistles, and other works which Woolman intended for general readers, excluding the Journal. While some, but not all, of the essays have been published at various times, and while several of the epistles in the Texts have been incorporated into printed versions of the Journal, most of the ephemera in Texts 7 A, B, C, D, E, and F have never before been published and the children's primer in Text 10, as well as all eleven of the Appendix texts, have barely been known in modern times. By placing this body of Woolman's literary work in chronological order, the development of his thought in the context of his life experiences seems best revealed. The editor's introduction to each of the texts is intended to explain the context for each work in its historical moment....p. xxxv-xxxvi.
This concise volume contains the essential information an orthopaedic surgeon needs for safe access to the internal structures of the limbs for the whole range of orthopaedic operations.
This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
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This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
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