Jeroen Declercq's Books

Therapeutic Potential of Furin Inhibition

An Evaluation Using a Conditional Furin Knockout Mouse Model

By: Jeroen Declercq,Prof. Dr. J.W.M. Creemers

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Therapeutic Potential of Furin Inhibition

An Evaluation Using a Conditional Furin Knockout Mouse Model

By: Jeroen Declercq,Prof. Dr. J.W.M. Creemers

The proprotein convertase Furin is a serine endoprotease which cleaves protein precursors carboxyterminal of basic residues in motifs such as Arg–X–X–Arg and Lys/Arg–Arg. Cleavage usually results in activation of the proprotein but can also inactivate or modify the activity. Therefore, it is not surprising that it plays a major role in many physiological processes and pathologies, including cancer. The other proprotein convertases belonging to the same family, PC1/3, PC2, PACE4, PC4, PC5/6, and PC7, cleave at similar cleavage sites and provide partial redundancy. To unravel the specific role of Furin in vivo, knockout mouse models have been generated. Furin null mice die between e10.5 and e11.5 due to severe ventral closure defects and the failure of the heart tube to fuse and undergo looping morphogenesis. Therefore, a conditional Furin knockout mouse was generated to investigate the role of Furin in specific organs, such as pancreas, liver, T-cells, endothelial cells, and salivary glands, resulting in a severe or mild phenotype depending on the organ investigated. Partial or complete ablation of the Fur gene in salivary gland tumors significantly delayed tumorigenesis in mice. Therefore, Furin inhibition might be considered as a possible therapeutic strategy to treat certain pathologies, such as cancer.

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Biota Publishing

Published Date

ISBN 10

1615045260

ISBN 13

9781615045266

The House of Orange in Revolution and War

A European History, 1772–1890

By: Jeroen Koch,Dik van der Meulen,Jeroen van Zanten

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The House of Orange in Revolution and War

A European History, 1772–1890

By: Jeroen Koch,Dik van der Meulen,Jeroen van Zanten

An epic account of the House of Orange-Nassau over one hundred and fifty years of European history. Three rulers from the House of Orange-Nassau reigned over the Netherlands from 1813 to 1890: King William I from 1813 to 1840, King William II from 1840 to 1849, and King William III from 1849 to 1890. Theirs is an epic tale of joy and tragedy, progress and catastrophe, disappointment and glory—all set against the backdrop of a Europe plagued by war and revolution. The House of Orange in Revolution and War relates one and a half centuries of House of Orange history in a gripping narrative, leading the reader from the last stadholders of the Dutch Republic to the modern monarchy of the early twentieth century, from the French Revolution and the Napoleonic wars to World War I and the European Revolutions that came after it.

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441

Publisher

Reaktion Books

Published Date

ISBN 10

1789145414

ISBN 13

9781789145410

Therapeutic Potential of Furin Inhibition

An Evaluation Using a Conditional Furin Knockout Mouse Model

By: Jeroen Declercq,Prof. Dr. J.W.M. Creemers

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Therapeutic Potential of Furin Inhibition

An Evaluation Using a Conditional Furin Knockout Mouse Model

By: Jeroen Declercq,Prof. Dr. J.W.M. Creemers

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

Publisher

Biota Publishing

Published Date

ISBN 10

1615045260

ISBN 13

9781615045266

Book's by Jeroen Declercq

Therapeutic Potential of Furin Inhibition

Therapeutic Potential of Furin Inhibition

The House of Orange in Revolution and War

The House of Orange in Revolution and War

Therapeutic Potential of Furin Inhibition

Therapeutic Potential of Furin Inhibition

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