Coal is a topic that has been, remains, and will continue to be of significant interest to those concerned with the causes, course and consequences of industrialization and de-industrialization. This six-volume, reset collection provides scholars with a wide variety of sources relating to the Victorian coal industry.
Effectively manage parathyroid and bone metabolism disorders with The Parathyroid Gland and Bone Metabolism! Brought to you by the same leading endocrinologists responsible for the highly acclaimed two-volume textbook, Endocrinology: Adult and Pediatric, this eBook presents a compilation of chapters covering all endocrinology material related to parathyroid and bone metabolism. Never before available as a stand-alone offering, this content will enable you to give your patients the benefit of today’s best know-how on parathyroid and bone metabolism from the leading resource in endocrinology. Stay abreast of the newest knowledge and advances on parathyroid and bone metabolism, including... pediatric parathyroid disorders and bone metabolism disorders major diseases common to the aging population, such as osteoporosis advances in the genetics of disorders involving calciotropic hormones newer diagnostic approaches and therapies for bone diseases, from osteoporosis to Paget’s disease and much more. Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and De Groot, the go-to clinical medical reference for endocrinologists worldwide. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.
Actins are a highly conserved family of proteins found in virtually all eukaryotic cells. They have prolific roles in cell motility - from the contraction of striated muscle to the movement of organelles within cells, and are known to interact with a diverse number of proteins families from myosins to gelsolins. This up-to-date edition gives a comprehensive account of actin sequence, mutation and structure as well as providing insight into ligand-binding sites and drug and toxin binding. Illustrated throughout, this modern text also contains an extensive bibliography for the interested reader.
At a time when policing is undergoing significant changes, in particular the move to regional arrangements and the focus on international criminality, The Obedient Servant remembers the period when a relatively small town in the north of England had its own local police force. Doncaster Borough police was part of, and could not be separated from, the town and its community as it grew from a small market town to a major industrial borough. The Obedient Servant is about some of the people in that force, the style of policing influenced by a powerful watch committee, and how the town managed to fight off the constant attempts by central government to amalgamate the Doncaster police with the surrounding West Riding of Yorkshire. The Obedient Servant also focuses on how the force was involved with vagrancy and the administration of the Poor Laws and Union workhouses, and the danger of assault faced by the Victorian policemen who could not call upon limitless resources to support them in a confrontation. As the town grew in size, the force had to deal with militant suffragettes, and it also provided many of its officers to the armed services in both World Wars. The police force’s problems continued to grow, and from the early 1950s onward it became apparent that the town could not sustain its own police force for much longer. In 1968, after 132 years, the Doncaster Borough police became part of the new West Yorkshire police. This fascinating story of the Doncaster Borough police force will particularly appeal to those interested in police history, as well as those familiar with that part of South Yorkshire.
In combining and revising the two titles 'Past Glacial Environments' and 'Modern Glacial Environments', Dr Menzies and his contributors provide the most comprehensive and wide-ranging book ever prepared on both topics. This text is produced with the student mind, providing accessibility to a complex subject and introducing topics that provide the fundamental underpinnings of knowledge on glaciers, ice sheets, their sediments and landscapes. Modern and Past Glacial Environments features a large collection of photographs, line diagrams and tables and includes examples of glacial environments and landscapes which are drawn from a world wide perspective. Together with a web- based set of current and comprehensive references and bibliographic sources, it provides an ideal reference text. This survey includes coverage of the glaciology, geomorphology and sedimentology of modern glaciers and ice sheets, and the sediments and forms generated within Pleistocene and pre-Pleistocene glacial environments. Quaternary scientists and students will find this work their first point of reference. Likewise students of Physical Geography, Geology, Earth Science, Engineering Geology, Civil Engineering, and Environmental Sciences should find this a useful guide and reference to Glacial Geomorphology and Geology. - Essential new academic version - Highest contributors in their fields - Well reviewed first editions
This book is about the recent advances in the structural and functional characterization of receptors that influence intracellular signalling events through interaction with intracellular GTP-binding proteins (G proteins). Molecular cloning of members of the G protein-coupled receptor superfamily has complemented pharmacological investigations in providing a realization of the structural and functional diversity of these receptors. An increased understanding of the involvement of particular receptor subtypes in normal and pathophysiological processes represents exciting possibilities for the development of highly specific and effective therapeutic agents.
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.RNA Interference will cover RNAi in non-vertebrates (plants, C. elegans, drosophila, and S. pombe), and Mammalian systems (human and non-human cells). This volume discusses extensive methodology related to delivery methods high throughput strategies and prospects as a human therapy agent.* One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences
Collecting an extensive amount of information from thousands of publications by leading investigators in this rapidly developing field, this book provides a convenient and up-to-date one volume source for research in neural tumors of various cellular origins. With over 3,500 references, 110 figures and 120 tables, this volume gathers an astonishing body of knowledge regarding human neural tumors. This book is the first of its kind, encyclopedic and wide-ranging.
Paratransit services are more expensive to provide on a per-trip basis than fixed-route transit, so operating efficiencies could be achieved by attracting some paratransit riders to fixed route. The Guidebook identifies the characteristics and preferences of four distinct market segments: people with disabilities who use fixed-route transit; people with disabilities who use paratransit; others who currently use paratransit; and people with disabilities who normally do not use transit. The Guidebook also provides step-by-step procedures for estimating demand, locating bus stops, training drivers, providing travel training for patrons, marketing services, and evaluating successes.
Te Linde’s Operative Gynecology has been the premier text in the field of gynecologic surgery for more than 60 years. This text covers all of the aspects of gynecologic surgery – from the most general topics of surgical ethics to instruction on detailed surgical procedures. General background/pathology for surgical problems is covered as are patient/treatment selection, step-by-step surgical techniques and post-operative concerns.
This book takes an in-depth look at the emerging technologies that are transforming the way clinicians manage patients, while at the same time emphasizing that the best practitioners use both artificial and human intelligence to make decisions. AI and machine learning are explored at length, with plain clinical English explanations of convolutional neural networks, back propagation, and digital image analysis. Real-world examples of how these tools are being employed are also discussed, including their value in diagnosing diabetic retinopathy, melanoma, breast cancer, cancer metastasis, and colorectal cancer, as well as in managing severe sepsis. With all the enthusiasm about AI and machine learning, it was also necessary to outline some of criticisms, obstacles, and limitations of these new tools. Among the criticisms discussed: the relative lack of hard scientific evidence supporting some of the latest algorithms and the so-called black box problem. A chapter on data analytics takes a deep dive into new ways to conduct subgroup analysis and how it’s forcing healthcare executives to rethink the way they apply the results of large clinical trials to everyday medical practice. This re-evaluation is slowly affecting the way diabetes, heart disease, hypertension, and cancer are treated. The research discussed also suggests that data analytics will impact emergency medicine, medication management, and healthcare costs. An examination of the diagnostic reasoning process itself looks at how diagnostic errors are measured, what technological and cognitive errors are to blame, and what solutions are most likely to improve the process. It explores Type 1 and Type 2 reasoning methods; cognitive mistakes like availability bias, affective bias, and anchoring; and potential solutions such as the Human Diagnosis Project. Finally, the book explores the role of systems biology and precision medicine in clinical decision support and provides several case studies of how next generation AI is transforming patient care.
David is a refugee from the late sixties and early seventies, now teaching at a community college in Western Massachusetts. Committed to helping his working-class students, he is also a part-time father who is trying to raise his son in a responsible and loving way. When he meets an old lover from the seventies who runs a center for battered women in Boston, and she asks him to help out in an emergency, David finds that his life and his son’s begin to spiral into an increasingly dangerous and terrifying sequence of events. David is finally forced to confront his own violence and to examine his life from a different perspective.
Reprint of the original, first published in 1873. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.
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