The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.
Now totally revised and rewritten for today’s female pelvic medicine and reconstructive surgery practice, Ostergard’s Textbook of Urogynecology: Female Pelvic Medicine & Reconstructive Surgery, 7th Edition, offers comprehensive guidance on all aspects of this complex field. Drs. Ali Azadi, Jeffrey L. Cornella, Peter L. Dwyer, and Felicia L. Lane bring you up to date with current diagnosis and treatment of all female pelvic floor dysfunctions, including urinary incontinence and other lower urinary tract conditions, disorders of the anus and rectum, and disorders of pelvic support. Thorough updates include revised and rewritten content throughout, new full-color illustrations, new surgical videos, new chapters on current clinical topics, and much more.
Comprehensive and complete, Shackelford’s Surgery of the Alimentary Tract delivers the definitive, clinically oriented, cutting-edge guidance you need to achieve optimal outcomes managing the entire spectrum of gastrointestinal disorders. Make effective use of the latest endoscopic, robotic, and minimally invasive procedures as well as medical therapies with unbeatable advice from a "who’s who" of international authorities! Find expert answers to any clinical question in gastrointestinal surgery, from the esophagus to the colon. See exactly what to look for and how to proceed from an abundance of beautifully detailed intraoperative and laparoscopic photographs.
A fresh look at the issue of Privatizing the government. This book looks at the history of government and government organizations from the beginning through the period of Re-invention. The issue of privatization is not seen as the end all to solve governments problems rather it is seen as just one tool available to the politicians and government managers. Privatization is viewed as one method of improving management in government by removing many political constraints and barriers from the government manager. This book looks at the specific example of privatizing the nations Air Traffic Control System. A system that has a history of inefficiency, cost overruns, and resistance to change yet it enjoys a solid political backing which continues to offer it protection from privatization. The last part of the book offers some recommendations for long term change by establishing a commission on privatization.
This volume focuses on constitutional ratification, the procedure in which a draft constitution is submitted by its creators to the people or their representatives in an up or down vote determining implementation. Ratification is increasingly common and routinely recommended by experts. Nonetheless, it is neither neutral nor inevitable. Constitutions can be made without it and when it is used it has significant effects. This raises the central question of the book: should ratification be recommended? Put another way: is there a reason for treating the procedure as a default for the constitution-making process? Surprisingly, these questions are rarely asked. The procedure's worth is assumed, not demonstrated, while ratification is generally overlooked in the literature. In fact, this is the first sustained study of ratification. To address these oversights, this book defines ratification and its types, explains the procedure's effects, conceptual origins, and history, and then concentrates on finding reasons for its use. Specifically, it builds up and analyzes the three most likely normative justifications. These urge the implementation of ratification because the procedure: enables the constituent power to make its constitution; fosters representation during constitution-making; or helps create a legitimate constitution. Ultimately, these justifications are found wanting, leading to the conclusion that ratification lacks a convincing, context-independent justification. Thus, until new arguments are developed, experts should not give recommendations for ratification as a matter of course, practitioners should not reach for it uncritically, and-more generally-one should avoid the blanket application of concepts from democratic theory to extraordinary contexts such as constitution-making.
Newt Gingrich is one of the most polarizing and consequential figures in US politics. First elected to the House of Representatives in 1978, he rose from a minority party backbencher to become the first Republican Speaker of the House in forty years. Though much has been written about Gingrich, accounts of his time in Congress are incomplete and often skewed. In their book Newt Gingrich: The Rise and Fall of a Party Entrepreneur, political scientists Matthew N. Green and Jeffrey Crouch draw from newly uncovered archival material, original interviews, and other data to provide a fresh and insightful look at Gingrich’s entire congressional career. Green and Crouch argue that Gingrich is best understood as a “party entrepreneur,” someone who works primarily to achieve their congressional party’s collective goals. From the moment he entered Congress, Gingrich was laser-focused on achieving two party-related objectives—a Republican majority in the House and a more conservative society—as well as greater influence for himself. Using a conceptual framework taken from theories of military strategy, the authors explain how Gingrich initially struggled because of a mismatch between his lofty goals and the resources available to him. After years of patiently cultivating allies, tempering his immediate objectives, and waiting for favorable circumstances to emerge, Gingrich finally claimed victory in 1994, with Republicans winning control of the House and electing Gingrich as Speaker. Yet while Gingrich had been creative, patient, and ultimately successful at gaining power for himself and his party, he proved ineffective at balancing his goals with the demands of the Speakership, and he resigned from Congress just four years later. Newt Gingrich: The Rise and Fall of a Party Entrepreneur, the latest contribution to the Congressional Leaders series, sheds new light on a historically important congressional leader whose complicated legacy is still debated today by scholars, journalists, and politicians.
Uncertainty surrounds every major decision in international politics. Yet there is almost always room for reasonable people to disagree about what that uncertainty entails. No one can reliably predict the outbreak of armed conflict, forecast economic recessions, anticipate terrorist attacks, or estimate the countless other risks that shape foreign policy choices. Many scholars and practitioners therefore believe that it is better to keep foreign policy debates focused on the facts - that it is, at best, a waste of time to debate uncertain judgments that will often prove to be wrong. In War and Chance, Jeffrey A. Friedman shows how foreign policy officials often try to avoid the challenge of assessing uncertainty, and argues that this behavior undermines high-stakes decision making. Drawing on an innovative combination of historical and experimental evidence, he explains how foreign policy analysts can assess uncertainty in a manner that is theoretically coherent, empirically meaningful, politically defensible, practically useful, and sometimes logically necessary for making sound choices. Each of these claims contradicts widespread skepticism about the value of probabilistic reasoning in international politics, and shows how placing greater emphasis on assessing uncertainty can improve nearly any foreign policy debate. A clear-eyed examination of the logic, psychology, and politics of assessing uncertainty, War and Chance provides scholars and practitioners with new foundations for understanding one of the most controversial elements of foreign policy discourse.
Consult the leading text in the field that delivers the information you need to diagnose and treat pediatric gastrointestinal and liver diseases effectively. In one convenient and comprehensive volume, Drs. Robert Wyllie, Jeffrey S. Hyams, and Marsha Kay provide all the latest details on the most effective new therapies, new drugs, and new techniques in the specialty. In addition, the new two-color design throughout helps you find what you need quickly and easily. Full-color endoscopy images to help improve your visual recognition Definitive guidance from renowned international contributors who share their knowledge and expertise in this complex field Detailed diagrams that accurately illustrate complex concepts and provide at-a-glance recognition of disease processes More than 400 board review-style questions, answers, and rationales New therapies for hepatitis B and C, new drugs for the treatment of inflammatory bowel disease, and an expanded discussion of the newest endoscopic and motility techniques available for pediatric patients The most current information on diagnosing and treating abnormalities of protein, fat, and carbohydrate metabolism New chapters on pancreatic transplantation and liver pathology The latest surgical techniques for children with gastrointestinal conditions
Consult the leading text in the field that delivers the information you need to diagnose and treat pediatric gastrointestinal and liver diseases effectively. In one convenient and comprehensive volume, Drs. Robert Wyllie, Jeffrey S. Hyams, and Marsha Kay provide all the latest details on the most effective new therapies, new drugs, and new techniques in the specialty. In addition, the new two-color design throughout helps you find what you need quickly and easily. Full-color endoscopy images to help improve your visual recognition Definitive guidance from renowned international contributors who share their knowledge and expertise in this complex field Detailed diagrams that accurately illustrate complex concepts and provide at-a-glance recognition of disease processes More than 400 board review-style questions, answers, and rationales available in the eBook included with your purchase New therapies for hepatitis B and C, new drugs for the treatment of inflammatory bowel disease, and an expanded discussion of the newest endoscopic and motility techniques available for pediatric patients The most current information on diagnosing and treating abnormalities of protein, fat, and carbohydrate metabolism New chapters on pancreatic transplantation and liver pathology The latest surgical techniques for children with gastrointestinal conditions
This is your step-by-step guide on how to write successful research proposals in the health sciences, whether it is for a thesis or dissertation review committee, an ethical review committee or a grant funding committee. Using quantitative, qualitative, and mixed research approaches, follow the journey of Liang and Natasha, two fictional researchers who will help you complete your proposal alongside reading the chapters. This practical guide includes top tips from the authors, read-reflect-respond activities and examples of project plans to equip you with all the tools you need to succeed with your research proposal.
The BEST EDITION yet of the #1 text for surgical practice and education A Doody's Core Title for 2022! For half-a-century, no other text has provided such a solid grounding in basic science, anatomy, operative techniques, and more recently, professional development and leadership training, as Schwartz’s Principles of Surgery. Written by the world’s foremost surgeons, this landmark reference offers distinctly modern and all-encompassing coverage of every important topic in general surgery. Enhanced by a new two volume presentation, the Eleventh Edition has been completely updated and refreshed with an emphasis on state-of-the-art, evidence-based surgical care. You will find an exciting array of new contributors from around the world, new chapters on cutting-edge topics, plus the acclaimed learning aids that make the material easier to understand and memorize. This outstanding content is bolstered by more than 800 photographs and 1,300 line drawings, most in full color, as well as online videos demonstrating key operations. Here’s why the Eleventh Edition is the best edition yet: Six timely new chapters on important topics such as enhanced recovery after surgery (ERAS), ambulatory/outpatient surgery, evidence for surgery practice, skills and simulation, and web-based education and social media High-quality full-color design showcases an unsurpassed illustration program Emphasis on high-yield discussion of diagnosis and treatment of surgical disease, arranged by organ system and surgical specialty Acclaimed learning aids (many new to this edition), including an abundance of completely up-to-date tables that summarize the most current evidence, boxed key points, detailed anatomical figures, diagnostic and management algorithms, and an abundance of completely up-to-date tables, and key references More than the field’s cornerstone textbook, Schwartz’s Principles of Surgery is an international compendium of the knowledge and technique of the world’s leading surgeons.
This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Premium Edition includes access to the complete contents of the book online, fully searchable and updated quarterly by Dr. Hoffman himself. - Publisher.
Explore this concise and clinically focused approach to the field of blood banking and transfusion therapy The Fifth Edition of Transfusion Medicine delivers a succinct, thorough, clinically focused, practical and authoritative treatment of a full range of topics in transfusion therapy. This ranges from issues with the blood supply, recruitment of both whole blood and apheresis donors, blood collection and storage, blood testing, blood safety, and transmissible diseases. This edition has been fully updated and revised to include exciting cellular therapies for cancer, transplantation of both hematopoietic cells and solid organs, infectious diseases and regenerative medicine. The Fifth Edition includes new authors with highly relevant content that provides a solid grounding for readers in the field. The book: Is an approachable comprehensive guide to the field of blood banking and transfusion medicine Provides complete and timely perspective on crucial topics, including the HLA system in transfusion medicine and transplantation and quality programs in blood banking and transfusion medicine Is extensively referenced, making it simple for readers to conduct further research on the topics of interest to them Includes new chapters on pediatric transfusion medicine and pathogen reduction Has an expended chapter on patient blood management Provides extensive discussions of the clinical use of blood transfusion in a wide variety of clinical situations including recent development In the management of acute traumatic blood loss Provides updated information about blood groups and molecular testing making inroads into clinical practice along with discussions of laboratory detection of blood groups and provision of red cells Perfect for all those working in the field of blood banking, transfusion medicine and hematology or oncology and fellows in pathology, hematology, surgery and anesthesiology. Transfusion Medicine is a good introduction for technologists specializing in blood banking and non-medical personnel working in areas related to hematology and transfusion medicine. Transfusion Medicine will also earn a place in the libraries of practicing pathologists with responsibility for blood banks.
The Hematology: Diagnosis and Treatment eBook is the ideal mobile resource in hematology! It distills the most essential, practical information from Hematology: Basic Principles and Practice, 6th Edition - the comprehensive masterwork by Drs. Hoffman, Benz, Silberstein, Heslop, Weitz, and Anastasi - into a concise, clinically focused resource that's optimized for reference on any e-reader. Focusing on the dependable, state-of-the-art clinical strategies you need to optimally diagnose and manage the full range of blood diseases and disorders, this eBook is a must-have for every hematologist's mobile device! Apply the latest know-how on heparin-induced thrombocytopenia, stroke, acute coronary syndromes, hematologic manifestations of liver disease, hematologic manifestations of cancer, hematology in aging, and many other hot topics. Get quick, focused answers on the diagnosis and management of blood diseases - in a portable digital format that you can carry and consult anytime, anywhere. View abundant images that mirror the pivotal role hematopathology plays in the practice of modern hematology. Count on all the authority that has made Hematology: Basic Principles and Practice, 6th Edition, edited by Drs. Hoffman, Benz, Silberstein, Heslop, Weitz, and Anastasi, the go-to clinical reference for hematologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.
Elsevier now offers a series of derivative works based on the acclaimed Meyler’s Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician. This volume is essential for internal medicine physicians and general practitioners who prescribe antibiotic drugs, like penicillin and tetracycline that cure bacterial infections, and antiviral drugs used to treat patients with HIV and herpes viruses. The only drug guide that includes clinical case studies and expert analysis UNIQUE! Features not only antimicrobial drugs, but also all other drugs that act in an anti-microbial manner Most complete cross referencing of drug-drug interactions available Latest content from the most highly regarded compilation of drug side effects: Side Effects of Drugs Annual serial
This issue of Medical Clinics covers the current best practices surrounding the perioperative management of patients with chronic diseases. Guest edited by Jeffrey Kirsch and Ansgar Brambrink, the topics covered will include patients with pacemakers, patients with endocrine disease, immunocompromised patients, patients with heart disease, patients with renal disease, and more.
Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.
Written by leading authorities in database and Web technologies, this book is essential reading for students and practitioners alike. The popularity of the Web and Internet commerce provides many extremely large datasets from which information can be gleaned by data mining. This book focuses on practical algorithms that have been used to solve key problems in data mining and can be applied successfully to even the largest datasets. It begins with a discussion of the MapReduce framework, an important tool for parallelizing algorithms automatically. The authors explain the tricks of locality-sensitive hashing and stream-processing algorithms for mining data that arrives too fast for exhaustive processing. Other chapters cover the PageRank idea and related tricks for organizing the Web, the problems of finding frequent itemsets, and clustering. This third edition includes new and extended coverage on decision trees, deep learning, and mining social-network graphs.
Jeffrey McCullough offers a concise, clinically focused and practical approach to this important area of medicine. This book offers complete guidance on the full range of topics from donor recruitment, blood collection and storage, to testing and transfusing blood components, complications and transmissible diseases, as well as cellular engineering, therapeutic apheresis, and the role of hematopoietic growth factors. It is a good introduction to transfusion for hematology or oncology fellows and technologists specialising in blood banking.
This issue of Immunology and Allergy Clinics provides the latest essential updates in interstitial lung diseases and autoimmune lung diseases. This comprehensive issue covers causes, symptoms, diagnosis, and treatment.
This book, written by an experienced urban classroom teacher and coach, aims to document effective practices in urban schools and to provide insight into productive program building and educational practices. The book rejects the up-by-your-bootstraps theory of success, offering in its place a set of concrete strategies for teachers and educational leaders who are committed to fundamentally rethinking the business-as-usual approach which continues to fail urban school children. This book is well-suited for classes working with educational leaders, classroom teachers, sports coaches, and educational researchers.
This thoroughly updated and expanded second edition continues to be the singular reference for comprehensive clinical instruction in the use of high-frequency ultrasound for assessing peripheral nerves and their disorders, particularly focal neuropathies. Revised to integrate current advances in the field, new applications, and next-generation equipment, this top of the line text uses a "how-to" approach to describe clinical evaluation, inclusive of both normal and pathological findings with discussions of relevant non-neurologic tissue. The book begins with a review in ultrasound physics, instrumentation, image optimization, and anatomy before presenting a highly visual tour through multiple nerves of the neck, shoulder, and upper and lower limbs with new chapters on the evaluation of muscle and ultrasound guided principles. Anatomical chapters have been substantially updated to feature additional nerves and advanced concepts with updated drawings and unprecedented visualization of smaller nerve segments captured by cutting-edge equipment. Chapters include clinical cases unique to this edition that demonstrate the use of ultrasound in conjunction with clinical and electrophysiologic assessment to optimize diagnosis. In-text video callouts directly connect chapter content to over 430 detailed video examinations accessible online to better facilitate understanding of the ultrasound image. The definitive reference on peripheral nerve ultrasound and focal neuropathies, this practical text and atlas is the prime resource for neurologists, physiatrists, radiologists, sports medicine physicians, and other providers seeking to combine ultrasound with electrodiagnosis for entrapments of the upper and lower limbs. Key Features: Utilizes a "how-to" skills approach for imaging peripheral nerves with ultrasound and understanding anatomic, clinical, electrodiagnostic, and imaging considerations for focal neuropathies Thoroughly revised and updated Second Edition New chapters on imaging muscle and ultrasound-guided procedure Introduces ultra-high frequency imaging with many new sections covering less commonly scanned and smaller nerves Incorporates brand new clinical cases throughout to survey an array of disorders and conditions including an extended series on foot drop Includes hundreds of detailed anatomical drawings and state-of-the-art images with corresponding videos online New audiovisual EMG waveforms provided by Ernest W. Johnson, MD Purchase includes digital access for use on most mobile devices or computers
The #1 surgical practice and education resource -- completely updated and now in full-color! A Doody's Core Title ESSENTIAL PURCHASE for 2011! 4 STAR DOODY'S REVIEW! "In its evolution over nine editions, Schwartz's Principles of Surgery has reflected the latest in surgical practice. In the age of minimally invasive surgery, illustrations are important and these authors include a wealth of visual material of good to excellent quality."--Doody's Review Service Written by the world's foremost practitioners and instructors, this landmark reference logically progresses from basic science principles, including topics such as cells, genomics, and molecular surgery, to clinical areas such as pancreas. From cover to cover, the book reflects a distinctly modern approach in the dissemination of surgical knowledge, providing up-to-date coverage of all key surgical areas, from trauma and transplantation, to neurosurgery. In each chapter, this content is supported by a skill-building format that includes boxed key points, detailed anatomical figures, diagnostic and management algorithms, an abundance of informative tables, and key references. For every kind of procedure, this one-of-a-kind clinical companion helps you meet the sequential demands in the care of surgical patients, leading to the best possible outcomes. NEW TO THIS EDITION: Full color design for easier navigation 2 new chapters: “Accreditation Council for Graduate Medical Core Competencies,” examines the six areas designated as critical for general surgery resident training and “Ethics, Palliative Care, and Care at the End of Life,” offers an overview of biomedical ethics, and surveys specific issues in surgical and professional ethics, the general principles and considerations of palliative care, and care at the end of life Greater focus on evidence-based medicine with highlighted references in each chapter and separate key reference list Increased number of treatment and diagnostic algorithms Key points in every chapter International advisory board comprising renowned surgeons contributes important regional feedback on content and curricula Companion DVD of surgical video clips
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