This book contains theoretical and application-oriented methods to treat models of dynamical systems involving non-smooth nonlinearities. The theoretical approach that has been retained and underlined in this work is associated with differential inclusions of mainly finite dimensional dynamical systems and the introduction of maximal monotone operators (graphs) in order to describe models of impact or friction. The authors of this book master the mathematical, numerical and modeling tools in a particular way so that they can propose all aspects of the approach, in both a deterministic and stochastic context, in order to describe real stresses exerted on physical systems. Such tools are very powerful for providing reference numerical approximations of the models. Such an approach is still not very popular nevertheless, even though it could be very useful for many models of numerous fields (e.g. mechanics, vibrations, etc.). This book is especially suited for people both in research and industry interested in the modeling and numerical simulation of discrete mechanical systems with friction or impact phenomena occurring in the presence of classical (linear elastic) or non-classical constitutive laws (delay, memory effects, etc.). It aims to close the gap between highly specialized mathematical literature and engineering applications, as well as to also give tools in the framework of non-smooth stochastic differential systems: thus, applications involving stochastic excitations (earthquakes, road surfaces, wind models etc.) are considered. Contents 1. Some Simple Examples. 2. Theoretical Deterministic Context. 3. Stochastic Theoretical Context. 4. Riemannian Theoretical Context. 5. Systems with Friction. 6. Impact Systems. 7. Applications–Extensions. About the Authors Jérôme Bastien is Assistant Professor at the University Lyon 1 (Centre de recherche et d'Innovation sur le sport) in France. Frédéric Bernardin is a Research Engineer at Département Laboratoire de Clermont-Ferrand (DLCF), Centre d'Etudes Techniques de l'Equipement (CETE), Lyon, France. Claude-Henri Lamarque is Head of Laboratoire Géomatériaux et Génie Civil (LGCB) and Professor at Ecole des Travaux Publics de l'Etat (ENTPE), Vaulx-en-Velin, France.
Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies.
Information retrieval is a central and essential activity. It is indeed difficult to find a human activity that does not need to retrieve information in an environment which is often increasingly digital: moving and navigating, learning, having fun, communicating, informing, making a decision, etc. Most human activities are intimately linked to our ability to search quickly and effectively for relevant information, the stakes are sometimes extremely important: passing an exam, voting, finding a job, remaining autonomous, being socially connected, developing a critical spirit, or simply surviving. The author of this book presents a summary of work undertaken over several years relative to the behaviors and cognitive processes involved in information retrieval in digital environments. He presents several examples of theoretical models and studies to better understand the difficulties, behaviors and strategies of individuals searching for information in digital environments.
The most widely acclaimed book for practicing dermatologists, now expanded and improved. A must for every dermatologist's office --and for hospital consultations--this updated and substantially enlarged edition answers the busy physician's need for a comprehensive, authoritative guide to the known adverse side effects of newly approved as well as commonly prescribed and over-the-counter drugs, herbals, and supplements. The easy-to-use format and wealth of information make this book and CD-ROM combination an essential resource for dermatologists and general practitioners. Important features in this edition: Extensive listing of over 1,000 adverse reactions More than 950 generic and over 5,400 trade name drugs, herbals, and supplements Identification of potentially hazardous drug-drug interactions Citations of more than 25,000 references, up to October 2003 Coverage of dermatologic and other side effects that can develop from the use of commonly prescribed medications, OTC drugs, herbals, and supplements Sixty-four color illustrations and descriptions of 101 common reaction patterns Fully cross-referenced by drug and trade names with names of pharmaceutical companies plus indications, category, and half-life for each drug The CD-ROM provides rapid access to all the drug profiles in the book
It inspired written testimonials from William McKinley, Thomas Edison, and Sarah Bernhardt; merited a medal from Pope Leo XIII; produced "exhilaration and lasting euphoria" in Sigmund Freud. Once the stimulant of choice of the enlightened and the elite, cocaine has become, a century later, a plague, ravaging the lives of millions. This book is the first to draw together all the facts about this pervasive drug--from its natural occurrence in a tea-like native South American plant to its devastating appearance as crack in the inner cities of the United States. Drawing on the latest work in medicine, psychiatry, neuroscience, pharmacology, epidemiology, social work, and sociology, the volume is a highly accessible reference on the history and use of cocaine, its physical and psychological effects, and the etiology and epidemiology of cocaine addiction. It also provides a critical evaluation of the pharmaceutical agents and psychosocial interventions that have been used to treat this addiction. Author Jerome J. Platt answers such basic questions as: What is cocaine? What forms does it come in? How is it administered? What does it do? What are the medical complications of cocaine addiction? What are the treatments, and how successful are they? Uniquely comprehensive, Cocaine Addiction makes all the latest information on this urgent subject readily available to medical professionals and practitioners, social workers and scholars, and anyone who cares to know more about this perennially troubling drug.
Double Helix History examines the interface between genetics and history in order to investigate the plausibility of ‘new’ knowledge derived from scientific methods and to reflect upon what it might mean for the practice of history. Since the mapping of the human genome in 2001, there has been an expansion in the use of genetic information for historical investigation. Geneticists are confident that this has changed the way we know the past. This book considers the practicalities and implications of this seemingly new way of understanding the human past using genetics. It provides the first sustained engagement with these so-called ‘genomic histories’. The book investigates the ways that genetic awareness and practice is seemingly changing historical practice and conceptualisation. Linking six concepts – ‘Public’, ‘Practice’, ‘Ethics’, ‘Politics’, ‘Self’, and ‘Imagination – Double Helix History outlines the ways that genetic information, being postgenomic, the public life of DNA, and the genetic historical imaginary work on the body, on collective memory, on the historical imagination, on the ethics of historical investigation, on the articulation of history, and on the collection and interpretation of data regarding the ‘past’. This book will appeal to researchers and students alike interested in DNA, genetics, and historiography.
Drawing on the vast amount of experience the author has gained from working in industrial and university laboratories, this collection of excerpt reports contains essential details from literature relevant to the synthesis of compounds on a milligram to kilogram scale. The excerpts are composed using ChemDraw software and compiled in a Word document. A number of the compounds that have eluded efficient preparation in the past are now presented. Material which will improve any chemist's existing synthetic methodology can be found here. Each of the six chapters, with eighty excerpts, illustrates a novel application of syntheses selected from twenty-first-century literature. Jerome Zoeller graduated from Rensselaer Polytechnic Institute, USA, with a B.S. in Chemistry and began work at the Rohm & Haas Co. in applications and process development with acrylic polymers. Graduate study followed at the University of Texas, USA, with research concentration in physical organic chemistry. Upon completing the Ph.D. program, he went on for two years as a Postdoctoral Research Fellow in the use of organometallics in synthetic and structural studies. At the Southwest Foundation for Research and Education he developed preparative methods for cortisol analogs, and their use in affinity chromatography and primate brain research. In this decade he lectured at Trinity University, USA. A change in career occurred in which he studied Fuel Science at The Pennsylvania State University, USA. This specialty was pursued at Texas A&M University, USA, in the use of specialized oxidative transformations in studies of fossil fuel structure. Upon retirement he moved to a startup pharma company, Targacept Inc., for synthetic work on nicotinic acetylcholine esterase ligands of potential neurological activity. Upon moving to Texas, he was prompted to compile some of the synthetic sequences displayed in the twenty-first century literature, for this book.
Clinical Naturopathy: an evidence-based guide to practice, 2nd edition, E-book by Jerome Sarris and Jon Wardle, articulates evidence-based clinical practice. It details the principles, treatment protocols and interventions at the forefront of naturopathic practice in the 21st century. Clinical Naturopathy: an evidence-based guide to practice 2e E-book, equips you to critically evaluate your patients, analyse treatment protocols, and provide evidence-based prescriptions. This second edition promotes the fundamentals of traditional naturopathy, while pushing the scientific boundaries and driving the steady evolution of the profession of naturopathic medicine. Perfect for: Bachelor of Health Science (Naturopathy) Advanced diploma and Postgraduate students in: • Naturopathy • Western Herbal Medicine • Nutrition • Homoeopathy Complementary health therapists General Practitioners Nursing students Pharmacy students Benefits: • Provides an evidence-based, referenced analysis of the treatment protocols underpinning the therapeutic use of CAM interventions. • Emphasizes the treatment of patients not diseases within the systems based structure. • A rigorously researched update of common clinical conditions and their naturopathic treatment according to evidence-based guidelines (over 5,000 references). • Bridges conventional medical and naturopathic paradigms to help clinicians facilitate truly integrative models of care. • Augmented appendices including: herb/drug interaction charts, laboratory reference values, food sources of nutrients, cancer medication interactions and nutraceutical use. • Key Treatment Protocols throughout the text offer an evidence-based referenced critique. • Naturopathic Treatment trees for each condition, with Treatment Aims boxes that are easy to follow and understand. • Scientific and traditional evidence validating treatment protocols. • Decision trees, unique figures, tables and charts are a great aid to visual learners. • Expanded Diagnostics chapter including the emerging field of pharmacogenomics. • New Wellness, lifestyle and preventive medicine chapter to explore in detail the core principles of naturopathic practice. • New Liver dysfunction and disease, Headache and migraine, and Pain chapters. • A deepening scientific focus with inclusion of new and emerging naturopathic therapeutics such as injectable nutraceuticals.
This book contains theoretical and application-oriented methods to treat models of dynamical systems involving non-smooth nonlinearities. The theoretical approach that has been retained and underlined in this work is associated with differential inclusions of mainly finite dimensional dynamical systems and the introduction of maximal monotone operators (graphs) in order to describe models of impact or friction. The authors of this book master the mathematical, numerical and modeling tools in a particular way so that they can propose all aspects of the approach, in both a deterministic and stochastic context, in order to describe real stresses exerted on physical systems. Such tools are very powerful for providing reference numerical approximations of the models. Such an approach is still not very popular nevertheless, even though it could be very useful for many models of numerous fields (e.g. mechanics, vibrations, etc.). This book is especially suited for people both in research and industry interested in the modeling and numerical simulation of discrete mechanical systems with friction or impact phenomena occurring in the presence of classical (linear elastic) or non-classical constitutive laws (delay, memory effects, etc.). It aims to close the gap between highly specialized mathematical literature and engineering applications, as well as to also give tools in the framework of non-smooth stochastic differential systems: thus, applications involving stochastic excitations (earthquakes, road surfaces, wind models etc.) are considered. Contents 1. Some Simple Examples. 2. Theoretical Deterministic Context. 3. Stochastic Theoretical Context. 4. Riemannian Theoretical Context. 5. Systems with Friction. 6. Impact Systems. 7. Applications–Extensions. About the Authors Jérôme Bastien is Assistant Professor at the University Lyon 1 (Centre de recherche et d'Innovation sur le sport) in France. Frédéric Bernardin is a Research Engineer at Département Laboratoire de Clermont-Ferrand (DLCF), Centre d'Etudes Techniques de l'Equipement (CETE), Lyon, France. Claude-Henri Lamarque is Head of Laboratoire Géomatériaux et Génie Civil (LGCB) and Professor at Ecole des Travaux Publics de l'Etat (ENTPE), Vaulx-en-Velin, France.
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