Guide to Cell Therapy GxP is a practical guide to the implementation of quality assurance systems for the successful performance of all cell-based clinical trials. The book covers all information that needs to be included in investigational medicinal product dossier (IMPD), the launching point for any clinical investigation, and beyond. Guide to Cell Therapy GxP bridges a knowledge gap with the inclusion of examples of design of GLP-compliant preclinical studies; design of bioprocesses for autologous/allogeneic therapies; and instruction on how to implement GLP/GMP standards in centers accredited with other quality assurance standards. Guide to Cell Therapy GxP is an essential resource for scientists and researchers in hospitals, transfusion centers, tissue banks, and other research institutes who may not be familiar with the good scientific practice regulations that were originally designed for product development in corporate environments. This book is also a thorough resource for PhD students, Post-docs, Principal Investigators, Quality Assurance Units, and Government Inspectors who want to learn more about how quality standards are implemented in public institutions developing cell-based products. - Easy access to important information on current regulations, state-of-the-art techniques, and recent advances otherwise scattered on various funding websites, within conference proceedings, or maintained in local knowledge - Features protocols, techniques for trouble-shooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data - Includes practical examples of successful implementation of quality standards
Available in English for the first time, Joaquim Amat-Piniella’s searing Catalan novel, K.L. Reich, is a central work of testimonial literature of the Nazi concentration camps. Begun immediately after Amat-Piniella’s liberation in 1945, the book is based on his own four-year internment at Mauthausen. “When the war is over, remember all this. Remember me,” implores one of the book’s characters on his deathbed, and it is this call to bear witness that Amat-Piniella takes up in his account of the Spanish Republican fighters who were exiled in France at the end of the Spanish Civil War in 1939 and soon swept up into the German concentration camp system. As an already organized anti-fascist army, they played an important role as a nucleus of resistance within the camps, and their story is little known to English-language readers. Because of the length of his internment, his decision to write his book as fiction, and his staggering powers of observation and recollection, Amat-Piniella’s portrayal of life in the camps is unmatched in scope and detail. It is also a compelling study of three powerful ideological movements at work at the time: anarchism, communism, and fascism, all within the desperate and brutal world of the camps. “My book does not seek to deepen wounds or differences, but to unite people before cruelty,” said Amat-Piniella. This is an essential text as we ponder the twentieth century and its meaning to us today. This edition includes a new preface, annotations, and a translators’ note.
Maintaining the health of pigs is vital in pig farming and production. This new book written by experts from around the world focuses on the health of pigs, first with coverage of the disorders of pigs organised by clinical sign and body system. The book explores environmental medicine and then health maintenance. Treatment options are discussed, emphasizing a reduction in antimicrobial use and an increased awareness of a holistic approach to treatment. The book includes over 1,500 high-quality illustrations to enhance the clinical description, as well as a wealth of high-quality videos to test the reader in making differential diagnoses with treatment options. Quizzes at the end of each section also encourage reflective learning. International experts from the UK, USA, Australia, Spain and Taiwan cover clinical examination of the individual pig and groups along with environmental medicine, making this the ideal reference for veterinary practitioners and students. Those interested in population medicine (poultry, aquaculture, cattle and small ruminant and apiaries) will particularly enjoy the holistic approach to veterinary medicine. All those who appreciate the many talents of pigs will enjoy the practical approach to managing the health of their animals. This book moves veterinary science forward, promoting health rather than treating disease. It will be your number one reference for keeping your pigs healthy.
This book offers an essential guide to Public Finance and National Accounts in the context of the European Union. Since the creation of the Eurozone, fiscal policy has been at the heart of economic (but also political/media) discussions in the EU. From the Stability and Growth Pact (1997) to the more recent Fiscal Treaty, EU and Eurozone, countries have been subject to various fiscal rules. The importance of these rules, and of the subsequent procedures that every Eurozone country has to adhere to, is unquestionable. The book provides the reader with an in-depth understanding of the complex EU rules concerning fiscal policy, breaking down the corresponding legal texts into simple and accessible language. It has a broad interdisciplinary appeal, and scholars and practitioners whose work involves these areas will find it of particular interest.
Guide to Cell Therapy GxP is a practical guide to the implementation of quality assurance systems for the successful performance of all cell-based clinical trials. The book covers all information that needs to be included in investigational medicinal product dossier (IMPD), the launching point for any clinical investigation, and beyond. Guide to Cell Therapy GxP bridges a knowledge gap with the inclusion of examples of design of GLP-compliant preclinical studies; design of bioprocesses for autologous/allogeneic therapies; and instruction on how to implement GLP/GMP standards in centers accredited with other quality assurance standards. Guide to Cell Therapy GxP is an essential resource for scientists and researchers in hospitals, transfusion centers, tissue banks, and other research institutes who may not be familiar with the good scientific practice regulations that were originally designed for product development in corporate environments. This book is also a thorough resource for PhD students, Post-docs, Principal Investigators, Quality Assurance Units, and Government Inspectors who want to learn more about how quality standards are implemented in public institutions developing cell-based products. - Easy access to important information on current regulations, state-of-the-art techniques, and recent advances otherwise scattered on various funding websites, within conference proceedings, or maintained in local knowledge - Features protocols, techniques for trouble-shooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data - Includes practical examples of successful implementation of quality standards
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