Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.
This book really ought to be read on vacation, just for enjoyment. Granted, cancer is, literally, a deadly serious matter, and cancer research is primarily a part of medicine with Hippocrates in its back ground. Yet, cancer research is also natural science, and as such it yields the joys and sorrows of any science. The cancer problem is also a brain teaser, a challenge for the curious. This introductory report on experimental cancer research is there fore directed to curious students of many disciplines: naturally to medical students, but also to chemists and physicists who have an interest in biological phenomena; biology students will surely en counter pr9blems peculiar to their field in what is supposedly a medi cal one. We have attempted to write without assumptions to a certain degree, for a chemist is essentially in over his head in medicine, and a physician has only the slightest idea of the chemical problems im portant in cancer research. We had no intention of giving a complete view of the field, and from the large number of different lines of development we have chosen only a few. Chemotherapy, as an ex ample, has been treated quite cursorily, along with RNA tumor viruses, although it is possible that just these subjects are especially important for human tumors. Tumor induction via radiation could only be mentioned in passing, in spite of its great practical significance; similarly the role of hormones was only intimated.
Protein NMR Spectroscopy, Second Edition combines a comprehensive theoretical treatment of NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules in solution. Beginning with simple theoretical models and experimental techniques, the book develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments. Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. This updated version includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced. The book is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or wish to understand the latest developments in this field. Provides an understanding of the theoretical principles important for biological NMR spectroscopy Demonstrates how to implement, optimize and troubleshoot modern multi-dimensional NMR experiments Allows for the capability of designing effective experimental protocols for investigations of protein structures and dynamics Includes a comprehensive set of example NMR spectra of ubiquitin provides a reference for validation of experimental methods
Mössbauer Spectroscopy of Environmental Materials and their Industrial Utilization provides a description of the properties of materials formed on the earth's surface, their synthetic analogs where applicable, and the products of their modifications in the course of natural processes, such as weathering, or in industrial processing as reflected in their Mössbauer spectra. Particular emphasis is placed on the way in which these processes can be observed and elucidated through the use of Mössbauer spectroscopy. The first chapter covers the basic theory of the Mössbauer effect and Chapters 2 and 3 deal with the nuts and bolts of experimental Mössbauer spectroscopy. The principles of these first three chapters, illustrated with many case studies, are applied to different areas of interest in Chapters 4 through 12. The book is directed to a broad audience ranging from graduate students in environmental sciences or chemical engineering with little or no expertise in Mössbauer spectroscopy to researchers from other disciplines who are familiar with this technique but wish to learn more about possible applications to environmental materials and issues.
While recognizing a "progressive ethos" - a mixture of idealistic vision and pragmatic reforms that characterized the period - Chambers elaborates the role of civic volunteerism as well as the state in achieving directed social change. He also emphasizes the importance of radical and conservative forces in shaping the so-called "Progressive Era.""--BOOK JACKET.
Continuing the tradition of excellence that began in 1972, this latest edition of Tachdjian?s Pediatric Orthopaedics offers the detailed visual guidance; and unmatched expertise you need to effectively diagnose and treat pediatric musculoskeletal disorders. Extensive updates offer you the latest knowledge on etiology, imaging, differential diagnosis, and non-operative and surgical techniques for a wide range of pediatric orthopaedic conditions. "... delivers the most comprehensive text on this subject." Reviewed by Dr. Neel Kamal on behalf of BACCH Newsletter, March 2015 Access expert guidance on difficult diagnostic and clinical management issues for your most challenging cases. Perfect your technique with the visual guidance of nearly 2,500 full-color illustrations and 60 videos of pediatric surgical procedures, including a number that highlight clinical examination and unusual clinical findings. Produce the best possible outcomes using today's most effective approaches for management of severe spinal deformities, hip impingement, early-onset scoliosis, and other pediatric musculoskeletal conditions. See exactly how to proceed step-by-step with instructional videos demonstrating repair of bilateral dislocated hips, triple arthrodesis for planovalgus foot, patellofemoral ligament reconstruction, elbow arthroscopy, and more. Access the full contents online at Expert Consult.
With complete coverage appropriate for residents through experienced pediatric orthopaedic surgeons, Tachdjian's Pediatric Orthopaedics, 6th Edition, continues a 50-year tradition of excellence as the most comprehensive, authoritative guide to diagnosing and treating pediatric musculoskeletal disorders. Editor John Herring, MD, and experts from the Texas Scottish Rite Hospital for Children offer step-by-step instruction and detailed visual guidance on both surgical and non-surgical approaches. It’s everything the orthopaedic surgeon needs to know to accurately treat the full spectrum of pediatric orthopaedic conditions and injuries. Presents complete coverage of the latest knowledge on etiology, imaging, differential diagnosis, growth instrumentation, and non-operative and surgical techniques for a wide range of pediatric orthopaedic conditions. Provides expert guidance on difficult diagnostic and clinical management issues for your most challenging cases. Covers today’s most effective approaches for management of severe spinal deformities, early onset scoliosis, hip preservation methods, long-term follow-up of trauma conditions, and much more. Offers superb visual guidance with nearly 2,500 full-color illustrations and 70 videos (many are new!) of pediatric surgical procedures, including a number that highlight clinical examination and unusual clinical findings.
Heterocyclic compounds play a vital role in the metabolism of living cells. Their practical applications range from extensive clinical use to fields as diverse as agriculture, photography, biocide formulation and polymer science. Written by leading scholars and industry experts, the Handbook of Heterocyclic Chemistry is thoroughly updated with over 50% new content. It has been rewritten with a new expanded author team, who have carefully distilled essential information on the reactivity, structure and synthesis of heterocycles from the 2008 major reference work Comprehensive Heterocyclic Chemistry III. To bring the work up to date the author team have also added new synthetic examples and structures, key applications and new references from 2008-2010. Contains more than 1500 clearly drawn structures and reactions. The highly systematic coverage given to the subject makes this one of the most authoritative single-volume accounts of modern heterocyclic chemistry available and should be useful reference for those teaching a heterocyclic course. Covers the structure, reactivity and synthesis of all heterocyclic compounds as distilled from the larger 15-volume reference work Saves researchers time when they require important information on heterocycles--speeding them to thousands of clearly drawn chemical structures and pertinent reviews by leading experts Features 35% new material to compliment the completely revised text
Ever since the discovery of blood types early in the last century, transfusion medicine has evolved at a breakneck pace. This second edition of Blood Banking and Transfusion Medicine is exactly what you need to keep up. It combines scientific foundations with today's most practical approaches to the specialty. From blood collection and storage to testing and transfusing blood components, and finally cellular engineering, you'll find coverage here that's second to none. New advances in molecular genetics and the scientific mechanisms underlying the field are also covered, with an emphasis on the clinical implications for treatment. Whether you're new to the field or an old pro, this book belongs in your reference library. Integrates scientific foundations with clinical relevance to more clearly explain the science and its application to clinical practice. Highlights advances in the use of blood products and new methods of disease treatment while providing the most up-to-date information on these fast-moving topics Discusses current clinical controversies, providing an arena for the discussion of sensitive topics. Covers the constantly changing approaches to stem cell transplantation and brings you the latest information on this controversial topic.
Bats are highly charismatic and popular animals that are not only fascinating in their own right, but illustrate most of the topical and important concepts and issues in mammalian biology. This book covers the key aspects of bat biology, including evolution, flight, echolocation, hibernation, reproduction, feeding and roosting ecology, social behaviour, migration, population and community ecology, biogeography, and conservation. This new edition is fully updated and greatly expanded throughout, maintaining the depth and scientific rigour of the first edition. It is written with infectious enthusiasm, and beautifully illustrated with drawings and colour photographs.
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