Research on muscarinic receptors is advancing at an extraordinary rate. Ten years ago, the existence of muscarinic receptor sub types was a logical assumption with only scattered experimen tal support. The discovery that pirenzepine recognized apparent heterogeneity in muscarinic binding sites infused new life into the problem of subclassifying muscarinic receptors. Simultaneous advances in molecular biology created a frenzy to clone cell sur face receptors. The muscarinic receptor succumbed surprisingly quickly, revealing its structure and that of at least four closely related gene products within a year. Our hope of obtaining clear evidence for muscarinic receptor subtypes was answered with a vengeance. Now a family of muscarinic receptors sits before us, asking to be understood. The bounty is as attractive to those who have not previously studied muscarinic receptors as to those who have dedicated their research careers to this subject. The goal of this book is to ensure that the new generation of research will profit from the wisdom of the past. The tools of molecular biology are well suited to the tasks of characteriz ing the pharmacology, function, and regulation of the distinct muscarinic receptor subtypes. However, efficient and intelligent use of these tools is not possible, unless one understands the properties of the receptor, the molecular mechanisms by which it couples to effectors, and the ways that it is regulated.
A "hen frigate," traditionally, was any ship with the captain's wife on board. Hen frigates were miniature worlds -- wildly colorful, romantic, and dangerous. Here are the dramatic, true stories of what the remarkable women on board these vessels encountered on their often amazing voyages: romantic moonlit nights on deck, debilitating seasickness, terrifying skirmishes with pirates, disease-bearing rats, and cockroaches as big as a man's slipper. And all of that while living with the constant fear of gales, hurricanes, typhoons, collisions, and fire at sea. Interweaving first-person accounts from letters and journals in and around the lyrical narrative of a sea journey, maritime historian Joan Druett brings life to these stories. We can almost feel for ourselves the fear, pain, anger, love, and heartbreak of these courageous women. Lavishly illustrated, this breathtaking book transports us to the golden age of sail.
The author evaluates critiques of the concept of mental illness and of the way its expanding boundaries now define a far wider range of mental states, experiences and activities as pathological. Arguing that these boundaries need to be restricted, the author contends that many of the phenomena identified as mental illness are normal reactions to life's difficulties and that, while individuals may need support, it is not appropriate or helpful for such phenomena to be treated as indicative of mental disorder. Other important topics covered include the way mental illness is measured, its distribution across populations and over time, and the different types of care provided for those with identified mental illness.
Brigadier Warrington thinks of himself as a well-moneyed playboy. His main wish is to please his son Tom, but his main desire is unsuitable women. This time it's Irma, a mysterious adventuress, unfortunately married to a certain militant Herr Gantzenhausen. When Tom arrives at his father's villa at Trigoso he takes an immediate dislike to Irma. Then there's the threatened appearance of her husband that hangs like thunder round the villa and reduces its inhabitants to a state of siege. The murder comes almost as a relief ... 'One of the funniest moments of truth in recent fiction' Financial Times
Designed to help teachers meet the diverse needs of young children, this book offers differentiated strategies for promoting intellectual discovery and creative thinking across key disciplines.
The contents of this book cover what a Canon is and why it matters, the Canon backstory, modern Canons, factors that make a work Canonical, the literary Canon, and much more.
Working with thousands of previously unreleased documents and drawing on more than one thousand interviews, with many witnesses speaking out for the first time, Joan Mellen revisits the investigation of New Orleans district attorney Jim Garrison, the only public official to have indicted, in 1969, a suspect in President John F. Kennedy’s murder. Garrison began by exposing the contradictions in the Warren Report, which concluded that Lee Harvey Oswald was an unstable pro-Castro Marxist who acted alone in killing Kennedy. A Farewell to Justice reveals that Oswald, no Marxist, was in fact working with both the FBI and the CIA, as well as with US Customs, and that the attempts to sabotage Garrison’s investigation reached the highest levels of the US government. Garrison’s suspects included CIA-sponsored soldiers of fortune enlisted in assassination attempts against Fidel Castro, an anti-Castro Cuban asset, and a young runner for the conspirators, interviewed here for the first time by the author. Building upon Garrison’s effort, Mellen uncovers decisive new evidence and clearly establishes the intelligence agencies’ roles in both a president’s assassination and its cover-up. In this revised edition, to be published in time for the fiftieth anniversary of the president’s assassination, the author reveals new sources and recently uncovered documents confirming in greater detail just how involved the CIA was in the events of November 22, 1963. More than one hundred new pages add critical evidence and information into one of the most significant events in human history.
Critical Sociolinguistic Research Methods is a guide to conducting concrete ethnographic and discourse analytic research projects, written by top scholars for students and researchers in social science fields. Adopting a critical perspective focusing on the role of language in the construction of social difference and social inequality, the authors walk the reader through five key moments in the life of a research project: composing research questions, designing the project, doing fieldwork, performing data analysis and writing academic texts or otherwise engaging in conversation with different types of social actors about the project. These moments are illustrated by colour-coded examples from the authors’ experiences that help researchers and students follow the sequential stages of a project. Now in its second edition, this popular and original text has been revised and updated to reflect the latest developments in this field, including expanded sections on the centrality of the ethnographic gaze for the understanding of social processes, and on experiences of diversification in the communication of research results. Through the adoption of multimodal genres, authors share recent experiences of research presentations addressed to non-academic audiences, such as installations and photography, and interactive maps. Clear and highly applicable, with a detailed workbook full of practical tips and examples, this book is a great resource for graduate-level qualitative methods courses in linguistics and anthropology, as well as methods courses in the humanities and social sciences that focus on the role of language in research. It is a timely text for investigating language issues that matter and have consequences for people’s lives.
Step-by-Step Skill-Builders for Your Classroom. make reading and writing more meaningful to children, with author studies! This photo-filled guide supports you through every step in the process: choosing author, nurturing independent readers, celebrating writers with innovative projects, setting up author visits, assessment, and more.
These proven, practical early childhood teaching strategies and techniques help teachers identify young gifted children, differentiate and extend the curriculum, assess and document students’ development, and build partnerships with parents. Individual chapters focus on early identification, curriculum compacting, social studies, language arts, math and science, cluster grouping, social-emotional development, and finding and supporting giftedness in diverse populations. The text includes current information on brain research and learning; rigor and complexity; and integrating creativity, the arts, and higher-level thinking in accordance with learning goals. Scenarios and vignettes take readers into teachers’ classrooms. The book includes extensive references and resources to explore. Digital content includes customizable forms from the book.
This ambitious and long-awaited volume brings together foremost nursing scholars, researchers, and educators to review and critique the state of research across areas most relevant to clinical practice. The contributorship appears as a veritable "who′s who" of nursing research and the contents comprise primary areas in the vanguard of nursing science. In the first section, the authors explore theoretical issues, the variety of philosophical approaches to scientific inquiry in nursing, factors shaping nursing research, and the relationship of the philosophical perspectives to research methodologies. In later sections, the scientists review and analyze the state of nursing science in relation to community health, practice strategies, family care, health promotion, biobehavioral investigations, women′s health, gerontologic nursing, and health system perspectives and outcomes. For physiological as well as psychological research, the most relevant theories driving the research are presented along with the review of multiple diverse instruments and measurement issues. Comprehensive in scope, cogent and truly thought provoking, a book such as the Handbook of Clinical Nursing Research arrives only once or twice in a career. It is a must-have shelf reference for every nurse and for those who would teach them.
In this book, Joan Hoffman examines the watershed collaboration from an economic perspective as well as the possibility of alternative means of water protection such as regulation. The case is examined in the light of similar collaborations elsewhere in the world.
This is the most respected and authoritative college textbook available on human sexuality. Written in a direct, non-judgmental manner, this edition of OUR SEXUALITY has been thoroughly and carefully updated to reflect the most current research findings. It is the first college text to bring cutting-edge and in-depth emphasis on the impact of politics on sexuality. Crooks and Baur keep you interested with the most exciting, emerging research and coverage, and focus on strengthening healthy communication among partners. The authors also have revised their overall coverage on maintaining a responsible and healthy sexual relationship, with greater attention to diversity and inclusiveness. Available with InfoTrac Student Collections http://gocengage.com/infotrac.
The 43 million people with disabilities form this country's largest minority group, yet they are markedly under-employed as educators. Enhancing Diversity: Educators with Disabilities paves the way for correcting this costly omission. Editors Anderson, Karp, and Keller have called upon the knowledge of 19 other renowned contributors to address the important issues raised in Enhancing Diversity, including the place of disability in discussions of diversity in education, research on educators with disabilities that validates their capabilities, and information on the qualifications desired in and the demands made of education professionals. Legal precedents are cited and explained, and examples of efforts to place disabled educators are presented, along with recommendations on how disabled individuals and school administrators can work toward increased opportunities. Interviews with 25 disabled educators discussing how they satisfactorily fulfill their professional requirements completes this thoughtful-provoking book.
Little Athena finds herself on a Wizard of Oz inspired adventure in this first Little Goddess Girls story—part of the Aladdin QUIX line! After a strange and sparkly storm carries her away from home, Athena finds herself in a land filled with magic, talking animals, and incredible objects with magical powers—the land of Mount Olympus! When Athena arrives, she’s greeted by the talking Owlies and is paired with very special magical sandals—sandals with powers that Medusa, a green, snake-haired girl, wants for herself! A glowing goddess (of hearth and home) named Hestia appears and warns Athena that if Medusa gets her snakes on those sandals, she’ll surely use its powers to make trouble for Mount Olympus! But Athena has more important things on her mind—like going back home! Determined to find her way back, Athena heads off on an adventure through the magical landscape of Mount Olympus to try and elude Medusa—and find her way back to the mortal world once and for all with the help of the great and powerful Zeus!
Best known for its conceptual approach to nursing practice, Conceptual Foundations: The Bridge to Professional Nursing Practice, 6th Edition gives you the foundation you need to prepare for your role as a professional nurse. Expert educators Elizabeth E. Friberg and Joan L. Creasia bring together the best minds of nursing for a unique in-depth look at the profession's major theories, practices, and principles. Complete with three all-new chapters and updated content throughout, this expanded sixth edition challenges you to think critically and conceptually. In addition, new Evolve resources mean you can do more online than ever before. Critical thinking exercises at the end of each chapter help you use and apply what you have learned. Case studies throughout the text provide you with opportunities to develop your analytical skills. Objectives at the beginning of each chapter provide a framework for study. Profile in Practice scenarios at the beginning of each chapter introduce real-life situations that accompany the professional behaviors covered in the text. Key points at the end of each chapter reinforce learning objectives and help you focus on important information. NEW! Three all-new chapters bring you the latest information on telehealth in nursing practice, information management, and global rural nursing practice. UPDATED! Integrated and updated information on Health Care Reform Initiatives. UPDATED! Health Policy and Practice and the Nursing Practice Environment chapter features new content on the 2010 Affordable Health Care Act. UPDATED! 2010 Institute of Medicine (IOM) Future of Nursing (FOM) recommendations discussed in Beyond Professional Socialization chapter. UPDATED! Patient Safety chapter offers expanded coverage of QSEN competencies, including Nursing Quality Indicators. UPDATED! Health and Health Promotion chapter now covers the Healthy People 2020 and 2020 National Health Promotion Initiative. UPDATED! Concept of "group think" added to Think Like a Nurse: Essential Thinking Skills for Professional Nurses chapter. UPDATED! Legal Aspects of Nursing Practice chapter features the most up-to-date content on delegation, transferring authority, responsibility, accountability, nurse fatigue, criminalization of unintentional errors, use and abuse of social media and lateral violence.
Luchino Visconti (1906-1976) was one of Europe's most prestigious filmmakers, who rose to prominence as part of the Italian neo-realist movement, alongside contemporaries Vittorio De Sica and Roberto Rossellini. Famous for his elegant lifestyle, as friend of Jean Renoir and Coco Chanel amongst others, his vibrant technicolour dramas are also known for their decadence and stunning display of aesthetic mastery and sensory pleasure. Looking beyond this colourful façade, however, Resina explores the philosophical implications of decadence with a particular focus on three films from the late phase in Visconti's production, Damned (1969), Death in Venice (1971), and Ludwig (1972). From the incestuous relationship between decadence and power to decadence as an outcome of straining toward formal perfection, Resina uncovers the unity and philosophical cohesiveness of these films that deal with different subjects and historical periods. Reading these films and their decadence in light of the time of filming and Visconti's own sense of cultural doom, Resina further demonstrates the relevance of Visconti's philosophy today and how much they still have to say to our contemporary situation.
Sculpture Off the Pedestal is a behind-the-scenes look at the creative process of 25 leading sculptors from the Renaissance to the present through their own words or those who knew them. Aiming to avoid dry-as-dust art histories, Sculpture Off the Pedestal puts old and modern master sculptors by the reader's side, emptying their heads about their work and their ways of thinking. The book is intended not only for the art student or art lover, but also for the untutored and those who think of art as a remote subject. Most art histories focus on painting. Chronicling the lives of sculptors in and out of their studios fills a gap.
Joseph W. Young, Jr., was acknowledged as one of the five or six major city builders in boomtime Florida. From practically nothing in 1920 he created Hollywood By-the-Sea with an elegant Beaux Arts plan of circles and lakes, calling it a "City Beautiful," an ideal first propounded by Daniel Burnham of Chicago. Young had a rare talent for publicity and a knack for making and spending millions--supported by an immense personal charm that is still remembered decades after his death. This first full biography of Young covers his start as city builder in turn-of-the-century California where new cities blossomed and were ballyhooed, his move to Indianapolis, home of Carl Fisher who developed Miami Beach, his creation of Hollywood and Port Everglades, and his move to his Adirondack resort, ending with his dreams to expand Hollywood, fulfilled after his early death.
Covering the activities of the GEC Research Laboratories from 1919 until their end in 1984, this book includes sections on the original organisation and philosophy behind the laboratories, a decade by decade summary of the work, and specialist chapters focussing on such areas as lamps and lighting, valves, communications and semiconductors.
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