By focusing on the cellular mechanisms that underlie ontogeny, phylogeny and regeneration of complex physiologic traits, Evolution, the Logic of Biology demonstrates the use of homeostasis, the fundamental principle of physiology and medicine, as the unifying mechanism for evolution as all of biology. The homeostasis principle can be used to understand how environmental stressors have affected physiologic mechanisms to generate condition-specific novelty through cellular mechanisms. Evolution, the Logic of Biology allows the reader to understand the vertebrate life-cycle as an intergenerational continuum in support of effective, on-going environmental adaptation. By understanding the principles of physiology from their fundamental unicellular origins, culminating in modern-day metazoans, the reader as student, researcher or practitioner will be encouraged to think in terms of the prevention of disease, rather than in the treatment of disease as the eradication of symptoms. By tracing the ontogeny and phylogeny of this and other phenotypic homologies, one can perceive and understand how complex physiologic traits have mechanistically evolved from their simpler ancestral and developmental origins as cellular structures and functions, providing a logic of biology for the first time. Evolution, the Logic of Biology will be an invaluable resource for graduate students and researchers studying evolutionary development, medicine and biology, anthropology, comparative and developmental biology, genetics and genomics, and physiology.
An integrative view of the evolution of genetics and the naturalworld Even in this advanced age of genomics, the evolutionary processof unicellular and multicellular organisms is continually indebate. Evolutionary Biology, Cell–Cell Communication, andComplex Disease challenges current wisdom by using physiology topresent an integrative view of the nature, origins, and evolutionof fundamental biological systems. Providing a deeper understanding of the way genes relate to thetraits of living organisms, this book offers useful informationapplying evolutionary biology, functional genomics, and cellcommunication studies to complex disease. Examining the 4.5billion-year evolution process from environment adaptations tocell-cell communication to communication of genetic information forreproduction, Evolutionary Biology hones in on the "why and how" ofevolution by uniquely focusing on the cell as the smallest unit ofbiologic structure and function. Based on empirically derived data rather than associationstudies, Evolutionary Biology covers: A model for forming testable hypotheses in complex diseasestudies The integrating role played by the evolution of metabolism,especially lipid metabolism The evolutionary continuum from development to homeostasis Regeneration and aging mediated by signaling molecules Ambitious and game-changing Evolutionary Biology suggests thatbiology began as a mechanism for reducing energy within the cell,defying the Second Law of Thermodynamics. An ideal text for thoseinterested in forward thinking scientific study, the insightspresented in Evolutionary Biology help practitioners effectivelycomprehend the evolutionary process.
Quantum Mechanics, Cell-Cell Signaling, and Evolution offers a detailed accounting of the latest research and theorizing on the integration of quantum physics with biological action to produce a novel perspective on evolution. The book advocates for a paradigm shift towards understanding biology and medicine causally as predictive sciences, presenting quantum mechanics and physiology as vertically integrated. The author has taken a unique approach to the question of how and why evolution occurred. The account is based on extensive knowledge of lipid physical chemistry, and its role in the evolution of the lung under the influence of hormonal effects on structure and function. The title arranges lipid biochemistry and biophysics into an integrated explanation, guiding readers from the immersion of lipids in water as the origin of life, to lung surfactant in alveolar homeostasis, and leading to a new understanding of how consciousness interacts with the laws of nature. This volume argues for a novel understanding of evolutionary processes based on fundamental science and positions itself as seeking consilience among research disciplines. Starting from the origins of the cosmos, the author proceeds through nucleosynthesis and Endosymbiosis Theory, to finally describe consciousness in relation to natural law. - Offers a novel account of evolutionary mechanisms integrating quantum mechanics and cell-cell signaling - Presents the latest research and theorizing on the integration of quantum physics with biological action - Grounds theoretical insights in lipid physical chemistry and the evolution of the lung - Details an integrated, causal account of evolution operating across physical and biological domains - Argues for a paradigm shift in the way evolution is understood
Already established as a 'classic' in the field, Clinical Tests of Respiratory Function presents an authoritative yet accessible account of this complex area, fusing the basic principles of respiratory physiology with applications in clinical practice across a wide range of disorders. This third edition has been extensively revised to reflect
Time Charters is recognised as the most comprehensive reference work in its field. The book has been updated to include new developments that affect the law and practice of time charters. Maintaining the clear and logical format adopted in the previous editions, Time Charters provides access to the case law to enable users to find, easily and quickly, leading authorities on any particular question that might arise. There are also separate sections dealing with the Baltime Form and the STB Form of Tanker Time Charter.
To Catch a Virus To Catch a Virus Trace the evolution of diagnostic virology from yellow fever to COVID-19 Join expert storytellers John Booss, Marilyn J. August, and Marie Louise Landry in a journey through the history of viral epidemics and the detective work of those determined to identify the culprits and treat the infected. From the identification of the first virus in the late 1800s to the molecular techniques that enabled the rapid recognition of and vaccine development for the SARS-CoV-2 virus, viral diagnostic methods have progressed over the past century to become a formidable tool in human health care. This collection of gripping historical narratives covers a range of fascinating outbreaks and public health challenges, from yellow fever and smallpox to AIDS and COVID-19. This new edition chronicles the ongoing story of the COVID-19 pandemic, highlighting the people, the pathogen, and the progress in the diagnostic laboratory and clinical settings that has touched every aspect of global health. The many photographs and rich biographical sketches of key figures, diagrams of diagnostic procedures, micrographs of virus-infected cells, timelines, and a new glossary of key terms make To Catch a Virus compelling reading. This book serves as an excellent resource for courses in virology, immunology, microbiology, and public health. As the world struggles with the ongoing pandemic of SARS-CoV-2/COVID-19, To Catch a Virus is an insightful and superbly told story that chronicles the incredible metamorphosis of diagnostic virology and the technological advances that now make it possible to quickly and accurately detect and monitor the many disease-causing viruses that plague humankind. A stimulating, informative, and absorbing read that is highly recommended. —Richard L. Hodinka, PhD, Professor Emeritus, Perelman School of Medicine at the University of Pennsylvania; former Director, Clinical Virology Laboratory, Children’s Hospital of Philadelphia To Catch a Virus provides a beautifully written and compelling story of scientific discovery. It carefully traces the understanding of viral diseases from the turn of the twentieth century to the present. For general readers the authors provide timely and expert guidance to the extraordinary advances in diagnosis, surveillance, and therapeutics that constitute the silver lining in the otherwise somber years of COVID-19. For anyone wishing to understand the challenges confronting virologists and their accomplishments to date, this work is the place to start. —Frank M. Snowden, PhD, Andrew Downey Orrick Professor Emeritus of History, Yale University; former Chair, Program in History of Science and History of Medicine, Yale University
Completely updated and expanded for its second edition, the popular Oxford Handbook of Nephrology and Hypertension provides wide-ranging and practical advice for the day-to-day management of all forms of renal disease. This is the essential resource for all those all those involved in the care of patients with kidney disease, regardless of their professional background or seniority. Comprehensive, concise, easy to use, and with a strong focus on pragmatic guidance, this handbook will enable you to confidently manage both common and complex nephrological problems whenever, and wherever, they are encountered. This handbook covers all areas from early chronic kidney disease (CKD) through to dialysis and transplantation, with the chapters on AKI, CKD, transplantation and essential urology having been significantly expanded. Clear and concise, this handbook ensures that readers always have the information they need at their fingertips.
In this work, John Gill argues for the existence and characteristics of the triune God. These arguments are all given from a heavily Calvinist perspective but he uses a lot of scripture to back up his claims. He also argues that the character of God is shown through his work on Earth by the elect and most importantly through Christ. These characteristics then carry on in the final stages of life, when human beings pass away and move on to heaven or hell.
Written and edited by world leaders in nephrology, Comprehensive Clinical Nephrology, 6th Edition, by Drs. John Feehally, Jurgen Floege, Richard J. Johnson, and Marcello Tonelli, provides current information on clinical procedures and conditions as well as the scientific facts and pathophysiology that are foundational to nephrology practice. Ideal for practicing nephrologists, fellows, residents, and internists, it thoroughly covers fluids and electrolytes, hypertension, diabetes, dialysis, and transplantation, and more – all in a single convenient volume. - A "just right" amount of basic science and practical clinical guidance helps you make efficient and informed decisions. - More than 1,500 full-color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. - New quick-reference boxes with links to clinical guidelines in all relevant chapters. - New chapters on common issues regarding prescribing in kidney disease, palliative nephrology, endemic nephropathies, pathophysiology of chronic kidney disease, and outcomes of dialysis. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Featuring updated content throughout, this new edition of Clinical Medicine Lecture Notes is a concise guide to both history taking and examination, and to the essentials of clinical medicine on a system-by-system basis. The text is divided into two sections, with part one exploring communication and physical examination techniques, supported by the core knowledge required for assessing and diagnosing diseases in the main systems of the body. The second part of the text covers a range of common diseases, although accounts of rare conditions are also given. The level of information provided will equip junior clinicians with the necessary knowledge required to succeed in any clinical situation. A concise approach that contains all that medical students and junior doctors need to know, covering both the clinical approach and the essential background knowledge Summary and evidence-based medicine boxes to assist revision and learning Includes OSCE exam summaries Fully updated content throughout, with full colour illustrations and photographs Whether you need to develop your knowledge for clinical practice, or refresh that knowledge in the run up to examinations, Clinical Medicine Lecture Notes will help foster a systematic approach to the clinical situation for all medical students and junior doctors.
Comprehensive Clinical Nephrology provides you with all the tools you need to manage all forms of kidney disease. Drs. Jürgen Floege, Richard J. Johnson, John Feehally and a team of international experts have updated this fourth edition to include hot topics such as treatment of hypertensive emergencies, herbal and over-the-counter medicines and the kidney, neurologic complications of the kidney, and more. This essential resource gives you quick access to today’s best knowledge on every clinical condition in nephrology. Make efficient, informed decisions with just the right amount of basic science and practical clinical guidance for every disorder. Diagnose effectively and treat confidently thanks to more than 1100 illustrations, abundant algorithms, and tables that highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. Get coverage of the latest developments in the field with 18 new chapters on the Management of the Diabetic Patient with Chronic Kidney Disease, Treatment of Hypertensive Emergencies, Principles of Drug Dosing and Prescribing of Chronic Kidney Disease, Herbal and Over-the-Counter Medicines and the Kidney, Neurologic Complications of the Kidney, and more. Tap into the experience and expertise of the world’s leading authorities in the field of nephrology. Floege, Johnson, and Feehally give you the information you need to make quick and correct clinical decisions
Frankly, I dont know whether to call this manuscript fact or fiction. I know that what I have been able to check is fact, but this is mainly hearsay, as told to me by the real Harley Grant. I met Harley Grant (of course I have changed his name) in Public Market just as I have had Mike Bender meet him, in the beer isle. The second time I ran into him, I invited him over to the Green Flash our houseboat tied in Losers Lagoon for a drink. Dottie invited him for supper and after supper we sat around drinking Sam Adams. Dottie finally went to bed and we were still batting our gums. It was then that Harley told me this story that he swears is true. It was two in the morning when he finished. When he finished I shook my head in disbelief. I told him that I was going to check on it. He told me that I would find nothing. Big oil had destroyed any trace that it had ever happened. This I took with a grain of salt. I told this tale to a friend, a Lt. Commander in the Coast Guard. He said, Let me check on it, maybe I can find something in one of the old logs. I had almost forgotten about it when he got back to me. Jack, there may be something to that story you told me. I found this entry in the ships log of one of the decommissioned 84 foot cutters. Be on the lookout for a 70 or 80 foot yacht with xs and zs in its name which was last seen in Key West! This rekindled my interest and I went back to Harley and asked him to show me Hidden Cay. He took me down to the gate, but he said that Mike and Lois were on an extended stay in Goa. Yes, there were peafowl on the property! But that is the only verification that I could find, except I did locate Neal Forest and in a drunken stupor he admitted that he did row a couple of Chinks out to a big yacht. In this book I of course invented much of the dialogue and changed all the names. I tried to keep it as realistic as it was when Harley first told it by having Mike Bender tell the story. Further research proved fruitless. I was stonewalled everywhere I went! I even had one threat not to write a book about it. To hell with it, I am going to write it and call it FICTION!
Rely on Rosen's Emergency Medicine for the latest answers on every facet of emergency medicine practice. For decades, this medical reference book has set the standard in emergency medicine, offering unparalleled comprehensiveness, clarity, and authority - to help you put the latest and best knowledge to work for your patients in the ER. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Practice confidently with easily actionable, dependable guidance on the entire breadth of emergency medicine topics. Get expert guidance on how to approach specific clinical presentations in the ER. The "Cardinal Presentations Section" provides quick and easy reference to differential diagnosis and directed testing for fever in the adult patient; dizziness and vertigo; chest pain; and over 20 other frequently seen presentations in the emergency department. Effectively apply the newest emergency medicine techniques and approaches, including evidence-based therapies for shock; high-cost imaging; evaluation and resuscitation of the trauma patient; cardiovascular emergencies; evaluation and risk stratification for transient ischemic attack (TIA) patients; and much more. Locate the answers you need quickly thanks to a user-friendly, full-color design, complete with more illustrations than ever before. Access the complete contents on the go from your laptop or mobile device at Expert Consult, fully searchable, with links to PubMed.
Pathology and Pathogenesis of Human Viral Disease is a comprehensive reference that examines virus-induced clinical disease of humans in the context of the responsible virus and its epidemiology. Encompassing everything from cold and flu viruses to sexually transmitted diseases, this important resource describes the cellular and tissue pathological changes attributable to infection in the context of the pathogenic mechanisms involved. The author provides a comprehensive review of the older and contemporary literature, considering both the common and much rarer complications of infection. Pathology and Pathogenesis of Human Viral Disease is written from the unique perspective of the clinical pathologist. It will help clinicians and pathologists gain a better understanding of changes that occur in viral infected cells, tissues, and organs. It will also serve as a pathology source book for virologists, internists, and pediatricians. - Provides a comprehensive, worldwide perspective of viral disease pathology - Bridges the fields of pathology and virology; integrating clinical disease with cell and tissue pathology - Addresses topics from the perspective of the clinical pathologist - Illustrates unique, viral induced pathological lesions - Considers common and uncommon complications of infection
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