Discover the Carolinas and Georgia with Moon Travel Guides From humming bluegrass and rolling mountains, to lazy beach towns and buzzing cities, get to know the heart of the South with Moon Carolinas & Georgia. Strategic itineraries for every timeline and budget, designed for road-trippers, history buffs, beach bums, hikers, and more Activities and ideas for every traveler: Drive past mountains and waterfalls on a Blue Ridge Parkway road trip, or go camping in the Smokies. Stroll the winding streets of historic Charleston, or admire antebellum architecture in Savannah. Watch the sun set over the boardwalk at Myrtle Beach, or relax on remote stretches of the Outer Banks. Set a tee time in Hilton Head, or bar-hop through downtown Atlanta. Visit celebrated Civil Rights landmarks, or tour the illuminating remnants of the Civil War. Catch a live bluegrass show while savoring a local brew, and find the local best spots for finger-lickin good barbecue Firsthand perspective from Savannah local and regional expert Jim Morekis Honest advice on when to go, where to stay, and how to get around Full-color photos and detailed, easy-to-use maps for navigating the three states independently Detailed and thorough information, including crucial background on culture and history, geography, and regional vernacular With Moon Carolinas & Georgia's practical tips, myriad activities, and local insight on the best things to do and see, you can plan your trip your way. Diving deeper into the cities? Try Moon Charleston & Savannah. Hitting the road? Check out Moon Blue Ridge Parkway Road Trip.
That "kindly old investigator," Mr. Keen, sought missing persons and unraveled crimes longer than any other fictional detective ever heard or seen on the air. For 18 years (1937-1955) and 1690 nationwide broadcasts, Keen and his faithful assistant Mike Clancy kept listeners coming back for more. The nearest competitor, Nick Carter, Master Detective, ran for 726 broadcasts. This definitive history recounts the actors and creators behind the series, the changes the show underwent, and the development of the Mr. Keen character. A complete episode guide details all of the program's 1,690 broadcasts.
The new mobilities paradigm has yet to have the same impact on archaeology as it has in other disciplines in the social sciences - on geography, sociology and anthropology in particular - yet mobility is fundamental to archaeology: all people move. Moving away from archaeology’s traditional focus upon place or location, this volume treats mobility as a central theme in archaeology. The chapters are wide-ranging and methodological as well as theoretical, focusing on the flows of people, ideas, objects and information in the past; they also focus on archaeology’s distinctiveness. Drawing on a wealth of archaeological evidence for movement, from paths, monuments, rock art and boats, to skeletal and DNA evidence, Past Mobilities presents research from a range of examples from around the world to explore the relationship between archaeology and movement, thus adding an archaeological voice to the broader mobilities discussion. As such, it will be of interest not only to archaeologists and historians, but also to sociologists, geographers and anthropologists.
In the early days of radio, producers, directors and scriptwriters were well aware of the listening public's fascination with subject matter tinged with wrongdoing. Stories of right and wrong, crime and punishment, and law and order kept audiences of every age hooked for more than thirty years. This work covers 300+ syndicated radio mystery and adventure serials that aired in the early or middle twentieth century. To be included, a series must have had one or more regularly appearing characters who fought against espionage, theft, murder and other crimes. Each entry includes series name, air dates, sponsor, extant episodes, cast information and synopsis.
Human Rights Law in Scotland, Fourth Edition provides essential practical guidance to the Scottish legal profession. Written by two distinguished authors, the work explores the impact of human rights legislation in Scotland and provides a comprehensive review of ECHR (European Court of Human Rights) jurisprudence and relevant domestic legislation and case law as well as an overview of Strasbourg enforcement machinery. The fourth edition of this highly regarded work has been fully updated to reflect legislative changes to the Scotland Act 2012 (amending the Scotland Act 1998) and coverage of two new Protocols to the ECHR, as well as new case law and developments in jurisprudence. This highly regarded title is essential reading for legal practitioners, government agencies, students and others who require a clear and up-to-date guide to the application of European human rights law in Scotland. Previous print edition ISBN: 9781847665560
Health and safety risk issues such as AIDS, hazardous waste disposal, airline disasters, and health care policy frequently dominate the news and require a new level of sensitivity and expertise on the part of journalists. This volume focuses on a study of the trends in risk reporting and offers guidelines on how to report the dangers of these risks more accurately. It also examines the ethical implications of reporting risks to the public. This work will be of interest to those studying communication, specifically in the areas of ethics in journalism and public health and medical reporting.
JIM BLAKE's second volume of his photographs featuring the London Underground cover the period from 1985, shortly after the Thatcher regime's destruction of London Transport and its re-birth as London Underground Ltd., to 2021 when the Northern Line gained its new branch from Kennington to Battersea Power Station. This was a turbulent time in the system's history, encompassing the withdrawal of the last pre-war passenger rolling stock (in 1988) and then the abolition of two-person operated trains at the beginning of 2000. With the exception of the Waterloo & City Line, which was transferred from British Rail to London Underground in the 1990s, all Underground lines are covered together with the rolling stock operating them. Jim's photographs concentrate on the older types. What is very striking in them is how the system seemed to be going downhill rapidly during the Thatcher years when this survey begins - plagued by the curse of graffiti and liberally littered thanks to cuts in staff who once dealt with such problems. Fortunately, since Transport for London's takeover of the Underground from 2000 onwards, things in that respect have markedly improved, trains and stations are much cleaner and therefore welcoming to passengers. The contrast between the late 1980s/early 1990s and today's Underground is very clear in Jim's photographs featured here, most previously unpublished. It is unfortunate that further improvements, not to mention long-planned extensions to the system, continue to be frustrated by government spending restrictions at the time of writing.
The history and current state of tobacco from its Native origins in South America's Andes through its checkered history in North America as a "miracle" drug, powerful narcotic, friend of government revenue departments, and law-enforcement target as contraband and tax diversion are traced.
Old Lyme, Lyme and East Lyme were once one town, founded in the 1600s. Known for early innovations in industry, government and education, these towns also share a wealth of overlooked history. Discover the taverns where Patriots met during the Revolution, the Diving Horses at the Golden Spur Amusement Park and the Spiritualist Camp that has held séances since 1882. Meet the smuggler captain who routinely escaped prison to visit his wife, the Revolutionary War veteran who trailblazed the West and the abolitionist who helped Frederick Douglass escape to freedom. Authors Jim Lampos and Michaelle Pearson weave a fascinating tapestry of local legends, history and lore.
In Shadowtime Jim Reilly explores how the great Victorian and Edwardian works of literature can be read in the light of current radical historiography, which foresees the extinction not just of art but of history itself. This is an outstanding combination of original readings and critical survey. Shadowtime is ideal material for anyone studying nineteenth-century realism, modernism and the history of aesthetics.
Books 1, 2, 3, 4, 5: Murder at the Fitzwilliam, Murder at the British Museum, Murder at the Ashmolean, Murder at the Manchester Museum, Murder at the Natural History Museum
Books 1, 2, 3, 4, 5: Murder at the Fitzwilliam, Murder at the British Museum, Murder at the Ashmolean, Murder at the Manchester Museum, Murder at the Natural History Museum
These world-renowned museums hold some deadly secrets ... Murder at the Fitzwilliam 1894. Daniel Wilson, who made his name investigating the case of Jack the Ripper alongside the formidable Inspector Abberline, is now working as a private enquiry agent. When the Fitzwilliam Museum in Cambridge finds itself in need of urgent - and discreet - assistance, he is the natural first choice. The museum will soon unveil its new Egyptian collection, but strange occurrences have followed the exhibits to Britain including the discovery of a dead body in a previously empty sarcophagus. Aided by the talented resident archaeologist, Abigail Fenton, can Wilson unravel the mystery before the museum's public launch? Murder at the British Museum 1894, London. Professor Lance Pickering had been due to give a talk at the British Museum, when his brutally stabbed body is discovered. Daniel Wilson is called in to solve the mystery with the help and expertise of archaeologist Abigail Fenton. With their investigation hampered by persistent journalists, vandals and a fanatical society, and the pressure building with another fatality, Wilson and Fenton must race against time to salvage the reputation of the museum and catch a murderer desperate for revenge. Murder at the Ashmolean Museum 1895, Oxford. The Ashmolean Museum is a site of tragedy when a manager is found with a bullet hole between his eyes, a pistol discarded close by. Police have ruled the death as suicide but staff at the museum remain unconvinced. Daniel Wilson and Abigail Fenton's inquiries are hindered by an interfering lone agent from Special Branch, mislaid artefacts and a web of bureaucracy as the hunt for a dangerous killer intensifies. Murder at the Manchester Museum 1895. Former Jack the Ripper detective Daniel Wilson and his archaeologist assistant Abigail Fenton are summoned to investigate the murder of a young woman at the Manchester Museum. The case turns more sinister when the body of a second woman is discovered. With the help of a local journalist, Wilson and Fenton hope to unravel the mystery, but the journey to the truth is fraught with obstacles, and the mistakes of the past will not be forgotten ... Murder at the Natural History Museum 1895, London. When the Museum Detectives are asked to investigate a vandalised dinosaur skeleton at the Natural History Museum, there is evidence that the fossil-hunting mania of the notorious Bone Wars in America may have reached British shores. Events take a sinister turn though when a museum attendant is found dead by the famous theatre manager Bram Stoker, who may be more involved than he is willing to admit. Facing mounting pressure Wilson and Fenton must rely on their talents and instincts to solve their most intriguing case yet. 'A captivating new series' Marni Graff
Here, in a pictorial history, Jim Shaughnessy turns an eloquent photographer's eye to the Delaware & Hudson, the line that began in 1823 as a canal system to transport Pennsylvania coal to New York State. The D&H extended from Montreal to the coal fields of northeastern Pennsylvania. It was active for 170 years, when the route was sold in 1993 to the Canadian Pacific Railway Corporation. The line made early railroad fame by importing from England the famous Stourbridge Lion, the first steam locomotive in America. This occurred during a great expansion into gravity, an interesting phase which took advantage of the mountainous terrain. The nineteenth century saw a period of economic growth and amalgamation, which was shaped by extremely able and ambitiou company presidents. Eventually the D&H advertised itself as "the Bridge Line to New England and Canada." Mountainous terrain around the coal mines challenged the line with heavy grades, so it was natural for one of its presidents, L. F. Loree, to be fascinated with experimental traction power. The many Loree locomotives, leaders in progressive design, are pictured and described herein. Because a good railroad history is always an economic history of a region, this book will surely please historian, too. Delaware & Hudson is a definitive work, encompassing the mining of the region and detailing the steamboat operations on Lakes George and Champlain. Syracuse University Press is pleased to reissue this exemplary study of a railroad. Delaware & Hudson has—and will—continue to raise the standards for all future railroad books.
Extensive excavations by MOLA (Museum of London Archaeology) near Houghton Regis and Toddington, in south Central Bedfordshire, provide a detailed multi-period dataset for regional and national comparison. Evidence ranges from middle/late Bronze Age pits to medieval settlements.
Travel writer Jim Morekis shares the must-see sights and local secrets of the North and South Carolina coasts, from the grand houses of Charleston to the breezy beaches of the Outer Banks. Morekis provides unique travel ideas for visitors such as “Coastal Carolinas for Couples” and “Carolina Lighthouses.” Including expert advice on how best to revel in the celebrations of Wilmington's flower-festooned Azalea Festival and when to visit Myrtle Beach to get the best value, Moon Coastal Carolinas gives travelers the tools they need to create a more personal and memorable experience.
Accounting is a social practice: it should be evaluated in terms of its contribution to a notion of social well-being. In order to do this, this book elaborates a critique of contemporary accounting. The authors encourage those with a close interest in accounting to make the search for a more emancipatory and enabling accounting a core area of their interest. The book will stimulate debate and activity in the arenas of education, research, practice and policy-making.
This reference work contains exhaustive histories of 31 of network radio's most durable soap operas on the air between 1930 and 1960. The soap operas covered are Aunt Jenny's Real Life Stories, Backstage Wife, Big Sister, The Brighter Day, David Harum, Front Page Farrell, The Guiding Light, Hilltop House, Just Plain Bill, Life Can Be Beautiful, The Light of the World, Lora Lawton, Lorenzo Jones, Ma Perkins, One Man's Family, Our Gal Sunday, Pepper Young's Family, Perry Mason, Portia Faces Life, The Right to Happiness, Road of Life, The Romance of Helen Trent, Rosemary, The Second Mrs. Burton, Stella Dallas, This Is Nora Drake, Today's Children, Wendy Warren and the News, When a Girl Marries, Young Doctor Malone, and Young Widder Brown. Included for each series are the drama's theme and story line, an in-depth focus on the major characters, and a listing of producers, directors, writers, announcers, casts, sponsors, ratings, and broadcast dates, times and networks. Profiles of 158 actors, actresses, creators and others who figured prominently in a serial's success are also provided.
When fishing, there's always an element of chance. And the occasional opportunity to exaggerate just a bit, especially about the one that got away. In Lies, Damned Lies & Anglers, Bruce Sandison searches for the truth about angling, with all it's pleasures and frustrations, and reveals some of the secrets of success he has discovered over the years. For those drawn to river and loch, peace, tranquility and contentment are key. But catching fish is an altogether trickier business. Over the years, Bruce Sandison has caught prize fish almost by accident, suffered as absolute beginners have had more than their fair share of luck, battled the elements in small boats, worn inappropriate waders and has, by chance, also discovered the songs that fish simply can't resist. Through good times and bad, the odd big fish may have got away but, of course, the stories are all true . . .
Follow pastor Jim Belcher and his family as they take a pilgrimage through Europe, seeking substance for their faith in Christianity's historic, civilizational home. What they find, in places like Lewis's Oxford and Bonhoeffer's Germany, are glimpses of another kind of faith—one with power to cut through centuries and pierce our hearts today.
We Come Unseen, first published in 2001, follows the careers of six Royal Navy submariners from their graduation from Dartmouth's Britannia Royal Naval College in 1963, just after the Cuban Missile Crisis, to the fall of the Berlin Wall in 1989. Between these dates, it seemed that nuclear war was never far away - and Jim Ring explains not only the nuclear threat and its beginnings in the last days of the Second World War, but why the Polaris and Trident submarines ('capable of inflicting the damage of the bombs that fell on Hiroshima and Nagasaki many times over'), and their accompanying attack submarines, were critical to avoiding war. Alongside a gripping narrative of the Cold War game of hide-and-seek played out under the waves of the northern seas, Ring gives an account of the history of submarine warfare from its earliest, pre-nuclear days to the 1982 combat in the Falklands.'A welcome acknowledgement of one of the Cold War's little-known aspects.' Alan Judd, Sunday Telegraph'An extraordinary story . . . one of the most significant naval books of the year.' Ship's Telegraph'A remarkable story.' Navy News
With the powerful, rhythmic sounds of Aboriginal English and Kokatha language woven through the narrative, Mazin Grace is the inspirational story of a feisty girl who refuses to be told who she is, determined to uncover the truth for herself. Growing up on the Mission isn’t easy for clever Grace Oldman. When her classmates tease her for not having a father, she doesn’t know what to say. Pappa Neddy says her dad is the Lord God in Heaven, but that doesn’t help when the Mission kids call her a bastard. As Grace slowly pieces together clues that might lead to answers, she struggles to find a place in a community that rejects her for reasons she doesn’t understand. In this novel, author Dylan Coleman fictionalizes her mother’s childhood at the Koonibba Lutheran Mission in South Australia in the 1940s and 1950s.
A necessity for the professional journalist's library, Journalism: State of the Art will prove a valuable resource for the student journalist as well. This book summarizes some 200 media studies many from the most prestigious journal in the trade, Journalism Quarterly. In a paraphrased-synthesis format, and using informal terms, the author arranges some of the most interesting studies of the 1980s into eight subject headings including: Ethics Law, and the Journalist; Advertising in the 1980s; Polling and Precision Journalism; and Predictors of Readership and Viewship. For many years there has been a gap between media researchers and the practicing journalist. Published research about journalism as a discipline may receive attention in the classroom but seldom gets in the newsroom. Viewing the gap between the researcher and practitioner, Willis offers comments from both sides. He surveys nearly 150 news executives on media research and gives an insightful look at what factors cause readers or viewers to pay attention to the news media. From trends in the industry to types of audiences, Journalism: State of the Art uses practical research studies presented in an accessible style. Offering the most current data available on media research, this book will prove a great instructional as well as reference tool. It is a must for college journalists, working press, and media marketers.
Learn how to get the most horsepower out of the popular small-block Ford with this all-new full-color guide. The attention of the performance aftermarket has turned to the Coyote platform and swaps, but Ford is a little different than GM and Chrysler in that regard. The sheer size of the Coyote engine is problematic because it is very difficult to fit into any vehicle with shock towers. However, the shock-tower cars are often the most popular cars to modify. As such, the small-block Ford remains a viable option for making a large amount of horsepower in a much more affordable package. In Ford Small-Block Engines: How to Build Max Performance, Ford expert Jim Smart covers all of the major components, including crankshafts, rods and pistons, camshafts, the valvetrain, oiling systems, intakes, carburetors, ignition systems and exhaust systems. Featured are the latest street heads from AFR, Dart, Ford Performance, Edelbrock, and other prominent manufacturers. Aftermarket blocks are also covered extensively from a variety of manufacturers, such as Ford Performance, Dart, Speedmaster, Bill Mitchell Products, and World Products. The basic design of this engine is more than 60 years old, but the aftermarket for this powerplant has grown over the years and is still growing. While the Coyote engine family has earned a strong following, the original Ford small-block engine retains just as strong of a following, with the massive number of these engines still in use throughout the hobby. Whether you want to get started on your build or you just want to learn about the small-block Ford’s capabilities, this book will make a great addition to your library.
Rutter’s Child and Adolescent Psychiatry has become an established and accepted textbook of child psychiatry. Now completely revised and updated, the fifth edition provides a coherent appraisal of the current state of the field to help trainee and practising clinicians in their daily work. It is distinctive in being both interdisciplinary and international, in its integration of science and clinical practice, and in its practical discussion of how researchers and practitioners need to think about conflicting or uncertain findings. This new edition now offers an entirely new section on conceptual approaches, and several new chapters, including: neurochemistry and basic pharmacology brain imaging health economics psychopathology in refugees and asylum seekers bipolar disorder attachment disorders statistical methods for clinicians This leading textbook provides an accurate and comprehensive account of current knowledge, through the integration of empirical findings with clinical experience and practice, and is essential reading for professionals working in the field of child and adolescent mental health, and clinicians working in general practice and community pediatric settings.
With the advent of Aboriginal street gangs such as Indian Posse, Manitoba Warriors, and Native Syndicate, Winnipeg garnered a reputation as the “gang capital of Canada.” Yet beyond the stereotypes of outsiders, little is known about these street gangs and the factors and conditions that have produced them. “Indians Wear Red” locates Aboriginal street gangs in the context of the racialized poverty that has become entrenched in the colonized space of Winnipeg’s North End. Drawing upon extensive interviews with Aboriginal street gang members as well as with Aboriginal women and elders, the authors develop an understanding from “inside” the inner city and through the voices of Aboriginal people – especially street gang members themselves. While economic restructuring and neo-liberal state responses can account for the global proliferation of street gangs, the authors argue that colonialism is a crucial factor in the Canadian context, particularly in western Canadian urban centres. Young Aboriginal people have resisted their social and economic exclusion by acting collectively as “Indians.” But just as colonialism is destructive, so too are street gang activities, including the illegal trade in drugs. Solutions lie not in “quick fixes” or “getting tough on crime” but in decolonization: re-connecting Aboriginal people with their cultures and building communities in which they can safely live and work.
Johan S. Opheim, commonly known as "Joe", was inducted into the U.S. Army just a few days before Pearl Harbor in World War II. Having grown up on the plains of Eastern Montana and having experienced the struggles of the Great Depression, and challenging family situations, he was well prepared for the hardships he endured. He served with his fellow members of the 3rd Infantry Division in the Mediterranean theater, starting first with North Africa, then on to Sicily, then the Italian mainland and eventually on to the South of France where he met his untimely death. He was remembered for his jovial attitude towards life and his intellect, the later of which he did not have the opportunity to develop more fully. Relatives had saved 165 of his letters that he had written to them from the mid 1930s and up through his last campaign. The author has reprinted these letters and developed Joe's biography by filling in the gaps of information about his life which includes comments regarding the contents of the letters, and narratives about his travels and his unit's experiences.
Residues of drugs and chemicals in edible tissues of food-producing animals are a major public health concern. Until now, information on applications of pharmacokinetic principles to drug and chemical residue avoidance has been spread throughout literature. For the first time, this handbook brings this information together in a convenient and concise volume. For easier reference, text is divided into three parts: physicochemical constants and chemical structures, legal tissue tolerances, and pharmacokinetic parameters derived from open literature. This is the only publication that offers all this information in a single source. For fast access, numerous tables present valuable pharmacokinetic data for drugs in serum, plasma, or blood and in other matrices. The authors include their own previously unpublished pharmacokinetic parameters, results of statistical analyses performed on time/concentration data tabulated in the primary sources. Helpful appendices contain FDA approved tolerances and action levels as well as chemical structures and physicochemical properties. This is an essential handbook for veterinarians, toxicologists, pharmacologists, animal scientists, food hygienists, and regulatory personnel involved in human food safety.
Today, many scientists in different disciplines realize the power of graphics, but are also bewildered by the numerous graphics tools. More often than not, they choose the improper software tools and end up with unsatisfactory results. This book introduces and categorizes the most commonly used graphics tools and their applications. The purpose is not to provide an exhausting list of tools and their explicit functions, but rather to provide scientific researchers with different means and application areas in computer graphics, so as to help them efficiently use visualization, modeling, simulation, and virtual reality to complement their research needs. This guide includes coverage of the most widely used commercial software, freeware and open-source software.
A collection of columns by Jim Foster, an award-winning columnist for the Orillia Packet and Times, the Collingwood Enterprise-Bulletin, and the Oro Medonte Severn News.
Traveling US 25 through the Carolinas today is a much more pleasant experience than it was in the 1700s. Then, the road from the Tennessee Cherokee Towns to Augusta, Georgia, was a Cherokee trading path that followed a bison trace to the navigable port on the Savannah River. Drovers came from as far as Kentucky herding hogs, turkeys and mules. Lowcountry South Carolinians traveled by stagecoach and wagon to the foothills and mountains, staying for months. The Augusta Road, Saluda Gap and Buncombe Turnpike became the Dixie Highway Carolina Division and then US Route 25 by 1931. Authors Anne Peden and Jim Scott travel the trading path and concrete highway to explore this fascinating history.
Law and the Built Environment is a core textbook for all students undertaking compulsory law modules on construction, real estate and property management programmes. This single text provides an accessible introduction to the many areas of law studied by aspiring built environment professionals. Written by a team of lecturers with many years' teaching experience in these areas, key principles of English law are placed in their relevant professional context and clearly explained in exactly the right level of detail for success in the modules studied. The book also focuses in greater depth on some specialist areas of built environment professional practice, including construction contracts, health and safety, rent review, dilapidations, and lease renewals. It provides an essential resource for students studying for qualifications leading to professional membership of the Royal Institution of Chartered Surveyors (RICS) or the Chartered Institute of Building (CIOB). It caters primarily for students studying these subjects at bachelor's degree level, but will also be suitable for students on programmes at HNC and HND levels, as well as those undertaking professional examinations. It will also provide introductory reading for students undertaking master's level programmes, and particularly for the increasing numbers of graduates from other disciplines who are now studying on RICS-accredited master's degree conversion programmes.
Why was Oklahoma, of all places, more hospitable to socialism than any other state in America? In this provocative book, Jim Bissett chronicles the rise and fall of the Socialist Party of Oklahoma during the first two decades of the twentieth century, when socialism in the United States enjoyed its golden age. To explain socialism’s popularity in Oklahoma, Bissett looks back to the state’s strong tradition of agrarian reform. Drawing most of its support from working farmers, the Socialist Party of Oklahoma was rooted in such well-established organizations as the Farmers Alliance and the Indiahoma Farmers’ Union. And to broaden its appeal, the Party borrowed from the ideology both of the American Revolution and of Christianity. By making Marxism speak in American terms, the author argues, Party activists counteracted the prevailing notion that socialism was illegitimate or un-American.
This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously." Jay Herson, Johns Hopkins University The pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However, these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost, time, or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization, including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs, precision medicine, survival-endpoints, dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons, this book incorporates both statistical and "clinical/medical" perspectives.
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