To Catch a Virus Trace the evolution of diagnostic virology from yellow fever to COVID-19 Join expert storytellers John Booss, Marilyn J. August, and Marie Louise Landry in a journey through the history of viral epidemics and the detective work of those determined to identify the culprits and treat the infected. From the identification of the first virus in the late 1800s to the molecular techniques that enabled the rapid recognition of and vaccine development for the SARS-CoV-2 virus, viral diagnostic methods have progressed over the past century to become a formidable tool in human health care. This collection of gripping historical narratives covers a range of fascinating outbreaks and public health challenges, from yellow fever and smallpox to AIDS and COVID-19. This new edition chronicles the ongoing story of the COVID-19 pandemic, highlighting the people, the pathogen, and the progress in the diagnostic laboratory and clinical settings that has touched every aspect of global health. The many photographs and rich biographical sketches of key figures, diagrams of diagnostic procedures, micrographs of virus-infected cells, timelines, and a new glossary of key terms make To Catch a Virus compelling reading. This book serves as an excellent resource for courses in virology, immunology, microbiology, and public health. As the world struggles with the ongoing pandemic of SARS-CoV-2/COVID-19, To Catch a Virus is an insightful and superbly told story that chronicles the incredible metamorphosis of diagnostic virology and the technological advances that now make it possible to quickly and accurately detect and monitor the many disease-causing viruses that plague humankind. A stimulating, informative, and absorbing read that is highly recommended. —Richard L. Hodinka, PhD, Professor Emeritus, Perelman School of Medicine at the University of Pennsylvania; former Director, Clinical Virology Laboratory, Children’s Hospital of Philadelphia To Catch a Virus provides a beautifully written and compelling story of scientific discovery. It carefully traces the understanding of viral diseases from the turn of the twentieth century to the present. For general readers the authors provide timely and expert guidance to the extraordinary advances in diagnosis, surveillance, and therapeutics that constitute the silver lining in the otherwise somber years of COVID-19. For anyone wishing to understand the challenges confronting virologists and their accomplishments to date, this work is the place to start. —Frank M. Snowden, PhD, Andrew Downey Orrick Professor Emeritus of History, Yale University; former Chair, Program in History of Science and History of Medicine, Yale University
The aim of this book is to unite the seemingly disparate topics of Clifford algebras, analysis on manifolds, and harmonic analysis. The authors show how algebra, geometry, and differential equations play a more fundamental role in Euclidean Fourier analysis. They then link their presentation of the Euclidean theory naturally to the representation theory of semi-simple Lie groups.
Riemannian, symplectic and complex geometry are often studied by means ofsolutions to systems ofnonlinear differential equations, such as the equa tions of geodesics, minimal surfaces, pseudoholomorphic curves and Yang Mills connections. For studying such equations, a new unified technology has been developed, involving analysis on infinite-dimensional manifolds. A striking applications of the new technology is Donaldson's theory of "anti-self-dual" connections on SU(2)-bundles over four-manifolds, which applies the Yang-Mills equations from mathematical physics to shed light on the relationship between the classification of topological and smooth four-manifolds. This reverses the expected direction of application from topology to differential equations to mathematical physics. Even though the Yang-Mills equations are only mildly nonlinear, a prodigious amount of nonlinear analysis is necessary to fully understand the properties of the space of solutions. . At our present state of knowledge, understanding smooth structures on topological four-manifolds seems to require nonlinear as opposed to linear PDE's. It is therefore quite surprising that there is a set of PDE's which are even less nonlinear than the Yang-Mills equation, but can yield many of the most important results from Donaldson's theory. These are the Seiberg-Witte~ equations. These lecture notes stem from a graduate course given at the University of California in Santa Barbara during the spring quarter of 1995. The objective was to make the Seiberg-Witten approach to Donaldson theory accessible to second-year graduate students who had already taken basic courses in differential geometry and algebraic topology.
This new book contains the most up-to-date and focused description of the applications of Clifford algebras in analysis, particularly classical harmonic analysis. It is the first single volume devoted to applications of Clifford analysis to other aspects of analysis. All chapters are written by world authorities in the area. Of particular interest is the contribution of Professor Alan McIntosh. He gives a detailed account of the links between Clifford algebras, monogenic and harmonic functions and the correspondence between monogenic functions and holomorphic functions of several complex variables under Fourier transforms. He describes the correspondence between algebras of singular integrals on Lipschitz surfaces and functional calculi of Dirac operators on these surfaces. He also discusses links with boundary value problems over Lipschitz domains. Other specific topics include Hardy spaces and compensated compactness in Euclidean space; applications to acoustic scattering and Galerkin estimates; scattering theory for orthogonal wavelets; applications of the conformal group and Vahalen matrices; Newmann type problems for the Dirac operator; plus much, much more! Clifford Algebras in Analysis and Related Topics also contains the most comprehensive section on open problems available. The book presents the most detailed link between Clifford analysis and classical harmonic analysis. It is a refreshing break from the many expensive and lengthy volumes currently found on the subject.
This volume offers the proceedings from the workshop held at the University of Milan (Italy) on groups of homotopy self-equivalences and related topics. The book comprises the articles relating current research on the group of homotopy self-equivalences, homotopy of function spaces, rational homotopy theory, classification of homotopy types, and equivariant homotopy theory. Mathematicians from many areas of the globe attended the workshops to discuss their research and to share ideas. Included are two specially-written articles, by J.W. Rutter, reviewing the work done in the area of homotopy self-equivalences since 1988. Included also is a bibliography of some 122 articles published since 1988 and a list of problems. This book is suitable for both advanced graduate students and researchers.
This book is intended to help mankind realize the many medical and agricultural benefits of enhancing the alternative cellular energy (ACE) pathway. The research stemmed from the discovery of stealth adapted viruses, which bypass cellular immunity. Stealth adapted viruses were implicated in mental illnesses over 20 years ago. The concept evoked political resistance because some stealth adapted viruses unequivocally arose as contaminants of polio vaccines and likely led to the formation of HIV, the AIDS virus. The ACE pathway is distinct from the immune system. It also fundamentally differs from cellular energy obtained from food calories. Rather the ACE pathway is an expression of a kinetic energy limiting electrostatic attraction or KELEA. The physics of KELEA needs to be actively pursued. The book consists of six-academic-style chapters followed by narratives regarding political barriers and specific disease entities. Patients support groups and other organizations will be assisted in conducting their own clinical validation studies. Let the work begin!
The geometry of surfaces is an ideal starting point for learning geometry, for, among other reasons, the theory of surfaces of constant curvature has maximal connectivity with the rest of mathematics. This text provides the student with the knowledge of a geometry of greater scope than the classical geometry taught today, which is no longer an adequate basis for mathematics or physics, both of which are becoming increasingly geometric. It includes exercises and informal discussions.
The area of inverse scattering transform method or soliton theory has evolved over the past two decades in a vast variety of exciting new algebraic and analytic directions and has found numerous new applications. Methods and applications range from quantum group theory and exactly solvable statistical models to random matrices, random permutations, and number theory. The theory of isomonodromic deformations of systems of differential equations with rational coefficents, and mostnotably, the related apparatus of the Riemann-Hilbert problem, underlie the analytic side of this striking development. The contributions in this volume are based on lectures given by leading experts at the CRM workshop (Montreal, Canada). Included are both survey articles and more detailed expositionsrelating to the theory of isomonodromic deformations, the Riemann-Hilbert problem, and modern applications. The first part of the book represents the mathematical aspects of isomonodromic deformations; the second part deals mostly with the various appearances of isomonodromic deformations and Riemann-Hilbert methods in the theory of exactly solvable quantum field theory and statistical mechanical models, and related issues. The book elucidates for the first time in the current literature theimportant role that isomonodromic deformations play in the theory of integrable systems and their applications to physics.
This volume is based on a conference held at SUNY, Stony Brook (NY). The concepts of laminations and foliations appear in a diverse number of fields, such as topology, geometry, analytic differential equations, holomorphic dynamics, and renormalization theory. Although these areas have developed deep relations, each has developed distinct research fields with little interaction among practitioners. The conference brought together the diverse points of view of researchers from different areas. This book includes surveys and research papers reflecting the broad spectrum of themes presented at the event. Of particular interest are the articles by F. Bonahon, "Geodesic Laminations on Surfaces", and D. Gabai, "Three Lectures on Foliations and Laminations on 3-manifolds", which are based on minicourses that took place during the conference.
Collects CHEW #36-40 Anthony and Antonelle Chu are fraternal twins. Tony and Toni. Each with their own extraordinary, albeit diametrically opposed, ability. Tony is Cibopathic, able to get psychic sensations of the past of anything he bites into or ingests. Toni is Cibovoyant, able to flash onto a vision of the future of any living thing she bit into or ingested. Tony is alive. Toni is dead. Toni has been murdered. Tony has vowed to catch her killer. Toni is going to help. Presenting a new storyline of the New York Times Bestselling, Harvey and multiple Eisner Award-winning series about cops, crooks, cooks, cannibals, and clairvoyants.
For three decades psychiatrists have turned to Lishman's Organic Psychiatry as the standard neuropsychiatry reference. It stood as the last great single author reference text in medicine, a combination of meticulous, exhaustive research conveyed in a beautifully clear style. Now the mantle has been passed to a group of five distinguished authors and it is to their considerable credit that the attributes which made Organic Psychiatry such a distinctive voice remain. The fourth Edition of Lishman's Organic Psychiatry is a rich blend of detailed clinical inquiry and up to date neuroscience. It should be on every psychiatrist;s book shelf." —Anthony Feinstein, MPhil, PhD., FRCP, Professor, Department of Psychiatry, University of Toronto, Canada Over the past 30 years, thousands of physicians have depended on Lishman's Organic Psychiatry. Its authoritative and reliable clinical guidance was - and still is - beyond compare. The new edition of this classic textbook has now been extensively revised by a team of five authors, yet it follows the tradition of the original single-authored book. It continues to provide a comprehensive review of the cognitive, emotional and behavioural consequences of cerebral disorders and their manifestations in clinical practice. Enabling clinicians to formulate incisive diagnoses and appropriate treatment strategies, Lishman's Organic Psychiatry is an invaluable source of information for practising psychiatrists, neurologists and trainees. This new edition: covers recent theoretical and clinical developments, with expanded sections on neuropsychology and neuroimaging includes a new chapter on sleep disorders whilst the chapters on Alzheimer's disease and related dementias, Epilepsy, Movement disorders and Traumatic brain injury have been extensively revised reflecting the greatly improved understanding of their underlying pathophysiologies showcases the huge advances in brain imaging and important discoveries in the fields of molecular biology and molecular genetics has been enhanced with the inclusion of more tables and illustrations to aid clinical assessment incorporates important diagnostic tools such as magnetic resonance brain images.
For three decades psychiatrists have turned to Lishman's Organic Psychiatry as the standard neuropsychiatry reference. It stood as the last great single author reference text in medicine, a combination of meticulous, exhaustive research conveyed in a beautifully clear style. Now the mantle has been passed to a group of five distinguished authors and it is to their considerable credit that the attributes which made Organic Psychiatry such a distinctive voice remain. The fourth Edition of Lishman's Organic Psychiatry is a rich blend of detailed clinical inquiry and up to date neuroscience. It should be on every psychiatrist;s book shelf." —Anthony Feinstein, MPhil, PhD., FRCP, Professor, Department of Psychiatry, University of Toronto, Canada Over the past 30 years, thousands of physicians have depended on Lishman's Organic Psychiatry. Its authoritative and reliable clinical guidance was - and still is - beyond compare. The new edition of this classic textbook has now been extensively revised by a team of five authors, yet it follows the tradition of the original single-authored book. It continues to provide a comprehensive review of the cognitive, emotional and behavioural consequences of cerebral disorders and their manifestations in clinical practice. Enabling clinicians to formulate incisive diagnoses and appropriate treatment strategies, Lishman's Organic Psychiatry is an invaluable source of information for practising psychiatrists, neurologists and trainees. This new edition: covers recent theoretical and clinical developments, with expanded sections on neuropsychology and neuroimaging includes a new chapter on sleep disorders whilst the chapters on Alzheimer's disease and related dementias, Epilepsy, Movement disorders and Traumatic brain injury have been extensively revised reflecting the greatly improved understanding of their underlying pathophysiologies showcases the huge advances in brain imaging and important discoveries in the fields of molecular biology and molecular genetics has been enhanced with the inclusion of more tables and illustrations to aid clinical assessment incorporates important diagnostic tools such as magnetic resonance brain images.
Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.
This overview of neurology begins with a review of the neurologic examination of common conditions such as seizures and headache. The rest of the text is divided into categories of neurologic diseases and reviews of individual disorders.
Designed to assist the clinician who has responsibility for the diagnosis and management of viral encephalitis. The organization of information for the clinician is based on clinical and epidemiological information available at the time of presentation of the patient. Discussions are rooted in neuropathological descriptions and pathogenesis concepts.
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