John Blangero's Books

Ascaris: The Neglected Parasite

Chapter 12. Genetics of Human Host Susceptibility to Ascariasis

By: Sarah Williams-Blangero,Mona H. Fenstad,Satish Kumar,John Blangero

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Ascaris: The Neglected Parasite

Chapter 12. Genetics of Human Host Susceptibility to Ascariasis

By: Sarah Williams-Blangero,Mona H. Fenstad,Satish Kumar,John Blangero

Ascaris infections remain major global public health problems despite the wide availability of cheap, effective anthelminthic drugs. An improved understanding of host susceptibility to Ascaris infection may suggest new approaches for targeting available drugs more effectively, or may suggest novel targets for drug development efforts. This chapter explores our current understanding of the underlying genetic architecture of susceptibility to Ascaris infection. The past and potential future uses of different types of genetic approaches, from quantitative genetic studies of heritability, to gene localization, to sequencing of functional variants, are explored. The field of human complex disease genetics is moving rapidly as a result of both technological and theoretical advances. State-of-the-art genetic techniques promise to yield new insights which will dramatically improve our understanding of the determinants of differential host susceptibility to Ascaris infection.

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Elsevier Inc. Chapters

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ISBN 10

0128061359

ISBN 13

9780128061350

Reflections of Our Past

How Human History Is Revealed in Our Genes

By: John H. Relethford,Deborah A. Bolnick

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Reflections of Our Past

How Human History Is Revealed in Our Genes

By: John H. Relethford,Deborah A. Bolnick

The rise of the multi-billion dollar ancestry testing industry points to one immutable truth about us as human beings: we want to know where we come from and who our ancestors were. John H. Relethford and Deborah A. Bolnick explore this topic and many more in this second edition of Reflections of Our Past. Where did modern humans come from and how important are the biological differences among us? Are we descended from Neandertals? How should we understand the connections between genetic ancestry, race, and identity? Were Native Americans the first to inhabit the Americas? Can we see evidence of the Viking invasions of Ireland a millennium ago even in the Irish of today? Through engaging examination of issues such as these, and using non-technical language, Reflections of Our Past shows how anthropologists use genetic information to suggest answers to fundamental questions about human history. By looking at genetic variation in the world today and in the past, we can reconstruct the recent and remote events and processes that have created the variation we see, providing a fascinating reflection of our genetic past.

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499

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Routledge

Published Date

ISBN 10

0429891709

ISBN 13

9780429891700

Understanding Developmental Disorders

A Causal Modelling Approach

By: John Morton

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Understanding Developmental Disorders

A Causal Modelling Approach

By: John Morton

A long-awaited book from developmental disorders expert John Morton, Understanding Developmental Disorders: A Causal Modelling Approach makes sense of the many competing theories about what can go wrong with early brain development, causing a child to develop outside the normal range. Based on the idea that understanding developmental disorders requires us to talk about biological, cognitive, behavioral and environmental factors, and to talk about causal relationships among these elements. Explains what causal modelling is and how to do it. Compares different theories about particular developmental disorders using causal modelling. Will have a profound impact on research in the fields of psychology, neuroscience and medicine.

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320

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John Wiley & Sons

Published Date

ISBN 10

0470694319

ISBN 13

9780470694312

The Lives of the Brain

Human Evolution and the Organ of Mind

By: John S. Allen

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The Lives of the Brain

Human Evolution and the Organ of Mind

By: John S. Allen

Though we have other distinguishing characteristics (walking on two legs, for instance, and relative hairlessness), the brain and the behavior it produces are what truly set us apart from the other apes and primates. And how this three-pound organ composed of water, fat, and protein turned a mammal species into the dominant animal on earth today is the story John S. Allen seeks to tell. Adopting what he calls a “bottom-up” approach to the evolution of human behavior, Allen considers the brain as a biological organ; a collection of genes, cells, and tissues that grows, eats, and ages, and is subject to the direct effects of natural selection and the phylogenetic constraints of its ancestry. An exploration of the evolution of this critical organ based on recent work in paleoanthropology, brain anatomy and neuroimaging, molecular genetics, life history theory, and related fields, his book shows us the brain as a product of the contexts in which it evolved: phylogenetic, somatic, genetic, ecological, demographic, and ultimately, cultural-linguistic. Throughout, Allen focuses on the foundations of brain evolution rather than the evolution of behavior or cognition. This perspective demonstrates how, just as some aspects of our behavior emerge in unexpected ways from the development of certain cognitive capacities, a more nuanced understanding of behavioral evolution might develop from a clearer picture of brain evolution.

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351

Publisher

Harvard University Press

Published Date

ISBN 10

0674053494

ISBN 13

9780674053496

Generalized Linear Models with Random Effects

Unified Analysis via H-likelihood, Second Edition

By: Youngjo Lee,John A. Nelder,Yudi Pawitan

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Generalized Linear Models with Random Effects

Unified Analysis via H-likelihood, Second Edition

By: Youngjo Lee,John A. Nelder,Yudi Pawitan

This is the second edition of a monograph on generalized linear models with random effects that extends the classic work of McCullagh and Nelder. It has been thoroughly updated, with around 80 pages added, including new material on the extended likelihood approach that strengthens the theoretical basis of the methodology, new developments in variable selection and multiple testing, and new examples and applications. It includes an R package for all the methods and examples that supplement the book.

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446

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CRC Press

Published Date

ISBN 10

1498720625

ISBN 13

9781498720625

Case Studies in Diabetes

By: D John Betteridge

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Case Studies in Diabetes

By: D John Betteridge

With the increasing incidence of Type 2 diabetes in the adult population and the realization that this is a vascular disease and a major coronary risk factor, Professor Betteridge has chosen fifty diabetologists to contribute a case which has had an effect on their clinical practice. Both Types 1 and 2 diabetes are included, along with other forms of diabetes, eg gestational. Each case is presented in the same format. The various cases are informative and educational and should provide the reader with a sounder knowledge of patient and disease types.

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228

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CRC Press

Published Date

ISBN 10

1000939537

ISBN 13

9781000939538

Reflections Of Our Past

How Human History Is Revealed In Our Genes

By: John H Relethford

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Reflections Of Our Past

How Human History Is Revealed In Our Genes

By: John H Relethford

Where did modern humans come from and how important are the biological differences among us? Are we descended from Neanderthals? How many races of people are there? Were Native Americans the first settlers of the New World? How can we tell if Thomas Jefferson had a child with Sally Hemings? Through an engaging examination of issues such as these, and using non-technical language, Reflections of Our Past shows how anthropologists use genetic information to test theories and define possible answers to fundamental questions in human history. By looking at genetic variation in the world today, we can reconstruct the recent and remote events and processes that created the variation we see, providing a fascinating reflection of our genetic past. Reflections of Our Pastis a W. W. Howells Book Prize Winner and Choice Outstanding Academic Title.

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273

Publisher

Westview Press

Published Date

ISBN 10

0786741791

ISBN 13

9780786741793

The Neurology of Eye Movements

By: R. John Leigh,David S. Zee

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The Neurology of Eye Movements

By: R. John Leigh,David S. Zee

lt is a tremendous achievement to have provided this highly comprehensive but readable text, which informs such a large group of researchers and clinicians." Christopher Kennard, PhD, FRCP, FMedSci, Professor of Clinical Neurology, Head, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. "A monograph written with deep knowledge, understanding, wisdom, clarity, intelligibility - the superlatives could go on and on... A remarkable achievement and a great gift to all of us from the two modern giants of eye movement disorders." Michael Halmagyi, MD, Eye and Ear Research Unit, Neurology Department, Royal Prince Alfred Hospital, The University of Sydney, Australia. "The fifth edition of The Neurology of Eye Movements is a must for all neurologists and neuroscientists interested in how the human vestibular and oculomotor systems adapt to movement in space and to optimally viewing the world and its contents." Louis R. Caplan, MD, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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1137

Publisher

Oxford University Press, USA

Published Date

ISBN 10

0199969280

ISBN 13

9780199969289

The Human Illnesses

Neuropsychiatric Disorders and the Nature of the Human Brain

By: Peter Williamson,John Morgan Allman

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The Human Illnesses

Neuropsychiatric Disorders and the Nature of the Human Brain

By: Peter Williamson,John Morgan Allman

The genetic correlates of neuropsychiatric disorders are now known, but none have come close to explaining the great variety of human psychiatric illnesses. This volume, written by a neuropsychiatrist and an evolutionary biologist, offers a new paradigm for understanding these disorders. Proposing that neuronal pathways which underlie neuropsychiatric conditions mirror unique human capabilities, the authors iterate a new paradigm by which to understand human psychiatric illnesses. Human capabilities such as theory of mind, language, and complex social behaviors are explored through their histological, neuroanatomical and functional brain imaging correlates. The capacity for representation, the authors suggest, is central to the understanding of the human brain. Brain structures such as the frontal pole, temporal pole, and fronto-insular cortex are highly developed in humans and are associated with representation. Other brain regions, including the dorsal anterior cingulate cortex, auditory cortex, and hippocampus, are linked with directed effort while the ventral anterior cingulate cortex, orbital frontal cortex, and amygdala are related to emotional encoding. Both networks interact with representional regions and the dorsolateral prefrontal cortex. Conditions like schizophrenia may result, in part, from a failure of the networks associated with directed effort while bipolar disorders may arise from a failure of networks associated with emotional encoding. Similarly, autism may result from a failure of representational brain regions; frontotemporal dementia may be associated with failure of several discrete networks in later life. From this perspective, neuropsychiatric disorders are selective failures of brain networks involved in the integration of cognition, affect and perception. A better understanding of these brain networks will assist psychiatric and mental health researchers in the search for environmental factors and genetic correlates of disorders as well as aid in the development of more effective treatments for these diseases. This volume will be of interest to psychiatrists, neurologists, psychologists, biologists, and imaging scientists--anyone who has ever wondered what makes the human brain human.

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257

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ISBN 10

0195368568

ISBN 13

9780195368567

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

By: John E. Bennett,Raphael Dolin,Martin J. Blaser

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Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

By: John E. Bennett,Raphael Dolin,Martin J. Blaser

After thirty five years, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see. Get the answers to any questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you’ll find in any other ID resource. Apply the latest knowledge with updated diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on Influenza (new pandemic strains); New Middle East Respiratory Syndrome (MERS) Virus; Probiotics; Antibiotics for resistant bacteria; Antifungal drugs; New Antivirals for hepatitis B and C; Clostridium difficile treatment; Sepsis; Advances in HIV prevention and treatment; Viral gastroenteritis; Lyme Disease; Helicobacter pylori; Malaria; Infections in immunocompromised hosts; Immunization (new vaccines and new recommendations); and Microbiome. Benefit from fresh perspectives and expanded global insights from an expanded team of American and International contributors. Martin Blaser, MD, a leading expert and Muriel G. and George W. Singer Professional of Translational Medicine at New York University School of Medicine, joins veteran PPID editors John E. Bennett, MD, and Raphael Dolin, MD to continue a legacy of excellence. Find and grasp the information you need easily and rapidly with newly added chapter summaries.

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5094

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323263739

ISBN 13

9780323263733

A History of Nepal

By: John Whelpton

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A History of Nepal

By: John Whelpton

A comprehensive and accessible one-volume history of Nepal, first published in 2005.

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326

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Cambridge University Press

Published Date

ISBN 10

0521804701

ISBN 13

9780521804707

High Altitude Medicine and Physiology 5E

By: John West,Robert Schoene,Andrew Luks,James Milledge

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High Altitude Medicine and Physiology 5E

By: John West,Robert Schoene,Andrew Luks,James Milledge

A comprehensive update to this preeminent and accessible text, this fifth edition of a bestseller was developed as a response to man's attempts to climb unaided to higher altitudes and to spend more time in these conditions for both work and recreation. It describes the ever-expanding challenges that doctors face in dealing with the changes in huma

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541

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CRC Press

Published Date

ISBN 10

1444154338

ISBN 13

9781444154337

High Altitude Medicine and Physiology

By: James S Milledge,John B West,Robert B Schoene

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High Altitude Medicine and Physiology

By: James S Milledge,John B West,Robert B Schoene

More than half a century has passed since man first stood on the summit of Mount Everest, and the story of man's attempts to climb higher and higher unaided is one of the more colourful and exciting in medicine and physiology. The past few decades have seen an explosion in the interest in mountain pursuits in general, as increasing numbers of peopl

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485

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CRC Press

Published Date

ISBN 10

1444113682

ISBN 13

9781444113686

Human Population Genetics

By: John H. Relethford

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Human Population Genetics

By: John H. Relethford

Introductory guide to human population genetics and microevolutionary theory Providing an introduction to mathematical population genetics, Human Population Genetics gives basic background on the mechanisms of human microevolution. This text combines mathematics, biology, and anthropology and is best suited for advanced undergraduate and graduate study. Thorough and accessible, Human Population Genetics presents concepts and methods of population genetics specific to human population study, utilizing uncomplicated mathematics like high school algebra and basic concepts of probability to explain theories central to the field. By describing changes in the frequency of genetic variants from one generation to the next, this book hones in on the mathematical basis of evolutionary theory. Human Population Genetics includes: Helpful formulae for learning ease Graphs and analogies that make basic points and relate the evolutionary process to mathematical ideas Glossary terms marked in boldface within the book the first time they appear In-text citations that act as reference points for further research Exemplary case studies Topics such as Hardy-Weinberg equilibrium, inbreeding, mutation, genetic drift, natural selection, and gene flow Human Population Genetics solidifies knowledge learned in introductory biological anthropology or biology courses and makes it applicable to genetic study. NOTE: errata for the first edition can be found at the author's website: http://employees.oneonta.edu/relethjh/HPG/errata.pdf

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326

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John Wiley & Sons

Published Date

ISBN 10

0470464674

ISBN 13

9780470464670

High-Density Lipoproteins

Structure, Metabolism, Function and Therapeutics

By: Anatol Kontush,M. John Chapman

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High-Density Lipoproteins

Structure, Metabolism, Function and Therapeutics

By: Anatol Kontush,M. John Chapman

A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapies With high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL. Divided into three main parts, High-Density Lipoproteins first examines normal HDL particles, then describes defective HDL, and finally addresses the therapeutic normalization of subnormal levels and defective biological activities of this lipoprotein class. The book highlights the functional properties of HDL, which are relevant to the pathophysiology of atherosclerosis and thrombosis, and discusses the compositional and metabolic heterogeneity of HDL particles. Readers will come away with a clear understanding of the role of HDL in biological processes, the potential value of functional HDL as a therapeutic target, and how current and emerging therapies are poised to influence the treatment of heart disease in the future.

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786

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John Wiley & Sons

Published Date

ISBN 10

1118158660

ISBN 13

9781118158661

John Bachman

Selected Writings on Science, Race, and Religion

By: Gene Waddell

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John Bachman

Selected Writings on Science, Race, and Religion

By: Gene Waddell

John Bachman (1790-1874) was an internationally renowned naturalist and a prominent Lutheran minister. This is the first collection of his writings, containing selections from his three major books, his letters, and his articles on plants and animals, education, religion, agriculture, and the human species. Bachman was the leading authority on North American mammals. He was responsible for the descriptions of the 147 mammal species included in Viviparous Quadrupeds of North America, a massive work produced in collaboration with John James Audubon. Bachman relied entirely on scientific evidence in his work and was exceptional among his fellow naturalists for studying the whole of natural history. Bachman also relied on scientific evidence in his Doctrine of the Unity of the Human Race. He showed that human beings constitute a single species that developed as varieties equivalent to the varieties of domesticated animals. In this work, perhaps his most significant accomplishment, Bachman stood nearly alone in challenging the polygenetic views of Louis Agassiz and others that white and black people descended from different progenitors. Bachman was also an important figure in the establishment of Lutheranism in the Southeast. He wrote the first American monograph on the doctrines of Martin Luther and the history of the Reformation. Bachman served for fifty-six years as minister of St. John's Lutheran Church in Charleston, South Carolina, and was one of the founders of Newberry College.

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400

Publisher

University of Georgia Press

Published Date

ISBN 10

0820339644

ISBN 13

9780820339641

The Journal of John Woolman

By: John Whittier

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The Journal of John Woolman

By: John Whittier

Reprint of the original, first published in 1871. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.

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326

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BoD – Books on Demand

Published Date

ISBN 10

3382176254

ISBN 13

9783382176259

The Journal and Major Essays of John Woolman

By: John Woolman

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The Journal and Major Essays of John Woolman

By: John Woolman

Bonded Leather binding

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336

Publisher

Macmillan Publishing Company

Published Date

ISBN 10

0781284287

ISBN 13

9780781284288

JOURNAL & ESSAYS OF JOHN WOOLM

By: John 1720-1772 Woolman,Amelia M. (Amelia Mott) 1859-1 Gummere

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JOURNAL & ESSAYS OF JOHN WOOLM

By: John 1720-1772 Woolman,Amelia M. (Amelia Mott) 1859-1 Gummere

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

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732

Publisher

Wentworth Press

Published Date

ISBN 10

1363978101

ISBN 13

9781363978106

Book's by John Blangero

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