Jeffrey Schlom's Books

Cancer Immunotherapy

Chapter 20. Recombinant TRICOM-based Therapeutic Cancer Vaccines: Lessons Learned

By: Jeffrey Schlom,James W. Hodge,Claudia Palena,John W. Greiner,Kwong-Yok Tsang,Benedetto Farsaci,Ravi A. Madan,James L. Gulley

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Cancer Immunotherapy

Chapter 20. Recombinant TRICOM-based Therapeutic Cancer Vaccines: Lessons Learned

By: Jeffrey Schlom,James W. Hodge,Claudia Palena,John W. Greiner,Kwong-Yok Tsang,Benedetto Farsaci,Ravi A. Madan,James L. Gulley

This article reviews progress made in the design and development of recombinant poxviral-based vaccines that express transgenes for tumor-associated antigens (TAAs) and human T-cell co-stimulatory molecules (designated TRICOM). The TRICOM vaccine platform consists of priming with a recombinant vaccinia (rV-) vector and multiple boosts with a replication defective fowlpox (rF-) vector. The rV, rF-PSA-TRICOM (PROSTVAC) has demonstrated survival benefit in randomized trials. rV, rF-CEA-MUC1-TRICOM (PANVAC) has demonstrated evidence of benefit in patients with colorectal, breast and ovarian cancers. Preclinical studies with TRICOM-based vaccines have demonstrated their ability to be used in combination with anti-CTLA4 monoclonal antibody, radiation, chemotherapeutics, and small molecule targeted therapies to enhance vaccine-mediated immune responses and antitumor activity. Randomized clinical studies have been completed, are ongoing, and are planned employing several of these TRICOM vaccine combination therapies. The importance of trial design in terms of patient population and clinical trial endpoint has been demonstrated in these studies.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128059168

ISBN 13

9780128059166

Laparoscopic Colorectal Surgery

By: Jeffrey W. Milsom,Bartholomäus Böhm,Kiyokazu Nakajima

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Laparoscopic Colorectal Surgery

By: Jeffrey W. Milsom,Bartholomäus Böhm,Kiyokazu Nakajima

Laparoscopic Colorectal Surgery provides an authoritative, team-oriented approach to the latest state-of-the-art laparoscopic colorectal procedures and surgical techniques. Written by pioneers in the field, this text will supply surgeons with all the information necessary to accomplish advanced laparoscopic procedures. Comprehensive discussions of positioning, instrumentation, cannulas, surgical techniques, special considerations, and considerations in cancer surgery are featured for a wide variety of major operative procedures, including - smallbowel resection - abdominoperineal resection - ileocolectomy, right colectomy, and total abdominal colectomy - proctosigmoidectomy - stoma construction and closure using laparoscopic techniques.

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Page Count

311

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1475725329

ISBN 13

9781475725322

Computational Methods for Large Systems

Electronic Structure Approaches for Biotechnology and Nanotechnology

By: Jeffrey R. Reimers

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Computational Methods for Large Systems

Electronic Structure Approaches for Biotechnology and Nanotechnology

By: Jeffrey R. Reimers

While its results normally complement the information obtained by chemical experiments, computer computations can in some cases predict unobserved chemical phenomena Electronic-Structure Computational Methods for Large Systems gives readers a simple description of modern electronic-structure techniques. It shows what techniques are pertinent for particular problems in biotechnology and nanotechnology and provides a balanced treatment of topics that teach strengths and weaknesses, appropriate and inappropriate methods. It’s a book that will enhance the your calculating confidence and improve your ability to predict new effects and solve new problems.

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Page Count

568

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470934727

ISBN 13

9780470934722

Book's by Jeffrey Schlom

Cancer Immunotherapy

Cancer Immunotherapy

Laparoscopic Colorectal Surgery

Laparoscopic Colorectal Surgery

Computational Methods for Large Systems

Computational Methods for Large Systems

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