This unusual collection of 49 essays gives an overview of the trends and accomplishments of synthetic organic chemistry in recent years. Unique in its approach, it deals with almost every aspect of modern synthesis. The first part of the book describes methods and reagents, with particular emphasis on rapidly developing organometallic and biooriented procedures. In the second part, these tools are applied to the syntheses of interesting target compounds and natural compounds with remarkable physiological properties. Mechanistic discussions and retrosynthetic analyses are included. More than 1000 up-to-date references help the reader to pursue the topics highlighted here. This book gives both the active researcher and the advanced student insight into the competitive atmosphere, creativity, and resourcefulness so characteristic of organic synthesis today.
Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.
This unusual collection of 49 essays gives an overview of the trends and accomplishments of synthetic organic chemistry in recent years. Unique in its approach, it deals with almost every aspect of modern synthesis. The first part of the book describes methods and reagents, with particular emphasis on rapidly developing organometallic and biooriented procedures. In the second part, these tools are applied to the syntheses of interesting target compounds and natural compounds with remarkable physiological properties. Mechanistic discussions and retrosynthetic analyses are included. More than 1000 up-to-date references help the reader to pursue the topics highlighted here. This book gives both the active researcher and the advanced student insight into the competitive atmosphere, creativity, and resourcefulness so characteristic of organic synthesis today.
Definitive text of important prose eclogue, Baroque German's contribution to western literary genres. Prose eclogue, invented by Martin Opitz and perfected in Nuremberg during the 1640s, is perhaps the only original contribution of the German Baroque to the catalogue of western literary genres. Recently, Baroque scholars have recognized that the little-known Die Nymphe Noris, composed in 1650 by the physician and early Pegnitz Shepherd Johann Hellwig (1609-1674), a sequel to the paradigmatic works by Georg Philipp Harsdörffer, Johann Klaj and Sigmund von Birken, is in fact their equal, a highly inventive artifact worthy of serious attention in its own right: Noris forcefully exploits the negative potential of the Vergilian pastoral tradition to criticize blood nobility's privileged status vis-à-vis the nobilitas literata. Working from copies in both Europe and America, Professor Reinhart has established a definitive critical edition of the text (previously only available in the U.S. and U.K. on microfilm), including an introduction outlining the use of prose eclogue as a vehicle for the social mission of the early Pegnesischer Blumenorden. This book will be of interest to literary and cultural historians of early modern Germany, especially Nuremberg, to scholars of the European Baroque and European culture, and to bibliophiles. PROFESSOR REINHARTis associate professor of German at the University of Georgia.
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