Cryo-EM, as it is currently practiced in many laboratories, is limited to the visualization of molecules that are in thermal equilibrium at the time before freezing. A further limitation is that the existing software does not fully exploit the information that is contained in the images of large ensembles of molecules in thermal equilibrium. This book is a collection of recent articles by the author, reprinted with introductions, and they mainly describe two novel methods in cryo-EM, one computational and the other experimental that requires the use of a microfluidic device. Both methods have the capacity to shed light on the dynamic behavior of biomolecules. Combined, they greatly expand the range of applications of cryo-EM. The book describes a successful approach in which, based on cryo-EM data, all states visited by the molecule in thermal equilibrium are mapped by manifold embedding—a method of geometric machine learning—and the energy landscape of the molecule is derived. It also discusses methods and biological results of time-resolved cryo-EM, following a reaction in a non-equilibrium system over a short period of time and resulting in the capture of short-lived states that have been inaccessible by standard methods of cryo-EM.
Crystal growth far from thermodynamic equilibrium is nothing but homoepitaxy - thin film growth on a crystalline substrate of the same material. Because of the absence of misfit effects, homoepitaxy is an ideal playground to study growth kinetics in its pure form. Despite its conceptual simplicity, homoepitaxy gives rise to a wide range of patterns. This book explains the formation of such patterns in terms of elementary atomic processes, using the well-studied Pt/Pt(111) system as a reference point and a large number of Scanning Tunneling Microscopy images for visualization. Topics include surface diffusion, nucleation theory, island shapes, mound formation and coarsening, and layer-by-layer growth. A separate chapter is dedicated to describing the main experimental and theoretical methods.
The success of diagnostic knowledge systems has been proved over the last decades. Nowadays, intelligent systems are embedded in machines within various domains or are used in interaction with a user for solving problems. However, the development of a knowledge system is still a critical issue. Similarly to projects dealing with customized software at a highly innovative level a precise specification often cannot be given in advance. Moreover, necessary requirements of the knowledge system can be defined not until the project has been started or are changing during the development phase. This thesis motivates that classical, document-centered approaches cannot be applied in such a setting. We introduce an agile process model for developing diagnostic knowledge systems, mainly inspired by the ideas of the eXtreme Programming methodology known in software engineering. The engineering process is supported at a primary level by the introduction of knowledge containers, that define an organized view of knowledge contained in the system. The actual knowledge is acquired and formalized right from start, and the integration to runnable knowledge systems is done continuously in order to allow for an early and concrete feedback. The validity and maintainability of the collected knowledge is ensured by appropriate test methods and restructuring techniques, respectively. Additionally, we propose learning methods to support the knowledge acquisition process sufficiently. The process model and its activities are evaluated in two real life applications: in a medical and in an environmental project the benefits of the agile development are clearly demonstrated.
France and Germany have played a pivotal role in European politics and integration. Shaping Europe systematically investigates the interrelated reality of Franco-German bilateralism and multilateral European integration from the Elysée Treaty into the Twenty-first Century.
In this concise but stimulating book on history and Greek culture, Hans-Joachim Gehrke continues to refine his work on 'intentional history', which he defines as a history in the self-understanding of social groups and communities – connected to a corresponding understanding of the other – which is important, even essential, for the collective identity, social cohesion, political behaviour and the cultural orientation of such units. In a series of four chapters Gehrke illustrates how Greeks' histories were consciously employed to help shape political and social realities. In particular, he argues that poets were initially the masters of the past and that this dominance of the aesthetic in the view of the past led to an indissoluble amalgamation of myth and history and lasting tension between poetry and truth in the genre of historiography. The book reveals a more sophisticated picture of Greek historiography, its intellectual foundations, and its wider social-political contexts.
The 21st edition of this standard reference book – now published in English for the first time – provides indispensable, hands-on information for the delivery room, as well as before and after childbirth. The book combines proven facts and techniques with new insights through a consistent focus on practical and applied knowledge. All of those involved in the care of pregnant, laboring, and postnatal women and newborn can benefit from the established didactic concept of this book.
Voltaire's description of the Holy Roman Empire as 'neither holy, nor Roman, nor an empire' is often cited to underline its worthlessness. German historians traditionally despised it because it had allegedly impeded German unification. Since 1945 scholars have been more positive but the empire's history and significance is still largely misunderstood. In this Very Short Introduction Joachim Whaley outlines the fascinating thousand-year history of the Holy Roman Empire. Founded in 800 on the basis of Charlemagne's Frankish kingdom, its imperial title went to the German monarchy which became established in the ninth and ten centuries. They claimed Charlemagne's legacy, including his role as protector of the papacy and guardian of the Church. Around 1500 the title Holy Roman Empire of the German Nation was adopted. An elective monarchy, the empire gradually developed from a feudal monarchy into a legal system that pacified the territories and cities of German-speaking Europe. By 1519 it had a supreme court and a regional enforcement system ended feuding. Throughout its lifetime, the empire's growth and history was shaped by the major developments in Europe, from the Reformation, to the Thirty Years War, to the French revolutionary wars, which led to Napoleon destroying the empire in 1806. The sense of a common history over a thousand years and the legal traditions established by the empire have shaped the history of German-speaking Europe ever since. Joachim Whaley analyses the empire's crucial impact and role in the history of European power and politics, and shows that there has never been a more durable political system in German history. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Proteins interacting with diverse ligands - proteins, peptides or DNA - are the basic principles underlying many biological processes, such as antigen-antibody binding, signal transduction or receptor binding. The technique of oligopeptide synthesis on a cellulose membrane and the subsequent binding assays allow the investigation of protein interactions. A particular advantage of these peptide arrays (SPOT - technology) is the high number of oligopeptide probes that can be tested in parallel. Detailed protocols for peptide synthesis, and the analysis of protein-protein, protein-DNA interactions as well as epitope mapping are presented in this manual. It is ideally suited not only for basic research laboratories but also for diagnostic and therapeutic applications since many diseases are related to dysfunctions in protein recognition and binding.
The only listing of historic persons and birth, deaths and affiliations for western Canadian native peoples and fur trade workers for the Fur Trade eras of 1600 to 1900.
“The best single volume available on the torturous life and savage reign of Adolf Hitler.” —Time A bestseller in its original German edition and subsequently translated into more than a dozen languages, Joachim Fest’s Hitler has become a classic portrait of a man, a nation, and an era. Fest tells and interprets the extraordinary story of a man’s and nation’s rise from impotence to absolute power, as Germany and Hitler, from shared premises, entered into their covenant. He shows Hitler exploiting the resentments of the shaken, post–World War I social order and seeing through all that was hollow behind the appearance of power, at home and abroad. Fest reveals the singularly penetrating politician, hypnotizing Germans and outsiders alike with the scope of his projects and the theatricality of their presentation. Perhaps most importantly, he also brilliantly uncovers the destructive personality that aimed for and achieved devastation on an unprecedented scale. As history and biography, this is a towering achievement, a compelling story told in a way only a German could tell it: “dispassionately, but from the inside” (Time).
The only existant listing of historic Fur Trade and aboriginal personages with births, deaths and affiliations for western Canada and adjacent areasfrom 1600-1900.
The Allied invasion of Normandy on June 6, 1944, marked a critical turning point in the European theater of World War II. The massive landing on France's coast had been meticulously planned for three years, and the Allies anticipated a quick and decisive defeat of the German forces. Many of the planners were surprised, however, by the length of time it ultimately took to defeat the Germans. While much has been written about D-day, very little has been written about the crucial period from August to September, immediately after the invasion. In Rückzug, Joachim Ludewig draws on military records from both sides to show that a quick defeat of the Germans was hindered by excessive caution and a lack of strategic boldness on the part of the Allies, as well as by the Germans' tactical skill and energy. This intriguing study, translated from German, not only examines a significant and often overlooked phase of the war, but also offers a valuable account of the conflict from the perspective of the German forces.
A comprehensive compilation of the previously untold aboriginal history of the Central Alberta/Red Deer area from the Ice Age to recent times.Includes a 50 page listing of known residents from before 1880, and a look into the little-known deglaciation sequence and history of the area. 456 pages.
For fifty years The Jazz Book has been the most encyclopedic interpretive history of jazz available in one volume. In this new seventh edition, each chapter has been completely revised and expanded to incorporate the dominant styles and musicians since the book’s last publication in 1992, as well as the fruits of current research about earlier periods in the history of jazz. In addition, new chapters have been added on John Zorn, jazz in the 1990s and beyond, samplers, the tuba, the harmonica, non-Western instruments, postmodernist and repertory big bands, how the avant-garde has explored tradition, and many other subjects. With a widespread resurgence of interest in jazz, The Jazz Book will continue well into the 21st century to fill the need for information about an art form widely regarded as America’s greatest contribution to the world’s musical culture.
A practical handbook for the planning and construction of all forms of apertures and openings, from doors to skylights, from the first design idea to the final details, ideal for quick and targeted consultation.
The first comprehensive, encyclopaedic work devoted exclusively to every Jewish contributor, large and small, to Major League Baseball. Its packed with: Rare photographs of players on and off the field; Full player statistics; Rare memorabilia; Exclusive original interviews. Jews who impacted upon the Great American Pastime extend far beyond the record strikeouts and round trippers of the legendary Sandy Koufax and Hank Greenberg. And there are scores of ballplayers like Lipman Pike, Shawn Green, Cal Abrams and Eddie Zosky whose little-known Baseball stories will touch or amuse readers of any background. Beyond life-time batting averages, there are intriguing players like catcher Moe Berg who served his country as a secret agent during WWII. While the tragic life of Bruce Gardner may bring tears to readers eyes, the exploits of 'Clown Princes' Al Schact and Max Patkin will have fans rolling with laughter. Nowhere else will one read tributes to great Jewish baseball executives and owners whose vision built some of historys most successful teams. Al Rosen may have gone from the All-Star team to the front-office Hall of Fame, but some of the most famous self-made success stories of this century honed their competitive spirit on the stickball courts of Jewish ghettos. This one-of-a-kind book will be much-in-demand by both baseball and Judaica book buyers.
In Poetry and Memory in Karaite Prayer Joachim Yeshaya offers an edition of liturgical poems which the Karaite poet Moses Darʿī composed in twelfth-century Egypt as introductory poems for the Torah readings on each Sabbath. The Hebrew text and Judaeo-Arabic heading of each poem are provided in the original order attested in the manuscript NLR Evr. I 802, dated to the fifteenth century. Every poem comes with a commentary section consisting of English commentary essays and bilingual (Hebrew / English) line-by-line annotations. In the conclusion following this edition, Joachim Yeshaya demonstrates how Darʿī’s liturgical poems are among the earliest examples of the introduction of poetry, Andalusian Rabbanite poetical norms, and the “memory” of being exiled from Jerusalem into Karaite prayer.
This book will make you a perfume insider. Discover the effects, trends and future of perfume. Perfumery is on the verge of its third revolution, neuroperfumery, due to new methods of brain research and current findings in fragrance psychology. With this exciting and well-written book, you will gain a comprehensive insight into the creation, world and practice of modern perfumery, as well as interesting insider information. Current findings in psychology, aromatherapy, brain research and neuroperfumery on the effects of fragrances make Beautiful SCENT a treasure trove of new insights. As a non-fiction book with an advice component, it is easy to read without prior knowledge and provides many practical tips. Among other things, you will learn that some perfumes can do much more than just smell good, how perfumers and marketers create their perfumes, which scent preferences prevail and how the effect of scent can specifically influence one's own experience and enjoyment of life. Target groups All those who love perfumes and fragrances and would like to learn more about the magical effect of perfumes on well-being and perhaps play with the idea of creating their own perfume one day. It is also ideal for those who work in the fragrance, cosmetics and beauty industry and would like to refresh their knowledge of perfumes. About the author Dr. Joachim Mensing is a qualified psychologist, sociologist and trained nose with over 30 years of professional experience in perfumery and fragrance therapy. At one of the largest fragrance manufacturers, he became a trend coach for perfumers and developed methods of perfume development and marketing. Many of the perfumes he worked on received coveted awards such as the Fifi Award, the Oscar for perfumes. He himself received the honorary award of the FRAGRANCE FOUNDATION for the development and marketing of the perfumes Cool Water by Davidoff, Joop! and Jil Sander, and he was also recognized for studies in neuroperfumery and neuropsychology.
This book is the first major study of the history of environmentalism, from its origins in romanticism and the nature cults of the late 18th century to the global environmental movements of today. Radkau shows that this is not a single story of the steady ascent of environmentalism but rather a multiplicity of stories, each with its own dramatic tension: between single-issue movements and the challenges posed by the interconnection of environmental issues, between charismatic leaders and bureaucratic organizations, and between grassroot movements and global players. While the history can be traced back several centuries, environmentalism has flourished since the ‘environmental revolution’ of 1970, spurred on by the Chernobyl nuclear disaster in 1986 and the growing concern about global warming. While environmentalists often opposed the scientific mainstream, they were also often led by scientific knowledge. Environmentalism is the true Enlightenment of our time Ð so much so that we can call our era ‘the age of ecology’. This timely and comprehensive global history of environmentalism will be essential reading for anyone concerned with the most pressing global issues of our time.
In the first single-author account of German history from the Reformation to the early nineteenth century since Hajo Holborn's study written in the 1950s, Dr Whaley provides a full account of the history of the Holy Roman Empire. Volume II extends from the Peace of Westphalia to the Dissolution of the Reich.
When the former allies of World War II divided Germany into two provisional states, no one would have predicted that this would last for nearly half a century. Nor could anyone have predicted that sixty years later, Germany would have shaken off its Nazi past so thoroughly as to emerge as a key player in Western politics.Gert-Joachim Glaessner explains this historic transformation and provides an in-depth introduction to the German political system, its foundations and developments since 1949. Themes covered include the development of the FDR and GDR during the Cold War, the politics of Westernization, the controversies of West Germany's role in NATO and European integration. The author also examines parliamentary institutions, the role of the German Chancellor, party structure and organized interest groups. The book includes reference material from key documents, such as the German Constitution.Demonstrating how Germany went from political pariah to a model of modern liberal democracy, Glaessner offers a concise overview of the German political system in the post-war period.
In the last two decades remarkable progress has been made in understanding and describing tunneling processes in complex systems in terms of classical trajectories. This book introduces recent concepts and achievements. There is particular emphasis on a dynamical formulation and relations to specific systems in mesoscopic, molecular, atomic and nuclear physics.
Learning How to Feel explores the ways in which children and adolescents learn not just how to express emotions that are thought to be pre-existing, but actually how to feel. The volume assumes that the embryonic ability to feel unfolds through a complex dialogue with the social and cultural environment and specifically through reading material. The fundamental formation takes place in childhood and youth. A multi-authored historical monograph, Learning How to Feel uses children's literature and advice manuals to access the training practices and learning processes for a wide range of emotions in the modern age, circa 1870-1970. The study takes an international approach, covering a broad array of social, cultural, and political milieus in Britain, Germany, India, Russia, France, Canada, and the United States. Learning How to Feel places multidirectional learning processes at the centre of the discussion, through the concept of practical knowledge. The book innovatively draws a framework for broad historical change during the course of the period. Emotional interaction between adult and child gave way to a focus on emotional interactions among children, while gender categories became less distinct. Children were increasingly taught to take responsibility for their own emotional development, to find 'authenticity' for themselves. In the context of changing social, political, cultural, and gender agendas, the building of nations, subjects and citizens, and the forging of moral and religious values, Learning How to Feel demonstrates how children were provided with emotional learning tools through their reading matter to navigate their emotional lives.
The Nazi Years brings together documents that tell the whole essential story of National Socialism, from its obscure ideological beginnings to its seizure of power to the exercise of that power in Germany and abroadto the bitter end of the Third Reich. Historian Joachim Remak has collected, and has introduced with illuminating commentaries, key letters, speeches, memoirs, political tracts, secret memos and tabulationswritten by the actors, victims, or simple witnesses of the time. Here is the fanatical enthusiasm of dedicated Nazis as revealed in their own writingsa catalog of anti-Semitism and propaganda, volkisch idealism and pan-Germanism, ideas of natural selection and race eugenics. Here too is the history of sincere but ill-fated resistance to Nazism by church people and plain citizens, of the anti-Nazi underground, and of Count von Stauffenbergs plot to assassinate Hitler. Now available from Waveland Press, these vivid accounts by Germans at every level of society and of every political and moral persuasion provide a shattering view of one of the most terrible, tempestuous periods of modern history.
How do engineering materials deform when bearing mechanical loads? To answer this crucial question, the book bridges the gap between continuum mechanics and materials science. The different kinds of material deformation are explained in detail. The book also discusses the physical processes occurring during the deformation of all classes of engineering materials and shows how these materials can be strengthened to meet the design requirements. It provides the knowledge needed in selecting the appropriate engineering material for a certain design problem. This book is both a valuable textbook and a useful reference for graduate students and practising engineers.
Includes terms from: health care administration, public health & epidemiology, government regulation, ethics & patient empowerment, finance & reimbursement, medical staff organization, clinical medicine & nursing, science, research & technology, law & legislation, and healthy communities movement.
In this book, the business of international freight forwarding is examined from both a theoretical and empirical point of view with a special emphasis on multimodal transport chains, including sea or air transport operations. In such contexts, the freight forwarder is always considered "The Architect of Transport", but this intermediary role seems to be largely neglected in research to date. Therefore, relevant concepts from economic theory and economic sociology are employed to produce both an intermediary and a network perspective of freight forwarding in order to provide a better understanding of this kind of transportation business. Furthermore, its intermediary role in such inherent network structures is explored by mapping relationship patterns in a stylized model framework applied to a questionnaire-based sample collected among freight forwarders engaged in such multimodal transport chains in Germany (especially from Hamburg, Bremen and Bremerhaven) as well as in Austria in 2003.
Concepts and research approach; A record of drought and famine in Ethiopia; Household responses to drought and famine; Agricultural constraints: conflict, policy, and drought; Prices and markets during famine; Public intervention during famine.
Ötzi the iceman could not do without wood when he was climbing his Alpine glacier, nor could medieval cathedral-builders or today's construction companies. From time immemorial, the skill of the human hand has developed by working wood, so much so that we might say that the handling of wood is a basic element in the history of the human body. The fear of a future wood famine became a panic in the 18th century and sparked the beginnings of modern environmentalism. This book traces the cultural history of wood and offers a highly original account of the connection between the raw material and the human beings who benefit from it. Even more, it shows that wood can provide a key for a better understanding of history, of the pecularities as well as the varieties of cultures, of a co-evolution of nature and culture, and even of the rise and fall of great powers. Beginning with Stone Age hunters, it follows the twists and turns of the story through the Middle Ages and the Industrial Revolution to the global society of the twenty-first century, in which wood is undergoing a varied and unexpected renaissance. Radkau is sceptical of claims that wood is about to disappear, arguing that such claims are self-serving arguments promoted by interest groups to secure cheaper access to, and control over, wood resources. The whole forest and timber industry often strikes the outsider as a world unto itself, a hermetically sealed black box, but when we lift the lid on this box, as Radkau does here, we will be surprised by what we find within. Wide-ranging and accessible, this rich historical analysis of one of our most cherished natural resources will find a wide readership.
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