Practising evidence-based medicine necessarily depends on the clinician having access to the best evidence available, but in a fast-moving field, keeping up to date with the latest developments is a challenging prospect. In this new volume, leading experts focus on the most important clinical issues associated with the management of lipid disorders, evaluating and interpreting the evidence available to provide the reader with a reliable summary of our current knowledge. Topics covered include therapeutical strategies for managing hereditary lipid disorders, including familial hypercholesterolemia, both in adults and children, and familial combined hypercholesterolemia. The authors also evaluate the evidence for a link between inflammatory disease and cardiovascular risk; the metabolic syndrome and the interconnections between dyslipidemias and diabetes. They also look at therapeutic challenges such as the management of patients who are statin resistant, and the control of lipid levels in those suffering renal insufficiency. Tables highlight important data, evidence from trial results and expert reports, and each section concludes with a series of key points that present a summary of evidence-based recommendations for best practice, graded according to the quality of that evidence. Evidence-based Management of Lipid Disorders provides the busy clinician with a unique analysis of the data supporting current therapies and will help the reader formulate effective strategies for treating their own patients.
Practising evidence-based medicine necessarily depends on the clinician having access to the best evidence available, but in a fast-moving field, keeping up to date with the latest developments is a challenging prospect. In this new volume, leading experts focus on the most important clinical issues associated with the management of lipid disorders, evaluating and interpreting the evidence available to provide the reader with a reliable summary of our current knowledge. Topics covered include therapeutical strategies for managing hereditary lipid disorders, including familial hypercholesterolemia, both in adults and children, and familial combined hypercholesterolemia. The authors also evaluate the evidence for a link between inflammatory disease and cardiovascular risk; the metabolic syndrome and the interconnections between dyslipidemias and diabetes. They also look at therapeutic challenges such as the management of patients who are statin resistant, and the control of lipid levels in those suffering renal insufficiency. Tables highlight important data, evidence from trial results and expert reports, and each section concludes with a series of key points that present a summary of evidence-based recommendations for best practice, graded according to the quality of that evidence. Evidence-based Management of Lipid Disorders provides the busy clinician with a unique analysis of the data supporting current therapies and will help the reader formulate effective strategies for treating their own patients.
A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapies With high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL. Divided into three main parts, High-Density Lipoproteins first examines normal HDL particles, then describes defective HDL, and finally addresses the therapeutic normalization of subnormal levels and defective biological activities of this lipoprotein class. The book highlights the functional properties of HDL, which are relevant to the pathophysiology of atherosclerosis and thrombosis, and discusses the compositional and metabolic heterogeneity of HDL particles. Readers will come away with a clear understanding of the role of HDL in biological processes, the potential value of functional HDL as a therapeutic target, and how current and emerging therapies are poised to influence the treatment of heart disease in the future.
Many marine mammals communicate by emitting sounds that pass through water. Such sounds can be received across great distances and can influence the behavior of these undersea creatures. In the past few decades, the oceans have become increasingly noisy, as underwater sounds from propellers, sonars, and other human activities make it difficult for marine mammals to communicate. This book discusses, among many other topics, just how well marine mammals hear, how noisy the oceans have become, and what effects these new sounds have on marine mammals. The baseline of ambient noise, the sounds produced by machines and mammals, the sensitivity of marine mammal hearing, and the reactions of marine mammals are also examined. An essential addition to any marine biologist's library, Marine Mammals and Noise will be especially appealing to marine mammalogists, researchers, policy makers and regulators, and marine biologists and oceanographers using sound in their research.
The study of immunology encompasses a vast and ever-growing body of information that in some way or other incorporates most areas of medical biological research. As the body of information in the medical sciences continues to increase its rate of expansion, one of the greatest challenges to investigators will be to integrate this information in a manner that is intellectually fruitful and productive. Considering the intended scope of this text, we could not pretend to have gone too far toward achieving such an integration--and considering the pace of change, in its very best form a measured approximation of such lofty goals might be the most we could hope for. Nevertheless, in these pages we have sought to produce a collection of information that is at once concise and up-to-date regarding areas where important developments are impacting on the way we understand the vertebrate immune system. In addition, although the information is geared toward advanced study, we have discussed some basic elements and concepts that we hope make the text a useful resource for both the immunologist and the nonspecialist. The intention is to provide the researcher, clinician, or advanced undergraduate student with a brief ov- view of specific components of the immune system, and to provide a place from which to begin further detailed study if necessary. To this end, we made every effort to supply extensive referencing--although limitations in space prevented exhaustive or complete referencing in some cases.
Taking an integrated approach to the biology of marine carnivores, cetaceans, and sirenians, twenty-two prominent researchers compare marine mammals with one another and with terrestrial mammals, providing a framework for fundamental biological and ecological concepts. They describe functional morphology, sensory systems, energetics, reproduction, communication and cognition, behavior, distribution, population biology, and feeding ecology. They also detail the physiological adaptations—for such activities and processes as diving, thermo-regulation, osmoregulation, and orientation—that enable marine mammals to exploit their aquatic environment.
Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
In this issue of Clinics in Sports Medicine, guest editors Dilaawar Mistry and John MacKnight have developed a team of experts to review updates and advances in Primary Care Sports Medicine, focusing on those areas that are recently and/or rapidly changing in the sports medicine world. Topics in this issue include common infectious conditions, pulmonary disorders, cardiac screening – pros and cons, pharmacy, neuropsychiatric considerations, recent advances in the management of eating disorders and female athlete triad, iron and nutritional issues, sickle cell, the international athlete, and Attention Deficit Disorder in athletes.
Vascular Protection explores advances in vascular biology and how they translate into innovations in drug therapy for vascular disease. It addresses recent advances in the knowledge of endothelial vasoactive factors and other biologically active molecules as well as gene therapy. Written by leading experts in their respective fields, each chapter e
Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential. Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections: Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry. Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses. Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products. Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.
One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.
Completely updated edition, written by a close-knit author team Presents a unique approach to stroke - integrated clinical management that weaves together causation, presentation, diagnosis, management and rehabilitation Includes increased coverage of the statins due to clearer evidence of their effectiveness in preventing stroke Features important new evidence on the preventive effect of lowering blood pressure Contains a completely revised section on imaging Covers new advances in interventional radiology
Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. The right amount of basic science and practical clinical guidance assists in making efficient and informed decisions. Extensive updates on key topics keep you at the forefront of the field. New chapters on glomerulonephritis associated with complement disorders, interventional treatments for hypertension, renal disease and cancer, and epidemiology and prognostic impact of acute kidney injury. Over 1,500 color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. Hundreds of color coded algorithms promote quick reference and to help you retain concepts. Over 400 NEW self-assessment questions available at Expert Consult.
For the first time in over 20 years, a comprehensive collection of photographs and descriptions of species in the fungal genus Fusarium is available. This laboratory manual provides an overview of the biology of Fusarium and the techniques involved in the isolation, identification and characterization of individual species and the populations in which they occur. It is the first time that genetic, morphological and molecular approaches have been incorporated into a volume devoted to Fusarium identification. The authors include descriptions of species, both new and old, and provide protocols for genetic, morphological and molecular identification techniques. The Fusarium Laboratory Manual also includes some of the evolutionary biology and population genetics thinking that has begun to inform the understanding of agriculturally important fungal pathogens. In addition to practical “how-to” protocols it also provides guidance in formulating questions and obtaining answers about this very important group of fungi. The need for as many different techniques as possible to be used in the identification and characterization process has never been greater. These approaches have applications to fungi other than those in the genus Fusarium. This volume presents an introduction to the genus Fusarium, the toxins these fungi produce and the diseases they can cause. "The Fusarium Laboratory Manual is a milestone in the study of the genus Fusarium and will help bridge the gap between morphological and phylogenetic taxonomy. It will be used by everybody dealing with Fusarium in the Third Millenium." --W.F.O. Marasas, Medical Research Council, South Africa
Unparalleled in scope and content, Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas provides the most relevant and up-to-date clinical, etiologic, molecular, and therapeutic management information for surgical pathologists in training and in practice. The fully revised 4th Edition of this award-winning title offers a wealth of information in this fast-changing field, including recent advances in molecular biology and immunohistochemistry, in a clearly written, well-structured manner that is easy to read and navigate. This one-stop reference for the entire gastrointestinal system enables you to improve turnaround time when diagnosing a specimen and to clearly report on the prognosis and therapeutic management options to surgical and medical colleagues. Covers the latest developments in molecular technologies and immunohistochemical markers to provide useful diagnostic and prognostic information and inform therapeutic decisions. Provides all the necessary tools to make a comprehensive diagnostic workup, including data from ancillary techniques and molecular findings whenever appropriate. Incorporates more than 3000 high-quality color illustrations to help you recognize and diagnose any tissue sample under the microscope. Reviews next-generation sequencing (NGS) to help identify targetable mutations in gastrointestinal tract tumors and provide more accurate classification and precision therapies. Features extensive tables, graphs, and flowcharts to help you effectively grasp complex topics and streamline your decision-making. Helps you avoid diagnostic errors with practical advice on pitfalls in differential diagnosis. Incorporates the latest WHO guidelines throughout. Winner of the 2015 BMA Medical Book Awards First Prize Award in Pathology.
With your heavy case load, you can't afford to waste time searching for answers. Cardiology, 3rd Edition, by Drs. Crawford, DiMarco, and Paulus, offers you just the practical, problem-based guidance you need to quickly overcome any clinical challenge. 8 color-coded sections cover the 8 major clinical syndromes of cardiovascular disease—each section a virtual "mini textbook" on its topic! 40 new chapters keep you up to date with the latest advances in the field, while more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs capture clinical manifestations as they present in practice. It’s current, actionable information that you can put to work immediately for your patients! Offers a problem-based approach that integrates basic science, diagnostic investigations, and therapeutic management in one place for each cardiovascular disease so you can quickly find all of the actionable knowledge you need without flipping from one section to another. Features introductory bulleted highlights in each chapter that present the most pertinent information at a glance. Presents abundant algorithms to expedite clinical decision making. Includes more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs that capture clinical manifestations as they present in practice, and promote readability and retention. Includes 40 new chapters including Inherited Arrhythmia Syndromes, Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy in CHD, Management of the Cyanotic Patient with CHD, Special Problems for the Cardiology Consultant Dealing with Bariatric/Gastric Bypass — and many more — that equip you with all of the latest knowledge. Presents "Special Problem" sections—many new to this edition—that provide practical advice on problems that can be difficult to treat.
The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today’s ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science. The only all-embracing textbook of basic science suitable for trainee ophthalmologists, optometrists and vison scientists – other books concentrate on the individual areas such as anatomy. Attractive page design with clear, colour diagrams and text boxes make this a much more accessible book to learn from than many postgraduate textbooks. Presents in a readable form an account of all the basic sciences necessary for an understanding of the eye – anatomy, embryology, genetics, biochemistry, physiology, pharmacology, immunology, microbiology and infection and pathology. More on molecular pathology. Thorough updating of the sections on pathology, immunology, pharmacology and immunology. Revision of all other chapters. More colour illustrations.
The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today's ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science. For the first time, this (print) edition also now comes with bonus access to the complete, fully searchable electronic text - including carefully selected additional information and new video content to further explain and expand on key concepts - making The Eye a more flexible, comprehensive and engaging learning package than ever before. The only all-embracing textbook of basic science suitable for trainee ophthalmologists, optometrists and vision scientists - other books concentrate on the individual areas such as anatomy. Attractive page design with clear, colour diagrams and text boxes make this a much more accessible book to learn from than many postgraduate textbooks. Presents in a readable form an account of all the basic sciences necessary for an understanding of the eye - anatomy, embryology, genetics, biochemistry, physiology, pharmacology, immunology, microbiology and infection and pathology. More on molecular pathology. Thorough updating of the sections on pathology, immunology, pharmacology and immunology. Revision of all other chapters. More colour illustrations Comes with complete electronic version
Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.
The 2001 edition (1st) was a comprehensive review of history, research, and discussions on religion and health through the year 2000. The Appendix listed 1,200 separate quantitative studies on religion and health each rated in quality on 0-10 scale, followed by about 2,000 references and an extensive index for rapid topic identification. The 2012 edition (2nd) of the Handbook systematically updated the research from 2000 to 2010, with the number of quantitative studies then reaching the thousands. This 2022 edition (3rd) is the most scientifically rigorous addition to date, covering the best research published through 2021 with an emphasis on prospective studies and randomized controlled trials. Beginning with a Foreword by Dr. Howard K. Koh, former US Assistant Secretary for Health for the Department of Health and Human Services, this nearly 600,000-word volume examines almost every aspect of health, reviewing past and more recent research on the relationship between religion and health outcomes. Furthermore, nearly all of its 34 chapters conclude with clinical and community applications making this text relevant to both health care professionals (physicians, nurses, social workers, rehabilitation therapists, counsellors, psychologists, sociologists, etc.) and clergy (community clergy, chaplains, pastoral counsellors, etc.). The book's extensive Appendix focuses on the best studies, describing each study in a single line, allowing researchers to quickly locate the existing research. It should not be surprising that for Handbook for the past two decades has been the most cited of all references on religion and health"--
The undisputed leader in medical pharmacology, without equal. Updated to reflect all critical new developments in drug action and drug-disease interaction. This is the “desert island” book of all medical pharmacology—if you can own just one pharmacology book, this is it.
This book is a venture in the worlds of modeling and of metamodeling. At this point, I will not reveal to readers what constitutes metamodeling. Suf fice it to say that the pitfalls and shortcomings of modeling can be cured only if we resort to a higher level of inquiry called metainquiry and metadesign. We reach this level by the process of abstraction. The book contains five chapters from my previous work, Applied General Systems Theory (Harper and Row, London and New York, First Edition 1974, Second Edition 1978). More than ten years after its publication, this material still appears relevant to the main thrust of system design. This book is dedicated to all those who are involved in changing the world for the better. In a way we all are involved in system design: from the city manager who struggles with the problems of mass transportation or the consolidation of a city and its suburbs to the social worker who tries to provide benefits to the urban poor. It includes the engineer who designs the shuttle rockets. It involves the politician engaged in drafting a bill to recycle containers, or one to prevent pesticide contamination of our food. The politician might even need system design to chart his or her own re-election campaign.
The landmark text that belongs in the hands of every cardiologist―fully updated and reorganized to make it more patient-centric than ever A Doody's Core Title for 2023! World-famous for its authority and clinical relevance, Fuster and Hurst’s The Heart is cardiology’s longest continuously published reference book. Written to meet the ever-changing needs of cardiologists, fellows, and interns, this trusted classic offers a solid foundation in cardiovascular medicine and complete coverage of all major cardiovascular topics. This fifteenth edition presents a greater focus on the practicalities of patient care. Additionally, the content is ordered in a more methodical pattern, from mechanism to management. Reflecting the latest technical, therapeutic, and clinical advances, Fuster and Hurst’s The Heart provides invaluable concise summaries of major new trials and guidelines. Authoritative Coverage and Unmatched Utility: Central Illustrations New section on cardiovascular critical care New chapter "Cardiovascular Disease and COVID-19" Chapter summaries ACC/AHA/ESC guidelines in all chapters 1,200+ photos and illustrations Sections Include: Risk Factors for Cardiovascular Disease Atherosclerosis and Coronary Heart Disease Diseases of the Great Vessels and Peripheral Vessels Valvular Heart Disease Rhythm and Conduction Abnormalities Heart Failure Diseases of the Pericardium Cardiopulmonary Disease Critical Cardiovascular Care Adult Congenital Heart Disease Special Populations and Topics in Cardiovascular Disease
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