In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development created new regulatory dilemmas and unanticipated therapeutic problems. The sulfa drugs also proved extraordinarily fruitful as starting points for new drugs or classes of drugs, both for bacterial infections and for a number of important non-infectious diseases. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II. It also shows how researchers came to an understanding of how the sulfa drugs worked, adding a new theoretical dimension to the science of pharmacology and at the same time providing a basis for the discovery of new medicinal drugs in the 1940s, 1950s, and 1960s. A concluding chapter summarizes the transforming impact of the sulfa drugs on twentieth-century medicine, tracing the therapeutic revolution from the initial breakthrough in the 1930s to the current search for effective treatments for AIDS and the new horizons opened up by the human genome project and stem cell research.
Following the opening of The Met Breuer, this fascinating Bulletin contextualizes the architectural masterpiece now dedicated to displaying The Met’s collection of modern and contemporary art. Designed by one of the twentieth century’s most visionary architects, the Breuer building is a Brutalist icon and a work of art in its own right, known for its monumentality and stark purity of materials. Providing not just a history of the building commission, but also charting the artistic journey of Marcel Breuer from Bauhaus-educated furniture designer to world-renowned architect, this informative publication both records and contributes to the rich history surrounding Breuer and his landmark museum.
Going far beyond previous empirical work, John Kotter and James Heskett provide the first comprehensive critical analysis of how the "culture" of a corporation powerfully influences its economic performance, for better or for worse. Through painstaking research at such firms as Hewlett-Packard, Xerox, ICI, Nissan, and First Chicago, as well as a quantitative study of the relationship between culture and performance in more than 200 companies, the authors describe how shared values and unwritten rules can profoundly enhance economic success or, conversely, lead to failure to adapt to changing markets and environments. With penetrating insight, Kotter and Heskett trace the roots of both healthy and unhealthy cultures, demonstrating how easily the latter emerge, especially in firms which have experienced much past success. Challenging the widely held belief that "strong" corporate cultures create excellent business performance, Kotter and Heskett show that while many shared values and institutionalized practices can promote good performances in some instances, those cultures can also be characterized by arrogance, inward focus, and bureaucracy -- features that undermine an organization's ability to adapt to change. They also show that even "contextually or strategically appropriate" cultures -- ones that fit a firm's strategy and business context -- will not promote excellent performance over long periods of time unless they facilitate the adoption of strategies and practices that continuously respond to changing markets and new competitive environments. Fundamental to the process of reversing unhealthy cultures and making them more adaptive, the authors assert, is effective leadership. At the heart of this groundbreaking book, Kotter and Heskett describe how executives in ten corporations established new visions, aligned and motivated their managers to provide leadership to serve their customers, employees, and stockholders, and thus created more externally focused and responsive cultures.
This comparative history of the higher education systems in Poland, East Germany, and the Czech lands reveals an unexpected diversity within East European stalinism. With information gleaned from archives in each of these places, John Connelly offers a valuable case study showing how totalitarian states adapt their policies to the contours of the societies they rule. The Communist dictum that universities be purged of "bourgeois elements" was accomplished most fully in East Germany, where more and more students came from worker and peasant backgrounds. But the Polish Party kept potentially disloyal professors on the job in the futile hope that they would train a new intelligentsia, and Czech stalinists failed to make worker and peasant students a majority at Czech universities. Connelly accounts for these differences by exploring the prestalinist heritage of these countries, and particularly their experiences in World War II. The failure of Polish and Czech leaders to transform their universities became particularly evident during the crises of 1968 and 1989, when university students spearheaded reform movements. In East Germany, by contrast, universities remained true to the state to the end, and students were notably absent from the revolution of 1989.
Housing provides shelter, in a variety of forms, but it is also resonant with meaning on many other levels--as a financial asset, a status symbol, an expression of private aspirations and identities, a means of inclusion or exclusion, and finally as a battleground for social change. John Adams' impressive new study explores this complex topic in all its dimensions. Using census data and other housing surveys, Adams describes the recent history of housing in America; the nature of housing supply and demand; patterns of housing use; and selected housing policy questions. Adams supplements this national and regional analysis with a remarkable set of small-area analyses, revealing how neighborhood settings affect housing use and how market forces and other trends interact to shape a neighborhood. These analyses focus on a sample of over fifty urbanized areas, including the nation's three largest cities (New York, Los Angeles, and Chicago). Special two-color maps illustrate the dynamics of housing use in each of these communities. Clearly and insightfully, this volume paints a unique picture of the American "housing landscape," a landscape that reflects and regulates significant aspects of our national life. A Volume in the Russell Sage Foundation Census Series
Much research on the city in developing societies has focused mainly on one of three areas—planning, demography, or economics—and has emphasized either power elites or the masses, but not both. The published literature on Latin America has reflected these interests and has so far failed to provide a comprehensive view of Latin American urbanization. Urban Latin America is an attempt to integrate research on Latin American social organization within a single theoretical framework: development as fundamentally a political problem. Alejandro Portes and John Walton have included material on both elites and marginal populations and on the three major areas of research in order to formulate and address some of the key questions about the structure of urban politics in Latin America. Following an introduction that delineates the scope of Latin American urban studies, Portes discusses the Latin American city as a creation of European colonialism. He goes on to examine political behavior among the poor, with central reference to system support and countersystem potential. Walton provides material for a comparative study of four cities: Monterrey and Guadalajara in Mexico and Medellín and Cali in Colombia. He also summarizes a large number of urban elite studies and develops a theoretical interpretation of their collective results, based on class structure and vertical integration. Material in each chapter is cross-referenced to other chapters, and the authors have used a common methodological approach in synthesizing and interpreting the research literature. In the final chapter they generalize current findings, elaborating on the interface between elite and mass politics in the urban situation. They make some observations on approaching changes and pinpoint possible research strategies for the future.
Metal-Oxygen Clusters is the first book, providing an overview of the surface chemistry and catalytic properties of heteropoly oxometalates. After a brief look at the early knowledge of heteropoly oxometalates, the book discusses the synthesis, characterization, structure, bulk properties and stability of these materials. The remainder and the largest portion of the book explores the properties of these solids as catalysts in acid-catalyzed and oxidation processes in supported or unsupported forms. The book provides an up-to-date review of the methods for synthesizing heteropoly oxometalates of Keggin structure, techniques from spectroscopic through electrochemical to elemental analysis for their characterization and the current information on their structure, bulk properties and their stabilities at high temperatures and under acid and alkaline conditions. The book discusses the materials employed as supports for the title solid and the results of the examination of the supported materials. Methods for the identification of the nature and source of the two catalytic functions, the acidic and oxidative properties, of the heteropoly oxometalates are reviewed and discussed. The use of both the supported and unsupported heteropoly oxometalates as catalysts in acidity-requisite processes ranging from methanol conversion to hydrocarbons to ring-expansion and contraction processes and in oxidation processes from methane cyclohexane are described and related to the aforementioned properties.
Build Exam Confidence and Strengthen Time Management Skills Up to date to the latest exam specifications, Electronics, Controls and Communications Practice Exam contains one realistic full-length 80 question exam which is consistent with the NCEES PE Electrical Electronics, Controls, and Communications Exam format. The topics within each knowledge area are fairly represented to ensure understanding of what will be seen on the exam, to help test exam day readiness and focus your study time efficiently. Key Features Identify the best references to use during the exam Consistent with the exam scope and format Learn accurate and efficient problem-solving approaches Connect relevant theory to exam-like problems Solve problems under exam-like timed conditions Binding: Paperback Publisher: PPI, A Kaplan Company
This fifth and concluding volume of The Early Works of John Dewey is the only one of the series made up entirely of essays. The appear-ance during the four-year period, 1895-98, of thirty-eight items amply indicates that Dewey continued to maintain a high level of published out-put. These were the years of Dewey's most extensive work and involvement at the University of Chicago. Like its predecessors in this series, this volume presents a clear text, free of interpretive or reference material. Apparatus, including references, corrections, and emendations, is confined to appendix material. Fredson Bowers, the Consulting Textual Editor, has provided an essay on the textual principles and procedures, and William P. McKenzie, Professor of Philoso-phy and Education at Southern Illinois University, has written an introduc-tion identifying the thread connecting the apparently diffuse material in the many articles of this volume--Dewey's attempt to unite philosophy with psychology and sociology and with education.
Most books about Jesus and the Gospels deal with texts, background, culture and authorial intentions. A new approach to the Gospels called Practice Interpretation puts the emphasis on the actual happenings behind the Gospel stories – on what first hearers might have made of them, and on what contemporary disciples today make of them. The concern of the studies in this series is with the "use" of a Gospel story by disciples today, and of its "influence" on them. In this ground-breaking collection, the first in the Practice Interpretation series, people from many different situations describe what the story of Jesus Stilling the Storm actually "sparked off" in their lives.
This third volume in the definitive edition of Dewey's early work opens with his tribute to George Sylvester Morris, the former teacher who had brought Dewey to the University of Michigan. Morris's death in 1889 left vacant the Department of Philosophy chairmanship and led to Dewey's returning to fill that post after a year's stay at Minnesota. Appearing here, among all his writings from 1889 through 1892, are Dewey's earliest comprehensive statements on logic and his first book on ethics. Dewey's marked copy of the galley-proof for his important article The Present Position of Logical Theory, recently discovered among the papers of the Open Court Publishing Company, is used as the basis for the text, making available for the first time his final changes and corrections. The textual studies that make The Early Works unique among American philosophical editions are reported in detail. One of these, A Note on Applied Psychology, documents the fact that Dewey did not co-author this book frequently attributed to him. Six brief unsigned articles written in 1891 for a University of Michigan student publication, the Inlander, have been identified as Dewey's and are also included in this volume. In both style and content, these articles reflect Dewey's conviction that philosophy should be used as a means of illuminating the contemporary scene; thus they add a new dimension to present knowledge of his early writing.
This text integrates various statistical techniques with concepts from business, economics and finance, and demonstrates the power of statistical methods in the real world of business. This edition places more emphasis on finance, economics and accounting concepts with updated sample data.
This is the story of Grand Central Terminal in New York City, a remarkable and beautiful building whose birth, survival, and restoration reflect the critical role architecture plays in the expansion of our cities.
The second edition of History of the Development of Building Construction in Chicago is a tribute to Frank Randall's vision and resource to Chicago area architects, engineers, preservation specialists, and other members of the building industry."--BOOK JACKET.
The book of Revelation is perhaps the most theologically complex and literarily sophisticated — and also the most sensual — document in the New Testament. In this commentary John Christopher Thomas’s literary and exegetical analysis makes the challenging text of Revelation more accessible and easier to understand. Frank Macchia follows up with sustained theological essays on the book’s most significant themes and issues, accenting especially the underappreciated place of the Holy Spirit in the theology of Revelation.
The masses of neutron stars are limited by an instability to gravitational collapse and an instability driven by gravitational waves limits their spin. Their oscillations are relevant to x-ray observations of accreting binaries and to gravitational wave observations of neutron stars formed during the coalescence of double neutron-star systems. This volume includes more than forty years of research to provide graduate students and researchers in astrophysics, gravitational physics and astronomy with the first self-contained treatment of the structure, stability and oscillations of rotating neutron stars. This monograph treats the equations of stellar equilibrium; key approximations, including slow rotation and perturbations of spherical and rotating stars; stability theory and its applications, from convective stability to the r-mode instability; and numerical methods for computing equilibrium configurations and the nonlinear evolution of their oscillations. The presentation of fundamental equations, results and applications is accessible to readers who do not need the detailed derivations.
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