Pandemics, epidemics and food borne diseases are a major global challenge. Focusing on the food and farming sector, and mobilising social theory as well as empirical enquiry, Pathological Lives investigates current approaches to biosecurity and ask how pathological lives can be successfully ‘regulated’ without making life more dangerous as a result. Uses empirical and social theoretical resources developed in the course of a 40-month research project entitled ‘Biosecurity borderlands’ Focuses on the food and farming sector, where the generation and subsequent transmission of disease has the ability to reach pandemic proportions Demonstrates the importance of a geographical and spatial analysis, drawing together social, material and biological approaches, as well as national and international examples The book makes three main conceptual contributions, reconceptualising disease as situated matters, the spatial or topological analysis of situations and a reformulation of biopolitics Uniquely brings together conceptual development with empirically and politically informed work on infectious and zoonotic disease, to produce a timely and important contribution to both social science and to policy debate
The concise yet authoritative presentation of key techniques for basic mixtures experiments Inspired by the author's bestselling advanced book on the topic, A Primer on Experiments with Mixtures provides an introductory presentation of the key principles behind experimenting with mixtures. Outlining useful techniques through an applied approach with examples from real research situations, the book supplies a comprehensive discussion of how to design and set up basic mixture experiments, then analyze the data and draw inferences from results. Drawing from his extensive experience teaching the topic at various levels, the author presents the mixture experiments in an easy-to-follow manner that is void of unnecessary formulas and theory. Succinct presentations explore key methods and techniques for carrying out basic mixture experiments, including: Designs and models for exploring the entire simplex factor space, with coverage of simplex-lattice and simplex-centroid designs, canonical polynomials, the plotting of individual residuals, and axial designs Multiple constraints on the component proportions in the form of lower and/or upper bounds, introducing L-Pseudocomponents, multicomponent constraints, and multiple lattice designs for major and minor component classifications Techniques for analyzing mixture data such as model reduction and screening components, as well as additional topics such as measuring the leverage of certain design points Models containing ratios of the components, Cox's mixture polynomials, and the fitting of a slack variable model A review of least squares and the analysis of variance for fitting data Each chapter concludes with a summary and appendices with details on the technical aspects of the material. Throughout the book, exercise sets with selected answers allow readers to test their comprehension of the material, and References and Recommended Reading sections outline further resources for study of the presented topics. A Primer on Experiments with Mixtures is an excellent book for one-semester courses on mixture designs and can also serve as a supplement for design of experiments courses at the upper-undergraduate and graduate levels. It is also a suitable reference for practitioners and researchers who have an interest in experiments with mixtures and would like to learn more about the related mixture designs and models.
This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Premium Edition includes access to the complete contents of the book online, fully searchable and updated quarterly by Dr. Hoffman himself. - Publisher.
Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field. Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas. Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more. Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies. New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Hematology, 6th Edition encompasses all of the latest scientific knowledge and clinical solutions in the field, equipping you with the expert answers you need to offer your patients the best possible outcomes. Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, John Anastasi, MD, and a host of world-class contributors present the expert, evidence-based guidance you need to make optimal use of the newest diagnostic and therapeutic options. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Make confident, effective clinical decisions by consulting the world's most trusted hematology reference. Access the complete contents online at www.expertconsult.com, with a downloadable image collection, regular updates, case studies, patient information sheets, and more. Apply all the latest knowledge on regulation of gene expression, transcription splicing, and RNA metabolism; pediatric transfusion therapy; principles of cell-based gene therapy; allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults; hematology in aging; and much more, thanks to 27 brand-new chapters plus sweeping updates throughout. Find the information you need quickly and easily thanks to a completely reworked organization that better reflects today’s clinical practice. Visualize clinical problems more clearly with new and updated images that reflect the pivotal role of hematopathology in modern practice. Benefit from the experience and fresh perspective of new editor Dr. Jeffrey Weitz, Professor of Medicine at McMaster University School of Medicine and Executive Director of the Thrombosis and Atherosclerosis Research Institute in Ontario.
This review volume consists of articles by outstanding scientists who explore Archimedes' influence on the development of mathematics, particularly on Geometry, Analysis and Mechanics.
The most comprehensive, single-volume guide to conductingexperiments with mixtures "If one is involved, or heavily interested, in experiments onmixtures of ingredients, one must obtain this book. It is, as wasthe first edition, the definitive work." -Short Book Reviews (Publication of the International StatisticalInstitute) "The text contains many examples with worked solutions and with itsextensive coverage of the subject matter will prove invaluable tothose in the industrial and educational sectors whose work involvesthe design and analysis of mixture experiments." -Journal of the Royal Statistical Society "The author has done a great job in presenting the vitalinformation on experiments with mixtures in a lucid and readablestyle. . . . A very informative, interesting, and useful book on animportant statistical topic." -Zentralblatt fur Mathematik und Ihre Grenzgebiete Experiments with Mixtures shows researchers and students how todesign and set up mixture experiments, then analyze the data anddraw inferences from the results. Virtually every technique thathas appeared in the literature of mixtures can be found here, andcomputing formulas for each method are provided with completelyworked examples. Almost all of the numerical examples are takenfrom real experiments. Coverage begins with Scheffe latticedesigns, introducing the use of independent variables, and endswith the most current methods. New material includes: * Multiple response cases * Residuals and least-squares estimates * Categories of components: Mixtures of mixtures * Fixed as well as variable values for the major componentproportions * Leverage and the Hat Matrix * Fitting a slack-variable model * Estimating components of variances in a mixed model using ANOVAtable entries * Clarification of blocking mates and choice of mates * Optimizing several responses simultaneously * Biplots for multiple responses
The Hematology: Diagnosis and Treatment eBook is the ideal mobile resource in hematology! It distills the most essential, practical information from Hematology: Basic Principles and Practice, 6th Edition - the comprehensive masterwork by Drs. Hoffman, Benz, Silberstein, Heslop, Weitz, and Anastasi - into a concise, clinically focused resource that's optimized for reference on any e-reader. Focusing on the dependable, state-of-the-art clinical strategies you need to optimally diagnose and manage the full range of blood diseases and disorders, this eBook is a must-have for every hematologist's mobile device! Apply the latest know-how on heparin-induced thrombocytopenia, stroke, acute coronary syndromes, hematologic manifestations of liver disease, hematologic manifestations of cancer, hematology in aging, and many other hot topics. Get quick, focused answers on the diagnosis and management of blood diseases - in a portable digital format that you can carry and consult anytime, anywhere. View abundant images that mirror the pivotal role hematopathology plays in the practice of modern hematology. Count on all the authority that has made Hematology: Basic Principles and Practice, 6th Edition, edited by Drs. Hoffman, Benz, Silberstein, Heslop, Weitz, and Anastasi, the go-to clinical reference for hematologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.
WALL STREET JOURNAL BESTSELLER Do you want to lose fat, gain muscle and build the body of your dreams without having to step foot in a gym or on a treadmill? This book has the answer you've been searching for. No matter your age, sex, or conditioning status, this book will help you look and feel your best. And guess what? 10 MINUTES IS ALL YOU NEED & YOU WON'T EVEN HAVE TO LEAVE YOUR HOUSE! If you're like most people that have tried fruitless weight lifting or tedious cardio, your body probably feels the negative effects - like aching, painful joints and the inability to lose stubborn fat. Or perhaps you have: Spent years in the gym but struggle to gain muscle, lose belly fat and see real results. When you take your shirt off, it doesn't even look like you workout. • Tried all the fad diets that just leave you hungry, frustrated and not losing any weight. • Seen all the muscular athletes in the gym and wonder what you're doing wrong. • Wandered around the gym feeling defeated and confused about what exercises will help you achieve your dream body. • Suffered through injuries and pain from lifting weights with bad form and engaging in dangerous exercises. Well, we're glad you found this book. In Weight Lifting is a Waste of Time, authors Dr. John Jaquish and Henry Alkire present their scientifically proven approach that debunks myths surrounding traditional weightlifting and fad dieting. Enter the "Tony Stark of the Fitness Industry" John Jaquish, PhD, is well known for inventing what is now considered the most effective bone density building medical technology on the market. This discovery led to his second invention, X3: the world's most powerful muscle building device based on variable resistance. X3 is proven to develop muscle much faster than conventional weight lifting, all with the lowest risk of joint injury. Some of the world's most elite athletes train with X3 Bar, including dozens of Olympians, NFL players, and NBA players. By the end of this book, you'll know and understand clear and simple steps to gain muscle, burn fat, and refuel your body. FINALLY! You can feel confident at the beach and in the mirror —and you can do so at home. With the methods and tools laid out in this book, you can achieve the bigger, leaner and stronger body you've always wanted. Here's a quick sneak peek of what you'll learn: • Everything you've learned about weight training from bodybuilders and influencers is wrong. We'll explain how weightlifting does irreversible damage by overloading joints and underloading muscle. • You don’t need to spend endless hours in the gym to get your dream body. X3 provides the most effective at-home workout, no matter your age or sex. • You can grow muscle 3 times faster with the X3 workout system without taking harmful supplements or going to the gym. Fad diets like Keto simply don't work, and what nutrition system is scientifically proven to help keep the weight off. • Prolonged cardio keeps you fatter longer (and what to do instead). • Are you ready to get the knowledge and tools you need to become the healthiest, leanest, most muscular version of yourself? Scroll up and click "Buy Now"!
John Edward takes his fans with him on the extraordinary journey that has been his life. In the style of his TV show and personal appearances—poignant, funny, and remarkably candid—John Edward deals head-on with the controversial issues he has confronted on his voyage as a psychic medium. On his way to success and fame, John had to learn his own lessons about the meaning of his work, the motivations of some of the people he encountered, and the spirits who accompanied them. Through his very personal stories, John has brought peace and insight to those grieving for their loved ones—but what makes Edward’s memoir unique is how readily he exposes his own vanities and ego bruisings. In addition, he provides a behind-the-scenes look at being a television medium, offering an amusing—and at times disturbing—look at how the ethereal world clashes with the celebrity world. John Edward’s wit, warmth, and passion will captivate readers—just as it has riveted the millions who view his landmark program.
This is the first of three volumes providing a comprehensive presentation of the fundamentals of scientific computing. This volume discusses basic principles of computation, and fundamental numerical algorithms that will serve as basic tools for the subsequent two volumes. This book and its companions show how to determine the quality of computational results, and how to measure the relative efficiency of competing methods. Readers learn how to determine the maximum attainable accuracy of algorithms, and how to select the best method for computing problems. This book also discusses programming in several languages, including C++, Fortran and MATLAB. There are 80 examples, 324 exercises, 77 algorithms, 35 interactive JavaScript programs, 391 references to software programs and 4 case studies. Topics are introduced with goals, literature references and links to public software. There are descriptions of the current algorithms in LAPACK, GSLIB and MATLAB. This book could be used for an introductory course in numerical methods, for either upper level undergraduates or first year graduate students. Parts of the text could be used for specialized courses, such as principles of computer languages or numerical linear algebra.
The proliferation of harmful phytoplankton in marine ecosystems can cause massive fish kills, contaminate seafood with toxins, impact local and regional economies and dramatically affect ecological balance. Real-time observations are essential for effective short-term operational forecasting, but observation and modelling systems are still being developed. This volume provides guidance for developing real-time and near real-time sensing systems for observing and predicting plankton dynamics, including harmful algal blooms, in coastal waters. The underlying theory is explained and current trends in research and monitoring are discussed.Topics covered include: coastal ecosystems and dynamics of harmful algal blooms; theory and practical applications of in situ and remotely sensed optical detection of microalgal distributions and composition; theory and practical applications of in situ biological and chemical sensors for targeted species and toxin detection; integrated observing systems and platforms for detection; diagnostic and predictive modelling of ecosystems and harmful algal blooms, including data assimilation techniques; observational needs for the public and government; and future directions for research and operations.
This book unravels the role of Point-of-Care (POC) glucose monitoring as an essential part of diabetes management. It provides the reader with an in-depth knowledge and understanding of diabetes management, including: the need for POC glucose monitoring the glucose detection technologies (invasive, noninvasive and continuous) being used in the POC devices the analytical performance, characteristics, pros and cons of the POC devices developed to date the importance and role of glycated hemoglobin (HbA1c) monitoring for diabetes management the various POC devices and analyzers for the determination of HbA1c. This is the first book to provide complete up-to-date information on POC glucose detection technologies and devices for diabetic monitoring and management. It will be an important reference for healthcare professionals, biomedical engineers, researchers, economists and policy makers. This book also serves as an asset and teaching aid for professionals and researchers in diabetic monitoring and management.
The first book devoted to a critically important aspect of disaster planning, management, and mitigation Technology and Emergency Management, Second Edition describes best practices for technology use in emergency planning, response, recovery, and mitigation. It also describes the key elements that must be in place for technology to enhance the emergency management process. The tools, resources, and strategies discussed have been applied by organizations worldwide tasked with planning for and managing every variety of natural and man-made hazard and disaster. Illustrative case studies based on their experiences appear throughout the book. This new addition of the critically acclaimed guide has been fully updated and expanded to reflect significant developments occurring in the field over the past decade. It features in-depth coverage of major advances in GIS technologies, including the development of mapping tools and high-resolution remote sensing imaging. Also covered is the increase in computer processing power and mobility and enhanced analytical capabilities for assessing the present conditions of natural systems and extrapolating from them to create accurate models of potential crisis conditions. This second edition also features a new section on cybersecurity and a new chapter on social media and disaster preparedness, response, and recovery has been added. Explores the role of technology in emergency planning, response, recovery, and mitigation efforts Explores applications of the Internet, telecommunications, and networks to emergency management, as well as geospatial technologies and their applications Reviews the elements of hazard models and the relative strengths and weaknesses of modeling programs Describes techniques for developing hazard prediction models using direct and remote sensing data Includes test questions for each chapter, and a solutions manual and PowerPoint slides are available on a companion website Technology and Emergency Management, Second Edition is a valuable working resource for practicing emergency managers and an excellent supplementary text for undergraduate and graduate students in emergency management and disaster management programs, urban and regional planning, and related fields.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
This book may be used to simply entertain, support or reject positions or claims made by you in your defense of a position or to attack the credibility of someone that you wish to challenge. The author sincerely believes that a good quotation, timely and to the point, can do a great deal to influence a situation or position that might otherwise go unnoticed or not supported. This is a strong statement but the author believes that it happens all the time at all levels of meetings and conversations. WHY YOU SHOULD READ THIS BOOK: It will broaden your thoughts about what you BELIEVE and don’t believe! It will strengthen your SUPPORT or REJECTION on the thoughts of others! It will ease you into developing your OWN PERSONAL philosophy about life and other things! If you use an APPROPRIATE quotation in the RIGHT PLACE at the RIGHT TIME, people will think you are probably a little smarter than you actually are! WHO SHOULD PURCHASE THIS BOOK: Anyone who loves to read quotations for fun. Business persons who are often requested to defend their position or attack someone else with a powerful quotation. Professional business leaders working to improve their acceptance of points of his/her speech, letters or memos. High school/college students searching for persuasive material, especially in forensics and debate. Business executives looking for a great gift for his/her team. Subordinates looking to give a gift to impress their boss! (J)
With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.
Aims to demonstrate why demand-side management is critical to urban water supply planning and to provide methods for incorporation. This book explains how and why urban water demands have changed over time and includes methods for the analysis of urban water demands. It also offers methods for integrating supply side and demand-side planning and management.
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