Atheist Mind, Humanist Heart asks an essential question for the 45 million Americans who self-identify as nonreligious: “So, you don’t believe in God; now what?” This question is increasingly important, as one-third of young adults under the age of thirty consider themselves nonreligious. With a scientific eye and an empathetic heart, the authors turn conventional perceptions about atheism on their head. They show that atheism need not be reactionary (against religion and God), but rather that it can offer a clear set of constructive principles to live by, which establish atheism as a positive worldview. Following a philosophical approach grounded in logic and evidence, Bayer and Figdor take readers on an inspiring journey to discover how to live a reasonable, ethical, and happy life without God. The readers are engaged at every step, encouraged to self-reflect and ultimately uncover their own set of personal beliefs.
Atheist Mind, Humanist Heart asks an essential question for the 45 million Americans who self-identify as nonreligious: “So, you don’t believe in God; now what?” This question is increasingly important, as one-third of young adults under the age of thirty consider themselves nonreligious. With a scientific eye and an empathetic heart, the authors turn conventional perceptions about atheism on their head. They show that atheism need not be reactionary (against religion and God), but rather that it can offer a clear set of constructive principles to live by, which establish atheism as a positive worldview. Following a philosophical approach grounded in logic and evidence, Bayer and Figdor take readers on an inspiring journey to discover how to live a reasonable, ethical, and happy life without God. The readers are engaged at every step, encouraged to self-reflect and ultimately uncover their own set of personal beliefs.
Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
Complex endodontic problems that require further work on the part of the clinician can be time-consuming and problematic. This highly illustrated text, from one of the authors of the very successful Endodontics: Problem-Solving in Clinical Practice, tackles these difficult aspects and guides the practitioner through the problems and procedures invo
The past few years have seen considerable advances in our understanding of the molecular basis underlying cutaneous cell adhesion mechanisms. Co-authored by a number of leading experts in the field ^Cell Adhesion and Migration in Skin Disease provides a comprehensive overview of the critical role played by cell adhesion in determining the structure and function of both healthy and diseased human skin. The book is divided into three main sections, with each one addressing a principal function of adhesion molecules. The first part focuses on the epidermis, which as the skin's outermost layer, acts as the human body's primary barrier of defence. Roles played by cytoskeletal intermediate filaments and junctional complexes in cutaneous cell adhesion are emphasised with descriptions of blistering skin diseases that can arise if these molecules malfunction. The second part describes the macromolecular interactions responsible for the anchorage of cells to the underlying extracellular basement membrane. The experimental approaches detailed in the text not only reveal how the molecular components of the dermal-epidermal junction have been elucidated, but also highlight how mutations in the genes which encode these molecules are responsible for many heritable skin diseases. Leukocytes continually infiltrate the skin and patrol it for potentially harmful pathogens. Control of leukocyte adhesion to resident cells within the skin and to the extracellular matrix plays a key role in controlling these processes. These mechanisms constitute the primary focus of the final section. The pivotal role of leukocytes is examined in conjunction with the chronic inflammatory diseases which arise when components of the skin's finely tuned defence strategy go awry and the potential for these anomalies to be pinpointed as important immunotherapeutic targets for skin diseases.
Completely non-technical in its approach and focusing exclusively on managing the human element of energy consumption, this book demonstrates how to apply proven management techniques to significantly reduce these unnecessary energy expenses within an organization. It includes a broad array of examples of companies that have pioneered these efforts, actual savings, step-by-step methods, and typical energy-wasting pitfalls to avoid. The author communicates in an easy-to-understand and cohesive manner how to break the cycle of energy waste, making employees cooperative in saving energy and accountable for the energy they use.
This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic solid tumors! Written by over 40 world renowned experts in the field and containing more than 1450 references for in-depth exploration of the subject, Allogeneic Immunotherapy for Malignant Diseases investigates the capacity of the donor-and the host-to destroy residual leukemia cells by allogeneic immune reaction determines how to direct immune reactions against hematopoietic malignancies safely reveals which other malignant conditions may be responsive to allogeneic-mediated graft-versus-tumor reactions covers the mechanisms that contribute to the development of responses to minor histocompatibility complex (mHC) molecules focuses on the biology of effector cells and their role in mediating GVL reactions in chronic myeloid leukemia (CML) summarizes the putative impact of human mHag on the GVL effect in bone marrow transplantation (BMT) addresses the potential and limitations of oncogene-based immunotherapy examines ways to isolate and control the GVL component of allograft immunity discusses efforts to develop specific anti-leukemic T-cell immunotherapy and more! Attributing the curative effect of allogeneic stem cell transplantation to the GVL or GVT effect, Allogeneic Immunotherapy for Malignant Diseases is an indispensable reference for hematologists, clinical oncologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, residents, and medical school students in these disciplines.
Emil Kemeny appeared on the American chess scene in 1890, a Hungarian chess player on the Lower East Side who had difficulty with English. Within a decade he was considered one of the country's finest chess players and writers. He dominated chess in both Philadelphia and Chicago, where he lived between 1893 and early 1906. Congenial and modest, Kemeny was appreciated for his chess play and valued for the strong friendships he formed during his years in the United States. A tenacious competitor despite poor health, he fought Showalter for the national title, ran his own chess magazine, and provided detailed coverage of Monte Carlo 1903. His chess career as player and writer is presented in detail. Common databases rarely include more than 35 of his games; this book has 227--sixty or more against Halpern, Hanham, Voigt, Showalter and Pillsbury--most with annotations; 361 diagrams. Forty additional period games, hundreds of source notes, tournament and match records, crosstables, a bibliography, and openings, player, and general indexes complete the work.
The study of immunology encompasses a vast and ever-growing body of information that in some way or other incorporates most areas of medical biological research. As the body of information in the medical sciences continues to increase its rate of expansion, one of the greatest challenges to investigators will be to integrate this information in a manner that is intellectually fruitful and productive. Considering the intended scope of this text, we could not pretend to have gone too far toward achieving such an integration--and considering the pace of change, in its very best form a measured approximation of such lofty goals might be the most we could hope for. Nevertheless, in these pages we have sought to produce a collection of information that is at once concise and up-to-date regarding areas where important developments are impacting on the way we understand the vertebrate immune system. In addition, although the information is geared toward advanced study, we have discussed some basic elements and concepts that we hope make the text a useful resource for both the immunologist and the nonspecialist. The intention is to provide the researcher, clinician, or advanced undergraduate student with a brief ov- view of specific components of the immune system, and to provide a place from which to begin further detailed study if necessary. To this end, we made every effort to supply extensive referencing--although limitations in space prevented exhaustive or complete referencing in some cases.
Treasuries of France, and other sources. The works of Limoges were created for important ecclesiastical and royal patrons. The wealth of enameling preserved from the Treasury of the abbey of Grandmont, just outside Limoges, is due chiefly to the Plantagenet patronage of Henry II and his queen, Eleanor of Aquitaine. Enamels created during their reign resonate with the elegant style of the court, and the dramatic history of Henry's monarchy is evoked by such works as the.
John M. Doris presents a new account of agency and responsibility, which reconciles our understanding of ourselves as moral agents with psychological research on the unconscious mind. Much philosophical theorizing maintains that the exercise of morally responsible agency consists in judgment and behavior ordered by accurate reflection. On such theories, when human beings are able to direct their lives in the manner philosophers have dignified with the honorific 'agency', it's because they know what they're doing, and why they're doing it. This understanding is compromised by quantities of psychological research on unconscious processing, which suggests that accurate reflection is distressingly uncommon; very often behavior is ordered by surprisingly inaccurate self-awareness. Thus, if agency requires accurate reflection, people seldom exercise agency, and skepticism about agency threatens. To counter the skeptical threat, John M. Doris proposes an alternative theory that requires neither reflection nor accurate self-awareness: he identifies a dialogic form of agency where self-direction is facilitated by exchange of the rationalizations with which people explain and justify themselves to one another. The result is a stoutly interdisciplinary theory sensitive to both what human beings are like—creatures with opaque and unruly psychologies-and what they need: an account of agency sufficient to support a practice of moral responsibility.
The techniques and methods that can be applied to materials characterization on the microscale are numerous and well-established. Divided into two parts, Characterization of Nanostructures provides thumbnail sketches of the most widely used techniques and methods that apply to nanostructures, and discusses typical applications to single nanoscale o
2015 BMA Medical Book Awards Highly Commended in Oncology Category!The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. - Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. - Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. - Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. - Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. - Access the entire text and illustrations online, fully searchable, at Expert Consult.
Mathematical Modeling and Immunology An enormous amount of human effort and economic resources has been directed in this century to the fight against cancer. The purpose, of course, has been to find strategies to overcome this hard, challenging and seemingly endless struggle. We can readily imagine that even greater efforts will be required in the next century. The hope is that ultimately humanity will be successful; success will have been achieved when it is possible to activate and control the immune system in its competition against neoplastic cells. Dealing with the above-mentioned problem requires the fullest pos sible cooperation among scientists working in different fields: biology, im munology, medicine, physics and, we believe, mathematics. Certainly, bi ologists and immunologists will make the greatest contribution to the re search. However, it is now increasingly recognized that mathematics and computer science may well able to make major contributions to such prob lems. We cannot expect mathematicians alone to solve fundamental prob lems in immunology and (in particular) cancer research, but valuable sup port, however modest, can be provided by mathematicians to the research aspirations of biologists and immunologists working in this field.
Surgical Intensive Care Medicine has been specifically designed to be a practical reference for medical students and house officers to help manage the critically ill surgical patient. The first section is titled “Resuscitation” and exposes the reader to a condensed version of generic topics in primary intensive care medicine. The sections that follow have been categorized according to medical and surgical subspecialties and cover the most germane of problems encountered in a tertiary surgical intensive care unit. Sections of certain chapters, while repetitive, have been left intact in an attempt to maintain the authors' messages and provide the reader with some contradictory but referenced views. The technical chapters describe a very introductory approach to various exercises such as airway management and vascular cannulation.
Bacterial Endotoxic Lipopolysaccharides provides an up-to-date, two-volume review of the latest information regarding bacterial lipopolysaccharide structure and activities. These volumes cover the biochemistry, pharmacology, and pathophysiologic properties of endotoxins. The volumes also thoroughly discuss the strengths and weaknesses of new therapies for septic shock that are based on an immunological attack on endotoxins and the cytokines induced by endotoxins. All scientists involved in endotoxin research, clinical infectious disease specialists, and medical students interested in the pathogenesis of septic shock will find Bacterial Endotoxic Lipopolysaccharides invaluable as a reference resource.
Increasingly viewed as the future of medicine, the field of tissue engineering is still in its infancy. As evidenced in both the scientific and popular press, there exists considerable excitement surrounding the strategy of regenerative medicine. To achieve its highest potential, a series of technological advances must be made. Putting the numerous
Used by generations of physicians who encounter patients with dermatological diseases, Lever’s Dermatopathology: Histopathology of the Skin comprehensively covers skin disease in which histopathology plays an important role in diagnosis. The updated 12th Edition, edited by Drs. David E. Elder, Rosalie Elenitsas, George F. Murphy, Misha Rosenbach, Adam I. Rubin, John T. Seykora, and Xiaowei Xu, maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a “primer” on pattern-algorithm diagnosis. It features larger images throughout, as well as thoroughly revised content with new diseases and new information on pathophysiology and molecular pathogenesis—all in an easy-to-navigate, highly readable format.
John M. Doris has been a leading proponent of interdisciplinary approaches to moral psychology for decades. His work has transformed the way in which philosophers approach questions of character, virtue, and agency. This selection of his work focuses on the ways in which human personality orders (or fails to order) moral cognition and behaviour.
This monograph explains the considerable impact that monoclonal antibodies and molecular probes have had on the diagnosis of tumor types and sub-types. It explains how radiolabelled monoclonal antibodies have also been used as imaging agents to try to improve the oncologist's ability to define residual tumor deposits after combination chemo/radiotherapy. Finally, the childhood malignancies that still have a poor prognosis are presented, and new novel ways of therapy are explained.
Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel’s Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases. Full-color design enhances teaching points and highlights challenging concepts. Understand clinical applications and the scientific principles of respiratory medicine. Detailed explanations of each disease entity allow you to work through differential diagnoses. Expert Consult eBook version included with purchase. This enhanced eBook experience offers content updates, videos, review questions, and Thoracic Imaging Cases (TICs), all of which are easily navigable on any device for access on rounds or in the clinic. Includes more than 1,000 figures and over 200 videos and audio files. Key Points and Key Reading sections highlight the most useful references and resources for each chapter. An expanded sleep section now covers four chapters and includes control of breathing, consequences of sleep disruption, as well as obstructive and central apnea. New chapters in the Critical Care section cover Noninvasive Ventilation (NIV) and Extracorporeal Support of Gas Exchange (ECMO). New chapters focusing on diagnostic techniques now include Invasive Diagnostic Imaging and Image-Guided Interventions and Positron Emission Tomography, and a new chapter on Therapeutic Bronchoscopy highlights the interventional role of pulmonologists. Embedded videos feature thoracoscopy, therapeutic bronchoscopy, volumetric chest CT scans, and more. Brand-new audio files highlight normal and abnormal breath sounds and the separate components of cough.
Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at www.expertconsult.com, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Search the full text online at expertconsult.com, along with downloadable images, regular updates, more than 50 videos, case studies, and self-assessment questions. Consult new chapters covering Ultrasound, Innate Immunity, Adaptive Immunity, Deposition and Clearance, Ventilator-Associated Pneumonia. Find critical information easily using the new full-color design that enhances teaching points and highlights challenging concepts. Apply the expertise and fresh ideas of three new editors—Drs. Thomas R. Martin, Talmadge E. King, Jr., and Dean E. Schraufnagel. Review the latest developments in genetics with advice on how the data will affect patient care.
Copiously illustrated work depicts splendid array of 13th-16th-century heraldic motifs, drawn from numerous sources and encompassing various media. 8 color plates. Over 250 black-and-white illustrations.
This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Premium Edition includes access to the complete contents of the book online, fully searchable and updated quarterly by Dr. Hoffman himself. - Publisher.
The Hematology: Diagnosis and Treatment eBook is the ideal mobile resource in hematology! It distills the most essential, practical information from Hematology: Basic Principles and Practice, 6th Edition - the comprehensive masterwork by Drs. Hoffman, Benz, Silberstein, Heslop, Weitz, and Anastasi - into a concise, clinically focused resource that's optimized for reference on any e-reader. Focusing on the dependable, state-of-the-art clinical strategies you need to optimally diagnose and manage the full range of blood diseases and disorders, this eBook is a must-have for every hematologist's mobile device! Apply the latest know-how on heparin-induced thrombocytopenia, stroke, acute coronary syndromes, hematologic manifestations of liver disease, hematologic manifestations of cancer, hematology in aging, and many other hot topics. Get quick, focused answers on the diagnosis and management of blood diseases - in a portable digital format that you can carry and consult anytime, anywhere. View abundant images that mirror the pivotal role hematopathology plays in the practice of modern hematology. Count on all the authority that has made Hematology: Basic Principles and Practice, 6th Edition, edited by Drs. Hoffman, Benz, Silberstein, Heslop, Weitz, and Anastasi, the go-to clinical reference for hematologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.
Hematology, 6th Edition encompasses all of the latest scientific knowledge and clinical solutions in the field, equipping you with the expert answers you need to offer your patients the best possible outcomes. Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, John Anastasi, MD, and a host of world-class contributors present the expert, evidence-based guidance you need to make optimal use of the newest diagnostic and therapeutic options. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Make confident, effective clinical decisions by consulting the world's most trusted hematology reference. Access the complete contents online at www.expertconsult.com, with a downloadable image collection, regular updates, case studies, patient information sheets, and more. Apply all the latest knowledge on regulation of gene expression, transcription splicing, and RNA metabolism; pediatric transfusion therapy; principles of cell-based gene therapy; allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults; hematology in aging; and much more, thanks to 27 brand-new chapters plus sweeping updates throughout. Find the information you need quickly and easily thanks to a completely reworked organization that better reflects today’s clinical practice. Visualize clinical problems more clearly with new and updated images that reflect the pivotal role of hematopathology in modern practice. Benefit from the experience and fresh perspective of new editor Dr. Jeffrey Weitz, Professor of Medicine at McMaster University School of Medicine and Executive Director of the Thrombosis and Atherosclerosis Research Institute in Ontario.
Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field. Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas. Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more. Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies. New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
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