This book presents a language integrated query framework for big data. The continuous, rapid growth of data information to volumes of up to terabytes (1,024 gigabytes) or petabytes (1,048,576 gigabytes) means that the need for a system to manage and query information from large scale data sources is becoming more urgent. Currently available frameworks and methodologies are limited in terms of efficiency and querying compatibility between data sources due to the differences in information storage structures. For this research, the authors designed and programmed a framework based on the fundamentals of language integrated query to query existing data sources without the process of data restructuring. A web portal for the framework was also built to enable users to query protein data from the Protein Data Bank (PDB) and implement it on Microsoft Azure, a cloud computing environment known for its reliability, vast computing resources and cost-effectiveness.
This book presents an improved design for service provisioning and allocation models that are validated through running genome sequence assembly tasks in a hybrid cloud environment. It proposes approaches for addressing scheduling and performance issues in big data analytics and showcases new algorithms for hybrid cloud scheduling. Scientific sectors such as bioinformatics, astronomy, high-energy physics, and Earth science are generating a tremendous flow of data, commonly known as big data. In the context of growing demand for big data analytics, cloud computing offers an ideal platform for processing big data tasks due to its flexible scalability and adaptability. However, there are numerous problems associated with the current service provisioning and allocation models, such as inefficient scheduling algorithms, overloaded memory overheads, excessive node delays and improper error handling of tasks, all of which need to be addressed to enhance the performance of big data analytics.
The international migration of health workers has been described by Nelson Mandela as the poaching of desperately needed skills from under-privileged regions. This book examines the controversial recent history of skilled migration, and explores the economic and cultural rationale behind this rise of a complex global market in qualified migrants and its multifaceted outcomes. John Connell pays particular attention to the increase in demand for migrants in more developed countries due to the complex ramifications of aging, and new opportunities and expectations. He illustrates how globalization has linked sub-Saharan Africa to Europe and North America, and created new demand in Japan for international migrants from China and isolated island states. The long-established skill-drain, with its impact on household relations and negative consequences for health care, is carefully balanced against new flows of remittances, the return of skills and complex regional changes. Wide-ranging policy interventions, and greater social justice, have been challenged by the rise of the competition state and limitations to economic growth in the global south. This comprehensive and definitive analysis of the global migration of health workers will prove an essential resource for academics and research students in health and social policy, and in the various disciplines that relate to migration, including sociology, economics and geography.
This new edition of Fungi in Ecosystem Processes continues the unique approach of examining the roles of fungi from the perspective of ecosystem functions. It explores how fungi have adapted to survive within particular constraints, how they help to maintain homeostasis in ecosystems, how they facilitate resistance to perturbations, and how they influence the communities of other organisms. Updated and revised, the second edition Expands the section on plant pathogens, invasive species, and insect–fungal interactions Provides more extensive coverage on insect–fungal interactions, including entomopathogens, the links between entomopathogens and endophytes, and symbiotic and mutualistic interactions Adds a new section on fungi in the built environment Presents new material on below-ground to above-ground interactions mediated through fungi, such as mycorrhizal signaling systems for herbivory defense The book also includes expanded coverage of the role of fungi in suppressive soils, aquatic and marine fungi, modern methods of following food chains in fungal–invertebrate trophic interactions, and the physiology of nutrient uptake by mycorrhizae. A necessary update and expansion to previous material, this book provides an essential reference on the current understanding of fungal roles in ecosystem processes. It also identifies directions for future study, including an emphasis on the need for further research on fungi in built environments.
In contrast to the second edition, the third edition of ‘‘Fungi and Food Spoilage’’ is evolutionary rather than revolutionary. The second edition was intended to cover almost all of the species likely to be encountered in mainstream food supplies, and only a few additional species have been included in this new edition. The third edition represents primarily an updating – of taxonomy, physiology, mycotoxin production and ecology. Changes in taxonomy reflect the impact that molecular methods have had on our understanding of classification but, it must be said, have not radically altered the overall picture. The improvements in the understanding of the physiology of food spoilage fungi have been relatively small, reflecting perhaps the lack of emphasis on physiology in modern mic- biological science. Much remains to be understood about the specificity of particular fungi for particular substrates, of the influence of water activity on the growth of many of the species treated, and even on such basic parameters as cardinal temperatures for growth and the influence of pH and preservatives. Since 1997, a great deal has been learnt about the specificity of mycotoxin production and in which commodities and products-specific mycotoxins are likely to occur. Changes in our understanding of the ecology of the included species are also in most cases evolutionary. A great number of papers have been published on the ecology of foodborne fungi in the past few years, but with few exceptions the basic ecology of the included species remains.
After thirty five years, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see. Get the answers to any questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you’ll find in any other ID resource. Apply the latest knowledge with updated diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on Influenza (new pandemic strains); New Middle East Respiratory Syndrome (MERS) Virus; Probiotics; Antibiotics for resistant bacteria; Antifungal drugs; New Antivirals for hepatitis B and C; Clostridium difficile treatment; Sepsis; Advances in HIV prevention and treatment; Viral gastroenteritis; Lyme Disease; Helicobacter pylori; Malaria; Infections in immunocompromised hosts; Immunization (new vaccines and new recommendations); and Microbiome. Benefit from fresh perspectives and expanded global insights from an expanded team of American and International contributors. Martin Blaser, MD, a leading expert and Muriel G. and George W. Singer Professional of Translational Medicine at New York University School of Medicine, joins veteran PPID editors John E. Bennett, MD, and Raphael Dolin, MD to continue a legacy of excellence. Find and grasp the information you need easily and rapidly with newly added chapter summaries.
Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects. The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.
Comprehensive and complete, Shackelford’s Surgery of the Alimentary Tract delivers the definitive, clinically oriented, cutting-edge guidance you need to achieve optimal outcomes managing the entire spectrum of gastrointestinal disorders. Make effective use of the latest endoscopic, robotic, and minimally invasive procedures as well as medical therapies with unbeatable advice from a "who’s who" of international authorities! Find expert answers to any clinical question in gastrointestinal surgery, from the esophagus to the colon. See exactly what to look for and how to proceed from an abundance of beautifully detailed intraoperative and laparoscopic photographs.
Unparalleled in scope and content, Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas provides the most relevant and up-to-date clinical, etiologic, molecular, and therapeutic management information for surgical pathologists in training and in practice. The fully revised 4th Edition of this award-winning title offers a wealth of information in this fast-changing field, including recent advances in molecular biology and immunohistochemistry, in a clearly written, well-structured manner that is easy to read and navigate. This one-stop reference for the entire gastrointestinal system enables you to improve turnaround time when diagnosing a specimen and to clearly report on the prognosis and therapeutic management options to surgical and medical colleagues. Covers the latest developments in molecular technologies and immunohistochemical markers to provide useful diagnostic and prognostic information and inform therapeutic decisions. Provides all the necessary tools to make a comprehensive diagnostic workup, including data from ancillary techniques and molecular findings whenever appropriate. Incorporates more than 3000 high-quality color illustrations to help you recognize and diagnose any tissue sample under the microscope. Reviews next-generation sequencing (NGS) to help identify targetable mutations in gastrointestinal tract tumors and provide more accurate classification and precision therapies. Features extensive tables, graphs, and flowcharts to help you effectively grasp complex topics and streamline your decision-making. Helps you avoid diagnostic errors with practical advice on pitfalls in differential diagnosis. Incorporates the latest WHO guidelines throughout. Winner of the 2015 BMA Medical Book Awards First Prize Award in Pathology.
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