Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.
The commercial nuclear power industry was flourishing in the United States in the early 1970s; fifteen years later, the enterprise had collapsed. John L. Campbell examines the history of this debacle in order to explore how state and market shape each other under modern capitalism. In Collapse of an Industry, Campbell confronts controversial issues whose implications range far beyond the specifics of the nuclear power industry: the relative merits of free and controlled markets, the reliability of industrial planning, and the appropriate role of the state in managing economic activity. Ultimately, Campbell sheds light on the central question of whether modern democracy and capitalism may be essentially incompatible. A complex, expensive, and potentially very dangerous technology, nuclear energy requires careful long-range planning to sustain commercial success. Campbell's narrative account shows how political and economic institutions unique to the United States made the nuclear energy industry particularly vulnerable to a series of policy failures that undermined that planning. Drawing on industry histories and trade publications, government documents and personal interviews, he considers four key areas central to the collapse of the sector: competition and the failure to standardize equipment; growing public concern over reactor safety and the disposal of radioactive waste; the industry's financial crisis; and the complex politics of regulation. Campbell argues that the democratic institutions of the contemporary United States will not support the predictable conditions needed for accumulation in so capital-intensive and potentially hazardous a sector as commercial nuclear power. He emphasizes the importance of institutional forms to the making of public policy by contrasting the industry's demise in the United States with its modest successes in Western Europe, demonstrating how variations in important governmental and private institutions affected the general health of the industry in France, Sweden, and West Germany. A theoretically informed analysis free of the usual polemics about nuclear power, Collapse of an Industry merits the close attention of anyone concerned with the future of the commercial nuclear power industry.
Recent years have witnessed a revival of research in the interplay between cognition and emotion. The reasons for this renaissance are many and varied. In the first place, emotion theorists have come to recognize the pivotal role of cognitive factors in virtually all aspects of the emotion process, and to rely on basic cognitive factors and insight in creating new models of affective space. Also, the successful application of cognitive therapies to affective disorders has prompted clinical psychologists to work towards a clearer understanding of the connections between cognitive processes and emotional problems. And whereas the cognitive revolutionaries of the 1960s regarded emotions with suspicion, viewing them as nagging sources of "hot" noise in an otherwise cool, rational, and computer-like system of information processing, cognitive researchers of the 1990s regard emotions with respect, owing to their potent and predictable effects on tasks as diverse as object perception, episodic recall, and risk assessment. These intersecting lines of interest have made cognition and emotion one of the most active and rapidly developing areas within psychological science. Written in debate format, this book covers developing fields such as social cognition, as well as classic areas such as memory, learning, perception and categorization. The links between emotion and memory, learning, perception, categorization, social judgements, and behavior are addressed. Contributors come from the U.S., Canada, Australia, and France.
A volume celebrating the foundation of the IWA 25 years ago, comprising a collection of contributions by 25 Welsh men and women reflecting on their personal experiences during the past 25 years and recording their hopes for the next 25 years.
William Alwyn: A Research and Information Guide is a catalogue, discography and annotated bibliography of the nearly 500 works of this twentieth-century British composer. It will be invaluable to twentieth-century British composer researchers and aficionados, music history courses, and film music courses.
Designing new products and improving existing ones is a continual process. Industrial design engineering is an industrial engineering process applied to product designs that are to be manufactured through techniques of production operations. Excellent industrial design engineering programs are essential for the nation’s industry to succeed in selling useful and ecologically justifiable and usable products on a market flooded with goods and services. This unique text on industrial design engineering integrates basic knowledge, insight, and working methods from industrial engineering and product design subjects. Industrial Design Engineering: Inventive Problem Solving provides a combination of engineering thinking and design skills that give the researchers, practitioners, and students an excellent foundation for participation in product development projects and techniques for establishing and managing such projects. The design principles are presented around examples related to the designing of products, goods, and services. Case studies are developed around real problems and are based on the customer’s needs.
Since 1949 Screen World has been acclaimed as the definitive record of the past movie season. Volume 41 provides an illustrated listing of American and foreign films released in the U.S. in 1989, all documented in more than 1,000 photos.
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