I must thank my friend, Professor HANS WEBER, for being, as it were, the prime mover in causing this book to be written. He persuaded me in 1960 to contribute a review to the Ergebnisse der Physiologie. As originally planned, it was to be relatively short. However, the interest and scope of the whole subject of synapses stimulated me to write a much more comprehensive and extensive account. I was not even then satisfied, particularly as so many new and attractive investigations and ideas were being evolved during and after the writing of this review; and during the writing of this book most interesting developments are occurring in so many centres of research. Through the kind cooperation of my friends I have been given the opportunity to quote and even to illustrate from these new and fascinating developments before their final publication. There would be some justification if the author were to make the claim that this book is the fruit of a life-time of enquiry into the physiology of synapses. In 1927 the subject of Excitatory and Inhibitory Synapses was chosen for investigation in the course leading to the Oxford D. Phil. But there have been such remarkable developments during the last 12 years that in this book very little reference will be made to work earlier than 1951 except in the historical introductions.
This book has had a three-fold origin, corresponding to the discoveries made by the three authors and their collaborators during the last few years - mostly since 1962. A most fruitful symposium on the cerebellum was held in Tokyo at the time of the International Physiological Congress in September 1965, and there was then formulated the project of writing this book so as to organize all this new knowledge and make it readily available, and to give opportunity for the con ceptual developments that may be seen in Chapters XI, XII and XV in particular. The present account of the physiological properties of the cerebellar cortex is based to a large extent on systematic investigations that were concerned with discovering the mode of operation of the constituent neuronal elements of the cerebellar cortex. This work was carried out in the Physiology Department of the Australian National University from 1963 to 1966 in collaboration with several visiting scientists - initially Drs. ANDERSEN, OscARssaN and VooRHOEVE and later Drs. LuNAs, SAsAKI and STRATA - to all of whom grateful thanks are extended for a great many of the figures, and even more significantly for the original and critical contributions that they made to so many aspects of this exploration into the mode of operation of the neural machinery of the cerebellar cortex.
The problem of the relation between our bodies and our minds, and espe cially of the link between brain structures and processes on the one hand and mental dispositions and events on the other is an exceedingly difficult one. Without pretending to be able to foresee future developments, both authors of this book think it improbable that the problem will ever be solved, in the sense that we shall really understand this relation. We think that no more can be expected than to make a little progress here or there. We have written this book in the hope that we have been able to do so. We are conscious of the fact that what we have done is very conjectur al and very modest. We are aware of our fallibility; yet we believe in the intrinsic value of every human effort to deepen our understanding of our selves and of the world we live in. We believe in humanism: in human rationality, in human science, and in other human achievements, however fallible they are. We are unimpressed by the recurrent intellectual fashions that belittle science and the other great human achievements. An additional motive for writing this book is that we both feel that the debunking of man has gone far enough - even too far. It is said that we had to learn from Copernicus and Darwin that man's place in the universe is not so exalted or so exclusive as man once thought. That may well be.
In this book the author has collected a number of his important works and added an extensive commentary relating his ideas to those of other prominentnames in the consciousness debate. The view presented here is that of a convinced dualist who challenges in a lively and humorous way the prevailing materialist "doctrines" of many recent works. Also included is a new attempt to explain mind-brain interaction via a quantum process affecting the release of neurotransmitters. John Eccles received a knighthood in 1958 and was awarded the Nobel Prize for Medicine/Physiology in 1963. He has numerous other awards honouring his major contributions to neurophysiology.
In the brain information is coded into sequences of impulses which are unit responses travelling from neurones or nerve cells along nerve fibres. The neural code is equivalent to a Morse code of dots only in a great variety of temporal patterns and with thousands of connections in parallel. Fig. lA is a diagram of Figure 1: Drawing of Four Neurones of the Cerebral Cortex. This shows the excitatory synaptic connections set up by an input fibre from the thalamus labelled (spec. aff. ), which is an enormous nucleus in the brain that provides the principal inputs to the cerebral cortex. This spec. aff. fibre branches profusely to make excitatory synapses on the spiny stellate cell (Sst) and on one pyramidal cell (Pyr). All three pyramidal cells receive on their spines excitatory synapses from Sst, and there is a special excitatory structure, called by Szentagothai a cartridge, formed by the synaptic endings on the apical dendrites of two pyramidal cells. All three pyramidal cells but not the Sst, send their axons out of the cerebral cortex as shown by the lower projecting arrows. The upper inset shows an enlargement of a spine synapse with synaptic vesicles in the presynaptic ending and the spine arising from a dendrite. The lower two insets show diagrammatically normal and hypertrophied spine synapses. (SZENTAGOTHAI, 1978).
Winner of the BMA 2011 book awards: psychiatry category Winner of the Australian Journal of Ageing book of the year award This definitive work on dementia and related disorders has been fully updated and revised to reflect recent advances in this fast-moving field. The incidence of dementia continues to rise as the population of the world ages, and the condition represents one of the most significant challenges facing societies and health professionals in the next half-century. In this, the most comprehensive single volume work available on the subject, the editors have met this challenge by assembling a team of the world's leading experts on all aspects of the condition, from history, epidemiology and social aspects to the latest neurobiological research and advanced therapeutic strategies.
Sir John Eccles, a distinguished scientist and Nobel Prize winner who has devoted his scientific life to the study of the mammalian brain, tells the story of how we came to be, not only as animals at the end of the hominid evolutionary line, but also as human persons possessed of reflective consciousness.
This book is the first comprehensive methodological guide for accounting researchers on Interventionist Research (IVR). It provides all the fundamental components needed for understanding what IVR is, and how to plan, design, and conduct legitimate intervention studies, which can endure the scrutiny of institutions and peer review. This text systematically opens the ‘black box’ of an alternative research paradigm seeking to contribute simultaneously to theory and practice, through direct and collaborative engagement with organisations, practitioners, managers and professionals. It mobilises the production of innovative and theoretically grounded research for academe, and of practical relevance or usefulness and interest to the field of practice. Interventionist Research in Accounting: A Methodological Approach unpacks current thinking on IVR to forge a confident path ahead for IVR through adopting a forward-thinking approach. This book recognises the remedial potential of IVR to address the research-practice-relevance gap in accounting research and deliberates the challenges of IVR in accounting. It addresses the design, development, and implementation of interventions, critical to solving real-world problems as well as guiding readers in planning the IVR project including budgetary and ethical aspects, utilising suitable research methods and data collection techniques, and establishing validity and reliability. Further, it offers guidance on selecting and managing the research team and recruiting, accessing, and retaining intervention participants; these two components are crucial to creating collaborative relationships required for effective intervention. This book is a guide serving as a valuable resource for accounting researchers conducting intervention studies, for doctoral and other research students undertaking accounting research, and academics working in universities and business schools or teaching courses in accounting and research methodology.
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