This book is about the recent advances in the structural and functional characterization of receptors that influence intracellular signalling events through interaction with intracellular GTP-binding proteins (G proteins). Molecular cloning of members of the G protein-coupled receptor superfamily has complemented pharmacological investigations in providing a realization of the structural and functional diversity of these receptors. An increased understanding of the involvement of particular receptor subtypes in normal and pathophysiological processes represents exciting possibilities for the development of highly specific and effective therapeutic agents.
In this wise and compelling biography, Dean--no stranger to controversy himself--recovers the truths and explodes the myths surrounding the 29th president's tarnished legacy.
Jay G - detective extraordinaire - made his mark in the West Indies. This second case sees Jay G in the Netherlands. One day Jay G is called into the Nottingham office and told that he has an urgent new assignment. He is given a brown package and the case begins ...
George G. Higgins and the Quest for Worker Justice: The Evolution of Catholic Social Thought in America is a comprehensive and fascinating examination of the Catholic Church's involvement in social issues from the late 19th to the end of the 20th century through the lens of the life, career, writings, and ministry of the legendary Monsignor Higgins. Inspiring to both the clergy and laity, Msgr. George G. Higgins put a human face on the institutional commitments of the Church, advocated the role of the laity, remained loyal to the vision of the Second Vatican Council, and took the side of the working poor in his movement with organized labor. Much more than a limited biography, author John O' Brien offers a sweeping history of the "social questions" facing America over the past 100 years, the thought behind one of the leading figures in the worker justice movement, and a moving application of the rich heritage of Catholic Social Thought.
Building on the foundation set by its best-selling predecessors, the Groundwater Chemicals Desk Reference, Fourth Edition is both a broad, comprehensive desk reference and a guide for field research. This fourth edition contains more than 1,700 additional references, including adsorption data for more than 800 organic compounds and metals, s
Although intended primarily for Indonesian users, the dictionary will be helpful to speakers of English who wish to know the Indonesian equivalent of an English word or phrase.
This book is intended to be an introductory text for mathematics and computer science students at the second and third year levels in universities. It gives an introduction to the subject with sufficient theory for students at those levels, with emphasis on algorithms and applications.
In this luminous novel -- winner of Britain's prestigious Booker Prize -- John Berger relates the story of "G.," a young man forging an energetic sexual career in Europe during the early years of this century. With profound compassion, Berger explores the hearts and minds of both men and women, and what happens during sex, to reveal the conditions of the Don Juan's success: his essential loneliness, the quiet cumulation in each of his sexual experiences of all of those that precede it, the tenderness that infuses even the briefest of his encounters, and the way women experience their own extraordinariness through their moments with him. All of this Berger sets against the turbulent backdrop of Garibaldi and the failed revolution of Milanese workers in 1898, the Boer War, and the first flight across the Alps, making G. a brilliant novel about the search for intimacy in history's private moments.
Geometric Invariant Theory" by Mumford/Fogarty (the firstedition was published in 1965, a second, enlarged editonappeared in 1982) is the standard reference on applicationsof invariant theory to the construction of moduli spaces.This third, revised edition has been long awaited for by themathematical community. It is now appearing in a completelyupdated and enlarged version with an additional chapter onthe moment map by Prof. Frances Kirwan (Oxford) and a fullyupdated bibliography of work in this area.The book deals firstly with actions of algebraic groups onalgebraic varieties, separating orbits by invariants andconstructionquotient spaces; and secondly with applicationsof this theory to the construction of moduli spaces.It is a systematic exposition of the geometric aspects ofthe classical theory of polynomial invariants.
Written for general chemistry courses, 'Chemical Principles' helps students develop chemical insight by showing the connection between chemical principles and their applications.
This is the second edition of the best-selling introduction to linear algebra. Presupposing no knowledge beyond calculus, it provides a thorough treatment of all the basic concepts, such as vector space, linear transformation and inner product. The concept of a quotient space is introduced and related to solutions of linear system of equations, and a simplified treatment of Jordan normal form is given.Numerous applications of linear algebra are described, including systems of linear recurrence relations, systems of linear differential equations, Markov processes, and the Method of Least Squares. An entirely new chapter on linear programing introduces the reader to the simplex algorithm with emphasis on understanding the theory behind it.The book is addressed to students who wish to learn linear algebra, as well as to professionals who need to use the methods of the subject in their own fields.
Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
These notes were first used in an introductory course team taught by the authors at Appalachian State University to advanced undergraduates and beginning graduates. The text was written with four pedagogical goals in mind: offer a variety of topics in one course, get to the main themes and tools as efficiently as possible, show the relationships between the different topics, and include recent results to convince students that mathematics is a living discipline.
This book is an introductory text in functional analysis. Unlike many modern treatments, it begins with the particular and works its way to the more general. From the reviews: "This book is an excellent text for a first graduate course in functional analysis....Many interesting and important applications are included....It includes an abundance of exercises, and is written in the engaging and lucid style which we have come to expect from the author." --MATHEMATICAL REVIEWS
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