This book introduces semantic representations of multiscale, multidomain physiological systems that link to qualitative reasoning and to quantitative analysis of biophysical processes in health and disease. Two major public health problems, diabetes and hypertension, serve as use-cases to illustrate the depth and rigor of such representations for logical inference and quantitative analysis. Central to this approach is the Ontology of Physics for Biology (OPB) that formally represents the foundations of classical physics and engineering system dynamics that are the basis for our understanding of biomedical entities, processes, and functional relationships. Furthermore, we introduce OPB-based software for annotating and abstracting available biosimulation models for reuse, recombination, and for archiving of physics-based biomedical knowledge. We have formalized and leveraged physics-based biological knowledge as a working view of physiology and biophysics from three distinct perspectives: (1) biologists and biomedical investigators, (2) biophysicists and bioengineers, and (3) biomedical ontologists and informaticists. We present a logical and intuitive semantics of classical physics as a tool for mediating and translating biophysical knowledge among biomedical domains. Daniel L. Cook, MD, PhD John H. Gennari, PhD Maxwell L. Neal, PhD
This authoritative reference equips you with the essential knowledge to provide comprehensive and effective care to children in an emergency setting. From age-specific diagnoses and chief complaints through developmental considerations and psychosocial issues, this text guides you through the full range of medical and surgical conditions commonly encountered when treating pediatric emergencies. The use of full color throughout, diagnostic algorithms, text boxes, charts, clinical pearls and pitfalls, and other visual features ensure the book will make crucial clinical information easy to find and apply. Tap into expert guidance on all aspects of pediatric emergency medicine, from the physical exam and usual and unusual presentations through to disposition criteria and transfer issues. Access step-by-step guidance on administering critical life support interventions and providing effective diagnostic and therapeutic ambulatory care. Quickly review specific treatment protocols for various emergency settings, including general emergency departments, community hospitals, tertiary care centers, EMS and transport, and triage. Find information fast with or without a known diagnosis, with content organized both by chief complaints and by specific diagnoses. Better understand how problems present differently in infants, children, and adolescents with age-specific diagnoses. Identify and manage the psychosocial issues surrounding pediatric patients, including major depression and suicidality, sexual and physical abuse, child neglect, and violence. Easily absorb key information with the aid of text boxes, algorithms, clinical pearls, and pitfalls. Retrieve information easily with a consistent templated format.
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