Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.
This text helps the reader determine whether or not the gastrointestinal mucosa ulcerates can be viewed as a balance between aggressive factors present in the lumen and the mucosal defence system. Several of these aggressive factors, such as acid, bile and pepsin, are endogenous substances. Similarly, several endogenous substances exert control over mucosal blood flow and secretion and thus are important mediators of mucosal defence. In this volume, experts in this field have contributed chapters on some of the most important of these endogenous mediators, including histamine, prostaglandins, leukotrienes and platelet-activating factor. The potential contribution of these mediators to gastrointestinal disease has been assessed. Also discussed is the role these mediators play in gastrointestinal side effects of drugs (i.e. non-steroidal anti-inflammatory drugs). Also covered are the mechanisms of action of endogenous mediators relative to the the drugs used clinically for the treatment of maladies of the digestive system. This volume will be of interest to the basic scientist, the clinical investigator and to students of pathophysiology and medicine.
The cup was presented to the Wagga Wagga CA on the October 20, 1925, by Mr. Thomas Joseph “Tom” O’Farrell, who was a tailor with a business in Wagga Wagga. Its purpose was to raise the standard of country cricket and help arouse the interest and enthusiasm of both players and public in the game. By the original rules, which were drawn up by Mr. O’Farrell, Mr. M. Cusick, and Mr. G. Pinkstone, the cup was won outright by Wagga, who wisely redonated it, and it was put into play in the 1930–31 season as a perpetual challenge trophy for teams within one hundred miles radius of Wagga Wagga. O’Farrell was a frequent spectator at games and often handed over the cup to the winning captain. He was later to say, “I am particularly glad that the competition is doing so much to let the residents of surrounding towns learn more of each other in so friendly a way.”
Probably no Native American handicrafts are more widely admired than Navajo weaving and Navajo and Pueblo silver work. This book, which is now in its third large printing, contains the most important and complete account of Indian jewelry fashioned by the Navajo, the Zuni, the Hopi, and other Pueblo peoples. "With the care of a meticulous and thorough scholar, the author has told the story of his several years' investigation of jewelry making among the Southwestern Indians," says The Dallas Times Herald. "So richly decorative are the plates he uses ... that the conscientious narrative is surrounded by an atmosphere of genuinely exciting visual experience." John Adair is a trained ethnologist who has lived and worked among these Indians. To prepare his book, Mr. Adair made an exhaustive examination of the principal museum collections of Navajo and Pueblo silver work, both early and modem, in Santa Fe, Colorado Springs, Chicago, New York, and Philadelphia. He visited trading posts in the Indian country and examined and photographed silver on the pawn racks and in important private collections. He lived for a time among the Navajo, watched them make their jewelry, and actually learned to work silver himself in the hogan of one of the leading artisans, Tom Burnsides. Many of the photographs he made at the time are used as illustrations in this book. He spent months among the Indians in New Mexico and Arizona and became personally acquainted with many of their silversmiths. Later, as field worker for the Indian Arts and Crafts Board, he studied the economics of Navajo and Pueblo silversmithing; and still later he became manager of the Navajo Arts and Crafts Guild, a tribal enterprise. The Navajo and Pueblo Silversmiths provides a full history of the craft and the actual names and localities of the pioneer craftsmen who introduced the art of the silversmith to their people. Despite its present high stage of development, with its many subtle and often exquisite designs, the art of working silver is not an ancient one among the Navajo and Pueblo Indians. There are men still living today who remember the very first silversmiths. Mr. Adair gives full details, as he observed them, of the methods and techniques of manufacture over a primitive forge with homemade tools. He tells both of the fine pieces made for trade among the Indians themselves and of the newer, cheaper types of jewelry produced for sale to tourists. He discusses standards and qualities of Indian silver and describes the work of the Indian schools in helping preserve traditional design in the fine silver of today. His excellent photographs of some of the most notable pieces, old and new, provide examples for evaluation. This volume, therefore, will serve the layman, the ethnologist, and the dealer alike as a guide to proper values in Indian silver jewelry, and will provide the basis for authoritative knowledge and appreciation of a highly skilled creative art.
Schools for Thought provides a straightforward, general introduction to cognitive research and illustrates its importance for educational change. If we want to improve educational opportunities and outcomes for all children, we must start applying what we know about mental functioning--how children think, learn, and remember in our schools. We must apply cognitive science in the classroom. Schools for Thought provides a straightforward, general introduction to cognitive research and illustrates its importance for educational change. Using classroom examples, Bruer shows how applying cognitive research can dramatically improve students' transitions from lower-level rote skills to advanced proficiency in reading, writing, mathematics, and science. Cognitive research, he points out, is also beginning to suggest how we might better motivate students, design more effective tools for assessing them, and improve the training of teachers. He concludes with a chapter on how effective school reform demands that we expand our understanding of teaching and learning and that we think about education in new ways. Debates and discussions about the reform of American education suffer from a lack of appreciation of the complexity of learning and from a lack of understanding about the knowledge base that is available for the improvement of educational practice. Politicians, business leaders, and even many school superintendents, principals, and teachers think that educational problems can be solved by changing school management structures or by creating a market in educational services. Bruer argues that improvement depends instead on changing student-teacher interactions. It is these changes, guided by cognitive research, that will create more effective classroom environments. A Bradford Book
This best-selling textbook returns for a seventh edition with material on the most fundamental and fascinating issues in sociology today. The authors continue their tradition of focusing on the big picture, with an emphasis on race, class, and gender in every chapter. The text continues to frame sociological debates around the major theoretical perspectives of sociology and focus on capturing students’ imaginations with cutting-edge research and real-world events. The hallmark of the book continues to be clear writing that helps students understand the intricacies of the discipline like no other textbook on the market. New to the seventh edition Expanded focus on new social movements such as Black Lives Matter, Occupy Wall Street, and the Tea Party. Updates on both the 2012 and 2016 elections. New discussions of Donald Trump and the immigration debate; causes and consequences. New discussions of "patriot" movements, racism, and the reaction to the first African American president. Expanded coverage of sexual orientation and LGBT issues. Updates on gay rights and the historic legalization of same-sex marriage. New sections on cyber life discussion issues such as cyber bullying and public shaming; WikiLeaks, Edward Snowden, and NSA spying; sexting and youth culture; the Arab Spring; and social media activism. New coverage of the so-called "he-cession" and the rise of women managers (whom employers still see as risky but, increasingly, as highly talented). Updates on health-care reform, five years on and the efforts to repeal and replace "Obamacare". Expanded coverage of mass shootings and the corresponding policy debates. Expanded coverage and new focus on police-involved shootings and gun control in the "Deviance, Crime, and Social Control" chapter. New discussions of the sociology of finance, including the role of financial derivatives in the 2008 global financial crisis. New photos and updated figures and tables throughout the text.
The goal of image synthesis is to create, using the computer, a visual experience that is identical to what a viewer would experience when viewing a real environment. Radiosity and Realistic Image Synthesis offers the first comprehensive look at the radiosity method for image synthesis and the tools required to approach this elusive goal. Basic concepts and mathematical fundamentals underlying image synthesis and radiosity algorithms are covered thoroughly. (A basic knowledge of undergraduate calculus is assumed). The algorithms that have been developed to implement the radiosity method ranging from environment subdivision to final display are discussed. Successes and difficulties in implementing and using these algorithms are highlighted. Extensions to the basic radiosity method to include glossy surfaces, fog or smoke, and realistic light sources are also described. There are 16 pages of full colour images and over 100 illustrations to explain the development and show the results of the radiosity method. Results of applications of this new technology from a variety of fields are also included. Michael Cohen has worked in the area of realistic image synthesis since 1983 and was instrumental in the development of the radiosity method. He is currently an assistant professor of computer science at Princeton University. John Wallace is a software engineer at 3D/EYE, Inc., where he is the project leader for the development of Hewlett-Packard's ATRCore radiosity and ray tracing library. A chapter on the basic concepts of image synthesis is contributed by Patrick Hanrahan. He has worked on the topic of image synthesis at Pixar, where he was instrumental in the development of the Renderman software. He has also led research on the hierarchical methods at Princeton University, where he is an associate professor of computer science. All three authors have written numerous articles on radiosity that have appeared in the SIGGAPH proceedings and elsewhere. They have also taught the SIGGRAPH course on radiosity for 5 years. - The first comprehensive book written about radiosity - Features applications from the fields of computer graphics, architecture, industrial design, and related computer aided design technologies - Offers over 100 illustrations and 16 pages of full-color images demonstrating the results of radiosity methods - Contains a chapter authored by Pat Hanrahan on the basic concepts of image synthesis and a foreword by Donald Greenberg
The story of how a young Wyatt Earp and his brothers defeated the Old West’s biggest outlaw gang, by the New York Times–bestselling author of Texas Ranger. Wyatt Earp is regarded as the most famous lawman of the Old West, best known for his role in the Gunfight at the O.K. Corral in Tombstone, Arizona. But the story of his two-year war with a band of outlaws known as the Cowboys has never been told in full. The Cowboys were the largest outlaw gang in the history of the American West. After battles with the law in Texas and New Mexico, they shifted their operations to Arizona. There, led by Curly Bill Brocius, they ruled the border, robbing, rustling, smuggling and killing with impunity until they made the fatal mistake of tangling with the Earp brothers. Drawing on groundbreaking research into territorial and federal government records, John Boessenecker’s Ride the Devil’s Herd reveals a time and place in which homicide rates were fifty times higher than those today. The story still bears surprising relevance for contemporary America, involving hot-button issues such as gang violence, border security, unlawful immigration, the dangers of political propagandists parading as journalists, and the prosecution of police officers for carrying out their official duties. Wyatt Earp saw it all in Tombstone. Praise for Ride the Devil’s Herd A Pim County Public Library Southwest Books of the Year 2021 A True West Reader’s Choice for Best 2020 Western Nonfiction Winner of the Best Book Award by the Wild West History Association “A marvelous book. By means of meticulous research and splendid writing John Boessenecker has managed to do something never before attempted or accomplished, tying together the many violent clashes between lawmen and outlaws in the American southwest of the 1870-1890 period and showing how depredations by loosely organized gangs of outlaws actually threatened “Manifest Destiny” and the successful taming of the Wild West.” —Robert K. DeArment, author and historian “A ripsnortin’ ramble across the bloodstained Arizona desert with Wyatt Earp and company. . . . Boessenecker displays a fine eye for period detail. . . . A pleasure for thoughtful fans of Old West history, revisionist without being iconoclastic.” —Kirkus Reviews
From Beauregard and Custer to Lee and Sherman, twelve commanders from each side vividly describe what they and their men experienced at twelve of the war’s most legendary battles from Fort Sumter to Appomattox Court House in accounts gathered from letters, memoirs, reports, and testimonies. They relate noted incidents and personal triumphs and tragedies while covering strategies and explaining battlefield decisions. Trench warfare at Petersburg and Sherman’s scorched earth policy in Georgia foreshadowed the world wars to come, and technological advancements—such as armored steamships, landmines, and machine guns—literally changed the landscape of war. Submarines and a time bomb even came into play. Informative biographies and headnotes for each battle give parallel statistics at a glance and establish context; sidebars cover notable tactics and technologies, including espionage, aerial reconnaissance, and guerilla warfare; and a concise roll-call outline each commander's life in full after the war. Here, from the men who conducted and controlled it, is an invaluable sourcebook of what happened in the War Between the States and why.
In Columbia Rising, Bancroft Prize-winning historian John L. Brooke explores the struggle within the young American nation over the extension of social and political rights after the Revolution. By closely examining the formation and interplay of political structures and civil institutions in the upper Hudson Valley, Brooke traces the debates over who should fall within and outside of the legally protected category of citizen. The story of Martin Van Buren threads the narrative, since his views profoundly influenced American understandings of consent and civil society and led to the birth of the American party system. Brooke's analysis of the revolutionary settlement as a dynamic and unstable compromise over the balance of power offers a window onto a local struggle that mirrored the nationwide effort to define American citizenship.
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