Drawing on hundreds of examples, this study of human ingenuity argues that all inventions are the result of the same basic principles rather than random inspiration. The author, a cognitive psychologist, reveals the mind's capacity for problem-solving from the Stone Age to the present day.
The updated third edition of the definitive guide to water treatment engineering, now with all-new online content Stantec's Water Treatment: Principles and Design provides comprehensive coverage of the principles, theory, and practice of water treatment engineering. Written by world-renowned experts in the field of public water supply, this authoritative volume covers all key aspects of water treatment engineering, including plant design, water chemistry and microbiology, water filtration and disinfection, residuals management, internal corrosion of water conduits, regulatory requirements, and more. The updated third edition of this industry-standard reference includes an entirely new chapter on potable reuse, the recycling of treated wastewater into the water supply using engineered advanced treatment technologies. QR codes embedded throughout the book connect the reader to online resources, including case studies and high-quality photographs and videos of real-world water treatment facilities. This edition provides instructors with access to additional resources via a companion website. Contains in-depth chapters on processes such as coagulation and flocculation, sedimentation, ion exchange, adsorption, and gas transfer Details membrane filtration technologies, advanced oxidation, and potable reuse Addresses ongoing environmental concerns, pharmacological agents in the water supply, and treatment strategies Describes reverse osmosis applications for brackish groundwater, wastewater, and other water sources Includes high-quality images and illustrations, useful appendices, tables of chemical properties and design data, and more than 450 exercises with worked solutions Stantec's Water Treatment: Principles and Design, Updated Third Edition remains an indispensable resource for engineers designing or operating water treatment plants, and is an essential textbook for students of civil, environmental, and water resources engineering.
This textbook takes physics and engineering undergraduates through the mathematics they need in the first years of study. It offers an accessible approach which is characterized by the combination of the textbook with a detailed study guide. This study guide, supplied as freely accessible downloads for each chapter, divides the whole learning task into small units. You will read and study a limited section of the textbook and then return to the study guide afterwards. Learning results are controlled, monitored and deepened by graded questions, exercises, repetitions and finally by problems and applications of the content studied. The degree of difficulty slowly rises, which will let you gain confidence and experience your own progress, thus fostering motivation. The sequence of studies can be individualized according to performance and can be regarded as a full tutorial course. This combination of a textbook with a detailed study guide is a powerful means to meet the rising importance of learning outside of lectures at home and will be of great benefit, especially to students learning remotely.
Each year, Elsevier's Advances in Surgery reviews the latest techniques, data, and evidence in general surgery. A distinguished editorial board, led by Dr. John L. Cameron of Johns Hopkins, identifies current areas of major progress and controversy, and invites specialists from around the world to contribute comprehensive, detailed reviews on these topics.
Building on the foundation set by its best-selling predecessors, the Groundwater Chemicals Desk Reference, Fourth Edition is both a broad, comprehensive desk reference and a guide for field research. This fourth edition contains more than 1,700 additional references, including adsorption data for more than 800 organic compounds and metals, s
For Junior, Senior, and Graduate courses in Human Evolution taught in anthropology and biology departments. This book is the most comprehensive collection of cutting edge articles on human evolution. Designed for use by students in anthropology, paleontology, and evolutionary biology, this edited volume brings together the major ideas and publications on human evolution of the past three decades. The book spans the entire scope of human evolution with particular emphasis on the fossil record, including archaeological studies.
The first three editions of Fungi and Food Spoilage established, then consolidated, a reputation as the leading book on foodborne fungi. It details media and methods for isolation and identification, descriptions of species, and information on their physiology, ecology and mycotoxin formation. It is an invaluable reference for food microbiologists investigating fungal food spoilage problems, both in field crops and processed foods, and the likelihood of mycotoxin production in either. The Fourth Edition incorporates major differences from the Third: multiple changes in nomenclature due to changes in the International Code of Nomenclature for algae, fungi and plants; many taxonomic changes due to improvements in, and more widespread application of, molecular methods in taxonomy; the introduction of colour colony photographs where appropriate; and a new chapter on mycotoxins. The introductory chapters of the book deal with the ecology of food spoilage, and provide an overview of how food processing, packaging and storage parameters influence fungal growth. A subsequent chapter overviews the fundamentals of naming and classifying fungi. Morphological methods and media suitable for low cost and effective isolation, enumeration and identification of foodborne fungi are provided, together with many more specialised media and techniques. The major part of the book provides keys, descriptions and illustrations of all yeasts and filamentous fungi commonly encountered in foods. Other known characteristics of the species, including physiology and ecology are included. Chapters on the types and species of fungi likely to be found in fresh, harvested and variously processed foods are followed by a new chapter on mycotoxins, both major and minor, their sources, both fungal and food, and their implications for human health. The broad and practical nature of the coverage will appeal to microbiologists, mycologists and biotechnologists in the food industry, as well scientists in academic, research and public health institutions. Drs Pitt and Hocking worked for CSIRO Food for more than 100 years combined. Both are now retired from CSIRO: Dr Pitt continues to work part time with Microbial Screening Technologies, a biodiscovery company.
Cardiovascular MR imaging has become a robust, clinically useful mod- ity, and the rapid pace of innovation and important information it conveys have attracted many students whose goal is to become adept practitioners. In turn, many excellent textbooks have been written to aid this process. These books are necessary and useful in helping the student learn the underlying pulse sequences used in CMR, as well as the imaging findings in a variety of disorders. However, one of the difficulties inherent in learning CMR from a book is that the printed format is not the ideal medium to d- play the dynamic imaging that comprises a typical CMR case. For instance, it may be difficult to perceive focal areas of wall motion abnormality on serial static pictures, but these abnormalities are often easily seen on cine loops. One might say that trying to learn CMR solely from a standard textbook with illustrations is like trying to learn to drive by looking at snapshots obtained through the windshield of a moving car. The learner needs to see the cardiac motion and decide if it is normal or abnormal; he or she needs to be in the driver’s seat. An additional limitation of the ava- able textbooks on CMR is that while they often have superb illustrations of abnormal findings, these images have been preselected.
The Handbook of Vacuum Technology consists of the latest innovations in vacuum science and technology with a strong orientation towards the vacuum practitioner. It covers many of the new vacuum pumps, materials, equipment, and applications. It also details the design and maintenance of modern vacuum systems. The authors are well known experts in their individual fields with the emphasis on performance, limitations, and applications rather than theory. There aremany useful tables, charts, and figures that will be of use to the practitioner. - User oriented with many useful tables, charts, and figures of use to the practitioner - Reviews new vacuum materials and equipment - Illustrates the design and maintenance of modern vacuum systems - Includes well referenced chapters
A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapies With high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL. Divided into three main parts, High-Density Lipoproteins first examines normal HDL particles, then describes defective HDL, and finally addresses the therapeutic normalization of subnormal levels and defective biological activities of this lipoprotein class. The book highlights the functional properties of HDL, which are relevant to the pathophysiology of atherosclerosis and thrombosis, and discusses the compositional and metabolic heterogeneity of HDL particles. Readers will come away with a clear understanding of the role of HDL in biological processes, the potential value of functional HDL as a therapeutic target, and how current and emerging therapies are poised to influence the treatment of heart disease in the future.
Now more streamlined and focused than ever before, the 6th edition of CT and MRI of the Whole Body is a definitive reference that provides you with an enhanced understanding of advances in CT and MR imaging, delivered by a new team of international associate editors. Perfect for radiologists who need a comprehensive reference while working on difficult cases, it presents a complete yet concise overview of imaging applications, findings, and interpretation in every anatomic area. The new edition of this classic reference — released in its 40th year in print — is a must-have resource, now brought fully up to date for today's radiology practice. - Includes both MR and CT imaging applications, allowing you to view correlated images for all areas of the body. - Coverage of interventional procedures helps you apply image-guided techniques. - Includes clinical manifestations of each disease with cancer staging integrated throughout. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. - Over 5,200 high quality CT, MR, and hybrid technology images in one definitive reference. - For the radiologist who needs information on the latest cutting-edge techniques in rapidly changing imaging technologies, such as CT, MRI, and PET/CT, and for the resident who needs a comprehensive resource that gives a broad overview of CT and MRI capabilities. - Brand-new team of new international associate editors provides a unique global perspective on the use of CT and MRI across the world. - Completely revised in a new, more succinct presentation without redundancies for faster access to critical content. - Vastly expanded section on new MRI and CT technology keeps you current with continuously evolving innovations.
The aim of this book is to provide a systematic approach to echocardiographic diagnosis based upon a comprehensive understanding of cardiac anatomy. We shall provide abundant anatomic correlates of echocardiographic findings throughout the book.The book will be divided into three sections. Each chapter will cover both normal and pathological findings on echocardiography with anatomic correlation. The first section will address the normal findings which can be appreciated by current day echocardiography. The impact of aging on cardiac structure and function will also be covered in this section. In the second section, specific cardiac diseases will be discussed. The differentiating features between normal and pathologic conditions will be discussed. The last section will address specific clinical settings where echocardiography is pivotal for diagnosis and patient management.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
In the past ten years, heteroepitaxy has continued to increase in importance with the explosive growth of the electronics industry and the development of a myriad of heteroepitaxial devices for solid state lighting, green energy, displays, communications, and digital computing. Our ever-growing understanding of the basic physics and chemistry underlying heteroepitaxy, especially lattice relaxation and dislocation dynamic, has enabled an ever-increasing emphasis on metamorphic devices. To reflect this focus, two all-new chapters have been included in this new edition. One chapter addresses metamorphic buffer layers, and the other covers metamorphic devices. The remaining seven chapters have been revised extensively with new material on crystal symmetry and relationships, III-nitride materials, lattice relaxation physics and models, in-situ characterization, and reciprocal space maps.
Covering the latest advances in CNS drug development, this bookwill guide all those involved in pre-clinical to early clinicaltrials. The authors describe how recent innovations can acceleratethe development of novel CNS compounds, improve early detection ofefficacy and toxicity signals, and increase the safety oflater-stage clinical trials. The current crisis in the drug development industry iscritically reviewed, as well as the steps needed to correct theproblems, including new government-backed regulations andindustry-based innovations designed to accelerate CNS drugdevelopment in the future. Animal-based models of major CNS disorders are described indetail, and the ability of the latest in vitro and computer-basedmodels to simulate CNS disease states and predict drug efficacy andside-effects are examined. Particular attention is given tothe growing use of biomarkers and how they can be used effectivelyin early human trials as signals of potential drug efficacy, aswell as the increasingly important role of imaging studies to guidedose selection. Cognitive assessments that can be useful indicatorsof effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drugtrials for over 20 years, and based on a wealth of drug developmentand clinical trial experience, Critical Pathways to Success inCNS Drug Developmentis full of practical advice forsuccessfully designing and executing CNS drug trials, avoidingpotential pitfalls, and complying with government regulations
Basic immunology relating to corneal graft rejection is presented in this book. All aspects of corneal graft rejection, from the historical perspective to the diagnosis, treatment and prevention of corneal graft rejection, are discussed. The author includes controversial topics such as the roles of systemic immunosuppressant agents and tissue matching.
The Chemistry of Medical and Dental Materials examines the properties and interactions of these materials within the body at a molecular level, with accounts of the surgical procedures used, as well as extensive coverage of the possible biological reactions to the presence of foreign materials in the body.
This volume of Orthopedic Clinics will focus on Perioperative Pain Management. Edited by members of a distinguished board from the Campbell Clinic, topics in the issue will include: Enhancing Recovery Following Total Knee Arthroplasty; Perioperative Pain Management and Anesthesia; Perioperative Pain Management Strategies in Primary Hip and Knee Arthroplasty; Patient Satisfaction after Total Knee Arthroplasty; The Effect of Opioids, Alcohol, and NSAIDS on Fracture Union; Indications and Contraindications to Peripheral Nerve Blockage; Multimodal Analgesia in Foot and Ankle Surgery; and Peripheral Nerve Blocks in Foot and Ankle Surgery, among others.
Taxonomy, nomenclature and geographical distribution. Description of the cultivated species. Uses and properties. Origin and domestication. Genetic resources. Genetic improvement estrategies. Propagation. Agronomy of fruit and heart-of-palm production. Production areas and commercial potential.
This is the first book to concentrate on dysphagia in rare conditions those that occur infrequently or those that may occur more frequently but are only sometimes associated with dysphagia. Covering a wide range of conditions from progressive supranuclear palsy (PSP), through connective tissue disease, to conditions as diverse as West Nile virus the editors and expert contributors efficiently synthesize the available information to provide the essentials needed to help clinicians to perform sophisticated assessments, based on their knowledge of both the conditions and the expected swallowing signs and treatments. Each entry covers the neurology of the given condition, including the signs and symptoms, neuropathology, epidemiology and genetics. Thereafter, coverage of swallowing in each condition examines the diagnostic signs and symptoms, etiology, swallowing neuropathology, associated cognitive, linguistic, and communicative signs and symptoms, special diagnostic considerations, treatment, nutrition, hydration, and medications.
Offering comprehensive coverage of the clinical, physical, and technical aspects of radiation treatment planning, Khan’s Treatment Planning in Radiation Oncology, Fifth Edition, provides a team approach to this complex field. Drs. Paul W. Sperduto and John P. Gibbons are joined by expert contributing authors who focus on the application of physical and clinical concepts to solve treatment planning problems—helping you provide effective, state-of-the-art care for cancer patients. This unique, well-regarded text has been updated throughout to reflect the most current practices in today’s radiation oncology treatment.
This book discusses the photosynthesis for ecosystem models, in particular the strengths and limitations of four methods used for predicting photosynthesis. The methods usage depends upon the purpose of the prediction to be made, as well as improvements in associated techniques that seem to revolutionize the methodology. Therefore comparisons between methods are valuable justifying this state of the art review for all photosynthetic scientists.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research
. . . fascinating and stimulating book, which is both comprehensive and partial in equal degree. Peter Wells, Journal of Environmental Policy and Planning Greening the Car Industry is an innovative book in the Varieties of Capitalism tradition. Its interviews and analysis offer rich insights into why the US car industry struggles, particularly on environmental impact, compared to Japanese and German firms. John Mikler shows that regulatory institutions matter, and how they matter. For the car industry at least, more collaborative forms of capitalism show more promise. Mikler gives us a masterpiece of regulatory scholarship. John Braithwaite, The Australian National University Corporations, including those in the car industry, are increasingly keen to proclaim their green credentials. But what motivates firms to reduce the environmental impact of their products? Rather than accepting the conventional wisdom, John Mikler addresses this question in a novel way by taking a comparative institutionalist approach informed by the Varieties of Capitalism literature. Focusing on Germany, the US and Japan, the author shows that national variations in capitalist relations of production are central to explaining how the car industry tackles the issue of climate change, such variations are crucial for understanding the normative as well as material basis for firms motivations. This ground-breaking book will be of great benefit to students and academics, particularly those with an interest in comparative politics, public policy and international political economy. It may also serve as a resource for courses on environmental politics and environmental management as well as aspects of international relations and business/management. Given the book s contemporary policy relevance, it will be a valuable reference for policy practitioners with an interest in industry policy, multinational corporations, the environment, and institutional approaches to comparative politics.
Rely on Rosen's Emergency Medicine for the latest answers on every facet of emergency medicine practice. For decades, this medical reference book has set the standard in emergency medicine, offering unparalleled comprehensiveness, clarity, and authority - to help you put the latest and best knowledge to work for your patients in the ER. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Practice confidently with easily actionable, dependable guidance on the entire breadth of emergency medicine topics. Get expert guidance on how to approach specific clinical presentations in the ER. The "Cardinal Presentations Section" provides quick and easy reference to differential diagnosis and directed testing for fever in the adult patient; dizziness and vertigo; chest pain; and over 20 other frequently seen presentations in the emergency department. Effectively apply the newest emergency medicine techniques and approaches, including evidence-based therapies for shock; high-cost imaging; evaluation and resuscitation of the trauma patient; cardiovascular emergencies; evaluation and risk stratification for transient ischemic attack (TIA) patients; and much more. Locate the answers you need quickly thanks to a user-friendly, full-color design, complete with more illustrations than ever before. Access the complete contents on the go from your laptop or mobile device at Expert Consult, fully searchable, with links to PubMed.
This book discusses the major Natural and Alternative treatments for the Herpes Family viruses that have been documented in the Scientific and Medical Literature. It discusses several nutritional supplements and inexpensive over-the-counter medications that boost the immune system. It also discusses several foods, supplements and herbs that have anti-viral properties. The emphasis is on correlating potential natural and alternative therapies with relevant published research. Some have substantial supporting research and others very little. Get the documented facts, not unfounded claims.
Endothelin-1 (ET-1), a peptide discovered in 1988, is one of the most potent contractors of vascular smooth muscle. Since their discovery, ETs have generated enormous interest in the scientific and pharmaceutical communities, prompting extensive research. This book addresses the latest findings regarding ETs-how they function, their effects, and characteristics. Divided into five sections, the book covers: endothelin receptors, endothelin synthesis and degradation, endothelin pathophysiology, ligand structure and activity relationships, and clinical studies. Pharmacologists, toxicologists, and pharmaceutical researchers will all benefit from this thorough review of current findings and future directions in ET research.
This book provides reviews of the epidemiology, evaluation, and patient management of central nervous system (CNS) injuries. Internationally recognized clinicians and basic scientists discuss recent research that has significantly advanced the understanding of the pathophysiology of neuronal death and facilitated development of new therapeutic approaches. Novel therapeutic agents evaluated in animal models and currently in clinical trials include: calcium antagonists glutamate receptor antagonists inhibitors of glutamate release endothelial adhesion and nerve growth factors opioids antioxidants, gangliosides thrombolytic agents All of these options, as well as hypothermia as a potentially therapeutic approach, are discussed in this comprehensive volume. It will be invaluable to neurologists, neurosurgeons, intensivists, and emergency medicine physicians who care for CNS injured patients.
This book examines Social Impact Bonds as a means to finance social services, and how mainstream and heterodox economic theory can help understand their existence and emergence.
Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.
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