For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips. - Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource. - Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis. - Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases. - Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases. - Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci. - PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America. - Includes regular updates online for the life of the edition. - Features more than 1,500 high-quality, full-color photographs—with hundreds new to this edition. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.
Citizenship and Identity offers an analysis of contemporary politics and of the scepticism and apathy which characterise the political life of modern democracies. Starting from exploration of liberal-democracy and a critique of the fragmentation of contemporary politics, this book develops a republican perspective as an alternative framework for political institutions and civic participation.
This book presents the refereed proceedings of the 8th International Conference on Advanced Information Systems Engineering, CAiSE '96, held in Herakleion, Crete, Greece, in May 1996. The 30 revised full papers included in the book were selected from a total of some 100 submissions. The book is organised in sections on CASE environments, temporal and active database technologies, experience reports, interoperability in information systems, formal methods in system development, novel architectures, workflow management and distributed information systems, information modelling, object-oriented database design, and semantic links and abstraction.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
Since its first edition over 60 years ago, Rockwood and Wilkins’ Fractures in Children has been the go-to reference for treating a wide range of fractures in children and adolescents. The landmark tenth edition continues this tradition with the addition of four associate editors, a refreshed mix of contributors, and fully revised content throughout, bringing you fully up to date with today’s techniques and technologies in fractures in pediatric orthopaedics. Drs. Peter M. Waters, David L. Skaggs, John M. Flynn, Lindsay Andras, Donald S. Bae, Keith D. Baldwin, and Jonathan G. Schoenecker lead a team of experts who ensure that the most up-to-date information is presented in a comprehensive yet easy to digest manner.
Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research
This report considers key trends and characteristics of labour migration towards and within Europe, including labour migrant concepts and definitions, statistics on labour migrant flows, geographical patterns, demographic and occupational characteristics, irregular labour migration, management of migration flows, and impact on the labour market.
Petrarch’s revival of the ancient practice of laureation in 1341 led to the laurel being conferred on poets throughout Europe in the later Middle Ages and the Early Modern period. Within the Holy Roman Empire, Maximilian I conferred the title of Imperial Poet Laureate especially frequently, and later it was bestowed with unbridled liberality by Counts Palatine and university rectors too. This handbook identifies more than 1300 poets laureated within the Empire and adjacent territories between 1355 and 1804, giving (wherever possible) a sketch of their lives, a list of their published works, and a note of relevant scholarly literature. The introduction and various indexes provide a detailed account of a now largely forgotten but once significant literary-sociological phenomenon and illuminate literary networks in the Early Modern period. A supplementary Volume 5 of Poets Laureate in the Holy Roman Empire. A Bio-bibliographical Handbook will be published in June 2019.
This book ranks countries with respect to their achievement of the Sustainable Development Goals and their vulnerability to climate change. Human livelihoods, stable economies, health, and high quality of life all depend on a stable climate and earth system, and a diversity of species and ecosystems. Climate change significantly impacts human trafficking, modern slavery, and global hunger. This book examines these global problems using techniques from mathematics of uncertainty. Since accurate data concerning human trafficking and modern slavery is impossible to obtain, mathematics of uncertainty is an ideal discipline to study these problems. The book also considers the interconnection between climate change, world hunger, human trafficking, modern slavery, and the coronavirus. Connectivity properties of fuzzy graphs are used to examine trafficking flow between regions in the world. The book is an excellent reference source for advanced undergraduate and graduate students in mathematics and the social sciences as well as for researchers and teachers.
Resistance arteries have been recognized for some time as key factors in the regulation of vascular flow resistance, where they determine the regional and local distribution of blood and arterial pressure. Chapters provide an overview of the physiological, biochemical, and electrophysiological characteristics of these vessels, as well as a critical evaluation of the methodologies for studying small arteries and an examination of the membrane and neural mechanisms involved in the control of vascular tone.
Includes details of alkaloid and anti-tumour screening of nearly 2000 species, the pharmacological testing of the alkaloids of selected species, and the chemical fractionation of those species which had reproducible tumour-inhibiting properties.
A Complete Reference Covering the Latest Technology in Metal Cutting Tools, Processes, and Equipment Metal Cutting Theory and Practice, Third Edition shapes the future of material removal in new and lasting ways. Centered on metallic work materials and traditional chip-forming cutting methods, the book provides a physical understanding of conventional and high-speed machining processes applied to metallic work pieces, and serves as a basis for effective process design and troubleshooting. This latest edition of a well-known reference highlights recent developments, covers the latest research results, and reflects current areas of emphasis in industrial practice. Based on the authors’ extensive automotive production experience, it covers several structural changes, and includes an extensive review of computer aided engineering (CAE) methods for process analysis and design. Providing updated material throughout, it offers insight and understanding to engineers looking to design, operate, troubleshoot, and improve high quality, cost effective metal cutting operations. The book contains extensive up-to-date references to both scientific and trade literature, and provides a description of error mapping and compensation strategies for CNC machines based on recently issued international standards, and includes chapters on cutting fluids and gear machining. The authors also offer updated information on tooling grades and practices for machining compacted graphite iron, nickel alloys, and other hard-to-machine materials, as well as a full description of minimum quantity lubrication systems, tooling, and processing practices. In addition, updated topics include machine tool types and structures, cutting tool materials and coatings, cutting mechanics and temperatures, process simulation and analysis, and tool wear from both chemical and mechanical viewpoints. Comprised of 17 chapters, this detailed study: Describes the common machining operations used to produce specific shapes or surface characteristics Contains conventional and advanced cutting tool technologies Explains the properties and characteristics of tools which influence tool design or selection Clarifies the physical mechanisms which lead to tool failure and identifies general strategies for reducing failure rates and increasing tool life Includes common machinability criteria, tests, and indices Breaks down the economics of machining operations Offers an overview of the engineering aspects of MQL machining Summarizes gear machining and finishing methods for common gear types, and more Metal Cutting Theory and Practice, Third Edition emphasizes the physical understanding and analysis for robust process design, troubleshooting, and improvement, and aids manufacturing engineering professionals, and engineering students in manufacturing engineering and machining processes programs.
Computational Intelligence: A Compendium presents a well structured overview about this rapidly growing field with contributions of leading experts in Computational Intelligence. The main focus of the compendium is on applied methods tired-and-proven effective to realworld problems, which is especially useful for practitioners, researchers, students and also newcomers to the field. The 25 chapters are grouped into the following themes: I. Overview and Background II. Data Preprocessing and Systems Integration III. Artificial Intelligence IV. Logic and Reasoning V. Ontology VI. Agents VII. Fuzzy Systems VIII. Artificial Neural Networks IX. Evolutionary Approaches X. DNA and Immune-based Computing.
Conflict is inevitable, but educators can work together effectively if they understand how to defuse difficult situations before they escalate. This resource describes the Six-C process, a conflict resolution method that allows educators to take progressively more assertive steps as necessary to resolve disagreements. Based on research and easy to remember, this approach helps readers handle challenging situations using the least amount of time and energy. Illustrated with many examples and scenarios, the six steps are: - Concern: identifying actionable concerns - Confer: expressing concerns in nonthreatening ways - Consult: reviewing and clarifying the situation collaboratively - Confront: considering consequences and giving clear warnings - Combat: taking sustained, logical action - Conciliation: mending the wounds and restoring relationships Focused on preserving relationships while resolving disagreements, From Conflict to Conciliation can be used in any situation or setting, from the classroom to the community.
An expanded edition filled with ideas, strategies, and tools for school counselors This Survival Guide helps counselors plan and implement an effective counseling program tailored to the needs of all students. Step by step, the book walks readers through every aspect of the school counselor job, including: designing a comprehensive counseling program, communicating with students and fellow staff, facilitating groups, promoting positive school discipline, integrating a guidance curriculum, intervening in times of crisis, and taking personal and professional care of oneself. Discusses how to reach out to diverse student and parent populations Shows how to integrate the American School Counselor Association's National Model for designing, delivering, and evaluating a school's counseling program Reveals how new technology can improve services to students and parents Other titles by Wiggin: I.O.U.S.A., Demise of the Dollar, and Financial Reckoning Day This comprehensive resource also includes a wealth of reproducible worksheets, letters, checklists, and forms designed to save time and effort for busy school counselors.
Essential reading for both medical students and academics in the fields of ophthalmology, neurology and oncology, this is the first textbook to cover the subject of primary intraocular lymphoma (PIOL). The book serves to educate ophthalmologists, neurologists and oncologists on a disease process that is often difficult to diagnose. To help readers recognize the malignancy, a presentation of common and less frequently occurring clinical manifestations of the disease is given. The book provides ophthalmologists the guidelines on current diagnostic and therapeutic modalities as well as the historical background of PIOL.
Completely updated edition, written by a close-knit author team Presents a unique approach to stroke - integrated clinical management that weaves together causation, presentation, diagnosis, management and rehabilitation Includes increased coverage of the statins due to clearer evidence of their effectiveness in preventing stroke Features important new evidence on the preventive effect of lowering blood pressure Contains a completely revised section on imaging Covers new advances in interventional radiology
For the gold-standard resource on pediatric fractures, reach for Rockwood and Wilkins’ Fractures in Children. Written by leading orthopaedic surgeons from around the world, the revised and expanded 8th edition of this classic bestselling text presents complete, up-to-date coverage of all types of children’s fractures. A must-read for pediatric orthopedic surgeons and orthopedic residents.
Is depression simply the result of chemical imbalances, or Schizophrenia a wholly biological disorder? What role do the broader circumstances of an individual's social, cultural and heuristic world play in the wider scheme of their psychological wellbeing? In this ground-breaking and highly innovative text, Cromby et al deliver an introduction to the the biopsychosocial paradigm for understanding and treating psychological distress, taking into consideration the wider contexts that engender the onset of mental illness and critiquing the limitations in the sole use of the biomedical model in psychological practice. Rather than biologically determined or clinically measurable, readers are encouraged to consider mental illness as a subjective experience that is expressed according to the individual experiences of the sufferer rather than the rigidity of diagnostic categories. Similarly, approaches to recovery expand beyond psychiatric medication to consider the fundamental function of methods such as psychotherapy, community psychology and service-user movements in the recovery process. Offering a holistic account of the experience of psychological distress, this text draws upon not only statistical evidence but places an integral emphasis on the service-user experience; anecdotal accounts of which feature throughout in order to provide readers with the perspective of the mental health sufferer. Taking an integrative approach to the psychology of mental health, the authors draw from a wealth of experience, examples and approaches to present this student-friendly and engaging text. This is core reading for anyone serious about understanding mental health issues and is suitable for undergraduate students taking introductory courses in psychology and abnormal psychology.
This book provides an introduction to the underlying theory, fundamentals, and applications of EPR spectroscopy, as well as new developments in the area. Knowledge of the topics presented will allow the reader to interpret of a wide range of EPR spectra, as well as help them to apply EPR techniques to problem solving in a wide range of areas: organic, inorganic, biological, and analytical chemistry; chemical physics, geophysics, and minerology. Includes updated information on high frequency and multi-frequency EPR, pulsed microwave techniques and spectra analysis, dynamic effects, relaxation phenomena, computer-based spectra simulation, biomedical aspects of EPR, and more Equips readers with sufficient knowledge of EPR techniques to go on in their specialized area of interest Provides problem sets and concise bibliographies at the end of each chapter, plus several tutorial appendices on topics like mathematical operations, quantum mechanics of angular momentum, experimental considerations.
Largely reorganised and much expanded in this second edition, Practice and Procedures brings together in a single volume general methods of pain assessment and presents the wide range of therapies that can be provided by a range of health care disciplines. Authored by a multidisciplinary team of experts, chapters can stand alone for readers looking for a general overview of the methods of techniques for pain management available to them or work to complement chapters in the preceeding three volumes, providing practical procedures and applications in the management of acute, chronic and cancer pain. The book is divided into three parts. Part One covers the principles of measurement and diagnosis, including history taking and examination, the selection of pain measures, diagnostic tests and novel imaging techniques. Part Two discusses the full range of therapeutic protocols available, from pharmacological therapies, through psychological techniques, physical therapy and international procedures, to techniques specific to pain assessment and management in paediatric patients. Part Three provides information on planning, conducting, analysing and publishing clinical trials, with invaluable guidance on the techniques of systematic review and meta-analysis in pain research. Part Four considers the role of multidisciplinary pain management teams, their organization, their place within different health care systems, and how best to manage change when implementing such a service. Part Five concludes the volume, investigating the use of guidelines, standards and quality improvement initiatives in the management of post-operative pain, and discussing the expert medicolegal report.
This book gathers thousands of up-to-date equations, formulas, tables, illustrations, and explanations into one invaluable volume. It includes over a thousand pages of mathematical material as well as chapters on probability, mathematical statistics, fuzzy logic, and neural networks. It also contains computer language overviews of C, Fortran, and Pascal.
This second edition includes updated chapters from the first edition as well as five additional new chapters (Light detection and ranging (LiDAR), CORONA historical de-classified products, Unmanned Aircraft Vehicles (UAVs), GNSS-reflectometry and GNSS applications to climate variability), shifting the main focus from monitoring and management to extreme hydro-climatic and food security challenges and exploiting big data. Since the publication of first edition, much has changed in terms of technology, and the demand for geospatial data has increased with the advent of the big data era. For instance, the use of laser scanning has advanced so much that it is unavoidable in most environmental monitoring tasks, whereas unmanned aircraft vehicles (UAVs)/drones are emerging as efficient tools that address food security issues as well as many other contemporary challenges. Furthermore, global navigation satellite systems (GNSS) are now responding to challenges posed by climate change by unravelling the impacts of teleconnection (e.g., ENSO) as well as advancing the use of reflected signals (GNSS-reflectometry) to monitor, e.g., soil moisture variations. Indeed all these rely on the explosive use of “big data” in many fields of human endeavour. Moreover, with the ever-increasing global population, intense pressure is being exerted on the Earth’s resources, leading to significant changes in its land cover (e.g., deforestation), diminishing biodiversity and natural habitats, dwindling fresh water supplies, and changing weather and climatic patterns (e.g., global warming, changing sea level). Environmental monitoring techniques that provide information on these are under scrutiny from an increasingly environmentally conscious society that demands the efficient delivery of such information at a minimal cost. Environmental changes vary both spatially and temporally, thereby putting pressure on traditional methods of data acquisition, some of which are highly labour intensive, such as animal tracking for conservation purposes. With these challenges, conventional monitoring techniques, particularly those that record spatial changes call for more sophisticated approaches that deliver the necessary information at an affordable cost. One direction being pursued in the development of such techniques involves environmental geoinformatics, which can act as a stand-alone method or complement traditional methods.
Topics include: Why Economics Matters to Critical Care Clinicians, Overview of Health Economics: Basics Concept for Clinicians;Health Economic Methods; Costs of Critical Care Medicine; Economic Aspects of Sepsis and Severe Infections; Economic Aspects of Renal Failure and Acute Kidney Injury; Economic Aspects of Cardiovascular Disease; Economics of Mechanical Ventilation and Respiratory Failure and Comparative Effective Research and Health Care Reform.
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