Damselfish neurofibromatosis is a disease affecting bicolor damselfish (Stegastes partitus) of Caribbean reefs. The causative agent of this disease has been identified and is termed the damselfish virus-like agent (DVLA), a small previously uncharacterized DNA-containing agent whose extrachromosomal DNA genome adopts a complicated secondary structure. This body of work focused on characterizing the RNAs of this agent and determining the role these might play in tumor formation. Five distinctly sized RNAs (0.3, 0.55, 0.8, 1.0 and 1.4 kb) were identified within established cell lines and tissues infected with DVLA. These transcripts were arranged in an overlapping fashion and this arrangement prevented identification of the strand of transcription for all but the largest transcript. Two possible positions were proposed for this 1.4 kb transcript based on the results from the strand analysis. 5' RACE data identified a putative 5' end for one of these 1.4 kb transcripts, asyell as the 5' ends for two of the smaller transcripts (0.3 and 0.8 kb). A 3' end was identified for the other 1.4 kb transcript. This data suggested that both 1.4 kb-sized transcripts were in fact present within infected cell culture lines. Sequence analysis detected the presence of multiple potential open reading frames; however most were of a small size and poorly correlated with the positions of the RNA transcripts. No conserved domains or sequence homology to published protein sequence was found and no DVLA-specific proteins were detected in any analysis suggesting a possible alternative role for these RNAs. The intense secondary structure suggests that these RNAs may act by RNA interference pathways. All transcripts were present within tumor tissue of infected fish but subsets of this complete pattern were found in other non-tumored tissue. Non-tumored tissues were found to contain both DVLA RNA and DNA although this material was lost following growth of the tissue in culture suggesting that infection of these tissues is halted. Analysis of the DVLA RNA in vivo indicated a correlation between the 1.4 kb transcript(s) and the presence of tumors in infected fish possibly suggesting a role of these transcripts in the process of tumorigenesis.
An unforgettable true story, The Midwife is the basis for the hit PBS drama Call the Midwife At the age of twenty-two, Jennifer Worth leaves her comfortable home to move into a convent and become a midwife in post war London's East End slums. The colorful characters she meets while delivering babies all over London-from the plucky, warm-hearted nuns with whom she lives to the woman with twenty-four children who can't speak English to the prostitutes and dockers of the city's seedier side-illuminate a fascinating time in history. Beautifully written and utterly moving, The Midwife will touch the hearts of anyone who is, and everyone who has, a mother.
This volume contains 30 chapters that provide an up-to-date account of key topics and areas of research in political psychology. In general, the chapters apply what is known about human psychology to the study of politics. Chapters draw on theory and research on biopsychology, neuroscience, personality, psychopathology, evolutionary psychology, social psychology, developmental psychology, cognitive psychology, and intergroup relations. Some chapters address the political psychology of political elites-their personality, motives, beliefs, and leadership styles, and their judgments, decisions, and actions in domestic policy, foreign policy, international conflict, and conflict resolution. Other chapters deal with the dynamics of mass political behavior: voting, collective action, the influence of political communications, political socialization and civic education, group-based political behavior, social justice, and the political incorporation of immigrants. Research discussed in the volume is fuelled by a mix of age-old questions and recent world events"--
Comprehensive index to current and retrospective biographical dictionaries and who's whos. Includes biographies on over 3 million people from the beginning of time through the present. It indexes current, readily available reference sources, as well as the most important retrospective and general works that cover both contemporary and historical figures.
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