Presents portraits of fourteen American women who played important roles in American history, including Emma Willard, Abigail Adams, and Harriet Beecher Stowe.
The Bibliotheca of Pseudo-Apollodorus, perhaps the best-known mythographic text, stands out for its comprehensive aim and state of preservation. The handbook has regularly been disregarded as a repository of 'standard' myths or as a primary witness to archaic stories, a reductive view at once underestimating and romanticizing the merits of the Bibliotheca. This monograph unlocks the Bibliotheca as a literary work in its own right by offering the first systematic commentary on an essential selection, the Cretan and Theban myths in Bibl. III.1-56, and by presenting an in-depth analysis of the text. In so doing, this volume closes a gap in current research, from which a philological commentary is entirely missing. The main part of the study focuses on various aspects of composition and organization by addressing structuring principles, narratorial interventions, and the author's method and sources. It lays to rest persistent misconceptions about the representative character of the Bibliotheca's myths, the author's merits, and his source use, all of which have divided the scholarship to this date. In addition, it provides an update on the author, date, purpose and readership, text history, and book division of the Bibliotheca.
Providing thorough, up-to-date coverage of the operation of marine insurance legislation, this text is an essential resource for today's marine insurance professional. Designed with the reader in mind, previous editions of this book have been heavily praised for its accessible and highly-practical format. Section by section, the authors deliver expert commentary on the Marine Insurance Act 1906 and related marine insurance legislation. The origin of each section or provision is clearly explained, along with the authorities decided since the legislation came into force. New to this edition: Heavily revised with the very latest case law since 2010, some of which having a dramatic effect on the law of marine insurance. The most important cases include The Cendor Mopu and Masefield v Amlin. All relevant new cases have been added from across the common law world Clarification on new legislation such as the Third Parties (Rights against Insurers) Act 2010 and the Consumer Insurance (Disclosure and Representations) Act 2012 The compulsory insurance provisions affecting oil pollution and passengers The rules on jurisdiction and choice of law in the Brussels Regulation and the Rome I Regulation This compressive text is indispensable for marine lawyers, industry professionals, and students of marine insurance law worldwide.
Protection of traditional knowledge and resources is of critical concern not only to the groups involved but also to the international trading community for which these resources are of increasing economic importance. This work examines the concept of 'community', intellectual property models and additional sources for protection at international law (including environmental and human rights frameworks). Intellectual property law is critiqued as an inadequate framework to address the fundamental object of protection for the communities themselves - the management of traditional use, as well as the biological and cultural sustainability of this use. The work sets out an international framework based on the concept of 'community resources', recognizing the unique claims embodied in traditional knowledge, incorporating customary law, and facilitating community management of resources. International in perspective and scope, the book will be a valuable resource for academics and researchers in law, international relations and cultural studies.
Situating the evolution of Methodist education for women in Ontario within the larger social and cultural context, Methodists and Women's Education in Ontario describes the often unintended and unforeseen forces unleashed by women's education and the ambi
In the past ten years, heteroepitaxy has continued to increase in importance with the explosive growth of the electronics industry and the development of a myriad of heteroepitaxial devices for solid state lighting, green energy, displays, communications, and digital computing. Our ever-growing understanding of the basic physics and chemistry underlying heteroepitaxy, especially lattice relaxation and dislocation dynamic, has enabled an ever-increasing emphasis on metamorphic devices. To reflect this focus, two all-new chapters have been included in this new edition. One chapter addresses metamorphic buffer layers, and the other covers metamorphic devices. The remaining seven chapters have been revised extensively with new material on crystal symmetry and relationships, III-nitride materials, lattice relaxation physics and models, in-situ characterization, and reciprocal space maps.
During the quarter of a century before the thirteen colonies became a nation, the northwest quadrant of North Carolina had just begun to attract permanent settlers. This seemingly primitive area may not appear to be a likely source for attractive pottery and ornate silverware and furniture, much less for an audience to appreciate these refinements. Yet such crafts were not confined to urban centers, and artisans, like other colonists, were striving to create better lives for themselves as well as to practice their trades. As Johanna Miller Lewis shows in this pivotal study of colonial history and material culture, the growing population of Rowan County required not only blacksmiths, saddlers, and tanners but also a great variety of skilled craftsmen to help raise the standard of living. Rowan County's rapid expansion was in part the result of the planned settlements of the Moravian Church. Because the Moravians maintained careful records, historians have previously credited church artisans with greater skill and more economic awareness than non-church craftsmen. Through meticulous attention to court and private records, deeds, wills, and other sources, Lewis reveals the Moravian failure to keep up with the pace of development occurring elsewhere in the county. Challenging the traditional belief that southern backcountry life was primitive, Lewis shows that many artisans held public office and wielded power in the public sphere. She also examines women weavers and spinsters as an integral part of the population. All artisans—Moravian and non-Moravian, male and female—helped the local market economy expand to include coastal and trans-Atlantic trade. Lewis's book contributes meaningfully to the debate over self-sufficiency and capitalism in rural America.
The Compendium of Insurance Law consolidates diverse insurance law sources, statutes and codes of practice in one comprehensive volume. Each piece of legislation is supplemented by detailed annotations, which explain the operation and relationship of the legislation with other sources of insurance law. The book is filled with comprehensive coverage of legislation relating to the following areas: regulation, reinsurance, life assurance, property insurance, marine insurance, liability insurance, motor insurance, insurance intermediaries, insurance contracts and competition.
Abortion is--and always has been--an arena for contesting power relations between women and men. When in 1973 the Supreme Court made the procedure legal throughout the United States, it seemed that women were at last able to make decisions about their own bodies. In the four decades that followed, however, abortion became ever more politicized and stigmatized. Abortion after Roe chronicles and analyzes what the new legal status and changing political environment have meant for abortion providers and their patients. Johanna Schoen sheds light on the little-studied experience of performing and receiving abortion care from the 1970s--a period of optimism--to the rise of the antiabortion movement and the escalation of antiabortion tactics in the 1980s to the 1990s and beyond, when violent attacks on clinics and abortion providers led to a new articulation of abortion care as moral work. As Schoen demonstrates, more than four decades after the legalization of abortion, the abortion provider community has powerfully asserted that abortion care is a moral good.
The high society of Stuart England found Frances Coke Villiers, Viscountess Purbeck (1602-1645) an exasperating woman. She lived at a time when women were expected to be obedient, silent, and chaste, but Frances displayed none of these qualities. Her determination to ignore convention contributed in no small measure to a life of high drama, one which encompassed kidnappings, secret rendezvous, an illegitimate child, accusations of black magic, imprisonments, disappearances, and exile, not to mention court appearances, high-speed chases, a jail-break, deadly disease, royal fury, and - by turns - religious condemnation and conversion. As a child, Frances became a political pawn at the court of King James I. Her wealthy parents, themselves trapped in a disastrous marriage, fought tooth and nail over whom Frances should marry, pulling both king and court into their extended battles. When Frances was fifteen, her father forced her to marry John Villiers, the elder brother of the royal favourite, the Duke of Buckingham. But as her husband succumbed to mental illness, Frances fell for another man, and soon found herself pregnant with her lover's child. The Viscountess paid a heavy price for her illicit love. Her outraged in-laws used their influence to bring her down. But bravely defying both social and religious convention, Frances refused to bow to the combined authority of her family, her church, or her king, and fought stubbornly to defend her honour, as well as the position of her illegitimate son. On one level a thrilling tale of love and sex, kidnapping and elopement, the life of Frances Coke Villiers is also the story of an exceptional woman, whose personal experiences intertwined with the court politics and religious disputes of a tumultuous and crucially formative period in English history.
Artists' books have emerged over the last 25 years as the quintessential contemporary art form, addressing subjects as diverse as poetry and politics, incorporating a full spectrum of artistic media and bookmaking methods, and taking every conceivable form. Female painters, sculptors, calligraphers, and printmakers, as well a growing community of hobbyists, have played a primary role in developing this new mode of artistic expression. The Book as Art presents more than 100 of the most engaging women's artist books created by major fine artists such as Meret Oppenheim, May Stevens, Kara Walker, and Renee Stout and distinguished book artists such as Susan King, Ruth Laxson, Claire Van Vliet, and Julie Chen. Culled from over 800 unique or limited-edition volumes held by the National Museum of Women in the Arts, these books explore the form as a container for ideas. Descriptions of the works are accompanied by colorful illustrations and reflections by their makers, along with essays by leading scholars and a lively introduction by the most famous book artist in our culture, best-selling author Audrey Niffenegger. The exquisitely crafted objects in the The Book as Art are sure to provoke unexpected and surprising conclusions about what constitutes a book. The Book as Art accompanies the exhibition of the same name at the Museum of Women in the Arts in Washington, D.C., beginning in October 2006.
A comprehensive history of the women’s suffrage movement in the United States, from 1776 to 1965 Most suffrage histories begin in 1848, when Elizabeth Cady Stanton first publicly demanded the right to vote at the Women’s Rights Convention in Seneca Falls, New York. And they end in 1920, when Tennessee became the 36th state to ratify the 19th Amendment, removing sexual barriers to the vote. And Yet They Persisted traces agitation for the vote over two centuries, from the revolutionary era to the civil rights era, excavating one of the greatest struggles for social change in this country and restoring African American women and other women of color to its telling. In this sweeping history, author Johanna Neuman demonstrates that American women defeated the male patriarchy only after they convinced men that it was in their interests to share political power. Reintegrating the long struggle for the women’s suffrage into the metanarrative of U.S. history, Dr. Neuman sheds new light on such questions as: Why it took so long to achieve equal voting rights for women How victories in state suffrage campaigns pressured Congress to act Why African American women had to fight again for their rights in 1965 How the struggle by eight generations of female activists finally succeeded And Yet They Persisted: How American Women Won the Right to Vote his is the ideal text for college courses in women’s studies and history covering the women’s suffrage movement, as well as courses on American History, Political History, Progressive Era reforms, or reform movements in general. Click here to read Johanna Neuman's two-part blog post about the hidden history of Women's Suffrage as we celebrate the centennial anniversary of the 19th Amendment.
Focusing on cases of extramarital sex, Johanna Rickman investigates fornication, adultery and bastard bearing among the English nobility during the Elizabethan and early Stuart period. Since members of the nobility were not generally brought before the ecclesiastical courts, which had jurisdiction over other citizens' sexual offences, Rickman's sources include collections of family papers (primarily letters), state papers, and literary texts (prescriptive manuals, love sonnets, satirical verse, and prose romances), as well as legal documents. Rickman explores how attitudes towards illicit sex varied greatly throughout the period of study, roughly 1560 - 1630. Whole some viewed it as a minor infraction, others, directed by a religious moral code, viewed it as a serious sin. seeks to illuminate the place of noblewomenin early modern aristocratic culture, both as historical subjects (considering personal circumstances) and as a social group (considering social position and status).She argues that two different gender ideals were in operation simultaneously: one primarily religious ideal, which lauded female silence, obedience, and chastity, and another, more secular ideal, which required noblewomen to be beautiful, witty, brave, and receptive to the games of courtly love.
This book investigates the portrayal of nationalities and sexualities in British post-Second World War crime film and melodrama. By focussing on these genres, and looking at the concept of melodrama as an analytical tool apt for the analysis of both sexuality and nation, the book offers insight into the desires, fears, and anxieties of post-war culture. The problem of returning to ‘normalcy’ after the war is one of the recurring themes discussed; alienation from society, family, and the self were central issues for both women and men in the post-war years, and the book examines the anxieties surrounding these social changes in the films of the period. In particular, it explores heterosexuality and nationality as some of the most prominent frameworks for the construction of identities in our time, structures that, for all their centrality, are made invisible in our culture.
Edge of the Map is equal parts inspiring, dramatic, and heartbreaking. One of America’s greatest high altitude mountaineers, Christine Boskoff was at the top of her career when she and her partner died in an avalanche in 2006. Charismatic, principled, and humble, Boskoff was also a deeply loved role model to her climbing partners and the Sherpa community. Edge of the Map traces the sharp twists and turns in Boskoff’s life, from her early years as a Lockheed engineer, through her first successes in the climbing world, to her purchase of Seattle-based Mountain Madness after owner and climber Scott Fischer died in the 1996 Everest disaster. Her life was one of constant achievement mixed with personal tragedy. The story follows Boskoff as she perseveres and moves on to even bigger peaks, earning acclaim as a world-class mountaineer, then later as she finds an alpine partnership with legendary Colorado climber Charlie Fowler.
Adolescents are often an overlooked clinical population. Among school-based practitioners, there is a natural inclination to focus the delivery of mental health services, assessment measures, and intervention plans on younger children, and there is a strong research base to support these programs. On the other hand, the waiting rooms of most practitioners in private practice are filled with young and middle-age adults, couples, or families with young children. Because most therapists do not specialize in working with teens, who might make up only a small portion of their overall caseload, there is a need for high quality, easily implemented activities to help engage with adolescent clients. This book provides an overview of the principles of therapeutic storytelling, developmental issues of adolescents and young adulthood, and their strengths-based model, before moving into a series of chapters devoted to specific issues. Commonly encountered topics such as sexuality, parent & peer relationships, substance abuse, violence & gangs, bereavement, and cultural and religious issues are covered within the chapters. Includes a convenient companion website designed to facilitate ease of use for the busy professional or academic contains printable storytelling and activity worksheets, color photographs for phototherapy and guided imagery, and additional resources/website links.
The Antarctic continent carries the greatest diversity of lake environments on the planet: freshwater and saline lakes, tidal freshwater epishelf lakes, lakes on ice shelves and glacier surfaces, and over three hundred subglacial lakes; extraordinary ecosystems that have been separated from the atmosphere for up to millions of years. This book provides a unique and cutting edge synthesis of Antarctic limnology, drawing together current knowledge on geomorphology, morphometry, chemistry, community structure and function. It emphasises throughout the value of these near-pristine ecosystems as barometers of climate change, showing how responsive and vulnerable they are to the indirect impacts of anthropogenic activity. Antarctic Lakes begins with an introduction to their physical, chemical, and biological characteristics, providing a basis for understanding the subsequent detailed chapters on different lake types, and ends with a chapter considering the application of new technologies to polar limnology as well as identifying future research directions. This accessible text is suitable for both senior undergraduate and graduate students taking courses in Antarctic and polar limnology, and will also be of broad interest to researchers working in the areas of polar science, microbial ecology (and extremophiles), climatology, glaciology, and astrobiology.
In a career that has spanned more than forty years, Matthew Carter has designed many of the typefaces that we see every day in and on publications, books, signs, and screens. Carter's celebrated typefaces include such stalwarts as Galliard, Mantinia, and Verdana. In 1975, he created the now-pervasive Bell Centennial specifically for use in phone books. Publications including Sports Illustrated, the Daily News, Wired, and the Washington Post, along with cultural institutions such as the Walker Arts Center and The Victoria & Albert Museum, have all commissioned Carter fonts. Typographically Speaking: The Art of Matthew Carter entered the field in the days of hand-cut punches and hot-metal type, and has continued to innovate through the eras of photocomposition and digital design. Essays discuss the form of his work, his position and use of typographic history, and his technological innovation. All of his fonts are reproduced in full for reference, and illustrations place his designs in context. Published in conjunction with the University of Maryland Baltimore County.
This volume presents the papers from the 3rd International Conference on Technology in Health Care: Socio-technical Approaches held in Sydney, Australia in 2007.
This comprehensive, trusted core text on media's impact on attitudes, behavior, elections, politics, and policymaking is known for its readable introduction to the literature and theory of the field. Mass Media and American Politics, Tenth Edition is thoroughly updated to reflect major structural changes that have shaken the world of political news, including the impact of the changing media landscape. It includes timely examples of the significance of these changes pulled from the 2016 election cycle. Written by Doris A. Graber—a scholar who has played an enormous role in establishing and shaping the field of mass media and American politics—and Johanna Dunaway, this book sets the standard.
Rob Ford—the most ridiculed and scandal-ridden mayor—is an international celebrity. When the photo of him smoking crack cocaine circulated, garnering billions of hits, it was the icing on the cake. Ford, not just the favorite buffoon of late-night comics and journalists, was also a known alcoholic and the subject of legal, political, and police investigations—stripped of his mayoral powers by Toronto’s City Council and a star subject in a murder investigation. Here for the first time, Ford’s former chief of staff Mark Towhey, who tried to wrangle Ford during his highly public meltdown, comes clean, filling in incredible behind-the-scenes details previously unknown and providing invaluable context. With this highly anticipated and much-talked-about tell-all, we go deep into Ford’s personal life, including his addictions and his rivalry with his brother; we watch him as he runs Toronto; we overhear hair-raising late-night phone calls and see private, after-hours events; and we also get the much-gossiped-about but little-known account of Towhey’s desperate struggle to protect the mayor from himself. This juicy read is, like Ford, political candy, but it doesn’t expose Ford for the sake of ridicule—it empathizes with him and explains him. It provides a fascinating portrait of twenty-first-century urban politics, as well as a character study of a larger-than-life personality, a mayor so colorful that he remains in office as a councillor and—despite it all—may one day become mayor again.
The politicization of ontology -- Foundational violence -- Dangerous animals -- The politics of gendered violence -- Political life -- The management of state violence -- The political ontology of neoliberalism -- Violence and neoliberal governmentality -- Terror and political spirituality.
The first comprehensive intellectual history of alphabet studies. Inventing the Alphabet provides the first account of two-and-a-half millennia of scholarship on the alphabet. Drawing on decades of research, Johanna Drucker dives into sometimes obscure and esoteric references, dispelling myths and identifying a pantheon of little-known scholars who contributed to our modern understandings of the alphabet, one of the most important inventions in human history. Beginning with Biblical tales and accounts from antiquity, Drucker traces the transmission of ancient Greek thinking about the alphabet’s origin and debates about how Moses learned to read. The book moves through the centuries, finishing with contemporary concepts of the letters in alpha-numeric code used for global communication systems. Along the way, we learn about magical and angelic alphabets, antique inscriptions on coins and artifacts, and the comparative tables of scripts that continue through the development of modern fields of archaeology and paleography. This is the first book to chronicle the story of the intellectual history through which the alphabet has been “invented” as an object of scholarship.
Is your school or district facing increased competition, diminishing resources, changing demographics, media scrutiny, and declining employee retention? How to Market Your School is a comprehensive guide that provides school administrators with the essential tools to create a positive public image; attract students, qualified personnel, and volunteers; and build community support through a strategic marketing effort. Author Johanna Lockhart draws on her extensive marketing and public relations experience to cover topics such as: School marketing: What it is and why it matters Developing a marketing strategy Marketing research and database marketing Marketing and electronic communication Media relations Building community partnerships Public relations and much more Although originally intended for public school administrators, How to Market Your School is equally valuable to private and charter schools. It will help principals, assistant principals, business managers, and district administrators apply the knowledge and tools used successfully in the private sector to organize, implement, and maintain an integrated marketing program to achieve their particular goals. Lockhart presents the fundamentals of integrated marketing in clear and concise terms and uses actual case studies to illustrate each aspect of successful school marketing.
A trusted person-centred resource to start you on the path to professional success Fundamentals of Nursing and Midwifery is a popular foundational nursing text specifically developed for Australian and New Zealand students. This comprehensive resource provides a detailed overview of key information with person-centred care highlighted throughout to focus on the individualistic, interactive and holistic nature of nursing and midwifery practice. It uses accessible language that introduces students to the ‘why’ as well as the ‘how’ of nursing and midwifery. It focuses not only on a person’s physical healthcare needs, but also on the intellectual, emotional, sociocultural and spiritual aspects of care. In this way, students learn to be holistic health care professionals while acquiring the foundational knowledge, procedures and skills required for successful nursing or midwifery practice.
Drawing on in-depth research into almost 500 organisations, this revised and updated text offers evidence of the evolution from traditional group-based equal opportunity policies towards inclusive strategies focusing on the individual's own contribution. It then puts forward a detailed model of diversity based on flexiblility, an empowering culture, universal benefits and business-related training defined by individual rather than group needs.
How should we approach life and its challenges? Are they real? What do we really know about reality? Could modern physics help us to understand? What kind of worldview does it really shape for us? What is the connection between reality and consciousness? Do we live in a simulation? In this book Johanna Blomqvist, Ph.D., is diving into the question of reality, a topic which has been of interest to her since childhood. The desire to understand the world, reality and the purpose of everything has also led her to the frontiers of science and to topics physicists do not often approach. Her first book ”From Quantum Physics to Energy Healing - A Physicist’s Journey to Mind and Healing” was published on Amazon in 2018. Hyperreality is a book about the nature of our reality and the hypotheses we have made about it through the centuries. Johanna Blomqvist describes many cases and research experiments that will puzzle your mind. Our reality seems to be something other than what the current prevailing materialistic worldview suggests. **From Chapter 2. Are we only machines?:** There are many phenomena that we encounter almost daily, but which do not fit into the current materialistic worldview. Such phenomena are often classified as anomalies or parapsychological when it is impossible to explain them with prevailing theories. Such phenomena include premonitions, intuition, telepathy, premonition dreams, and synchronicity. Science seeks to find objective truth, but is such a goal even possible? After all, all objective information is based on subjective observation. Robert Jahn and Brenda Dunne, founders of the PEAR (Princeton Engineering Anomalies Research) laboratory, which has studied the effect of the mind on matter for decades, say: "Mind without matter leaves us with a world of ephemeral abstraction; matter without mind eliminates the essence of life itself.” ** It seems that the transition to the so-called post-materialistic era is essential. We don’t have any alternatives, if we want to continue our life as humanity on Earth into the future. We have to change our thinking! It is time to understand our effect on physical reality and move to a new era, beyond materialism. You exist — dive into hyperreality, in which you are a significant participant! Hyperreality book has been written to everyone seeking for answers about the nature of our reality, purpose of everything, consciousness and the connection between science and spirituality. It may help you to understand phenomena that you earlier have only omitted. This book is the answer that Johanna Blomqvist herself wanted to find as a teen, when she was contemplating the question of reality, why we are here, and how should one live. *** About the Author Johanna Blomqvist, Ph.D., is a physicist, entrepreneur and internationally published author. In her work, she combines a wide variety of fields and methods in a unique way, often discussing topics from the cutting edge and unconventional areas of science. Blomqvist is also a sought-after lecturer, educator and energy healer. Since childhood she has been interested in understanding our reality, consciousness and our role in this universe. Johanna's first book "From Quantum Physics to Energy Healing - A Physicist's Journey to Mind and Healing" was published on May 2018. She has written also "Hyperreality - Beyond the Horizon where Physics Meets Consciousness" (2021) and "The Mystery of Water - A Physicist's Dive into Our Deepest Essence" (Fall, 2024). Johanna lives in Helsinki, Finland.
A comprehensive, trusted core text on media’s impact on attitudes, behavior, elections, politics, and policymaking, Mass Media and American Politics is known for its readable introduction to the literature and theory of the field, and for staying current with each new edition on issues of new and social media, media ownership, the regulatory environment, infotainment, and war-time reporting. Written by the late Doris Graber--a scholar who has played an enormous role in establishing and shaping the field of mass media and American politics--and now lead by Johanna Dunaway, this book has set the standard for the course. New to this edition: Extensive coverage of political misinformation - the role changing communication technologies and mass media more generally are playing in its consumption and dissemination, as well as how the press is handling and should handle reporting on political misinformation, especially as it pertains to the presidency, elections, and crises like Covid-19. Updated coverage of the role social media and other popular digital platforms are playing (or not playing) in the effort to stop the spread of mis- and dis-information on their platforms, with special attention to both foreign and domestic efforts to use these platforms to incite violence, cause confusion about, and/or encourage distrust in, democratic institutions. Expanded treatment of rising affective, social, and ideological polarization in politics, with a special focus on whether and how mass media are contributing to these forms of polarization. New updates on causes and consequences of expanding news deserts, declining local news, and rampant growth of hedge-fund media ownership. Up to date coverage of what researchers are learning about the implications of growth in digital, social and mobile media use. What does it mean for attention to news and politics?
Do professions really place duty to society above clients' or their own interests? If not, how can they be trusted? While some public relations (PR) scholars claim that PR serves society and enhances the democratic process, others suggest that it is little more than propaganda, serving the interests of global corporations. This is not an argument about definitions, but about ethics - yet this topic is barely explored in texts and theories that seek to explain PR and its function in society. This book places PR ethics in the wider context of professional ethics and the sociology of professions. By bringing together literature from fields beyond public relations - sociology, professional and philosophical ethics, and Jungian psychology - it integrates a new body of ideas into the debate. The unprecedented introduction of Jungian psychology to public relations scholarship shifts the debate beyond a traditional Western 'Good/Bad' ethical dichotomy towards a new holistic approach, with dynamic implications for theory and practice. This thought-provoking book will be essential reading for students, academics and professionals with an interest in public relations, ethics and professionalism.
This qualitative study asks whether structural transformation brought about by modernization in contemporary urban India can induce growing equality in the sense of mutual respect between the lower and the middle classes. From the idographic context of female domestic workers and their employers in Chennai (Tamil Nadu) a general type of modernity for the periphery is outlined. Even though changes in this relation are apparent and various forms of respect and recognition are developing, the deep hierarchical differences persist despite - or precisely because of - modernity in the form of capitalism. Johanna Vogel (Dr.) studied Intercultural Business Studies at the University of Passau and received 2017 her PhD in Human Geography at the University of Bayreuth.
There is life beyond your eating disorder—and you deserve to enjoy every minute of it. Johanna S. Kandel, founder and executive director of The Alliance for Eating Disorders Awareness, struggled with her eating disorder for ten years before finally getting help. Now fully recovered, Kandel knows firsthand how difficult the healing process can be. Through her work with The Alliance—leading support groups, speaking nationwide and collaborating with professionals in the field—she's developed a set of practical tools to address the everyday challenges of recovery.
The prevalence of allergic diseases has in the past century increased among children in affluent societies. Underlying causes are incompletely disentangled, but decreased diversity in environmental and microbial exposures could drive allergy development. Allergic individuals possess imbalanced immune responses, skewed in favour of Th2 cells along with lesser Th1 and Treg responses. As allergy development early in life increases the risk of developing further allergic manifestations later, early prevention is key. Thus, interventions in pregnancy, early life and childhood may modulate immunity towards tolerance, although underpinnings of immune maturation and modulation in allergy prevention throughout childhood are not entirely understood. In this thesis, these questions are addressed in children with a high propensity of developing allergic disease or who already have manifested allergies. Chemokines are crucial for immune cell recruitment to the allergic reaction site, and associate with allergy development in childhood. In Paper I, circulating levels of the allergy-related chemokines CCL17, CCL18, CCL22, CXCL10 and CXCL11 were studied in the natural course of allergic disease. Elevated levels of the Th2/Treg-regulated chemokine CCL18 in infancy and childhood associated with development of asthma and/or sensitisation. Moreover, this finding conferred higher odds of developing asthma and sensitisation from early school age until adolescence. Additionally, increased levels of the Th1-associated chemokines CXCL10 after birth, and decreased levels of CXCL11 at birth, preceded asthma development later in life. Hence, Paper I showed that circulating chemokine levels in different ways precede allergy development. Epigenetic modifications, such as DNA methylation, comprise a link between the genetic setup and environmental exposures, and regulate processes such as Th cell differentiation. Perinatal treatment with Lactobacillus reuteri and ?-3 fatty acids prevent development of some IgE-mediated manifestations. However, the drivers of the immunostimulating and pro-resolving effects of these treatments are sparsely examined. In Papers II and III, epigenome-wide DNA methylation patterns in CD4+ cells upon pre-and postnatal L. reuteri supplementation alone or in combination with ?-3 fatty acids were studied. In Paper II, the greatest epigenome wide differential methylation was evident at birth, mainly directed towards hypomethylation, indicating transcriptional availability of affected genes. Network analyses revealed several immune related pathways, and a relationship of differentially methylated genes to allergy development. Thus, prenatal L. reuteri treatment seemingly poises Th cells towards immune activation at birth, possibly influencing immune maturation as well as allergy development in the child. In Paper III, epigenome-wide DNA methylation patterns were surveyed at birth. In this on-going trial, mothers are treated during the latter half of pregnancy with a combination of L. reuteri and ?-3 fatty acids. Four different treatment groups were studied, and the largest differential methylation was seen in the double active treatment group. In contrast to Paper II, most CpGs and genes were hypermethylated, indicating repressed gene transcription. In line with Paper II, network analyses showed that T cell and immune mediated pathways were affected by treatment, and synergistic effects of the double treatment were indicated. Taken together, prenatal treatment with L. reuteri and/or ?-3 fatty acids altered the epigenome to different extents at birth, mainly towards hypermethylation, and often affected immune related pathways. Immunomodulatory effects of sublingual immunotherapy in children and adolescents are scarcely investigated. In Paper IV, circulating and salivary immune mediators were investigated in timothy grass-pollen allergic children treated with sublingual immunotherapy. Actively treated children had elevated levels of timothy grass pollen-specific IgA antibodies in saliva, along with increased circulating levels of the Th1-associated chemokines CXCL10 and CXCL11, both after treatment ending and two years later. Taken together, sublingual immunotherapy modulates local and peripheral immune responses in children with timothy grass pollen-induced allergy, by augmenting Th1-responses, lessening Th2-responses and inducing immunomodulatory responses, suggesting induction of tolerance, also partly in the long-term. Altogether, the studies in this thesis have shown altered immune regulation in children developing allergies. Moreover, immunomodulatory effects of prenatal treatment with probiotics and ?-3 fatty acids, and sublingual immunotherapy in children with grass pollen-induced allergic disease, were revealed. DNA methylation patterns and immunologic mediators in blood and saliva could potentially serve as appropriate biomarkers for allergic disease. Long term health benefits can be reached by intervening early in life, and further knowledge about the mechanisms behind this could promote the prevention of allergic diseases and hence improve the quality of life for children and adolescents. Förekomsten av allergiska sjukdomar, som böjveckseksem, hösnuva och astma, har under det senaste århundradet ökat markant bland barn i industrialiserade samhällen. De bakomliggande orsakerna är inte helt klarlagda, men samhälleliga förändringar har minskat vår mångfaldiga exponering för bakterier, virus och parasiter. Detta skulle kunna ligga till grund för immunförsvarets felaktiga reaktion mot egentligen ofarliga ämnen som ses vid allergier. Hos allergiska individer är immunförsvaret obalanserat, med en relativ övervikt av det så kallade Thjälpar- 2 (Th2)-svaret gentemot Th1- och det regulatoriska T-cells (Treg)-svaret. Allergiska sjukdomar utvecklas ofta tidigt i livet, vilket ökar risken för att utveckla vidare allergier senare i livet. Därför är det viktigt att motverka den allergiska marschens framfart tidigt genom förebyggande behandlingar. Ett tillvägagångsätt är att påbörja behandling under graviditeten och tidiga barndomen hos barn med hög risk för att bli allergiska, då grunden för immunsystemet läggs redan under fosterlivet. För redan utvecklade allergier är det tänkbart att omforma dessa immunsvar med immunterapi, som kan minska symptom av befintliga allergier samtidigt som det är möjligt att motverka utvecklingen av senare allergier. Det är dock inte helt klarlagt hur immunutmognaden under barndomen är reglerad, eller hur dessa typer av behandlingar skulle kunna påverka allergiutveckling under den perioden. I denna avhandling undersöks immunutmognad vid allergiutveckling hos barn, och möjliga immunmodulerande förebyggande behandlingar hos barn med genetisk benägenhet att bli allergiska eller som redan utvecklat allergisk sjukdom. För att celler ska rekryteras till platsen för en allergisk reaktion krävs bland annat s.k. kemokiner. I det första arbetet undersöktes dessa lockelseämnen, då våra tidigare studier visat att nivåerna av vissa kemokiner vid födseln förutspår utvecklingen av allergi hos barn. De allergirelaterade kemokinerna CCL17, CCL18, CCL22, CXCL10 och CXCL11 analyserades i blodprover vid födseln, 1 och 8 års ålder hos barn från en populationsbaserad observationsstudie. Förhöjda nivåer av CCL18, ett kemokin under reglering av både Th2- och Treg-svar, uppmättes vid 1 och/eller 8 års ålder hos barn som hade astma (särskilt svår astma) och/eller var sensibiliserade. De ökade nivåerna associerade också till högre odds för utveckling av astma från tidig skolålder upp till övre tonåren, med liknande resultat för sensibilisering. Även ökade nivåer av de Th1-associerade kemokinerna CXCL10 efter födseln och minskade nivåer av CXCL11 vid födseln föregick utvecklingen av astma senare i livet. Det första arbetet visade alltså på att cirkulerande kemokiner på olika vis föregår utvecklingen av allergier hos barn och ungdomar. Som länk mellan arv och miljö står s.k. epigenetiska modifieringar, vilka reglerar genaktiviteten utan att förändra den genetiska koden i arvsmassan. Till dessa modifieringar räknas DNAmetylering, en process som bl.a. styr utmognad av de allergirelaterade T-hjälparcellerna. Vi har i tidigare separata studier med den probiotiska stammen Lactobacillus reuteri och omega-3- behandling visat förebyggande av vissa IgE-medierade allergier. Vad som föranleder de immunstimulerande och immunmodulerande effekterna av behandlingarna är dock otillräckligt undersökt. I det andra och tredje arbetet undersöktes hur L. reuteri separat eller i kombination med omega-3-fettsyror påverkar DNA-metyleringsmönster i CD4+ Th-celler hos barn som behandlats före och efter födseln. I det andra arbetet undersöktes DNA-metyleringsmönster både lokalt och i hela genomet vid födseln, ett och två års ålder. Behandling med L. reuteri förändrade DNA-metyleringsmönster i allergirelaterade T-hjälparceller mest vid födseln mot s.k. hypometylering, vilket pekar på ökad tillgänglighet av generna för proteinuttryck. Vidare nätverksanalyser visade att flera immunrelaterade processer påverkades av behandlingen. Därtill var generna från nätverket till stor del associerade med allergiutveckling. Maternell behandling med L. reuteri under den sista graviditetsmånaden tycks alltså förändra DNA-metyleringsmönster i T-hjälparceller hos fostret mot ökad immunaktivering vid födseln, vilket i sin tur skulle kunna påverka både immunutmognad och allergiutveckling hos barnet. I likhet med det andra arbetet undersöktes i det tredje arbetet DNA-metyleringsmönster i hela epigenomet, fast endast vid födseln. I denna pågående studie behandlas mödrarna under den andra halvan av graviditeten med en kombination av L. reuteri och omega-3-fettsyror. Fyra olika behandlingsgrupper undersöktes och den största förändringen i DNA-metylering återfanns i den kombinerade aktiva behandlingsgruppen. I motsats till det andra arbetet var dock de flesta CpG positionerna och generna hypermetylerade, vilket tyder på att genernas tillgänglighet för proteinuttryck hämmas. I linje med det andra arbetet framkom T-cells- och immunrelaterade signalvägar i nätverksanalyser på dessa gener, och det fanns indikationer på synergistiska effekter mellan behandlingarna. Det tredje arbetet visade att behandling med L. reuteri och/eller omega- 3-fettsyror under senare delen av graviditeten förändrar T-hjälparcellernas epigenom i olika grad främst mot hypermetylering, och ofta påverkar immunrelaterade signalvägar. Relevansen av dessa fynd kommer i framtida studier att undersökas på proteinnivå och i relation till allergiutveckling. Med allergenspecifik immunterapi är det möjligt att modulera immunsvaret hos allergiska individer mot ett tolerant immunsvar, men effekter av sublingual immunterapi på immunförsvaret hos barn och ungdomar är knapphändigt undersökta. I det fjärde arbetet undersöktes olika immunologiska mediatorer i blod och saliv hos barn med gräspollenallergi, som deltagit i en studie med sublingual immunterapi. Nivåerna av allergirelaterade cytokiner och kemokiner undersöktes i blodprover från inklusionstillfället, efter tre år med behandling samt två år efter avslutad behandling i plasmaprov och allergenstimulerade blodceller. Dessutom mättes total-IgA, sekretoriskt IgA och gräspollenspecifikt IgA i saliv vid samma tillfällen. Barn som fått aktiv behandling hade högre nivåer av gräspollenspecifika IgA-antikroppar i saliv både när behandlingen avslutades och två år efter. Därtill ökade nivåerna av de Th1-associerade kemokinerna CXCL10 och CXCL11 i blodet vid samma tidpunkter. Sammantaget visade resultaten från det fjärde arbetet att behandlingen med sublingual immunterapi hos barn med gräspollenallergi modulerar immunsvaret både lokalt och i cirkulationen genom att öka Th1- svar, minska Th2-svar och inducera immunreglerande svar, vilket indikerar att tolerans har utvecklats hos dessa barn, delvis även på lång sikt. Sammanfattningsvis har studierna i denna avhandling visat på förändrad immunreglering hos barn som utvecklar allergi. Dessutom påvisades immunmodulerande effekter av prenatal behandling med probiotika och omega-3-fettsyror samt av sublingual immunterapi hos barn med gräspollenallergi. DNA-metyleringsmönster och immunologiska mediatorer i blod och saliv skulle kunna fungera som lämpliga biomarkörer för allergisk sjukdom, vilket är ett viktig led i att kunna förutsäga allergiutveckling och förbättra den kliniska behandlingen av allergier bland barn och ungdomar. Långsiktiga hälsofördelar kan uppnås genom att ingripa tidigt i livet, och vidare kunskap om mekanismerna bakom detta skulle kunna främja förebyggandet av allergiska sjukdomar och således kunna förbättra livskvaliteten för barn och ungdomar.
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