Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.
This research monograph focuses on a biomolecular separation process that occurs within most cells. Two types of molecules, receptors and ligands, are separated and routed along different intracellular pathways; this is a critical step in the process of receptor-mediated endocytosis. The development of an understanding of the basic mechanisms of this separation process is presented, with an emphasis on discovering the fundamental and measurable parameters that influence the event. Mathematical models of sorting are evaluated to predict the range of possible outcomes. These are compared with a variety of experimental data on different receptor/ligand systems. In addition, the influence of the separation on overall receptor/ligand processing dynamics is discussed. The book is intended for both biomathematicians and biologists. It is not necessary to understand the details of the model equations and their solution in order to test the models experimentally. The analysis suggests experiments that might be done to further investigate the sorting process and the text details methods for analyzing these experimental results.
Project Success is a blended-learning digital and print course with a strong focus on workplace skills, career readiness, and 21st century challenges. This unique video-based series engages learners with high-interest video vignettes that represent a "day in the life" of characters in diverse workplace settings that may simulate their own. Integrated skills lessons encourage critical thinking and problem solving woven into the students' English language learning journey.
This book offers a bridge at the interface between engineering and cell biology, demonstrating how a mathematical modelling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor ligand interactions. Model frameworks are described over the entire spectrum of receptor processes, from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioural functions they govern, including proliferation, adhesion, and migration.
This research monograph focuses on a biomolecular separation process that occurs within most cells. Two types of molecules, receptors and ligands, are separated and routed along different intracellular pathways; this is a critical step in the process of receptor-mediated endocytosis. The development of an understanding of the basic mechanisms of this separation process is presented, with an emphasis on discovering the fundamental and measurable parameters that influence the event. Mathematical models of sorting are evaluated to predict the range of possible outcomes. These are compared with a variety of experimental data on different receptor/ligand systems. In addition, the influence of the separation on overall receptor/ligand processing dynamics is discussed. The book is intended for both biomathematicians and biologists. It is not necessary to understand the details of the model equations and their solution in order to test the models experimentally. The analysis suggests experiments that might be done to further investigate the sorting process and the text details methods for analyzing these experimental results.
Childbirth defines families, communities, and nations. In Birthing the West, Jennifer J. Hill fills the silences around historical reproduction with copious new evidence and an enticing narrative, describing a process of settlement in the American West that depended on the nurturing connections of reproductive caregivers and the authority of mothers over birth. Economic and cultural development depended on childbirth. Hill’s expanded vision suggests that the mantra of cattle drives and military campaigns leaves out essential events and falls far short of an accurate representation of American expansion. The picture that emerges in Birthing the West presents a more complete understanding of the American West: no less moving or engaging than the typical stories of extraction and exploration but concurrently intriguing and complex. Birthing the West unearths the woman-centric practice of childbirth across Montana, the Dakotas, and Wyoming, a region known as a death zone for pregnant women and their infants. As public health entities struggled to establish authority over its isolated inhabitants, they collaborated with physicians, eroding the power and control of mothers and midwives. The transition from home to hospital and from midwife to doctor created a dramatic shift in the intimately personal act of birth.
Alongside images of racing chuckwagons, cowboys on bucking broncos and Aboriginal people in full regalia, one of the most recognizable and enduring symbols of the Calgary Stampede is a trio of pretty cowgirls wearing white-hat crowns. Not surprisingly, modern-day Stampede Queens and Princesses make more than 450 public appearances per year promoting the show and the city of Calgary both at home and abroad. But the fair was nearly six decades old before it appointed a royal representative to promote its interests. In 1946 Patsy Rodgers became the Stampede's first rodeo queen. The following year, a local service club raised funds by sponsoring a contest for "Queen of the Stampede." Although it bore little resemblance to its modern counterpart, this early competition based on ticket sales was widely popular and over the next few decades raised the equivalent of one million dollars for local charities and service projects. From the beginning, the Stampede recognized the promotional potential of the royal figureheads and worked to ensure that winners were credible representatives of what quickly became a year-round public relations job. In 1966 the Stampede officially took over and modernized the contest, but it would take many decades of trial and error evolution to perfect the process of selecting and training its royalty. Against a backdrop of changing times, and drawing on contemporary sources and personal interviews, the author traces the origin and development of the Calgary Stampede Queen contest and profiles its lucky young winners over seven exciting decades. Complete with a large selection of archival photos, Calgary's Stampede Queens tells the story from this fascinating corner of The Greatest Outdoor Show on Earth.
Parents and teachers can use this book to engage children with the world outside by opening their eyes to fascinating common bird species. Once upon a time, common bird species all had well-known stories associated with them. Legends and folklore about birds abound in almost every culture. It's likely their ability to fly, their beauty and grace, their distinctive and puzzling calls, and the fact that they live all around us is what makes them popular subjects for fables. This book presents a sampling of traditional bird tales retold in a fresh way that makes them especially relevant and memorable for today's children. Each story is complemented by a "Feathered Fact File," a "Backyard Bird Watching Tip" for kids, a classroom/home school activity suggestion, and a story sharing suggestion for parents and teachers. The teaching activities are designed with flexibility so that they may be used to either introduce new concepts of science and math or reinforce familiar concepts in a hands-on fashion. Reading selections are written at third to fourth grade reading levels, but are designed to engage both younger listeners and older readers.
Project Success is a blended-learning digital and print course with a strong focus on workplace skills, career readiness, and 21st century challenges. This unique video-based series engages learners with high-interest video vignettes that represent a "day in the life" of characters in diverse workplace settings that may simulate their own. Integrated skills lessons encourage critical thinking and problem solving woven into the students' English language learning journey.
The literary study of emotion is part of an important revisionary movement among scholars eager to recast emotional politics for the twenty-first century. Looking beyond the traditional categories of sentiment, sensibility, and sympathy, Jennifer Travis suggests a new approach to reading emotionalism among men. She argues that the vocabulary of injury, with its evaluations of victimhood and its assessments of harm, has deeply influenced the cultural history of emotions. From the Civil War to the early twentieth century, Travis traces the history of male emotionalism in American discourse. She argues that injury became a comfortable vocabulary--particularly among white middle-class men--through which to articulate and to claim a range of emotional wounds. The debates about injury that flourished in the cultural arenas of medicine, psychology, and the law spilled over into the realm of fiction, as Travis demonstrates through readings of works by Stephen Crane, William Dean Howells, Willa Cather, Henry James, and Edith Wharton. Travis concludes by linking this history to twenty-first-century preoccupations with "pain-centered politics," which, she cautions, too often focuses only on women and racial minorities.
A guide to pseudonyms, pen names, nicknames, epithets, stage names, cognomens, aliases, and sobriquets of twentieth-century persons, including the subjects' real names, basic biographical information, and citations for the sources from which the entries were compiled. Covers authors, sports figures, entertainers, politicians, military leaders, underworld figures, religious leaders, and other contemporary personalities.
Effective, holistic nursing is impossible without a firm grasp of how the human body functions, but knowledge of the scientific theory on its own is not enough. Written with the needs of nurses firmly in mind and using the person-centred practice framework as a guiding principle, this book brings anatomy and physiology to life, combining the best of print and online learning into one integrated package. Key features: Connects theory with nursing practice by exploring the science from the perspective of a fictional family Uses a rich array of full-colour figures, diagrams, and video material including interactive figures, animations and mini-tutorials – perfect for visual learners Full of engaging activities designed to complement self-directed learning. Supported by a collection of digital resources, including 170 online multiple choice questions, over 800 revision flashcards, and complete access to videos, animations, revision material and action plans. Ideal for revision and consolidating knowledge. Visit https://edge.sagepub.com/essentialaandp to find out more. Get 12 months FREE access to an interactive eBook* when you buy the paperback! (Print paperback version only, ISBN 9781473938465) Each purchase includes 12 months access to an interactive eBook version, meaning you can study when and how you want and make use of additional tools including search, highlighting, annotation note sharing and much more. *interactivity only available through Vitalsource eBook
The introduction by Brown and Brightman describes Nelson's career in the fur trade and explains the influences affecting his perception and understanding of Native religions. They also provide a comparative summary of Subarctic Algonquian religion, with emphasis on the beliefs and practices described by Nelson. Stan Cuthand, a Cree Anglican minister, author, and language instructor, who lived in Lac la Ronge in the 1940s, adds a commentary relating Nelson's writing to his own knowledge of Cree religion in Saskatchewan. Emma LaRoque, an author and instructor in Native Studies, presents a Native scholar's perspective on the ethics of publishing historical documents."--Amazon.com.
Protein engineering endeavors to design new peptides and proteins or to change the structural and/or functional characteristics of existing ones for specific purposes, opening the way for the development of new drugs. This work develops in a comprehensive way the theoretical formulation for the methods used in computer-assisted modeling and predictions, starting from the basic concepts and proceeding to the more sophisticated methods, such as Monte Carlo and molecular dynamics. An evaluation of the approximations inherent to the simulations will allow the reader to obtain a perspective of the possible deficiencies and difficulties and approach the task with realistic expectations. Examples from the authors laboratories, as well as from the literature provide useful information.
A comprehensive summary of species distribution modeling methods integrating ecological and statistical models with spatial data, and a framework for implementation.
We can all prevent virus, disease and fight infection using a simple yet powerful medicine - food. Understanding nutrition and correctly supplementing your diet is the key to boosting your immune system. Today, our immune systems also face a growing number of enemies, such as stress, pollution, pesticides and food additives. In BOOST YOUR IMMUNE SYSTEM, experts Jennifer Meek and Patrick Holford show you how to meet all these challenges in order to beat infections naturally, win the war against viruses, colds and flu, decrease your allergic potential, protect yourself against cancer, supplement for immune strength and much more. Easy to follow and practical, this book will help you stay free from disease, feel great and perform better.
Scott Heywood discovered oil in Jennings on September 21, 1901, starting a new industry for Louisiana. From the heart of Acadiana, oil fever spread north to Caddo and Pine Island, south to Hackberry and Cameron, east to Barataria and Lafourche, and into the Gulf of Mexico. The oil industry created a worker class in Louisiana that had not previously existed. Towns, complete with schools, churches, and grocery stores, developed in oil fields; in fact, cabins with clothes hanging on the line to dry were adjacent to derricks and open oil pits. Today, families proudly recount the number of their generations that have worked in the "oil patch," and workers continue to contribute to a current crude oil production of nearly 200,000 barrels per day. The legacy of Louisiana's first oil fields is evident in towns like Jennings, Evangeline, Oil City, Morgan City, Lake Charles, and Cameron, and the history of that once nascent industry is a permanent part of the culture of Louisiana.
In the first comprehensive study of African American war literature, Jennifer James analyzes fiction, poetry, autobiography, and histories about the major wars waged before the desegregation of the U.S. military in 1948. Examining literature about the Civil War, the Spanish-American Wars, World War I, and World War II, James introduces a range o...
The essential guide to anatomy and physiology for nursing students. The new edition of Essentials of Anatomy and Physiology for Nursing Practice brings together text, video, full-colour illustrations, interactive activities, and more, to provide nursing students with a comprehensive introduction to understanding the healthy functioning of the human body. This second edition has been thoroughly updated and includes new videos, improved online support, revised learning activities, and clear explanations that will help nursing students feel confident when learning anatomy and physiology for the first time. Key Features: Students can use their phone or tablet to scan QR codes throughout the book and instantly watch informative animations, mini-tutorials, and other useful videos. Introduces all the essential anatomy and physiology information in a carefully structured way, helping students to steadily build their knowledge and successfully apply it to nursing practice. All content is based around the person-centred nursing framework and a fictional family is used throughout to demonstrate how the biology applies to real people, helping students to apply the A&P knowledge directly to real-life nursing situations. Supported by new and improved online teaching and learning resources, including a teaching guide to the resources, a fully revised testbank, over 250 downloadable figures from the book, and a host of student resources such as multiple-choice questions and over 800 glossary flashcards to help aid revision. Essentials of Anatomy and Physiology for Nursing Practice is essential reading for all nursing students and nursing associate students learning anatomy and physiology for the first time.
Claire Danes" traces the New York native's enviable life and career from her childhood growing up in New York city's trendy Soho district with hippie-artist parents to her successful first year studying at Yale. Ambrose pays special tribute to Danes's big break: "My So-Called Life.
Contains over 450 entries that describe books that have female heroines; includes publishing information, a short overview of the plot, and recollections from famous women about what their favorite book was as a child.
Comprehensive index to current and retrospective biographical dictionaries and who's whos. Includes biographies on over 3 million people from the beginning of time through the present. It indexes current, readily available reference sources, as well as the most important retrospective and general works that cover both contemporary and historical figures.
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