A comprehensive resource on case studies of marketed kinase drugs and promising drug trials Since the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the treatment of chronic myelogenous leukemia and seven additional marketed kinase inhibitor drugs, researchers have compelling evidence that kinase inhibitors can be highly efficacious in the treatment of diseases caused by aberrant activity of protein kinase. Currently more than 100 protein kinase inhibitors are in clinical development. In one comprehensive volume, the editors, Dr. Rongshi Li and Dr. Jeffrey Stafford, present timely and important case studies of marketed kinase drugs and several of the most advanced kinase inhibitors in clinical trials. Kinase Inhibitor Drugs includes: Case studies from leading investigators and experts in the field that provide firsthand accounts of kinase inhibitor discovery Current thinking on kinase structure, biochemistry, and signal transduction pathways Information on state-of-the-art technologies and tools such as structure-based and fragment-based drug discovery A lineup of clinical-phase growth factor receptor inhibitors Inhibitors of cell cycle kinases The discovery of allosteric inhibitors of MEK kinase Information on pharmacogenomics and its application to kinase inhibitor clinical development
As large-scale emergencies continue to pose a threat to U.S. populations at the local, state, and national levels, the public and private sectors are demanding improved public health preparedness, response, and cooperation for such events. Emergency Public Health provides readers with important information and analysis of key public health crises threatening our local, state, and national jurisdictions. As the first text of its kind in the emerging field of emergency public health, it provides a framework for public health professionals, policy makers, first responders, and emergency healthcare providers to plan and implement effective measures to protect the public health of civilian populations during times of emergencies. Written by experts with both emergency healthcare and public health backgrounds, the case-based chapters provide valuable information on the preparedness, response, and mitigation of emergency public health topics. In addition, Emergency Public Health contains timely information of key areas such as public health law and the interactions among government jurisdictions. Each chapter also includes online resources for the reader to pursue additional web-based resources. Important features: - Chapters written by emergency physicians with public health degrees - Case-based chapters - Web resources provided - Covers large-scale issues such as public health law, government jurisdictions, NGO’s, - Chapter devoted to specific needs of children - Chapter on mental health issues in times of public health emergencies - Specific chapters on public health tools such as surveillance and rapid needs assessment - Each chapter follows a consistent structure to maintain clarity and continuity throughout the text: A. Introduction B. Historical perspectives C. Preparedness D. Response E. Case study F. On-line resources Competitive features: - Covers natural emergencies - Covers key topics in terrorism - Covers primary topics for disaster medicine Questions for instructors - What are the key topics in your course? - How do you like to prepare your students for public health emergencies? - What management principles are addressed in your course? - Do you teach special issues such as children and mental health issues during emergencies?
Darius Hubert (1823‒1893), a French-born Jesuit, made his home in Louisiana in the 1840s and served churches and schools in Grand Coteau, Baton Rouge, and New Orleans. In 1861, he pronounced a blessing at the Louisiana Secession Convention and became the first chaplain of any denomination appointed to Confederate service. Hubert served with the First Louisiana Infantry in Robert E. Lee’s Army of Northern Virginia for the entirety of the war, afterward returning to New Orleans, where he continued his ministry among veterans as a trusted pastor and comrade. One of just three full-time Catholic chaplains in Lee’s army, only Hubert returned permanently to the South after surrender. In postwar New Orleans, he was unanimously elected chaplain of the veterans of the eastern campaign and became well-known for his eloquent public prayers at memorial events, funerals of prominent figures such as Jefferson Davis, and dedications of Confederate monuments. In this first-ever biography of Hubert, Katherine Bentley Jeffrey offers a far-reaching account of his extraordinary life. Born in revolutionary France, Hubert entered the Society of Jesus as a young man and left his homeland with fellow Jesuits to join the New Orleans mission. In antebellum Louisiana, he interacted with slaves and free people of color, felt the effects of anti-Catholic and anti-Jesuit propaganda, experienced disputes and dysfunction with the trustees of his Baton Rouge church, and survived a near-fatal encounter with Know-Nothing vigilantism. As a chaplain with the Army of Northern Virginia, Hubert witnessed harrowing battles and their equally traumatic aftermath in surgeons’ tents and hospitals. After the war, he was a spiritual director, friend, mentor, and intermediary in the fractious and politically divided Crescent City, where he both honored Confederate memory and promoted reconciliation and social harmony. Hubert’s complicated and tumultuous life is notable both for its connection to the most compelling events of the era and its illumination of the complex and unexpected ways religion intersected with politics, war, and war’s repercussions.
Pediatric Gastrointestinal and Liver Disease, by Drs. Robert Wyllie and Jeffrey S. Hyams provides the comprehensive reference you need to treat GI diseases in children. Review the latest developments in the field and get up-to-date clinical information on hot topics like polyps, capsule endoscopy, and pancreatic treatments. With expert guidance from an expanded international author base and online access to 475 board-review-style questions, this latest edition is a must-have for every practicing gastroenterologist. Confirm each diagnosis by consulting a section, organized by symptoms, that presents the full range of differential diagnoses and treatment options for each specific condition. Recognize disease processes at a glance with detailed diagrams that accurately illustrate complex concepts. Stay current with advances in the field by reviewing new chapters on Polyps and Polyposis Syndromes, Capsule Endoscopy and Small Bowel Enteroscopy, Small Bowel Transplantation, IBD, Short Gut Syndrome, Steatosis and Non-Alcoholic Fatty Liver Disease, and Pancreatic and Islet Cell Transplants. Gain fresh global perspectives from an expanded list of expert international contributors. Sharpen your visual recognition by accessing a color-plate section that displays additional endoscopy images. Prepare for certification or recertification with 475 online board review-style questions, answers, and rationales.
Offering a comprehensive, multidisciplinary approach to head and neck oncology, Cancer of the Head and Neck, Fifth Edition, delivers authoritative guidance to the entire head and neck cancer care team. Retaining an expert surgical focus that has made it a classic in the field, this edition incorporates new disease- and site-specific chapters as well as a greater emphasis on reconstruction and rehabilitation. Written and edited by globally renowned head and neck surgeons, it’s an indispensable resource for practitioners, trainees, and other health care professionals who care for patients with head and neck cancer.
Market abuse and insider dealing remains and always has been a real concern for all those that operate in the financial sector. Some of the earliest laws relating to trade outlaw attempts to artificially interfere with the proper functions of the markets and ensure fairness. With recent changes to both the UK and European regimes the line between what is normal (and sensible) business practice and what may now be classified as market abuse is becoming increasingly fine. This raises questions about communications between financial institutions and investors, and about corporate and analyst access. Market Abuse and Insider Dealing provides guidance on and explanation of the range of potential legal and regulatory responses to this complex area of law. Providing a thorough analysis and assessment of the law relating to market abuse and insider dealing, the new fourth edition includes: - analysis of the impact of Brexit - significant new case law and legislation including MiFID II; Money Laundering Regulations 2017; the Money Laundering, Terrorist Financing and Transfer of Funds (Information on the Payer) Regulations 2017; Criminal Finances Act 2017 with Unexplained Wealth Orders; The Fifth Money Laundering Directive - the new Corporate Governance Code - new content on: control and senior managers' responsibility/liability; the FCAs competition law jurisdiction where it is appropriate to do so in relation to market abuse; a new table of UK decided market abuse cases This title is included in Bloomsbury Professional's Banking and Finance Law online service.
Since the early 1970s, observers have noted that complying with environmental regulations might be a significant new factor in determining the locations of industries involved in world trade. Two related hypotheses have been offered to explain how environmental regulations are altering international comparative advantage in industrial production: first, that stringent regulations push industries out of the United States and other advanced industrial nations; second, that less developed countries compete to attract multinational industries by minimizing their own regulations.
Jeff Selingo, journalist and editor-in-chief of the Chronicle for Higher Education, argues that colleges can no longer sell a four-year degree as the ticket to success in life. College (Un)Bound exposes the dire pitfalls in the current state of higher education for anyone concerned with intellectual and financial future of America.
Biosecurity and Bioterrorism is the first book to take a holistic approach to biosecurity with coverage of pathogens, prevention and response methodology. The book is organized into four thematic sections: Part I provides a conceptual understanding of biowarfare, bioterrorism and the laws we have to counteract this; Part II investigates known bioagents and the threat from emerging diseases; Part III focuses on agricultural terrorism and food security; Part IV outlines international, US, and local initiatives for biodefense and biosecurity. Case studies illustrate biodefense against both intentional terrorism and natural outbreaks. The authors bring an extraordinary combination of experience in academia and the clinical world, as well as real-world experience in technical and practical matters, to their writing. They make technical material clear and fascinating for readers with a basic knowledge of biology. Ryan and Glarum address the hazards in the context of vulnerability assessments and the planning strategies government and industry can take to prepare for and respond to such events. How are these agents used in biowarfare? How likely are we to face either a natural outbreak or intentional human/animal infection? How can we prepare for this effectively?
TRB's National Cooperative Highway Research Program (NCHRP) Synthesis 391: Public Sector Decision Making for Public-Private Partnerships examines information designed to evaluate the benefits and risks associated with allowing the private sector to have a greater role in financing and developing highway infrastructure"--Publisher's description.
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