Molecular Sensors and Nanodevices: Principles, Designs and Applications in Biomedical Engineering, Second Edition is designed to be used as a foundational text, aimed at graduates, advanced undergraduates, early-career engineers and clinicians. The book presents the essential principles of molecular sensors, including theories, fabrication techniques and reviews. In addition, important devices and recently, highly-cited research outcomes are also cited. This differentiates the book from other titles on the market whose primary focus is more research-oriented and aimed at more of a niche market. - Covers the fundamental principles of device engineering and molecular sensing, sensor theories and applications in biomedical science and engineering - Introduces nano/micro fabrication techniques, including MEMS, bioMEMS, microTAS and nanomaterials science that are essential in the miniaturization of versatile molecular sensors - Explores applications of nanomaterials and biomaterials, including proteins, DNAs, nanoparticles, quantum dots, nanotubes/wires and graphene in biomedicine
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
The book focuses on the design, materials, process, fabrication, and reliability of advanced semiconductor packaging components and systems. Both principles and engineering practice have been addressed, with more weight placed on engineering practice. This is achieved by providing in-depth study on a number of major topics such as system-in-package, fan-in wafer/panel-level chip-scale packages, fan-out wafer/panel-level packaging, 2D, 2.1D, 2.3D, 2.5D, and 3D IC integration, chiplets packaging, chip-to-wafer bonding, wafer-to-wafer bonding, hybrid bonding, and dielectric materials for high speed and frequency. The book can benefit researchers, engineers, and graduate students in fields of electrical engineering, mechanical engineering, materials sciences, and industry engineering, etc.
This book focuses on the assembly and reliability of lead-free solder joints. Both the principles and engineering practice are addressed, with more weight placed on the latter. This is achieved by providing in-depth studies on a number of major topics such as solder joints in conventional and advanced packaging components, commonly used lead-free materials, soldering processes, advanced specialty flux designs, characterization of lead-free solder joints, reliability testing and data analyses, design for reliability, and failure analyses for lead-free solder joints. Uniquely, the content not only addresses electronic manufacturing services (EMS) on the second-level interconnects, but also packaging assembly on the first-level interconnects and the semiconductor back-end on the 3D IC integration interconnects. Thus, the book offers an indispensable resource for the complete food chain of electronics products.
Heterogeneous integration uses packaging technology to integrate dissimilar chips, LED, MEMS, VCSEL, etc. from different fabless houses and with different functions and wafer sizes into a single system or subsystem. How are these dissimilar chips and optical components supposed to talk to each other? The answer is redistribution layers (RDLs). This book addresses the fabrication of RDLs for heterogeneous integrations, and especially focuses on RDLs on: A) organic substrates, B) silicon substrates (through-silicon via (TSV)-interposers), C) silicon substrates (bridges), D) fan-out substrates, and E) ASIC, memory, LED, MEMS, and VCSEL systems. The book offers a valuable asset for researchers, engineers, and graduate students in the fields of semiconductor packaging, materials sciences, mechanical engineering, electronic engineering, telecommunications, networking, etc.
The book focuses on the design, materials, process, fabrication, and reliability of chiplet design and heterogeneous integraton packaging. Both principles and engineering practice have been addressed, with more weight placed on engineering practice. This is achieved by providing in-depth study on a number of major topics such as chip partitioning, chip splitting, multiple system and heterogeneous integration with TSV-interposers, multiple system and heterogeneous integration with TSV-less interposers, chiplets lateral communication, system-in-package, fan-out wafer/panel-level packaging, and various Cu-Cu hybrid bonding. The book can benefit researchers, engineers, and graduate students in fields of electrical engineering, mechanical engineering, materials sciences, and industry engineering, etc.
Interest in green chemistry and clean processes has grown so much in recent years that topics such as fluorous biphasic catalysis, metal organic frameworks, and process intensification, which were barely mentioned in the First Edition, have become major areas of research. In addition, government funding has ramped up the development of fuel cells and biofuels. This reflects the evolving focus from pollution remediation to pollution prevention. Copiously illustrated with more than 800 figures, the Third Edition provides an update from the frontiers of the field. It features supplementary exercises at the end of each chapter relevant to the chemical examples introduced in each chapter. Particular attention is paid to a new concluding chapter on the use of green metrics as an objective tool to demonstrate proof of synthesis plan efficiency and to identify where further improvements can be made through fully worked examples relevant to the chemical industry. NEW AND EXPANDED RESEARCH TOPICS Metal-organic frameworks Metrics Solid acids for alkylation of isobutene by butanes Carbon molecular sieves Mixed micro- and mesoporous solids Organocatalysis Process intensification and gas phase enzymatic reactions Hydrogen storage for fuel cells Reactive distillation Catalysts in action on an atomic scale UPDATED AND EXPANDED CURRENT EVENTS TOPICS Industry resistance to inherently safer chemistry Nuclear power Removal of mercury from vaccines Removal of mercury and lead from primary explosives Biofuels Uses for surplus glycerol New hard materials to reduce wear Electronic waste Smart growth The book covers traditional green chemistry topics, including catalysis, benign solvents, and alternative feedstocks. It also discusses relevant but less frequently covered topics with chapters such as "Chemistry of Long Wear" and "Population and the Environment." This coverage highlights the importance of chemistry to everyday life and demonstrates the benefits the expanded exploitation of green chemistry can have for society.
This comprehensive guide to fan-out wafer-level packaging (FOWLP) technology compares FOWLP with flip chip and fan-in wafer-level packaging. It presents the current knowledge on these key enabling technologies for FOWLP, and discusses several packaging technologies for future trends. The Taiwan Semiconductor Manufacturing Company (TSMC) employed their InFO (integrated fan-out) technology in A10, the application processor for Apple’s iPhone, in 2016, generating great excitement about FOWLP technology throughout the semiconductor packaging community. For many practicing engineers and managers, as well as scientists and researchers, essential details of FOWLP – such as the temporary bonding and de-bonding of the carrier on a reconstituted wafer/panel, epoxy molding compound (EMC) dispensing, compression molding, Cu revealing, RDL fabrication, solder ball mounting, etc. – are not well understood. Intended to help readers learn the basics of problem-solving methods and understand the trade-offs inherent in making system-level decisions quickly, this book serves as a valuable reference guide for all those faced with the challenging problems created by the ever-increasing interest in FOWLP, helps to remove roadblocks, and accelerates the design, materials, process, and manufacturing development of key enabling technologies for FOWLP.
A Complete Reference Covering the Latest Technology in Metal Cutting Tools, Processes, and Equipment Metal Cutting Theory and Practice, Third Edition shapes the future of material removal in new and lasting ways. Centered on metallic work materials and traditional chip-forming cutting methods, the book provides a physical understanding of conventional and high-speed machining processes applied to metallic work pieces, and serves as a basis for effective process design and troubleshooting. This latest edition of a well-known reference highlights recent developments, covers the latest research results, and reflects current areas of emphasis in industrial practice. Based on the authors’ extensive automotive production experience, it covers several structural changes, and includes an extensive review of computer aided engineering (CAE) methods for process analysis and design. Providing updated material throughout, it offers insight and understanding to engineers looking to design, operate, troubleshoot, and improve high quality, cost effective metal cutting operations. The book contains extensive up-to-date references to both scientific and trade literature, and provides a description of error mapping and compensation strategies for CNC machines based on recently issued international standards, and includes chapters on cutting fluids and gear machining. The authors also offer updated information on tooling grades and practices for machining compacted graphite iron, nickel alloys, and other hard-to-machine materials, as well as a full description of minimum quantity lubrication systems, tooling, and processing practices. In addition, updated topics include machine tool types and structures, cutting tool materials and coatings, cutting mechanics and temperatures, process simulation and analysis, and tool wear from both chemical and mechanical viewpoints. Comprised of 17 chapters, this detailed study: Describes the common machining operations used to produce specific shapes or surface characteristics Contains conventional and advanced cutting tool technologies Explains the properties and characteristics of tools which influence tool design or selection Clarifies the physical mechanisms which lead to tool failure and identifies general strategies for reducing failure rates and increasing tool life Includes common machinability criteria, tests, and indices Breaks down the economics of machining operations Offers an overview of the engineering aspects of MQL machining Summarizes gear machining and finishing methods for common gear types, and more Metal Cutting Theory and Practice, Third Edition emphasizes the physical understanding and analysis for robust process design, troubleshooting, and improvement, and aids manufacturing engineering professionals, and engineering students in manufacturing engineering and machining processes programs.
This volume provides a detailed treatment of half-metallic materials and their properties from both an experimental and theoretical point of view. It discusses the methods used to understand and predict the properties of half-metals and the gamut of other materials amenable to these techniques. It also offers an expansive bibliography to facilitate further and deeper research. This book provides the precise definitions of all key terminology used in the vast and varied literature.This is the first comprehensive monograph on the subject and will serve as a starting point for graduate students and senior researchers who wish to enter the field. This book will also be an invaluable reference to those already working in the areaof half-metallic materials./a
This much-awaited final volume of The Birds of British Columbia completes what some have called one of the most important regional ornithological works in North America. It is the culmination of more than 25 years of effort by the authors who, with the assistance of thousands of dedicated volunteers throughout the province, have created the basic reference work on the avifauna of British Columbia.
The objective of this book is to present a fundamental development of the science and engineering underlying the design of exhaust aftertreatment systems for automotive internal combustion engines. No pre-requisite knowledge of the field is required: our objective is to acquaint the reader, whom we expect to be new to the field of emissions control, with the underlying principles, control methods, common problems, and fuel effects on catalytic exhaust aftertreatment devices. We do this in hope that they can better understand the previous and current generations of emissions control, and improve upon them. This book is designed for the engineer, researcher, designer, student, or any combination of those, who is concerned with the control of automotive exhaust emissions. It includes discussion of theory and fundamentals applicable to hardware development.
This book arose from the authors knowledge of a small number of doctors who were not behaving in a professional or proper manner. As he read about them, he found he was astonished at the extent of some offenders. Any human being can have flaws in their character, personality disorders or mental illnesses, what if that person is your doctor? This book takes the reader on a journey from the colorful life of Geoffrey Edelsten through Medawar's The Strange Case of the Spotted Mice, a fertility specialist who used his own sperm to impregnate over 50 women without their knowledge to the lasting and devastating effects of the MMR vaccine debacle. The author suggests that a test needs to be devised to detect character flaws such as greed before they harm innocent people through fraud and deceit. As much a reference book as it is a celebration of the brave‘whistleblower’and witty commentary on human nature, capturing the imagination, leading the reader to wonder why people make the decisions they do. Anderson himself had a colorful life and a brilliant career, leaving an immeasurable legacy to medicine. His wish was that this book would prompt change, leading to enhanced integrity in the medical and scientific world.
The one collection every healthcare leader needs. The landscape of today's healthcare industry is constantly changing, and it's your job to lead your team to success. This collection from Harvard Business Review offers the ideas and strategies to help get you there. HBR's 10 Must Reads for Healthcare Leaders Collection includes the popular books HBR's 10 Must Reads on Leadership for Healthcare, HBR's 10 Must Reads on Strategy for Healthcare, HBR's 10 Must Reads on Innovation, and HBR's 10 Must Reads on Change Management. This unique compilation offers insights from world-class experts on making the leap from being a good practitioner to being a great leader, leading effectively through times of rapid change, and achieving the best healthcare outcomes at the lowest cost. The collection includes forty articles selected by HBR's editors from renowned thought leaders including Michael Porter, Peter Drucker, John Kotter, Rosabeth Moss Kanter, Jim Collins, W. Chan Kim, and Renee Mauborgne, plus the bonus article "Engaging Doctors in the Health Care Revolution," by Thomas H. Lee, MD, and Toby Cosgrove, MD. HBR's 10 Must Reads for Healthcare Leaders Collection is an invaluable resource for any doctor or hospital administrator looking to grow as a leader and to having a positive impact on colleagues and patients alike. HBR's 10 Must Reads series is the definitive collection of ideas and best practices for leaders at every level. These books offer essential reading selected from the pages of Harvard Business Review on topics critical to the success of every manager. Each book is packed with advice and inspiration from leading experts such as Clayton Christensen, Peter Drucker, Rosabeth Moss Kanter, John Kotter, Michael Porter, Daniel Goleman, Theodore Levitt, and Rita Gunther McGrath.
Help your team excel. Go from being a good practitioner to being an extraordinary leader of healthcare professionals. If you read nothing else on leadership, read these articles. We've combed through hundreds of Harvard Business Review articles and selected the most important ones for healthcare leaders to help you and your team excel, maximize performance, and live into your mission. Leading experts, such as Thomas H. Lee, Daniel Goleman, Peter F. Drucker, John P. Kotter, and Amy C. Edmondson, provide the insights and advice you need to: Understand the difference between managers and leaders Motivate others to excel Create successful cross-functional teams on the fly Maintain your identity and values as a clinician as you move into an organizational leadership role Have an impact not only on your organization but on the surrounding system Work in complex environments where authority is diffuse Lead effectively in times of rapid change This collection of articles includes "What Makes a Leader?," by Daniel Goleman; "What Makes an Effective Executive," by Peter F. Drucker; "What Leaders Really Do," by John P. Kotter; "Level 5 Leadership: The Triumph of Humility and Fierce Resolve," by Jim Collins; "The Work of Leadership," by Ronald A. Heifetz and Donald L. Laurie; "Teamwork on the Fly," by Amy C. Edmondson; "Who Has the D? How Clear Decision Roles Enhance Organizational Performance," by Paul Rogers and Marcia Blenko; "In Praise of the Incomplete Leader," by Deborah Ancona, Thomas W. Malone, Wanda J. Orlikowski, and Peter M. Senge; "Using the Balanced Scorecard as a Strategic Management System," by Robert S. Kaplan and David P. Norton; "Health Care's Service Fanatics," by James I. Merlino and Ananth Raman; and "Engaging Doctors in the Health Care Revolution," by Thomas H. Lee and Toby Cosgrove.
With synthetic implants such as hip joints, heart valves and dental crowns now routinely used in the human body for medical purposes, study of the metals, ceramics and polymers used in these repairs is more important than ever. The Chemistry of Medical and Dental Materials examines the properties and interactions of these materials within the body at a molecular level, and includes discussion of bioengineering and cell biology, with accounts of the surgical procedures used, as well as extensive coverage of the possible biological reactions to the presence of foreign materials in the body. Acknowledging the substantial growth of the biomaterials field since the first edition, this second edition sees each chapter comprehensively revised and updated. The new edition also includes a new chapter on ethical perspectives, covering issues from animal and human subject testing to the availability of treatments for poorer socio-economic groups. With detailed reviews of the current literature, this book will be a key resource for researchers and practitioners in biomaterials science and dental biomaterials who are involved in the development of new and improved repair materials.
Did you know that a West Union native served as General Dwight D. Eisenhower's adjutant during World War II? Or that a Walhalla man had a U.S. Navy ship named in his honor after he was killed in action? Or that a Tamassee man flew in a bombing mission over Germany in a plane piloted by famous actor Jimmy Stewart? Looking Back, a Journey Through the Pages of the Keowee Courier for the World War II Years, 1941-1945 is about life on the home front during the war, as reported by a small weekly newspaper located in Walhalla, South Carolina.
Edited by the leaders in the fi eld, with chapters from highly renowned international researchers, this is the fi rst coherent overview of the latest in silicon nanomembrane research. As such, it focuses on the fundamental and applied aspects of silicon nanomembranes, ranging from synthesis and manipulation to manufacturing, device integration and system level applications, including uses in bio-integrated electronics, three-dimensional integrated photonics, solar cells, and transient electronics. The first part describes in detail the fundamental physics and materials science involved, as well as synthetic approaches and assembly and manufacturing strategies, while the second covers the wide range of device applications and system level demonstrators already achieved, with examples taken from electronics and photonics and from biomedicine and energy.
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