This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the “post-structural biology” era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities.
This book provides a wide-ranging examination of the Hongzhou school of Chan Buddhism—the precursor to Zen Buddhism—under Mazu Daoyi (709–788) and his successors in eighth- through tenth-century China, which was credited with creating a Golden Age or classical tradition. Jinhua Jia uses stele inscriptions and other previously ignored texts to explore the school's teachings and history. Defending the school as a full-fledged, significant lineage, Jia reconstructs Mazu's biography and resolves controversies about his disciples. In contrast to the many scholars who either accept or reject the traditional Chan histories and discourse records, she thoroughly examines the Hongzhou literature to differentiate the original, authentic portions from later layers of modification and recreation. The book describes the emergence and maturity of encounter dialogue and analyzes the new doctrines and practices of the school to revise the traditional notion of Mazu and his followers as iconoclasts. It also depicts the strivings of Mazu's disciples for orthodoxy and how the criticisms of and reflections on Hongzhou doctrine led to the schism of this line and the rise of the Shitou line and various houses during the late Tang and Five Dynasties periods. Jia refutes the traditional Chan genealogy of two lines and five houses and calls for new frameworks in the study of Chan history. An annotated translation of datable discourses of Mazu is also included.
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