A Complete Guide to Quality in Small-Scale Wine Making, Second Edition is the first and only book to focus specifically on the challenges relevant to non-industrial scale production of optimal wine with a scientifically rigorous approach. Fully revised and updated with new insights on the importance of all aspects of the production of consistent, quality wine, this book includes sections on organic wine production, coverage of the selection and culturing of yeast, and the production of sparkling, 'methode champenois' and fortified wines. The new edition includes insights into the latest developments in flavor chemistry, production protocols, NIR and FTIR for multipurpose analysis and microplate and PCR procedures, and IR methods for essential analysis among others. Written by an expert team with real-world experience and with a multi-cultural approach, this text will provide a complete guide to all the stages of the winemaking process and evaluation, and clearly explains the chemistry that underpins it all. - Fully revised and updated, each chapter includes new insights and latest information - Presents fully referenced, tested and proven methods - Elaborates on the chemistry to enable understanding of the processes and the impact of variation
BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.
Constrained Coding and Soft Iterative Decoding is the first work to combine the issues of constrained coding and soft iterative decoding (e.g., turbo and LDPC codes) from a unified point of view. Since constrained coding is widely used in magnetic and optical storage, it is necessary to use some special techniques (modified concatenation scheme or bit insertion) in order to apply soft iterative decoding. Recent breakthroughs in the design and decoding of error-control codes (ECCs) show significant potential for improving the performance of many communications systems. ECCs such as turbo codes and low-density parity check (LDPC) codes can be represented by graphs and decoded by passing probabilistic (a.k.a. `soft') messages along the edges of the graph. This message-passing algorithm yields powerful decoders whose performance can approach the theoretical limits on capacity. This exposition uses `normal graphs,' introduced by Forney, which extend in a natural manner to block diagram representations of the system and provide a simple unified framework for the decoding of ECCs, constrained codes, and channels with memory. Soft iterative decoding is illustrated by the application of turbo codes and LDPC codes to magnetic recording channels. For magnetic and optical storage, an issue arises in the use of constrained coding, which places restrictions on the sequences that can be transmitted through the channel; the use of constrained coding in combination with soft ECC decoders is addressed by the modified concatenation scheme also known as `reverse concatenation.' Moreover, a soft constraint decoder yields additional coding gain from the redundancy in the constraint, which may be of practical interest in the case of optical storage. In addition, this monograph presents several other research results (including the design of sliding-block lossless compression codes, and the decoding of array codes as LDPC codes). Constrained Coding and Soft Iterative Decoding will prove useful to students, researchers and professional engineers who are interested in understanding this new soft iterative decoding paradigm and applying it in communications and storage systems.
Haynes offers the best coverage for cars, trucks, vans, SUVs and motorcycles on the market today. Each manual contains easy to follow step-by-step instructions linked to hundreds of photographs and illustrations. Included in every manual: troubleshooting section to help identify specific problems; tips that give valuable short cuts to make the job easier and eliminate the need for special tools; notes, cautions and warnings for the home mechanic; color spark plug diagnosis and an easy to use index.
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