Gastroesophageal reflux disease and its complications effect 40 % of the US population. It is the most common reason for outpatient GI visits with treatment costs amounting to nearly $10 billion a year. Thisissue updates interested physicians on the new advance in GERD pathogenesis, diagnosis and medical/surgical treatment , especially over the last 5 years. Lots of advancements have been made in this time period and this will be a excellent reference book for the busy academic and community physician interested in GERD.
Completely updated, the Fifth Edition of this standard-setting two-volume reference presents the most advanced diagnostic techniques and the latest information on all currently known disease entities. More than 90 preeminent surgical pathologists offer expert advice on the diagnostic evaluation of every type of specimen from every anatomic site. The Fifth Edition contains over 4,400 full-color photographs. This edition provides detailed coverage of the latest developments in the field, including new molecular and immunohistochemical markers for diagnosis and prognosis of neoplasia, improved classification systems for diagnosis and prognosis, the role of pathology in new diagnostic and therapeutic techniques, and the recognition of new entities or variants of entities. All full-color illustrations have been color-balanced to dramatically improve image quality.
The peptide hormones are small proteins that regulate cellular metabolism through their specific interactions with tissues of the endocrine, nervous, and immune systems, as well as in embry onic development. During the past ten years, refinements in the techniques of recombinant DNA technology have resulted in the cloning of genes encoding approximately 50 different hormonal and regulatory peptides, including those in which the peptides themselves and the mRNAs encoding the peptides are present in only trace amounts in the tissues of origin. In addition to provid ing the coding sequences of recognized hormonal and regulatory peptides, gene sequencing has uncovered new bioactive peptides encoded in the precursor pro hormones that are then liberated along with the hormonal peptides during cellular cleavages of the precursors. The encoding of multiple peptides in a single mono cistronic mRNA appears to be a genetic mechanism for the gener ation of biologic diversification without requiring amplification of gene sequences. Two of the objectives in the assembly of this book are to pre sent, in one volume, the known primary structures of the genes encoding several of the polypeptide hormones and related regulatory peptides, and to provide an account of the various ap proaches that have been used to identify and select the cloned genes encoding these polypeptides. The contents of the two in troductory chapters are intended to provide the reader with a brief background of the approaches to gene cloning and the struc ture and expression of hormone-encoding genes.
Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. - Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. - Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. - Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. - Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. - Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. - Discusses today's key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
For well over two centuries the question of the composition of the Pentateuch has been among the most central and hotly debated issues in the field of biblical studies. In this book, Joel Baden presents a fresh and comprehensive argument for the Documentary Hypothesis. Critically engaging both older and more recent scholarship, he fundamentally revises and reorients the classical model of the formation of the Pentateuch. Interweaving historical and methodological chapters with detailed textual case studies, Baden provides a critical introduction to the history of Pentateuchal scholarship, discussions on the most pressing issues in the current debate, and a practical model for the study of the biblical text.
Laryngeal Surgery is the first in the series “Surgical Techniques in Otolaryngology – Head & Neck Surgery.” Divided into five sections, the book begins with an introduction to the basic principles and procedures of laryngeal surgery. The following chapters discuss surgery for different disorders including benign structural lesions, premalignant and malignant lesions of the larynx, neurogenic voice disorders and laryngeal trauma. Written by an internationally recognised author and editor team from the USA, led by series editor Robert T Sataloff from Drexel University College of Medicine, Philadelphia, this reference features numerous highly illustrated clinical photographs, flow charts and tables. An interactive DVD ROM of intraoperative photographs and videos of surgical procedures is included to help illustrate the techniques described in the book. Forthcoming topics in the series include atlases of otologic and neurotological surgery, rhinologic and sinus surgery, facial plastic and reconstructive surgery, pediatric otolaryngologic surgery, and head and neck surgery. Key points First title in Surgical Techniques in Otolaryngology – Head & Neck Surgery series covering laryngeal surgery Includes interactive DVD ROM of intraoperative photographs and surgical techniques US author and editor team, led by Robert T Sataloff
Foundations of Biochemical Psychiatry provides information pertinent to the development of biochemical psychiatry, including biochemical studies of psychiatric patients before and after pharmacological intervention and genetic studies. This book discusses the development of biochemical psychiatry as a significant experimental and conceptual approach to understanding mental illness. Organized into 24 chapters, this book begins with an overview of the neurochemical processes involved in the elaboration of a behavior and the extent to which alterations in those processes are responsible for behavioral differences. This text then discusses the clinical characteristics of schizophrenia, including common symptoms, natural history, and subtypes. Other chapters consider the contribution of genetic factors to the etiology of schizophrenia. This book discusses as well the similarities among hallucinations, dreams, and primary process thinking. The final chapter deals with the factors that may influence the neuroendocrine system. This book is a valuable resource for psychiatrists, neuropharmacologists, neurobiologists, behavioral biologists, and psychoanalysts.
The Bible promises the renewal of all creation--a new heaven and earth--based on the incarnation, life, death, and resurrection of Jesus Christ. For centuries this promise has been sidelined or misunderstood because of the church's failure to grasp the full meaning of biblical teachings on creation and new creation. The Bible tells the story of the broken and restored relationship between God, people, and land, not just God and people. This is the full gospel, and it has the power to heal the church's long theological divorce between earth and heaven. Jesus' resurrection in the power of the Holy Spirit is the key, and the church as Christ's body is the primary means by which God is reconciling all things through Jesus Christ. Jesus' ultimate healing of all creation is the great hope and promise of the gospel, and he calls the church to be his healing community now through evangelism, discipleship, and prophetic mission.
Clinics Collections: Gastrointestinal Diseases draws from Elsevier’s robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, gastroenterologists, otolaryngologists, oncologists, pathologists, and surgeons, with practical clinical advice and insights on this highly prevalent condition and its comorbidities. Clinics Collections: Gastrointestinal Diseases guides readers on how to apply current primary research findings on gastrointestinal diseases to everyday practice to help overcome challenges and complications, keep up with new and improved treatment methods, and improve patient outcomes. • Areas of focus include gastroesophageal reflux disease, Barrett’s esophagus, upper gastrointestinal bleeding, dyspepsia, eosinophilic esophagitis, gastroparesis, dysphagia, esophageal tumor, colon polyps/cancer, constipation, inflammatory bowel disease, gastroenteritis, lower gastrointestinal bleeding, and hemorrhoids. • Each article begins with keywords and key points for immediate access to the most critical information. • Articles are presented in an easy-to-digest and concisely worded format. Elsevier’s Clinics Collections provide concise reviews of today’s most prevalent conditions and significant medical developments. Other Clinics Collections titles available include Type II Diabetes Mellitus, Asthma, Obesity, Pain Management, Lipid Disorders, and Chronic Obstructive Pulmonary Disease.
Materials have the potential to be the centrepiece for the transition to viable renewable energy technologies and this book provides a perspective on the application of new technologies to this field as well as the broader techno-economic and social context.
Traces historical developments in scientific conceptions of physiology, ecology, behavior, and evolutionary biology during the mid-twentieth century Life Out of Balance focuses on a period in history when new ideas of self-regulation, adaptation, and fitness became central to a variety of biological disciplines. During the decades surrounding World War II, these ideas developed in several quite different contexts and led to greater debates about the merits of such models as applied to larger systems, including society at large. Particularly in its later cybernetic form, homeostasis seemed to provide new ways of discussing balance and regulation that avoided discredited approaches of earlier champions of vitalism and mechanism. It provided a common perspective and terminology for discussing self-regulating “systems,” whether biological, mechanical, or social. Although enormously fruitful and influential, homeostatic perspectives also generated numerous controversies when critics questioned the degree to which biological systems are characterized by balance and self-regulation. Resolving these controversies continues to be a challenge in modern biology. If natural selection constitutes the first law of biology, scientists who champion homeostasis as a theoretical model claim that it is a second law, equally important and closely related to the first. Such claims notwithstanding, homeostasis has generated a series of controversies since it was formalized by Walter Cannon in the late 1920s. Critics contended that Cannon took a too-optimistic view of life, not only ignoring pathological deviations from normality but also failing to adequately explain the ability of living things to respond adaptively to environmental challenges. Underlying these controversies was the unresolved problem of integrating physiology and other areas of functional biology with the emerging evolutionary synthesis of Mendelian genetics and Darwinian natural selection. The physiological idea of homeostasis as the adaptive “fit” between the organism and its environment and the Darwinian idea of adaptation and fitness in terms of reproductive success might seem to be complementary in an unproblematic way, but historically they have had an uneasy relationship.
This volume comprises studies by Joel B. Green on the Gospel of Luke and the Acts of the Apostles. These essays contribute to our understanding of the theological and narrative unity of Luke-Acts by pursuing a variety of topics including conversion, happiness, poverty and wealth, prayer, miracles, baptism, Mary the mother of Jesus, and Christology." --
Ancient cultures, such as that of the Hebrews, commonly associated wisdom with advanced years. In A Biblical Theology of Gerassapience the author investigates the validity of this correlation through an eclectic approach - including linguistic semantic, tradition-historical, and socio-anthropological methods - to pertinent biblical and extra-biblical texts. There are significant variations in the estimation of gerassapience (or «old-age wisdom») in each period of ancient Israel's life - that is, in pre-monarchical, monarchical, and post-monarchical Israel. Throughout this study, appropriate cross-cultural parallels are drawn from the cultures of ancient Israel's neighbors and of modern societies, such as the West African Yoruba tribe. The overall results are bi-dimensional. On the one hand, there are semantic elements of gerassapience, such as the elusiveness of «wisdom» and the mild fluidity of «old age». Both terms have strong contextual affinity with minimal exceptions. Thus, the attribution of wisdom to old age is evident but not absolute in the Hebrew Bible (Old Testament). On the other hand, gerassapience is depicted as primarily didactic, through direct and indirect instructions and counsels of the elderly, fostering the saging fear-of-Yahweh legacies. On the whole, socio-anthropocentric tendencies of gerassapience (that is, of making old age a repertoire of wisdom) are checked by theological warrants of theosapience (Yahwistic wisdom). Therefore, in the Hebrew Bible, the fear of Yahweh is also the beginning of growing old and wise.
This volume describes the structure and function of bacterial toxins and presents a comprehensive review of virulence factors, providing recent information concerning cell physiology and biochemistry, as well as new toxin tools for experimental studies and clinical therapy. A wide variety of toxic proteins, including the toxins that cause diptheria
Clinics Collections: Chronic Obstructive Pulmonary Disease is the most current, comprehensive, and complete resource on the clinical management of COPD and related conditions. Clinics Collections: Chronic Obstructive Pulmonary Disease draws from Elsevier's robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, pulmonologists, sleep specialists, radiologists,and critical care nurses, with practical clinical advice and insights on this highly prevalent condition and its comorbidities. Clinics Collections: Chronic Obstructive Pulmonary Disease guides readers on how to apply current primary research findings on COPD to everyday practice to help overcome challenges and complications, keep up with new and improved treatment methods, and improve patient outcomes. Areas of focus include pathogenesis, COPD and secondary disorders, clinical considerations and complications, treatment and pharmacotherapy, and special considerations. Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format. Elsevier's Clinics Collections provide concise reviews of today's most prevalent conditions and significant medical developments. Other Clinics Collections titles available include Type II Diabetes Mellitus, Asthma, Obesity, Pain Management, and Lipid Disorders.
The Word Biblical Commentary delivers the best in biblical scholarship, from the leading scholars of our day who share a commitment to Scripture as divine revelation. This series emphasizes a thorough analysis of textual, linguistic, structural, and theological evidence. The result is judicious and balanced insight into the meanings of the text in the framework of biblical theology. These widely acclaimed commentaries serve as exceptional resources for the professional theologian and instructor, the seminary or university student, the working minister, and everyone concerned with building theological understanding from a solid base of biblical scholarship. Overview of Commentary Organization Introduction—covers issues pertaining to the whole book, including context, date, authorship, composition, interpretive issues, purpose, and theology. Each section of the commentary includes: Pericope Bibliography—a helpful resource containing the most important works that pertain to each particular pericope. Translation—the author’s own translation of the biblical text, reflecting the end result of exegesis and attending to Hebrew and Greek idiomatic usage of words, phrases, and tenses, yet in reasonably good English. Notes—the author’s notes to the translation that address any textual variants, grammatical forms, syntactical constructions, basic meanings of words, and problems of translation. Form/Structure/Setting—a discussion of redaction, genre, sources, and tradition as they concern the origin of the pericope, its canonical form, and its relation to the biblical and extra-biblical contexts in order to illuminate the structure and character of the pericope. Rhetorical or compositional features important to understanding the passage are also introduced here. Comment—verse-by-verse interpretation of the text and dialogue with other interpreters, engaging with current opinion and scholarly research. Explanation—brings together all the results of the discussion in previous sections to expose the meaning and intention of the text at several levels: (1) within the context of the book itself; (2) its meaning in the OT or NT; (3) its place in the entire canon; (4) theological relevance to broader OT or NT issues. General Bibliography—occurring at the end of each volume, this extensive bibliographycontains all sources used anywhere in the commentary.
In two places in the First Gospel (Matt 10:5b-6; 15:24) the Messianic mission of Jesus and his disciples is limited to a group called ‘the lost sheep of the house of Israel’. In light of Matthew’s intense interest in Jesus’ Davidic Messiahship and the Jewish Shepard-King traditions surrounding King David it is argued that the 'lost sheep of the house of Israel' refers to remnants of the former northern kingdom of Israel who continued to reside in the northern region of the ideal Land of Israel.
Normal0falsefalsefalseMicrosoftInternetExplorer4 This book has been replaced by Treatment of Borderline Personality Disorder, Second Edition, ISBN 978-1-4625-4193-5.
Doctors in Denial examines the relationship between the Canadian medical profession and the pharmaceutical industry, and explains how doctors have become dependents of the drug companies instead of champions of patients' health. Big Pharma plays a role in every aspect of doctors' work. These giant, wealthy multinationals influence how medical students are trained and receive information, how research is done in hospitals and universities, what is published in leading medical journals, what drugs are approved, and what patients expect when they go into their doctors' offices. But almost all doctors deny the influence and control the drug companies exert. In this book Dr. Lexchin urges the medical profession to make the changes needed to give priority to protecting and promoting patients' health and benefitting society, rather than enabling Big Pharma to dominate health care while raking in billions in profits from citizens and governments.
The ideal of balance and its association with what is ordered, just, and healthful remained unchanged throughout the medieval period. The central place allotted to balance in the workings of nature and society also remained unchanged. What changed within the culture of scholasticism, between approximately 1280 and 1360, was the emergence of a greatly expanded sense of what balance is and can be. In this groundbreaking history of balance, Joel Kaye reveals that this new sense of balance and its potentialities became the basis of a new model of equilibrium, shaped and shared by the most acute and innovative thinkers of the period. Through a focus on four disciplines - scholastic economic thought, political thought, medical thought, and natural philosophy - Kaye's book reveals that this new model of equilibrium opened up striking new vistas of imaginative and speculative possibility, making possible a profound re-thinking of the world and its workings.
Clinics Collections: Type II Diabetes Mellitus draws from Elsevier’s robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, endocrinologists, and other healthcare professionals, with practical clinical insights on the evaluation and management of patients with this disease and other co-morbidities. Clinics Collections: Type II Diabetes Mellitus guides readers on how to apply current primary research findings on type II diabetes to everyday practice to help overcome management challenges, keep up with new and improved treatments, and improve patient outcomes. Areas of focus include diabetic complications associated with the foot, cardiovascular system, renal system, gastrointestinal system, ophthalmologic disorders, dermatologic disorders, neurologic and psychological disorders, special considerations, and more! Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format. Elsevier Clinics Collections provide concise reviews of today’s most prevalent conditions and significant medical developments.
Chandler and Grant’s Glaucoma—one of the field’s seminal texts on the medical practice and surgical management of glaucoma, now in its Sixth Edition—includes the latest updates in an area that is currently experiencing a surge of innovation. Edited by Drs. Malik Y. Kahook and Joel S. Schuman and with writings from the late Dr. David L. Epstein and more than 80 contributors, Chandler and Grant’s Glaucoma, Sixth Edition brings together the experience of world-class glaucoma experts who belong to a long line of surgeons trained using the teachings of the original authors of this classic work. Each chapter has been meticulously edited and updated from the previous edition, while maintaining the well-established historical teachings of Drs. Paul A. Chandler and W. Morton Grant. New chapters on medical therapy as well as thorough updates on novel and minimally invasive approaches for the surgical management of glaucoma have been added. New topics and features in the Sixth Edition include: Advances in imaging of the optic nerve and retina Rho-associated protein kinase inhibitors Glaucoma and cerebrospinal fluid pressure The FDA’s role in the development of new diagnostic and surgical devices for patients with glaucoma Chandler and Grant’s Glaucoma has been the most relevant and invaluable reference on glaucoma for generations of ophthalmologists. This updated Sixth Edition builds on the teachings of previous editions, making the Sixth Edition as relevant in the 21st century as when the first lectures were presented by Drs. Chandler and Grant more than 55 years ago.
The Muskogees' Struggle for a New World 'In Sacred Revolt Joel Martin places the 1813-1814 revolt of the people who were called 'Creek Indians' in the context of world history while forsaking nothing of the texture of their own culture. With a deft use of multiple perspectives, he has rewritten a chapter in the history of the Old South. His book will do much to freshen stale ways of thinking about a valiant people.' -Charles Hudson, author of The Southeastern Indians
This issue of the Atlas of the Oral and Maxillofacial Surgery Clinics, edited by Dr. Joel J. Napeñas, focuses on Oral Manifestations of Systemic Diseases. Articles will feature Evaluation of the Patient; Oral Manifestations of Gastrointestinal Disorders; Oral Manifestations of Immunodeficiencies and Transplantation Medicine; Oral Manifestations of Autoimmune and Connective Tissue Disorders; Oral Manifestations of Drug-induced Disorders; Oral Manifestations of Neurologic Disorders; Oral Complications of Nonsurgicial Cancer Therapies; Oral Complications of Hematologic Disorders; Oral Complications of Systemic Viral Infections; Oral Complications of Allergies and Immunologically Mediated Diseases; Oral Complications of Multi-Organ Disorders; Oral Complications of Endocrine Disorders; Oral Complications of Systemic Bacterial and Fungal Infections; Dental and Periodontal Manifestations of Systemic Disease; Oral Complications of Dermatologic Disorders, and more!
Clinics Collections: Lipid Disorders draws from Elsevier’s robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, cardiologists, endocrinologists, pathologists, cardiologists, rheumatologists, and hepatologists, with practical clinical advice and insights on this highly prevalent condition and its comorbidities. Clinics Collections: Lipid Disorders guides readers on how to apply current primary research findings on lipid disorders to everyday practice to help overcome challenges and complications, keep up with new and improved treatment methods, and improve patient outcomes. • Areas of focus include lipids and biomarkers, lipids and pharmacotherapy, lipids and heart disease, lipids and chronic disease, lipids and pediatrics, lipids and women’s health and special considerations. • Each article begins with keywords and key points for immediate access to the most critical information. • Articles are presented in an easy-to-digest and concisely worded format. Elsevier’s Clinics Collections provide concise reviews of today’s most prevalent conditions and significant medical developments. Other Clinics Collections titles available include Type II Diabetes Mellitus, Asthma, Obesity, and Pain Management
How do calendars and clocks influence considerations of school effectiveness? From the creation of compulsory education to the future of virtual schooling, Weiss and Brown trace two centuries of school practices, policies and research linking the concept of time with ‘opportunity to learn’. School calendars and clocks are shaped by both the physical and social worlds, and the ‘clock of schooling’ is shown to be one of the ‘great clocks of society’ that helps to frame school effectiveness. School time does not operate in a vacuum, but within curriculum, teaching and learning situations. The phrase ‘chrono-curriculum’ was devised by the authors as a metaphor for exploring issues of school effectiveness within the time dimension. Using American and Canadian sources, stories are created to illustrate four themes about time and school effectiveness. The first three stories utilize access, attendance and testing as criteria associated with these eras of schooling. How will the story read in the fourth era, the digital age, which forces us to a reconsideration of time and its influence on education? Quoting David Berliner in his Foreword: “ this is an opportune time for these authors to bring us insights into the reasons we in North America created our public school systems, and how the chrono-curriculum influences those systems. The authors’ presentation of our educational past provides educators a chance to think anew about how we might do schooling in our own times.”
A philosophical challenge to the ableist conflation of disability and pain More than 2,000 years ago, Aristotle said: “let there be a law that no deformed child shall live.” This idea is alive and well today. During the past century, Supreme Court Justice Oliver Wendell Holmes Jr. argued that the United States can forcibly sterilize intellectually disabled women and philosopher Peter Singer argued for the right of parents to euthanize certain cognitively disabled infants. The Life Worth Living explores how and why such arguments persist by investigating the exclusion of and discrimination against disabled people across the history of Western moral philosophy. Joel Michael Reynolds argues that this history demonstrates a fundamental mischaracterization of the meaning of disability, thanks to the conflation of lived experiences of disability with those of pain and suffering. Building on decades of activism and scholarship in the field, Reynolds shows how longstanding views of disability are misguided and unjust, and he lays out a vision of what an anti-ableist moral future requires. The Life Worth Living is the first sustained examination of disability through the lens of the history of moral philosophy and phenomenology, and it demonstrates how lived experiences of disability demand a far richer account of human flourishing, embodiment, community, and politics in philosophical inquiry and beyond.
Pittsburgh’s explosive industrial and population growth between the mid-nineteenth century and the Great Depression required constant attention to city-building. Private, profit-oriented firms, often with government involvement, provided necessary transportation, energy resources, and suitable industrial and residential sites. Meeting these requirements in the region’s challenging hilly topographical and riverine environment resulted in the dramatic reshaping of the natural landscape. At the same time, the Pittsburgh region’s free market, private enterprise emphasis created socio-economic imbalances and badly polluted the air, water, and land. Industrial stagnation, temporarily interrupted by wars, and then followed deindustrialization inspired the formation of powerful public-private partnerships to address the region’s mounting infrastructural, economic, and social problems. The sixteen essays in Making Industrial Pittsburgh Modern examine important aspects of the modernizing efforts to make Pittsburgh and Southwestern Pennsylvania a successful metropolitan region. The city-building experiences continue to influence the region’s economic transformation, spatial structure, and life experience.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.