Jens H. Henriksen's Books

Degradation of Bioactive Substances

Physiology and Pathophysiology

By: Jens H. Henriksen

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Degradation of Bioactive Substances

Physiology and Pathophysiology

By: Jens H. Henriksen

Intended primarily for researchers working with bioactive substances such as hormones, neurotransmitters, growth factors, and connective tissue makers, this book discusses the principles of degradation in major groups of bioactive materials with respect to physiology, location, and regulation. Peptidases; receptor-mediated endocytosis; organ extraction and clearance; and the degradation of specific proteins, peptides, amines, steroids, and polysaccharoides are featured. Pathophysiology and its role in diagnostics and disease are considered throughout the book, in addition to updates of recent literature and substantial new information on physiology and pathophysiology of degradation of bioactive material. No special mathematical or kinetic background is necessary to read this book because the mathematic and kinetic concepts are facilitated through the presentation of fundamental and more advanced principles. Furthermore, illustrations and tables are provided to facilitate the understanding of the dynamic aspects of degradation processes. Degradation of Bioactive Substances: Physiology and Pathophysiology is the first comprehensive work describing the degradation of bioactive material, including information not found in biochemical textbooks on internal metabolism or pharmacokinetic textbooks on drug metabolism.

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Page Count

332

Publisher

CRC Press

Published Date

ISBN 10

0849368588

ISBN 13

9780849368585

Physiological Engineering Aspects Of Penicillium Chrysogenum

By: Jens B Nielsen

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Physiological Engineering Aspects Of Penicillium Chrysogenum

By: Jens B Nielsen

The book gives a review of penicillin production by Penicillium chrysogenum, and also deals with a number of general aspects of fungal cultivations, e.g. primary metabolism of filamentous fungi, morphology, monitoring of fungal cultivations, and bioreactor performance (more than 750 references).The first two chapters give an introduction to the area of penicillin production; with a review of the history and a survey of the present status of this industrially very important process in the first chapter. In the second chapter is given an introduction to the microorganism, i.e. its nutritional requirements, its taxonomy, and an overview of different strain development programmes.Chapter 3 gives an introduction to the concept of Physiological Engineering. This is followed by a review of various monitoring techniques and different theoretical techniques for analysis of cultivation processes, e.g. mathematic modeling, metabolic flux analysis, and metabolic control analysis.Chapter 4 and 5 give a review of the metabolism, with the primary metabolism being the topic of Chapter 4 and the secondary metabolism, i.e. penicillin biosynthesis, being the topic of Chapter 5. The review of the penicillin biosynthetic pathway is followed by a description of a number of results obtained using metabolic flux and metabolic control analysis.Chapter 6 is devoted to the morphology of the fungus, and it gives a detailed description of the growth mechanisms of filamentous fungi.Chapter 7 deals with the bioreactor performance during fungal cultivations, i.e. medium rheology, gas-liquid mass transfer, and mixing.Finally is the fed-batch process applied for penicillin production described in Chapter 8. It gives an overview of the most important factors influencing penicillin production.

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Page Count

287

Publisher

World Scientific

Published Date

ISBN 10

9814498572

ISBN 13

9789814498579

Ascites

By: Jens H. Henriksen,Søren Møller

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Ascites

By: Jens H. Henriksen,Søren Møller

This volume deals with the history, aetiology, pathophysiology, symptoms, signs, prognosis, and rational treatment of ascites. During the past decade, our knowledge of the pathophysiology of ascites has increased substantially and more specific therapies are now based on aetiology and pathophysiology. It is the intention of this book to review recent progress in pathophysiology of ascites and therapies based on pathophysiology. Although the different types of ascites have a different aetiology and very different pathophysiology, the development of fluid in the peritoneal cavity is always a bad clinical sign. It has a severe prognosis, which is mainly dependent on the aetiology and progression of the underlying disease. However, among patients with ascites, the prognosis may be very different, mainly owing to the presence of portal venous hypertension, malignancy in the abdominal cavity, and end-stage congestive heart failure. The addition of complications like the hepatorenal syndrome and bacterial peritonitis, whether spontaneous or secondary, adds heavily to the bad prognosis. Since hepatic ascites are by far the most complex with respect to pathophysiology, complications, and treatment, emphasis is put on the description of this entity. Ascites of other aetiologies are mentioned along with hepatic ascites, in particular, if the pathophysiology differs from ascites of hepatic origin.

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Page Count

118

Publisher

Biota Publishing

Published Date

ISBN 10

1615045678

ISBN 13

9781615045679

Book's by Jens H. Henriksen

Degradation of Bioactive Substances

Degradation of Bioactive Substances

Physiological Engineering Aspects Of Penicillium Chrysogenum

Physiological Engineering Aspects Of Penicillium Chrysogenum

Ascites

Ascites

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